Two distinct knockout approaches highlight a critical role for p53 in rat development.

abstract：:Activation of cell cycle regulated transcription during the G1-to-S transition initiates S phase entry and cell cycle commitment. The molecular mechanisms involving G1/S transcriptional regulation are well established and have been shown to be evolutionary conserved from yeast to humans. Previous work has suggested th...

journal_title：Scientific reports

authors： Kishkevich A,Cooke SL,Harris MRA,de Bruin RAM

更新日期：2019-07-23 00:00:00

abstract：:The biodosimetric information is critical for evaluating the human health hazards caused by radon and its progeny. Here, we demonstrated that the formation of phosphorylated histone variant H2AX (γ-H2AX), p53-binding protein 1 (53BP1) and phosphorylated KRAB-associated protein 1 (pKAP-1) foci and their linear tracks i...

journal_title：Scientific reports

authors： Ding D,Zhang Y,Wang J,Wang X,Fan D,He L,Zhang X,Gao Y,Li Q,Chen H

更新日期：2016-12-06 00:00:00

abstract：:The objective of our in vivo study was to compare the effects of the osteotomy on the thermal alterations, the bone healing and count of polymorphonuclear cells, comparing the drill design (cylindrical or conical) using continuous or intermittent movement. Twelve rabbits were used, which were made four osteotomies (n ...

journal_title：Scientific reports

authors： Gehrke SA,Treichel TLE,Aramburú Júnior J,de Aza PN,Prados-Frutos JC

更新日期：2020-11-26 00:00:00

abstract：:The prominent comprehensive properties of solid-solution- and intermetallic-based Ti alloys are derived from their diverse microstructures induced by multi-component alloying, which results in a chemical composition complexity. A cluster-plus-glue-atom model, characterizing the chemical short-range orders, was introdu...

journal_title：Scientific reports

authors： Jiang B,Wang Q,Dong C,Liaw PK

更新日期：2019-03-04 00:00:00

abstract：:Studies have reported that neck and/or shoulder pain (NSP) was prevalent and a non-ignorable occupational health problem in healthcare providers. Considering data deficiency on NSP, we aimed to investigate the prevalence and sick leave absence of NSP among public hospital workers in Shandong, China and to explore the ...

journal_title：Scientific reports

authors： Dong H,Zhang Q,Liu G,Shao T

更新日期：2020-07-23 00:00:00

abstract：BACKGROUND:Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to impaired cortisol biosynthesis. Treatment includes glucocorticoid supplementation. We studied the specific metabolomics signatures in CAH patients using two different algorithms. METHODS:In a case-control study of CAH patients ma...

journal_title：Scientific reports

authors： Nguyen LS,Prifti E,Ichou F,Leban M,Funck-Brentano C,Touraine P,Salem JE,Bachelot A

更新日期：2020-06-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an efficacious treatment for some types of cancers. However, PDT-induced tumor hypoxia as a result of oxygen consumption and vascular damage can reduce the efficacy of this therapy. Measuring and monitoring intrinsic and PDT-induced tumor hypoxia in vivo during PDT is of high interest for...

journal_title：Scientific reports

authors： Tong X,Srivatsan A,Jacobson O,Wang Y,Wang Z,Yang X,Niu G,Kiesewetter DO,Zheng H,Chen X

更新日期：2016-08-22 00:00:00

abstract：:Serotonin (5-HT) is an important neurotransmitter and neuromodulator that controls a variety of sensory and motor functions through 5-HT receptors (5-HTRs). The 5-HT4R subfamily is linked to Gs proteins, which activate adenylyl cyclases (ACs), and is involved in many responses in peripheral organs. In this study, the ...

journal_title：Scientific reports

authors： Wang T,Yang Z,Zhou N,Sun L,Lv Z,Wu C

更新日期：2017-01-06 00:00:00

abstract：:A large number of drugs are administered on different mucosal surfaces. However, due to the poor mucoadhesion of the current formulations, their bioavailability is often very low. The development of efficient mucoadhesive drug delivery systems is thus crucial for improving the performance of these drugs. The mucoadhes...

journal_title：Scientific reports

authors： Ouellette M,Masse F,Lefebvre-Demers M,Maestracci Q,Grenier P,Millar R,Bertrand N,Prieto M,Boisselier É

更新日期：2018-09-25 00:00:00

abstract：:The decomposition of methane (CH4) is a catalytically important reaction in the production of syngas that is used to make a wide spectrum of hydrocarbons and alcohols, and a principal carbon deposition pathway in methane reforming. Literatures suggest that stepped Ni surface is uniquely selective toward methane decomp...

journal_title：Scientific reports

authors： Arevalo RL,Aspera SM,Escaño MCS,Nakanishi H,Kasai H

更新日期：2017-10-25 00:00:00

abstract：:Designer nucleases, like zinc-finger nucleases (ZFNs), represent valuable tools for targeted genome editing. Here, we took advantage of the gamma-retroviral life cycle and produced vectors to transfer ZFNs in the form of protein, mRNA and episomal DNA. Transfer efficacy and ZFN activity were assessed in quantitative p...

journal_title：Scientific reports

authors： Bobis-Wozowicz S,Galla M,Alzubi J,Kuehle J,Baum C,Schambach A,Cathomen T

更新日期：2014-04-11 00:00:00

abstract：:When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows that individuals with autism spectrum disorder (ASD) performed better in terms of hearing a target sequence among distractors that had similar...

journal_title：Scientific reports

authors： Lin IF,Yamada T,Komine Y,Kato N,Kashino M

更新日期：2015-05-22 00:00:00

abstract：:We present a comparative study of plasmonic antennas fabricated by electron beam lithography and direct focused ion beam milling. We have investigated optical and structural properties and chemical composition of gold disc-shaped plasmonic antennas on a silicon nitride membrane fabricated by both methods to identify t...

journal_title：Scientific reports

authors： Horák M,Bukvišová K,Švarc V,Jaskowiec J,Křápek V,Šikola T

更新日期：2018-06-25 00:00:00

abstract：:Giant unilamellar vesicles (GUVs) are increasingly used as a versatile research tool to investigate membrane structure, morphology and phase state. In these studies, GUV preparation is typically enhanced by an externally applied electric field, a process called electroformation. We find that upon osmotic deflation, GU...

journal_title：Scientific reports

authors： Steinkühler J,De Tillieux P,Knorr RL,Lipowsky R,Dimova R

更新日期：2018-08-07 00:00:00

abstract：:We assessed the relationship between the heterogeneity of HCC on preoperative non-contrast-enhanced CT and patient prognosis. The heterogeneity of CT images from 122 patients was assessed and texture feature parameters such as mean, standard deviation (SD), entropy, mean of the positive pixels (MPP), skewness, and kur...

journal_title：Scientific reports

authors： Kiryu S,Akai H,Nojima M,Hasegawa K,Shinkawa H,Kokudo N,Yasaka K,Ohtomo K

更新日期：2017-10-04 00:00:00

abstract：:Porous carbon spheres (CSs) have distinct advantages in energy storage and conversion applications. We report the preparation of highly monodisperse N-doped microporous CSs through the carbonization of polystyrene-based polymer spheres and subsequent activation. The N-doped microporous CSs have a remarkably high N-dop...

journal_title：Scientific reports

authors： Kim C,Kim K,Moon JH

更新日期：2017-10-31 00:00:00

abstract：:The ability to change the secondary electron emission properties of nitrogen-doped graphene (N-graphene) has been demonstrated. To this end, a novel microwave plasma-enabled scalable route for continuous and controllable fabrication of free-standing N-graphene sheets was developed. High-quality N-graphene with prescri...

journal_title：Scientific reports

authors： Bundaleska N,Dias A,Bundaleski N,Felizardo E,Henriques J,Tsyganov D,Abrashev M,Valcheva E,Kissovski J,Ferraria AM,do Rego AMB,Almeida A,Zavašnik J,Cvelbar U,Teodoro OMND,Strunskus T,Tatarova E

更新日期：2020-08-03 00:00:00

abstract：:The fungal communities of different soil compartments in mangrove ecosystem are poorly studied. We sequenced the internal transcribed spacer (ITS) regions to characterize the fungal communities in Avicennia marina root-associated soils (rhizosphere and pneumatophore) and bulk soil compartments. The rhizosphere but not...

journal_title：Scientific reports

authors： Sanka Loganathachetti D,Poosakkannu A,Muthuraman S

更新日期：2017-08-17 00:00:00

abstract：:To explore the predictive performance of machine learning on the recurrence of patients with gastric cancer after the operation. The available data is divided into two parts. In particular, the first part is used as a training set (such as 80% of the original data), and the second part is used as a test set (the remai...

journal_title：Scientific reports

authors： Zhou C,Hu J,Wang Y,Ji MH,Tong J,Yang JJ,Xia H

更新日期：2021-01-15 00:00:00

abstract：:Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred...

journal_title：Scientific reports

authors： Sello MM,Jafta N,Nelson DR,Chen W,Yu JH,Parvez M,Kgosiemang IKR,Monyaki R,Raselemane SC,Qhanya LB,Mthakathi NT,Sitheni Mashele S,Syed K

更新日期：2015-07-01 00:00:00

abstract：:Adolescence is a critical stage of development and has an important influence on energy balance-related behaviours (EBRBs). When adolescents are associated with obesity it can lead to increased cardiometabolic risk. Here we assess if EBRBs adopted by adolescents included in a subsample are associated with markers of t...

journal_title：Scientific reports

authors： Forkert ECO,Moraes ACF,Carvalho HB,Manios Y,Widhalm K,González-Gross M,Gutierrez A,Kafatos A,Censi L,De Henauw S,Moreno LA

更新日期：2019-04-23 00:00:00

abstract：:Asymmetric cell division is a ubiquitous feature during the development of higher organisms. Asymmetry is achieved by differential localization or activities of biological molecules such as proteins, and coding and non-coding RNAs. Here, we present subcellular transcriptomic and proteomic analyses along the animal-veg...

journal_title：Scientific reports

authors： Sindelka R,Abaffy P,Qu Y,Tomankova S,Sidova M,Naraine R,Kolar M,Peuchen E,Sun L,Dovichi N,Kubista M

更新日期：2018-05-29 00:00:00

abstract：:Prior to this study, complete mitochondrial genomes from Order Thysanoptera were restricted to a single family, the Thripidae, resulting in a biased view of their evolution. Here we present the sequences for the mitochondrial genomes of four additional thrips species, adding three extra families and an additional subf...

journal_title：Scientific reports

authors： Tyagi K,Chakraborty R,Cameron SL,Sweet AD,Chandra K,Kumar V

更新日期：2020-01-20 00:00:00

abstract：:The UCSC Cancer Genomics Browser (https://genome-cancer.ucsc.edu) offers interactive visualization and exploration of TCGA genomic, phenotypic, and clinical data, as produced by the Cancer Genome Atlas Research Network. Researchers can explore the impact of genomic alterations on phenotypes by visualizing gene and pro...

journal_title：Scientific reports

authors： Cline MS,Craft B,Swatloski T,Goldman M,Ma S,Haussler D,Zhu J

更新日期：2013-10-02 00:00:00

abstract：:CRISPR/Cas9-based gene knockout in animal cells, particularly in teleosts, has proven to be very efficient with regards to mutation rates, but the precise insertion of exogenous DNA or gene knock-in via the homology-directed repair (HDR) pathway has seldom been achieved outside of the model organisms. Here, we succeed...

journal_title：Scientific reports

authors： Simora RMC,Xing,Bangs MR,Wang W,Ma X,Su B,Khan MGQ,Qin Z,Lu C,Alston V,Hettiarachchi D,Johnson A,Li S,Coogan M,Gurbatow J,Terhune JS,Wang X,Dunham RA

更新日期：2020-12-17 00:00:00

abstract：:Bacillus thuringiensis insecticidal toxin (Bt) rice will be commercialized as a main food source. Traditional safety assessments on genetically modified products pay little attention on gastrointestinal (GI) health. More data about GI health of Bt rice must be provided to dispel public' doubts about the potential effe...

journal_title：Scientific reports

authors： Yuan Y,Xu W,He X,Liu H,Cao S,Qi X,Huang K,Luo Y

更新日期：2013-01-01 00:00:00

abstract：:A new miniplate applied differently from conventional application method for bone fixation has been developed. The novel approach is the insertion of the screw into the bone before miniplate installation. This study aimed to assess the stress distribution of a newly designed Yang's Keyhole (YK)- plate for segmental-bo...

journal_title：Scientific reports

authors： Kim JW,Park KN,Lee CH,Kim YS,Kim YH,Yang BE

更新日期：2018-06-12 00:00:00

abstract：:Silver nanobelts (AgNBs) have attracted a great interest due to their excellent electrical conductivity and mechanical strength, leading a facile synthesis of these AgNBs in great demand. In here, we are reporting a simple, aqueous phase, size tunable synthesis of smooth surfaced 1D-silver nanobelts using a Polyanilin...

journal_title：Scientific reports

authors： Padmanaban S,Kim M,Yoon S

更新日期：2017-03-20 00:00:00

abstract：:Poly(N-isopropylacrylamide) (PNIPAm) is widely used to fabricate cell sheet surfaces for cell culturing, however copolymer and interpenetrated polymer networks based on PNIPAm have been rarely explored in the context of tissue engineering. Many complex and expensive techniques have been employed to produce PNIPAm-base...

journal_title：Scientific reports

authors： Sanzari I,Buratti E,Huang R,Tusan CG,Dinelli F,Evans ND,Prodromakis T,Bertoldo M

更新日期：2020-04-09 00:00:00

abstract：:The expanding distribution of African swine fever (ASF) is threatening the pig industry worldwide. Most outbreaks occur in backyard and small-scale herds, where poor farmers often attempt to limit the disease's economic consequences by the emergency sale of their pigs. The risk of African swine fever virus (ASFV) rele...

journal_title：Scientific reports

authors： Costard S,Zagmutt FJ,Porphyre T,Pfeiffer DU

更新日期：2015-11-27 00:00:00