当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > The draft genome of mandrill (Mandrillus sphinx): An Old World monkey.

The draft genome of mandrill (Mandrillus sphinx): An Old World monkey.

Abstract：

:Mandrill (Mandrillus sphinx) is a primate species, which belongs to the Old World monkey (Cercopithecidae) family. It is closely related to human, serving as a model for human health related research. However, the genetic studies on and genomic resources of mandrill are limited, especially in comparison to other primate species. Here we produced 284 Gb data, providing 96-fold coverage (considering the estimated genome size of 2.9 Gb), to construct a reference genome for the mandrill. The assembled draft genome was 2.79 Gb with contig N50 of 20.48 Kb and scaffold N50 of 3.56 Mb. We annotated the mandrill genome to find 43.83% repeat elements, as well as 21,906 protein-coding genes. The draft genome was of good quality with 98% gene annotation coverage by Benchmarking Universal Single-Copy Orthologs (BUSCO). Based on comparative genomic analyses of  the Major Histocompatibility Complex (MHC) of the immune system in mandrill and human, we found that 17 genes in the mandrill that have been associated with disease phenotypes in human such as Lung cancer, cranial volume and asthma, barbored amino acids changing mutations. Gene family analyses revealed expansion of several genes, and several genes associated with stress environmental adaptation and innate immunity responses exhibited signatures of positive selection. In summary, we established the first draft genome of  the mandrill of value for studies on evolution and human health.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Yin Y,Yang T,Liu H,Huang Z,Zhang Y,Song Y,Wang W,Guang X,Sahu SK,Kristiansen K

doi

10.1038/s41598-020-59110-3

subject

Has Abstract

pub_date

2020-02-12 00:00:00

pages

2431

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59110-3

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Author Correction: Validation of the GRade, Age, Nodes and Tumor (GRANT) score within the Surveillance Epidemiology and End Results (SEER) database: A new tool to predict survival in surgically treated renal cell carcinoma patients.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-59358-9

    authors： Buti S,Karakiewicz PI,Bersanelli M,Capitanio U,Tian Z,Cortellini A,Taguchi S,Briganti A,Montorsi F,Leonardi F,Bandini M

    更新日期：2020-02-05 00:00:00

  • Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study.

    abstract：:Deferiprone (DFP) is a hydroxypyridinone-derived iron chelator currently in clinical use for iron chelation therapy. DFP has also been known to elicit antiproliferative activities, yet the mechanism of this effect has remained elusive. We herein report that DFP chelates the Fe2+ ion at the active sites of selected iro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39214-1

    authors： Khodaverdian V,Tapadar S,MacDonald IA,Xu Y,Ho PY,Bridges A,Rajpurohit P,Sanghani BA,Fan Y,Thangaraju M,Hathaway NA,Oyelere AK

    更新日期：2019-03-18 00:00:00

  • Microscopic analyses of weathered granite in ion-adsorption rare earth deposit of Jianxi Province, China.

    abstract：:Weathered granite of ion-adsorption rare earth elements (REEs) ore collected at Jiangxi Province, China was investigated to identify the minerals abundant in REEs. The analyses of scanning electron microscopy (SEM)-energy dispersive spectrometry (EDS) and laser ablation inductively coupled plasma mass spectrometry (LA...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76981-8

    authors： Mukai H,Kon Y,Sanematsu K,Takahashi Y,Ito M

    更新日期：2020-11-19 00:00:00

  • The daily resolved temperature dependence and structure of planktonic foraminifera blooms.

    abstract：:Planktonic foraminifera (PF) life cycles are highly sensitive to marine conditions, which are evolving rapidly due to anthropogenic climate change. Even though PF shells in the sedimentary record serve as prominent proxies of past ocean conditions, very little is still known about their life cycles, particularly in ol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74342-z

    authors： Chernihovsky N,Almogi-Labin A,Kienast SS,Torfstein A

    更新日期：2020-10-15 00:00:00

  • Probing Nanoscale Thermal Transport in Surfactant Solutions.

    abstract：:Surfactant solutions typically feature tunable nanoscale, internal structures. Although rarely utilized, they can be a powerful platform for probing thermal transport in nanoscale domains and across interfaces with nanometer-size radius. Here, we examine the structure and thermal transport in solution of AOT (Dioctyl ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16040

    authors： Cao F,Liu Y,Xu J,He Y,Hammouda B,Qiao R,Yang B

    更新日期：2015-11-04 00:00:00

  • Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver.

    abstract：:Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 week...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27782

    authors： Nakabori T,Hikita H,Murai K,Nozaki Y,Kai Y,Makino Y,Saito Y,Tanaka S,Wada H,Eguchi H,Takahashi T,Suemizu H,Sakamori R,Hiramatsu N,Tatsumi T,Takehara T

    更新日期：2016-06-09 00:00:00

  • Genome and transcriptome analysis of surfactin biosynthesis in Bacillus amyloliquefaciens MT45.

    abstract：:Natural Bacillus isolates generate limited amounts of surfactin (<10% of their biomass), which functions as an antibiotic or signalling molecule in inter-/intra-specific interactions. However, overproduction of surfactin in Bacillus amyloliquefaciens MT45 was observed at a titre of 2.93 g/l, which is equivalent to hal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40976

    authors： Zhi Y,Wu Q,Xu Y

    更新日期：2017-01-23 00:00:00

  • CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-β signaling.

    abstract：:Previous studies have shown that CD61 (integrin-β3) promotes the differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) into germ-like cells. However, the mechanism remains unclear. In this study, we showed that overexpression of CD61 in canine adipose-derived mesenchymal stem cells (cADMSCs) promot...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43851

    authors： Fang J,Wei Y,Lv C,Peng S,Zhao S,Hua J

    更新日期：2017-03-03 00:00:00

  • Interconnecting Carbon Fibers with the In-situ Electrochemically Exfoliated Graphene as Advanced Binder-free Electrode Materials for Flexible Supercapacitor.

    abstract：:Flexible energy storage devices are highly demanded for various applications. Carbon cloth (CC) woven by carbon fibers (CFs) is typically used as electrode or current collector for flexible devices. The low surface area of CC and the presence of big gaps (ca. micro-size) between individual CFs lead to poor performance...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11792

    authors： Zou Y,Wang S

    更新日期：2015-07-07 00:00:00

  • Mutation of two key aspartate residues alters stoichiometry of the NhaB Na+/H+ exchanger from Klebsiella pneumoniae.

    abstract：:Bacterial NhaB Na+/H+ exchangers belonging to the Ion Transporter superfamily are poorly characterized in contrast to Na+/H+ exchangers of the Cation Proton Antiporter superfamily which have NhaA from Escherichia coli as a prominent member. For a more detailed understanding of the intricacies of the exchanger's transp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51887-2

    authors： Patiño-Ruiz M,Fendler K,Călinescu O

    更新日期：2019-10-28 00:00:00

  • Novel method for immunofluorescence staining of mammalian eggs using non-contact alternating-current electric-field mixing of microdroplets.

    abstract：:Recently, a new technique was developed for non-catalytically mixing microdroplets. In this method, an alternating-current (AC) electric field is used to promote the antigen-antibody reaction within the microdroplet. Previously, this technique has only been applied to histological examinations of flat structures, such...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15371

    authors： Shirasawa H,Kumagai J,Sato E,Kabashima K,Kumazawa Y,Sato W,Miura H,Nakamura R,Nanjo H,Minamiya Y,Akagami Y,Terada Y

    更新日期：2015-10-19 00:00:00

  • Author Correction: Genetic structure of Mycoplasma ovipneumoniae informs pathogen spillover dynamics between domestic and wild Caprinae in the western United States.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-63944-2

    authors： Kamath PL,Manlove K,Cassirer EF,Cross PC,Besser TE

    更新日期：2020-04-22 00:00:00

  • Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors.

    abstract：:Serum and cerebrospinal fluid (CSF) levels of α-fetoprotein and β-subunit of human chorionic gonadotropin are used as biomarkers for the management of central nervous system (CNS) germ cell tumors (GCTs). However, additional discriminating biomarkers are required. Especially, biomarkers to differentiate non-germinomat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71161-0

    authors： Takayasu T,Shah M,Dono A,Yan Y,Borkar R,Putluri N,Zhu JJ,Hama S,Yamasaki F,Tahara H,Sugiyama K,Kurisu K,Esquenazi Y,Ballester LY

    更新日期：2020-08-31 00:00:00

  • Regulatory role of G9a and LSD1 in the Transcription of Olfactory Receptors during Leukaemia Cell Differentiation.

    abstract：:Recent studies have reported the ectopic expression of olfactory receptors (ORs) in non-olfactory tissues, however, their physiological roles were not well elucidated. ORs are expressed in and function in different types of cancers. Here, we identified that the H3K9me2 levels of several OR promoters decreased during d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46182

    authors： Jung H,Chae YC,Kim JY,Jeong OS,Kook H,Seo SB

    更新日期：2017-04-07 00:00:00

  • Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A.

    abstract：:Circadian clocks keep time via ~ 24 h transcriptional feedback loops. In Drosophila, CLOCK-CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback loop components whose transcriptional status varies over a circadian cycle. Although changes in the state of activators and repressors has been cha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75009-5

    authors： Mahesh G,Rivas GBS,Caster C,Ost EB,Amunugama R,Jones R,Allen DL,Hardin PE

    更新日期：2020-10-21 00:00:00

  • Dynamical complexity and computation in recurrent neural networks beyond their fixed point.

    abstract：:Spontaneous activity found in neural networks usually results in a reduction of computational performance. As a consequence, artificial neural networks are often operated at the edge of chaos, where the network is stable yet highly susceptible to input information. Surprisingly, regular spontaneous dynamics in Neural ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21624-2

    authors： Marquez BA,Larger L,Jacquot M,Chembo YK,Brunner D

    更新日期：2018-02-20 00:00:00

  • Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche.

    abstract：:While implicated in therapeutic resistance, malignant progenitor cell cycle kinetics have been difficult to quantify in real-time. We developed an efficient lentiviral bicistronic fluorescent, ubiquitination-based cell cycle indicator reporter (Fucci2BL) to image live single progenitors on a defined niche coupled with...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23885

    authors： Pineda G,Lennon KM,Delos Santos NP,Lambert-Fliszar F,Riso GL,Lazzari E,Marra MA,Morris S,Sakaue-Sawano A,Miyawaki A,Jamieson CH

    更新日期：2016-04-04 00:00:00

  • SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma.

    abstract：:Since the SOX2 amplification was identified in lung squamous cell carcinoma (lung SCC), SOX2 transcriptional downstream targets have been actively investigated; however, such targets are often cell line specific. Here, in order to identify highly consensus SOX2 downstream genes in lung SCC cells, we used RNA-seq data ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20113

    authors： Fukazawa T,Guo M,Ishida N,Yamatsuji T,Takaoka M,Yokota E,Haisa M,Miyake N,Ikeda T,Okui T,Takigawa N,Maeda Y,Naomoto Y

    更新日期：2016-02-05 00:00:00

  • Partridge and embryonated partridge egg as new preclinical models for candidiasis.

    abstract：:Candida albicans (C. albicans) is the most common cause of candidiasis in humans and animals. This study was established to a new experimental infection model for systemic candidiasis using partridge and embryonated partridge egg. First, we tested the induction of systemic candidiasis in partridge and embryonated part...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81592-y

    authors： Tavakkoli H,Khosravi A,Sharifi I,Salari Z,Salarkia E,Kheirandish R,Dehghantalebi K,Jajarmi M,Mosallanejad SS,Dabiri S,Keyhani A

    更新日期：2021-01-22 00:00:00

  • Author Correction: Phonological network fluency identifies phonological restructuring through mental search.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-55966-2

    authors： Neergaard KD,Luo J,Huang CR

    更新日期：2020-01-14 00:00:00

  • JAM-A overexpression is related to disease progression in diffuse large B-cell lymphoma and downregulated by lenalidomide.

    abstract：:Cancer stem cells play an important role on tumor progression. Biomarkers of stem cell property and their relationship to extranodal involvement of malignant lymphocytes are undefined in diffuse large B-cell lymphoma (DLBCL). Here we showed that junctional adhesion molecule-A (JAM-A) was highly expressed in DLBCL pati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07964-5

    authors： Xu PP,Sun YF,Fang Y,Song Q,Yan ZX,Chen Y,Jiang XF,Fei XC,Zhao Y,Leboeuf C,Li B,Wang CF,Janin A,Wang L,Zhao WL

    更新日期：2017-08-07 00:00:00

  • Spectrochemical differentiation in gestational diabetes mellitus based on attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy and multivariate analysis.

    abstract：:Gestational diabetes mellitus (GDM) is a hyperglycaemic imbalance first recognized during pregnancy, and affects up to 22% of pregnancies worldwide, bringing negative maternal-fetal consequences in the short- and long-term. In order to better characterize GDM in pregnant women, 100 blood plasma samples (50 GDM and 50 ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75539-y

    authors： Bernardes-Oliveira E,de Freitas DLD,de Morais CLM,Cornetta MDCM,Camargo JDAS,de Lima KMG,Crispim JCO

    更新日期：2020-11-06 00:00:00

  • Ocean acidification impairs vermetid reef recruitment.

    abstract：:Vermetids form reefs in sub-tropical and warm-temperate waters that protect coasts from erosion, regulate sediment transport and accumulation, serve as carbon sinks and provide habitat for other species. The gastropods that form these reefs brood encapsulated larvae; they are threatened by rapid environmental changes ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04189

    authors： Milazzo M,Rodolfo-Metalpa R,Chan VB,Fine M,Alessi C,Thiyagarajan V,Hall-Spencer JM,Chemello R

    更新日期：2014-02-28 00:00:00

  • Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression.

    abstract：:α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08316

    authors： Ohtsuka Y,Kanagawa M,Yu CC,Ito C,Chiyo T,Kobayashi K,Okada T,Takeda S,Toda T

    更新日期：2015-02-09 00:00:00

  • Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain.

    abstract：:Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37255

    authors： Shimada N,Inami S,Sato S,Kitamoto T,Sakai T

    更新日期：2016-11-17 00:00:00

  • Iron Pyrite/Titanium Dioxide Photoanode for Extended Near Infrared Light Harvesting in a Photoelectrochemical Cell.

    abstract：:The design of active and stable semiconducting composites with enhanced photoresponse from visible light to near infrared (NIR) is a key to improve solar energy harvesting for photolysis of water in photoelectrochemical cell. In this study, we prepared earth abundant semiconducting composites consisting of iron pyrite...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20397

    authors： Wang DY,Li CH,Li SS,Kuo TR,Tsai CM,Chen TR,Wang YC,Chen CW,Chen CC

    更新日期：2016-02-08 00:00:00

  • 3D Synthetic Peptide-based Architectures for the Engineering of the Enteric Nervous System.

    abstract：:Damage of enteric neurons and partial or total loss of selective neuronal populations are reported in intestinal disorders including inflammatory bowel diseases and necrotizing enterocolitis. To develop three-dimensional scaffolds for enteric neurons we propose the decoration of ionic-complementary self-assembling pep...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42071-7

    authors： Brun P,Zamuner A,Peretti A,Conti J,Messina GML,Marletta G,Dettin M

    更新日期：2019-04-03 00:00:00

  • MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus.

    abstract：:Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was down-regulated in Kmmig1. Consistently, introduction of HIS4 ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46411-5

    authors： Nurcholis M,Murata M,Limtong S,Kosaka T,Yamada M

    更新日期：2019-07-09 00:00:00

  • Signatures of balancing selection in toll-like receptor (TLRs) genes - novel insights from a free-living rodent.

    abstract：:Selective pressure from pathogens is considered a key selective force driving the evolution of components of the immune system. Since single components of the immune system may interact with many pathogens, and single pathogens may be recognized by multiple components of the immune system, gaining a better understandi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26672-2

    authors： Kloch A,Wenzel MA,Laetsch DR,Michalski O,Bajer A,Behnke JM,Welc-Falęciak R,Piertney SB

    更新日期：2018-05-30 00:00:00

  • Effects of whole-body cryotherapy on 25-hydroxyvitamin D, irisin, myostatin, and interleukin-6 levels in healthy young men of different fitness levels.

    abstract：:Skeletal muscle and adipose tissue play an important role in maintaining metabolic homeostasis and thermogenesis. We aimed to investigate the effects of single and repeated exposure to whole-body cryotherapy in volunteers with different physical fitness levels on 25-hydroxyvitamin D (25(OH)D) and myokines. The study i...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-020-63002-x

    authors： Śliwicka E,Cisoń T,Straburzyńska-Lupa A,Pilaczyńska-Szcześniak Ł

    更新日期：2020-04-10 00:00:00