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Interleukin 37 promotes angiogenesis through TGF-β signaling.

Abstract：

:IL-37 is a novel pro-angiogenic cytokine that potently promotes endothelial cell activation and pathological angiogenesis in our previous study, but the mechanisms behind the pro-angiogenic effect of IL-37 are less well understood. Extending our observations, we found that TGF-β interacts with IL-37, and potently enhances the binding affinity of IL-37 to the ALK1 receptor complex, thus allowing IL-37 to signal through ALK1 to activate pro-angiogenic responses. We further show that TGF-β and ALK1 are required in IL-37 induced pro-angiogenic response in ECs and in the mouse model of Matrigel plug and oxygen-induced retinopathy. The result suggests that IL-37 induces pro-angiogenic responses through TGF-β, which may act as the bridging molecule that mediates IL-37 binding to the TGF-β receptor complex.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhao M,Hu Y,Jin J,Yu Y,Zhang S,Cao J,Zhai Y,Wei R,Shou J,Cai W,Liu S,Yang X,Xu GT,Yang J,Corry DB,Su SB,Liu X,Yang T

doi

10.1038/s41598-017-06124-z

subject

Has Abstract

pub_date

2017-07-21 00:00:00

pages

6113

issue

1

issn

2045-2322

pii

10.1038/s41598-017-06124-z

journal_volume

7

pub_type

杂志文章

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