Abstract:
:Administration of dibutyl phthalate (DBP) to pregnant rats causes reproductive disorders in male offspring, resulting from suppression of intratesticular testosterone, and is used as a model for human testicular dysgenesis syndrome (TDS). DBP exposure in pregnancy induces focal dysgenetic areas in fetal testes that appear between e19.5-e21.5, manifesting as focal aggregation of Leydig cells and ectopic Sertoli cells (SC). Our aim was to identify the origins of the ectopic SC. Time-mated female rats were administered 750 mg/kg/day DBP in three different time windows: full window (FW; e13.5-e20.5), masculinisation programming window (MPW; e15.5-e18.5), late window (LW; e19.5-e20.5). We show that DBP-MPW treatment produces more extensive and severe dysgenetic areas, with more ectopic SC and germ cells (GC) than DBP-FW treatment; DBP-LW induces no dysgenesis. Our findings demonstrate that ectopic SC do not differentiate de novo, but result from rupture of normally formed seminiferous cords beyond e20.5. The more severe testis dysgenesis in DBP-MPW animals may result from the presence of basally migrating GC and a weakened basal lamina, whereas GC migration was minimal in DBP-FW animals. Our findings provide the first evidence for how testicular dysgenesis can result after normal testis differentiation/development and may be relevant to understanding TDS in human patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lara NLM,van den Driesche S,Macpherson S,França LR,Sharpe RMdoi
10.1038/s41598-017-02684-2subject
Has Abstractpub_date
2017-05-31 00:00:00pages
2521issue
1issn
2045-2322pii
10.1038/s41598-017-02684-2journal_volume
7pub_type
杂志文章abstract::The function of Latexin (LXN) in inflammation has attracted attention. However, no data are available regarding its role in colitis. We report that LXN is a suppressor of colitis. LXN deficiency leads to the severity of colitis in DSS-induced mice, and LXN is required for the therapeutic effect of retinoic acid on col...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66789-x
更新日期:2020-06-17 00:00:00
abstract::The present study shows chronic adjustments in the myotendinous junction (MTJ) in response to different ladder-based resistance training (LRT) protocols. Thirty adult male Wistar rats were divided into groups: sedentary (S), calisthenics (LRT without additional load [C]), and resistance-trained (LRT with extra weight ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70971-6
更新日期:2020-08-24 00:00:00
abstract::While there is a rich literature on transcription dynamics during the development of many organisms, protein data is limited. We used iTRAQ isotopic labeling and mass spectrometry to generate the largest developmental proteomic dataset for any animal. Expression dynamics of nearly 4,000 proteins of Xenopus laevis was ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04365
更新日期:2014-03-14 00:00:00
abstract::Design and development of efficient processes for continuous manufacturing of solid dosage oral formulations is of crucial importance for pharmaceutical industry in order to implement the Quality-by-Design paradigm. Supercritical solvent-based manufacturing can be utilized in pharmaceutical processing owing to its inh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80399-7
更新日期:2021-01-13 00:00:00
abstract::There is a global concern about the effects of climate change driven shifts in species phenology on crop pests. Using geographically and temporally extensive data set of moth trap catches and temperatures across the cotton growing states of India, we predicted the phenology of cotton pink bollworm Pectinophora gossypi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80184-6
更新日期:2021-01-11 00:00:00
abstract::TiNb6O17 and TiNb2O7 were synthesized using a solid-state method. The techniques were used to assess the electrochemical performance and lithium diffusion kinetics of TiNb6O17 related to the unit cell volume with TiNb2O7. The charge-discharge curves and cyclic voltammetry revealed TiNb6O17 to have a similar redox pote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16711-9
更新日期:2017-11-30 00:00:00
abstract::Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neuro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32616-7
更新日期:2018-09-21 00:00:00
abstract::Tau is a microtubule-associated protein whose C-terminal domain consisting of four repeat regions R1, R2, R3 and R4 binds to microtubules to stabilize them. In several neurodegenerative diseases, tau detaches from microtubules to form insoluble aggregates leading to tauopathy. Microtubules are made up of αβ tubulin su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47249-7
更新日期:2019-07-25 00:00:00
abstract::Organic matter production and decomposition primarily modulate the atmospheric O2 and CO2 levels. The long term marine primary productivity is controlled by the terrestrial input of phosphorus (P), while the marine P cycle would also affect organic matter production. In the past 540 million years, the evolution of ter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62816-z
更新日期:2020-04-02 00:00:00
abstract::Reversible polymeric networks can show self-healing properties due to their ability to reassemble after application of stress and fracture, but typically the relation between equilibrium molecular dynamics and self-healing kinetics has been difficult to disentangle. Here we present a well-characterized, self-assembled...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32356
更新日期:2016-09-01 00:00:00
abstract::A low-bandgap acceptor (ITIC) was added to a binary system composed of a wide-bandgap polymer (PBT-OTT) and an acceptor (PC71BM) to increase the light harvesting efficiency of the associated organic solar cells (OSCs). A ternary blend OSC with an acceptor ratio of PC71BM:ITIC = 8:2 was found to exhibit a power convers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48306-x
更新日期:2019-08-19 00:00:00
abstract::Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30782
更新日期:2016-07-29 00:00:00
abstract::Transcription factors (TFs) binding to specific DNA sequences or motifs, are elementary to the regulation of transcription. The gene is regulated by a combination of TFs in close proximity. Analysis of co-TFs is an important problem in understanding the mechanism of transcriptional regulation. Recently, ChIP-seq in ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43597
更新日期:2017-02-27 00:00:00
abstract::Most members of the poly(ADP-ribose)polymerase family, PARP family, have a catalytic activity that involves the transfer of ADP-ribose from a beta-NAD+-molecule to protein acceptors. It was recently discovered by Talhaoui et al. that DNA-dependent PARP1 and PARP2 can also modify DNA. Here, we demonstrate that DNA-depe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22673-3
更新日期:2018-03-08 00:00:00
abstract::Nanoparticles are widely used in commodities, and pregnant women are inevitably exposed to these particles. The placenta protects the growing fetus from foreign or toxic materials, and provides energy and oxygen. Here we report that autophagy, a cellular mechanism to maintain homeostasis, engulfs platinum nanoparticle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41927-2
更新日期:2019-04-02 00:00:00
abstract::A composite of manganese monoxide loaded onto carbon nanotubes (CNTs@MnO) has been synthesized by a facile approach, in which the CNTs form a continuous conductive network connecting the electrocatalyst MnO nanoparticles together to facilitate good electrochemical performance. The electrocatalyst MnO shows favourable ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08012
更新日期:2015-01-30 00:00:00
abstract::Flavonoids are potential antibacterial agents. However, key substituents and mechanism for their antibacterial activity have not been fully investigated. The quantitative structure-activity relationship (QSAR) and molecular docking of flavonoids relating to potent anti-Escherichia coli agents were investigated. Compar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23634
更新日期:2016-04-06 00:00:00
abstract::The combined regulation of a network of inhibitory and activating T cell receptors may be a critical step in the development of chronic HCV infection. Ex vivo HCV MHC class I + II tetramer staining and bead-enrichment was performed with baseline and longitudinal PBMC samples of a cohort of patients with acute, chronic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47024-8
更新日期:2019-07-23 00:00:00
abstract::The plasmonic waveguide made of uniform corrugated metallic strip can support and guide spoof surface plasmon polaritons (SSPPs) with high confinements. Here, we propose periodically-modulated plasmonic waveguide composed of non-uniform corrugated metallic strip to convert SSPPs to radiating waves, in which the main b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29600
更新日期:2016-07-12 00:00:00
abstract::Nanoscale real-time molecular sensing requires large signal enhancement, small background, short detection time and high spectral resolution. We demonstrate a new vibrational spectroscopic technique which satisfies all of these conditions. This time-resolved surface-enhanced coherent anti-Stokes Raman scattering (tr-S...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00891
更新日期:2012-01-01 00:00:00
abstract::Recent longitudinal neuroimaging and neurophysiological studies have shown that tracking relative age-related changes in neural signals, rather than a static snapshot of a neural measure, could offer higher sensitivity for discriminating typically developing (TD) individuals from those with autism spectrum disorder (A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67507-3
更新日期:2020-07-06 00:00:00
abstract::Sub-gap density of states (DOS) is a key parameter to impact the electrical characteristics of semiconductor materials-based transistors in integrated circuits. Previously, spectroscopy methodologies for DOS extractions include the static methods, temperature dependent spectroscopy and photonic spectroscopy. However, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24096
更新日期:2016-06-14 00:00:00
abstract::Amyloids are cross-β-sheet fibrillar aggregates, associated with various human diseases and native functions such as protein/peptide hormone storage inside secretory granules of neuroendocrine cells. In the current study, using amyloid detecting agents, we show that growth hormone (GH) could be stored as amyloid in th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23370
更新日期:2016-03-23 00:00:00
abstract::Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell adhesion molecule (NCAM). Several studies have shown that it is important for correct formation of brain circuitries during development and for synaptic plasticity, learning and memory in the adult. PSA also plays a major rol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26927
更新日期:2016-06-21 00:00:00
abstract::Quantifying multi-molecular complex assembly in specific cytoplasmic compartments is crucial to understand how cells use assembly/disassembly of these complexes to control function. Currently, biophysical methods like Fluorescence Resonance Energy Transfer and Fluorescence Correlation Spectroscopy provide quantitative...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28822
更新日期:2016-06-30 00:00:00
abstract::A generalization of the Raman scattering (RS) spectrum, the Raman excitation map (REM) is a hyperspectral two-dimensional (2D) data set encoding vibrational spectra, electronic spectra and their coupling. Despite the great potential of REM for optical sensing and characterization with remarkable sensitivity and select...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65757-9
更新日期:2020-06-08 00:00:00
abstract::Garnet is the archetypal cubic mineral, occurring in a wide variety of rock types in Earth's crust and upper mantle. Owing to its prevalence, durability and compositional diversity, garnet is used to investigate a broad range of geological processes. Although birefringence is a characteristic feature of rare Ca-Fe3+ g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51214-9
更新日期:2019-10-11 00:00:00
abstract::Enhanced and immediate expression of cyclooxygenase-2 (COX-2) mRNA is observed in IL-1β-stimulated OA chondrocytes but the synthesis of protein found significantly delayed. Here we investigated the role of stress granules (SGs), ribonucleoprotein complexes that regulate mRNA translation, in the delayed translation of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27611
更新日期:2016-06-08 00:00:00
abstract::Water Droplet Erosion (WDE) as a material degradation phenomenon has been a concern in power generation industries for decades. Steam turbine blades and the compressor blades of gas turbines that use water injection usually suffer from WDE. The present work focuses on studying erosion resistance of TiAl as a potential...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14182
更新日期:2015-09-22 00:00:00
abstract::In bacteria, selective promoter recognition by RNA polymerase is achieved by its association with σ factors, accessory subunits able to direct RNA polymerase "core enzyme" (E) to different promoter sequences. Using Chromatin Immunoprecipitation-sequencing (ChIP-seq), we searched for promoters bound by the σ(S)-associa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10469
更新日期:2015-05-28 00:00:00