CT-Finder: A Web Service for CRISPR Optimal Target Prediction and Visualization.

abstract：:IL-37 is a novel pro-angiogenic cytokine that potently promotes endothelial cell activation and pathological angiogenesis in our previous study, but the mechanisms behind the pro-angiogenic effect of IL-37 are less well understood. Extending our observations, we found that TGF-β interacts with IL-37, and potently enha...

journal_title：Scientific reports

authors： Zhao M,Hu Y,Jin J,Yu Y,Zhang S,Cao J,Zhai Y,Wei R,Shou J,Cai W,Liu S,Yang X,Xu GT,Yang J,Corry DB,Su SB,Liu X,Yang T

更新日期：2017-07-21 00:00:00

abstract：:We investigate the refractive error after phacovitrectomy for rhegmatogenous retinal detachment (RRD; 100 eyes) and epiretinal membrane (ERM; 102 eyes). Axial lengths were measured by optical biometry in most patients. The main outcome measures were the refractive and absolute prediction errors. The overall mean refra...

journal_title：Scientific reports

authors： Shiraki N,Wakabayashi T,Sakaguchi H,Nishida K

更新日期：2018-07-27 00:00:00

abstract：:While the Wnt/β-catenin pathway plays a critical role in the maintenance of the zonation of ammonia metabolizing enzymes in the adult liver, the mechanisms responsible for inducing zonation in the embryo are not well understood. Herein we address the spatiotemporal role of the Wnt/β-catenin pathway in the development ...

journal_title：Scientific reports

authors： Burke ZD,Reed KR,Yeh SW,Meniel V,Sansom OJ,Clarke AR,Tosh D

更新日期：2018-02-09 00:00:00

abstract：:Although diatoms have been extensively studied as bioreactors, only a limited number of efficient gene promoters are available. Therefore, the development of new endogenous promoters is important for the heterologous production of a variety of recombinant proteins. Herein, we identified the most abundant secreted prot...

journal_title：Scientific reports

authors： Erdene-Ochir E,Shin BK,Kwon B,Jung C,Pan CH

更新日期：2019-07-09 00:00:00

abstract：:In the aftermath of the financial crisis of 2007-2009, the growing body of literature on financial networks has widely documented the predictive power of topological characteristics (e.g., degree centrality measures) to explain the systemic impact or systemic exposure of financial institutions. This study shows that c...

journal_title：Scientific reports

authors： Gandica Y,Béreau S,Gnabo JY

更新日期：2020-10-19 00:00:00

abstract：:Anemia is commonly seen in preterm infants. It may reduce the capacity of hemoglobin to transport oxygen throughout the body and may result in tissue and organ dysfunction. This study aimed to investigate the effect of anemia on the development of bronchopulmonary dysplasia (BPD) in preterm infants. 243 infants who we...

journal_title：Scientific reports

authors： Duan J,Kong X,Li Q,Hua S,Zhang S,Zhang X,Feng Z

更新日期：2016-03-03 00:00:00

abstract：:Ctenodactylinae (gundis) is a clade of rodents that experienced, in Miocene time, their greatest diversification and widest distribution. They expanded from the Far East, their area of origin, to Africa, which they entered from what would become the Arabian Peninsula. Questions concerning the origin of African Ctenoda...

journal_title：Scientific reports

authors： López-Antoñanzas R,Knoll F,Maksoud S,Azar D

更新日期：2015-08-07 00:00:00

abstract：:Cardiac damage associated with iron overload is the most common cause of morbidity and mortality in patients with hereditary hemochromatosis, but the precise mechanisms leading to disease progression are largely unexplored. Here we investigated the effects of iron overload and age on cardiac hypertrophy using 1-, 5- a...

journal_title：Scientific reports

authors： Sukumaran A,Chang J,Han M,Mintri S,Khaw BA,Kim J

更新日期：2017-07-18 00:00:00

abstract：:Mammalian sperm are unable to fertilize the egg immediately after ejaculation. To gain fertilization competence, they need to undergo a series of modifications inside the female reproductive tract, known as capacitation. Capacitation involves several molecular events such as phosphorylation cascades, hyperpolarization...

journal_title：Scientific reports

authors： Ritagliati C,Luque GM,Stival C,Baro Graf C,Buffone MG,Krapf D

更新日期：2018-09-06 00:00:00

abstract：:Separation of enantiomers by flows is a promising chiral resolution method using cost-effective microfluidics. Notwithstanding a number of experimental and numerical studies, a fundamental understanding still remains elusive, and an important question as to whether it is possible to specify common physical properties ...

journal_title：Scientific reports

authors： Ro S,Yi J,Kim YW

更新日期：2016-10-14 00:00:00

abstract：:MicroRNAs are a class of small noncoding RNAs that regulate gene expression post-transcriptionally either by inhibiting protein translation or by causing the degradation of target mRNAs. Current evidence indicates that miR-33b is involved in the regulation of lipid metabolism, cholesterol homeostasis, glucose metaboli...

journal_title：Scientific reports

authors： Lin Y,Liu AY,Fan C,Zheng H,Li Y,Zhang C,Wu S,Yu D,Huang Z,Liu F,Luo Q,Yang CJ,Ouyang G

更新日期：2015-04-28 00:00:00

abstract：:The increasing demand for healthy baked goods boosted studies on sourdough microbiota with beneficial metabolic traits, to be used as potential functional starters. Here, 139 yeasts isolated from cereal-based fermented foods were in vitro characterized for their phytase and antioxidant activities. The molecular charac...

journal_title：Scientific reports

authors： Palla M,Blandino M,Grassi A,Giordano D,Sgherri C,Quartacci MF,Reyneri A,Agnolucci M,Giovannetti M

更新日期：2020-07-30 00:00:00

abstract：:Most studies on ungulate reproduction have focused on the covariates of male reproductive success, while there is much less information on female tactics of mate choice. The aim of this work is to fill this gap and to assess condition-dependent variations in female tactics in a lekking fallow deer (Dama dama) populati...

journal_title：Scientific reports

authors： Imperio S,Lombardi S,De Marinis A,Ronchi F,Santini G,Focardi S

更新日期：2020-02-27 00:00:00

abstract：:Reef coral assemblages are highly dynamic and subject to repeated disturbances, which are predicted to increase in response to climate change. Consequently there is an urgent need to improve our understanding of the mechanisms underlying different recovery scenarios. Recent work has demonstrated that reef structural c...

journal_title：Scientific reports

authors： Hata T,Madin JS,Cumbo VR,Denny M,Figueiredo J,Harii S,Thomas CJ,Baird AH

更新日期：2017-05-22 00:00:00

abstract：:We propose a novel class of mixed fluctuations with different orientations and fractal scaling features as a model for anisotropic two-dimensional (2D) trajectories hypothesized to appear in complex systems. Furthermore, we develop the oriented fractal scaling component analysis (OFSCA) to decompose such mixed fluctua...

journal_title：Scientific reports

authors： Seleznov I,Popov A,Kikuchi K,Kolosova E,Kolomiiets B,Nakata A,Kaneko M,Kiyono K

更新日期：2020-12-14 00:00:00

abstract：:Several microbes, including Staphylococcus epidermidis (S. epidermidis), a Gram-positive bacterium, live inside the human nasal cavity as commensals. The role of these nasal commensals in host innate immunity is largely unknown, although bacterial interference in the nasal microbiome may promote ecological competition...

journal_title：Scientific reports

authors： Chen HW,Liu PF,Liu YT,Kuo S,Zhang XQ,Schooley RT,Rohde H,Gallo RL,Huang CM

更新日期：2016-06-16 00:00:00

abstract：:Asymmetric cell divisions are of fundamental importance for the development of multicellular organisms, e.g. for the generation of founder cells. Prime examples are asymmetric cell divisions in germline precursors during the early embryogenesis of the transparent roundworm Caenorhabditis elegans, one of the major deve...

journal_title：Scientific reports

authors： Fickentscher R,Weiss M

更新日期：2017-08-24 00:00:00

abstract：:The endoplasmic reticulum (ER) is a multi functional organelle and plays a crucial role in protein folding and lipid biosynthesis. The SEC59 gene encodes dolichol kinase, required for protein glycosylation in the ER. The mutation of sec59-1 caused a protein N-glycosylation defect mediated ER stress resulting in increa...

journal_title：Scientific reports

authors： William James A,Ravi C,Srinivasan M,Nachiappan V

更新日期：2019-10-09 00:00:00

abstract：:We present active manipulation of the structural vibrations of an elastic body to generate an acoustic illusion. The resultant illusion misrepresents the nature, size and number of objects in the exterior acoustic domain. We demonstrate our technique, herein termed active structural acoustic illusion, using an elastic...

journal_title：Scientific reports

authors： Eggler D,Kessissoglou N

更新日期：2020-06-17 00:00:00

abstract：:MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 ...

journal_title：Scientific reports

authors： Zheng D,Ye S,Wang X,Zhang Y,Yan D,Cai X,Gao W,Shan H,Gao Y,Chen J,Hu Z,Li H,Li J

更新日期：2017-06-06 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Bruneau N,Toumi R,Wang S

更新日期：2018-04-17 00:00:00

abstract：:Macular edema due to neovascular age-related macular degeneration, diabetes or retinal vein occlusion can cause central vision loss. Intravitreal treatment with antibody-based biopharmaceutical compounds designed to neutralize vascular endothelial growth factor (VEGF) has proven to be an efficient strategy to ameliora...

journal_title：Scientific reports

authors： Sivertsen MS,Jørstad ØK,Grevys A,Foss S,Moe MC,Andersen JT

更新日期：2018-02-01 00:00:00

abstract：:We developed a new concept of X- and γ-ray radiation semiconductor detectors based on a large area graphene/semi-insulating single crystal CdTe Schottky-type heterojunction. These two terminal electronic devices can be easily fabricated by forming a Van der Waals contact between large area chemical vapor deposited gra...

journal_title：Scientific reports

authors： Brus VV,Maslyanchuk OL,Solovan MM,Maryanchuk PD,Fodchuk I,Gnatyuk VA,Vakhnyak ND,Melnychuk SV,Aoki T

更新日期：2019-01-31 00:00:00

abstract：:A fracture is the most dangerous complication of osteoporosis in patients because the associated disability and mortality rates are high. Osteoporosis impairs fracture healing and prognosis, but how intramembranous ossification (IO) or endochondral ossification (EO) during fracture healing are affected and whether the...

journal_title：Scientific reports

authors： Zhang H,Shi X,Wang L,Li X,Zheng C,Gao B,Xu X,Lin X,Wang J,Lin Y,Shi J,Huang Q,Luo Z,Yang L

更新日期：2018-03-01 00:00:00

abstract：:Rice bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most destructive rice diseases worldwide. Therefore, in addition to breeding disease-resistant rice cultivars, it is desirable to develop effective biocontrol agents against Xoo. Here, we report that a soil bacterium Pseudomonas taiwanen...

journal_title：Scientific reports

authors： Chen WJ,Kuo TY,Hsieh FC,Chen PY,Wang CS,Shih YL,Lai YM,Liu JR,Yang YL,Shih MC

更新日期：2016-09-08 00:00:00

abstract：:Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hypothesised that dogs with congestive heart failure have quantifiable ...

journal_title：Scientific reports

authors： Seo J,Matthewman L,Xia D,Wilshaw J,Chang YM,Connolly DJ

更新日期：2020-08-13 00:00:00

abstract：:The behavior of clogging has a close relationship with the biofilm attached on inner surface of the pipeline in a drip irrigation system using reclaimed water. Therefore, inhibiting biofilm growth is the key to completely addressing the clogging problem. Water shear forces play a vital role in the formation, developme...

journal_title：Scientific reports

authors： Wang T,Guo Z,Shen Y,Cui Z,Goodwin A

更新日期：2020-04-24 00:00:00

abstract：:The recent combination of ultra-intense lasers and laser-accelerated electron beams is enabling the development of a new generation of compact x-ray light sources, the coherence of which depends directly on electron beam emittance. Although the emittance of accelerated electron beams can be low, it can grow due to the...

journal_title：Scientific reports

authors： Golovin G,Banerjee S,Liu C,Chen S,Zhang J,Zhao B,Zhang P,Veale M,Wilson M,Seller P,Umstadter D

更新日期：2016-04-19 00:00:00

abstract：:Grazing and burrowing organisms usually homogenise microalgal mats that form on benthic sediments of many aquatic ecosystems. In the absence of this disruption, microalgal mats can accrete laminated deposits (stromatolites). Stromatolites are rare in modern coastal ecosystems, but persist at locations where metazoans ...

journal_title：Scientific reports

authors： Rishworth GM,Perissinotto R,Bird MS,Strydom NA,Peer N,Miranda NA,Raw JL

更新日期：2017-02-16 00:00:00

abstract：:Screening and in silico modeling are critical activities for the reduction of experimental costs. They also speed up research notably and strengthen the theoretical framework, thus allowing researchers to numerically quantify the importance of a particular subset of information. For example, in fields such as cancer a...

journal_title：Scientific reports

authors： Blanco JL,Porto-Pazos AB,Pazos A,Fernandez-Lozano C

更新日期：2018-10-24 00:00:00