Direct DNA and RNA detection from large volumes of whole human blood.

abstract：:Many behaviors of cancer, such as progression, metastasis and drug resistance etc., cannot be fully understood by genetic mutations or intracellular signaling alone. Instead, they are emergent properties of the cell community which forms a tumor. Studies of tumor heterogeneity reveal that many cancer behaviors critica...

journal_title：Scientific reports

authors： Zhou JX,Taramelli R,Pedrini E,Knijnenburg T,Huang S

更新日期：2017-08-18 00:00:00

abstract：:The objective of the study was to estimate if altered levels of alpha-synuclein can be detected in tear fluid of patients with Parkinson's disease (PD). Therefore, tear fluid samples of 75 PD patients, 75 control subjects and 31 atypical Parkinsonian patients were collected and analyzed in triplicates using an ultra-s...

journal_title：Scientific reports

authors： Maass F,Rikker S,Dambeck V,Warth C,Tatenhorst L,Csoti I,Schmitz M,Zerr I,Leha A,Bähr M,Lingor P

更新日期：2020-05-22 00:00:00

abstract：:Recent studies have shown that ionic direct current (iDC) can modulate the vestibular system in-vivo, with potential benefits over conventional pulsed stimulation. In this study, the effects of iDC stimulation on vestibular nerve fiber firing rate was investigated using loose-patch nerve fiber recordings in the acutel...

journal_title：Scientific reports

authors： Manca M,Glowatzki E,Roberts DC,Fridman GY,Aplin FP

更新日期：2019-12-12 00:00:00

abstract：:The characterization of network community structure has profound implications in several scientific areas. Therefore, testing the algorithms developed to establish the optimal division of a network into communities is a fundamental problem in the field. We performed here a highly detailed evaluation of community detec...

journal_title：Scientific reports

authors： Aldecoa R,Marín I

更新日期：2013-01-01 00:00:00

abstract：:Although graphene is a typical two dimensional materials, it has converted to multi-dimensional materials with many unique properties. As an example, the one dimensional graphene fiber is fabricated by utilizing ionic liquid as coagulation and functional diamines as cross-linkers to connect graphene oxide layers. The ...

journal_title：Scientific reports

authors： Fan T,Zhao C,Xiao Z,Guo F,Cai K,Lin H,Liu Y,Meng H,Min Y,Epstein AJ

更新日期：2016-07-08 00:00:00

abstract：:Mandrill (Mandrillus sphinx) is a primate species, which belongs to the Old World monkey (Cercopithecidae) family. It is closely related to human, serving as a model for human health related research. However, the genetic studies on and genomic resources of mandrill are limited, especially in comparison to other prima...

journal_title：Scientific reports

authors： Yin Y,Yang T,Liu H,Huang Z,Zhang Y,Song Y,Wang W,Guang X,Sahu SK,Kristiansen K

更新日期：2020-02-12 00:00:00

abstract：:The aim of this systematic review was taken to investigate the efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone for treating androgen-independent prostate cancer (AIPC). Data were collected from different databases independently by three researchers according to the pre-defined inclusion and exclu...

journal_title：Scientific reports

authors： Chen L,Qiu X,Wang R,Xie X

更新日期：2014-04-28 00:00:00

abstract：:Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek's disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumorigenesis, the dynamic splenic transcriptome of GaHV2-infected chickens during early infection and pathogenic phases has been determi...

journal_title：Scientific reports

authors： Dang L,Teng M,Li HW,Li HZ,Ma SM,Zhao P,Li XJ,Deng RG,Zhang GP,Luo J

更新日期：2017-09-14 00:00:00

abstract：:Novel predictive biomarkers are needed to improve patient selection and optimize the use of bevacizumab (B) in metastatic colorectal cancer. We analyzed the potential of five circulating biomarkers to predict B efficacy and monitor response. Peripheral blood samples collected at baseline, at the first clinical evaluat...

journal_title：Scientific reports

authors： Marisi G,Scarpi E,Passardi A,Nanni O,Ragazzini A,Valgiusti M,Casadei Gardini A,Neri LM,Frassineti GL,Amadori D,Ulivi P

更新日期：2017-05-02 00:00:00

abstract：:Depressive disorder (DD) is a mental illness affecting more than 300 million people worldwide, whereas social stigma and subtle, variant symptoms impede diagnosis. Psychomotor retardation is a common component of DD with a negative impact on motor function, usually reflected on patients' routine activities, including,...

journal_title：Scientific reports

authors： Mastoras RE,Iakovakis D,Hadjidimitriou S,Charisis V,Kassie S,Alsaadi T,Khandoker A,Hadjileontiadis LJ

更新日期：2019-09-16 00:00:00

abstract：:The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug. Studies show that ATO exerts a profound antiproliferative effect in several cancer cells, including breast, ovarian, and glioma. Analogous to the mechanism of action proposed in parasites, ATO inhibits mitoch...

journal_title：Scientific reports

authors： Cheng G,Hardy M,Topchyan P,Zander R,Volberding P,Cui W,Kalyanaraman B

更新日期：2020-10-21 00:00:00

abstract：:This study aimed to determine whether bisphosphonates exert an effect on preventing femoral head collapse after osteonecrosis of the femoral head (ONFH) in an animal model and in clinical trials. A systematic literature search was performed for studies published up to January 2017. Twenty-three articles (16 animal stu...

journal_title：Scientific reports

authors： Li D,Yang Z,Wei Z,Kang P

更新日期：2018-01-23 00:00:00

abstract：:PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein that interacts with diverse membrane proteins. PICK1 has been shown to regulate the clustering and membrane localization of synaptic receptors such as AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, metabotropic glutama...

journal_title：Scientific reports

authors： Xu J,Wang N,Luo JH,Xia J

更新日期：2016-02-12 00:00:00

abstract：:The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated "mcDESPOT", uses a more efficient steady-state acquisition to generate an eq...

journal_title：Scientific reports

authors： Dvorak AV,Ljungberg E,Vavasour IM,Lee LE,Abel S,Li DKB,Traboulsee A,MacKay AL,Kolind SH

更新日期：2021-01-14 00:00:00

abstract：:Molybdenum disulfide (MoS2) has been attracting much attentions due to its excellent electrical and optical properties. We report here the synthesis of large-scale and uniform MoS2 nanosheets with vertically standing morphology using chemical vapor deposition method. TEM observations clearly reveal the growth mechanis...

journal_title：Scientific reports

authors： Li H,Wu H,Yuan S,Qian H

更新日期：2016-02-18 00:00:00

abstract：:Since the hemorrhage in severe dengue seems to be primarily related to the defect of the platelet, the possibility that dengue virus (DENV) is selectively tropic for one of its surface receptors was investigated. Flow cytometric data of DENV-infected megakaryocytic cell line superficially expressing human glycoprotein...

journal_title：Scientific reports

authors： Attatippaholkun N,Kosaisawe N,U-Pratya Y,Supraditaporn P,Lorthongpanich C,Pattanapanyasat K,Issaragrisil S

更新日期：2018-02-09 00:00:00

abstract：:The cysteine-rich PLAC8 domain of unknown function occurs in proteins found in most Eukaryotes. PLAC8-proteins play important yet diverse roles in different organisms, such as control of cell proliferation in animals and plants or heavy metal resistance in plants and fungi. Mammalian Onzin can be either pro-proliferat...

journal_title：Scientific reports

authors： Daghino S,Di Vietro L,Petiti L,Martino E,Dallabona C,Lodi T,Perotto S

更新日期：2019-04-29 00:00:00

abstract：:The effective differentiation between multiple primary lung tumors (MPs) and intrapulmonary metastases (IMs) in patients is imperative to discover the exact disease stage and to select the most appropriate treatment. In this study, the authors was to evaluate the efficacy and validity of large-scale targeted sequencin...

journal_title：Scientific reports

authors： Duan J,Ge M,Peng J,Zhang Y,Yang L,Wang T,Qin T,Yuan R,Zhang Y,Cheng W

更新日期：2020-11-02 00:00:00

abstract：:Improving the affinity of protein-protein interactions is a challenging problem that is particularly important in the development of antibodies for diagnostic and clinical use. Here, we used structure-based computational methods to optimize the binding affinity of VHNAC1, a single-domain intracellular antibody (intrab...

journal_title：Scientific reports

authors： Mahajan SP,Meksiriporn B,Waraho-Zhmayev D,Weyant KB,Kocer I,Butler DC,Messer A,Escobedo FA,DeLisa MP

更新日期：2018-12-04 00:00:00

abstract：:In the European Union, the use of recombinant bovine somatotropin (rbST) in dairy cattle is forbidden. Monitoring rbST (ab)use by its direct detection in animal matrices still remains a challenging task. New monitoring methods based on indirect detection of the substance are necessary. A new transcriptomic system base...

journal_title：Scientific reports

authors： Lamas A,Regal P,Vázquez B,Miranda JM,Cepeda A,Franco CM

更新日期：2019-03-18 00:00:00

abstract：:NLRP3 inflammasomes recognize non-microbial danger signals and induce release of proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular disease. Because sterile inflammation is involved in doxorubicin (Dox)-induced cardiotoxicity, we investigated the role of NLRP3 inflammasomes...

journal_title：Scientific reports

authors： Kobayashi M,Usui F,Karasawa T,Kawashima A,Kimura H,Mizushina Y,Shirasuna K,Mizukami H,Kasahara T,Hasebe N,Takahashi M

更新日期：2016-05-26 00:00:00

abstract：:This study aims to identify a panel of blood-cell neuroplasticity-related genes expressed following environmental enrichment stimulation (EE). The Drug detection (DD) training course was an excellent model for the study of EE in the working dog. This research is divided into two experimental trials. In the First Trial...

journal_title：Scientific reports

authors： Guelfi G,Casano AB,Menchetti L,Bellicci M,Suvieri C,Moscati L,Carotenuto P,Santoro MM,Diverio S

更新日期：2019-05-06 00:00:00

abstract：:PC4, a well-known general transcription cofactor, has multiple functions in transcription and DNA repair. Residue W89, is engaged in stacking interactions with DNA in PC4, but substituted by tyrosine in some PC4 orthologous proteins. In order to understand the consequences and reveal the molecular details of this subs...

journal_title：Scientific reports

authors： Huang J,Zhao Y,Liu H,Huang D,Cheng X,Zhao W,Taylor IA,Liu J,Peng YL

更新日期：2015-03-05 00:00:00

abstract：:Roots have important roles for plants to withstand adverse environmental conditions, including salt stress. Biostimulant application was shown to enhance plant resilience towards abiotic stresses. Here, we studied the effect of a tannin-based biostimulant on tomato (Solanum lycopersicum L.) grown under salt stress con...

journal_title：Scientific reports

authors： Campobenedetto C,Mannino G,Beekwilder J,Contartese V,Karlova R,Bertea CM

更新日期：2021-01-11 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Yun JH,Cho DH,Lee B,Kim HS,Chang YK

更新日期：2020-02-20 00:00:00

abstract：:Previous studies in model eukaryotes have demonstrated that phosphorylation of heterochromatin protein 1 (HP1) is important for dynamically regulating its various functions. However, in the malaria parasite Plasmodium falciparum both the function of HP1 phosphorylation and the identity of the protein kinases targeting...

journal_title：Scientific reports

authors： Bui HTN,Niederwieser I,Bird MJ,Dai W,Brancucci NMB,Moes S,Jenoe P,Lucet IS,Doerig C,Voss TS

更新日期：2019-11-13 00:00:00

abstract：:Bending light in a controllable way is desired in various applications such as beam steering, navigating and cloaking. Different from the conventional way to bend light by refractive index gradient, transformation optics or special beams through wavefront design such as Airy beams and surface plasmons, we proposed a m...

journal_title：Scientific reports

authors： Han B,Xu L,Dou Y,Xu J,Zhang G

更新日期：2015-10-29 00:00:00

abstract：:Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...

journal_title：Scientific reports

authors： Extramiana F,Milleron O,Elbitar S,Uccellini A,Langeois M,Spentchian M,Delorme G,Arnoult F,Denjoy I,Bouleti C,Fressart V,Iserin F,Maison-Blanche P,Abifadel M,Leenhardt A,Boileau C,Jondeau G

更新日期：2018-08-29 00:00:00

abstract：:Schistosomes, unlike malaria parasites, are in their diploid stage when targeted by the human immune system. Diploids can be either homozygous or heterozygous. The difference has profound significance for developing immunity and yet has not previously been addressed. We examined the implications of zygosity on immunit...

journal_title：Scientific reports

authors： Xu X,Sun J,Zhang J,Wellems D,Qing X,McCutchan T,Pan W

更新日期：2012-01-01 00:00:00

abstract：:Neural networks can efficiently encode the probability distribution of errors in an error correcting code. Moreover, these distributions can be conditioned on the syndromes of the corresponding errors. This paves a path forward for a decoder that employs a neural network to calculate the conditional distribution, then...

journal_title：Scientific reports

authors： Krastanov S,Jiang L

更新日期：2017-09-08 00:00:00