Abstract：
:MicroRNA-200 (miR-200) family is highly expressed in ovarian cancer. We evaluated the levels of family members relative to the internal control miR-103a in ovarian cancer and control blood specimens collected from American and Hong Kong Chinese institutions, as well as from a laying hen spontaneous ovarian cancer model. The levels of miR-200a, miR-200b and miR-200c were significantly elevated in all human cancer versus all control blood samples. Further analyses showed significantly higher miR-200 levels in Chinese control (except miR-429) and cancer (except miR-200a and miR141) samples than their respective American counterparts. Subtype-specific analysis showed that miR-200b had an overall elevated level in serous cancer compared with controls, whereas miR-429 was significantly elevated in clear cell and endometrioid cancer versus controls. MiR-429 was also significantly elevated in cancer versus control in laying hen plasma samples, consistent with the fact that endometrioid tumor is the prevalent type in this species. A neural network model consisting of miR-200a/200b/429/141 showed an area under the curve (AUC) value of 0.904 for American ovarian cancer prediction, whereas a model consisting of miR-200b/200c/429/141 showed an AUC value of 0.901 for Chinese women. Hence, miR-200 is informative as blood biomarkers for both human and laying hen ovarian cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Choi PW,Bahrampour A,Ng SK,Liu SK,Qiu W,Xie F,Kuo WP,Kwong J,Hales KH,Hales DB,Wong KK,Norwitz ER,Chow CK,Berkowitz RS,Ng SWdoi
10.1038/s41598-020-77068-0subject
Has Abstractpub_date
2020-11-18 00:00:00pages
20071issue
1issn
2045-2322pii
10.1038/s41598-020-77068-0journal_volume
10pub_type
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