Abstract:
:Activation of cell cycle regulated transcription during the G1-to-S transition initiates S phase entry and cell cycle commitment. The molecular mechanisms involving G1/S transcriptional regulation are well established and have been shown to be evolutionary conserved from yeast to humans. Previous work has suggested that changes to the chromatin state, specifically through histone acetylation, has an important role in the regulation of G1/S transcription in both yeast and human cells. Here we investigate the role of histone acetylation in G1/S transcriptional regulation in the budding yeast Saccharomyces cerevisiae. Our work shows that histone acetylation at specific sites at G1/S target gene promoters peaks at the G1-to-S transition, coinciding with their peak transcription levels. Acetylation at G1/S target promoters is significantly reduced upon deletion of the previously implicated histone acetyltransferase Gcn5, but G1/S cell cycle regulated transcription is largely unaffected. The histone deacetylase Rpd3, suggested to have a role in Whi5-dependent repression, is required for full repression of G1/S target genes in the G1 and S phases. However, in the context of transcriptionally active levels during the G1-to-S transition, this seems to play a minor role in the regulation of cell cycle transcription. Our data suggests that histone acetylation might modulate the amplitude of G1/S cell cycle regulated transcription in Saccharomyces cerevisiae, but has a limited role in its overall regulation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kishkevich A,Cooke SL,Harris MRA,de Bruin RAMdoi
10.1038/s41598-019-47170-zsubject
Has Abstractpub_date
2019-07-23 00:00:00pages
10686issue
1issn
2045-2322pii
10.1038/s41598-019-47170-zjournal_volume
9pub_type
杂志文章abstract::Prostate cancer is the most commonly diagnosed cancer in men with African American men disproportionally suffering from the burden of this disease. Biomarkers that could discriminate indolent from aggressive and drug resistance disease are lacking. MicroRNAs are small non-coding RNAs that affect numerous physiological...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46170-3
更新日期:2019-07-05 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-35437-w
更新日期:2018-11-22 00:00:00
abstract::Circularly polarized laser sources with small footprints and high efficiencies can possess advanced functionalities in optical communication and biophotonic integrated systems. However, the conventional lasers with additional circular-polarization converters are bulky and hardly compatible with nanophotonic circuits, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26578
更新日期:2016-05-25 00:00:00
abstract::The fishery for Antarctic krill is currently managed using a precautionary, ecosystem-based approach to limiting catch, with performance indices from a long-term monitoring program focused on several krill-dependent predators that are used to track ecosystem health. Concerns over increased fishing in concentrated area...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75148-9
更新日期:2020-10-28 00:00:00
abstract::The aberrant accumulation of ubiquitinated protein aggregates in cells plays a critical role in the pathogenesis of several degenerative diseases, including Parkinson disease (PD) and cystic fibrosis (CF). In this study, we found that Ras GTPase-activating protein-binding protein 1 (G3BP1) inhibits ubiquitinated prote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46237-1
更新日期:2019-09-09 00:00:00
abstract::T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the performance of a 3-slice approach to full left ventricular (LV) coverage for the AAR by T1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05127-0
更新日期:2017-07-07 00:00:00
abstract::Carotenoids are anti-oxidative agents. Human skin and eyes contain specific carotenoid species known to prevent various pathologies caused by oxidative stress. We quantified skin and eye carotenoid levels and investigated their potential correlation in a population including 985 Japanese patients and staff members of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45751-6
更新日期:2019-06-27 00:00:00
abstract::Ubiquitous in nature, polyamines (PAs) are a class of low-molecular aliphatic amines critically involved in cell growth, survival and differentiation. The polycation behavior is validated as a successful strategy in delivery systems to enhance oligonucleotide loading and cellular uptake. In this study, the chemical fe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77957-4
更新日期:2020-12-03 00:00:00
abstract::Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine metabolism with 6-diazo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42932-1
更新日期:2019-04-23 00:00:00
abstract::Little is known about the composition and clinical implications of lung microbiome in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia requiring invasive mechanical ventilation and intensive care unit admission. Therefore, this study aimed to explore the longitudinal changes ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68100-4
更新日期:2020-07-06 00:00:00
abstract::Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35047
更新日期:2016-10-19 00:00:00
abstract::Human phosphoglucomutase 1 (PGM1) is an evolutionary conserved enzyme that belongs to the ubiquitous and ancient α-D-phosphohexomutases, a large enzyme superfamily with members in all three domains of life. PGM1 catalyzes the bi-directional interconversion between α-D-glucose 1-phosphate (G1P) and α-D-glucose 6-phosph...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62548-0
更新日期:2020-03-27 00:00:00
abstract::Solving river engineering problems typically requires river flow characterization, including the prediction of flow depth, flow velocity, and flood extent. Hydraulic models use governing equations of the flow in motion (conservation of mass and momentum principles) to predict the flow characteristics. However, solving...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65232-5
更新日期:2020-05-19 00:00:00
abstract::A Quality Improvement bundle was implemented with the goal of standardizing the multidisciplinary approach to delivery room management. We used a Pre-Post Quality Improvement initiative with the following aims: (1) Placement of a functioning pulse oximeter by two minutes after birth, (2) Delayed intubation, (3) Normot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37397
更新日期:2016-11-21 00:00:00
abstract::Procalcitonin (PCT) is a useful marker for the diagnosis of systemic inflammatory response syndrome. In addition, PCT is affected by renal function. However, few studies have investigated the relationship between PCT and the development of acute kidney injury (AKI). Hence, we investigated whether serum PCT levels at t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41291-1
更新日期:2019-03-18 00:00:00
abstract::Phase transition is a natural phenomenon happened around our daily life, represented by the process from ice to water. While melting and solidifying at a certain temperature, a high heat of fusion is accompanied, classified as the latent heat. Phase change material (PCM) has been widely applied to store and release la...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08884
更新日期:2015-03-09 00:00:00
abstract::The family of materials defined as ZrSiX (X = S, Se, Te) has been established as Dirac node-line semimetals, and subsequent study is urgent to exploit the promising applications of unusual magnetoresistance (MR) properties. Herein, we systematically investigated the anisotropic MR in the newly-discovered Dirac node-li...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27148-z
更新日期:2018-06-19 00:00:00
abstract::Ion mobility mass spectrometry (IM-MS) is a technique capable of investigating structural changes of biomolecules based on their collision cross section (CCS). Recent advances in IM-MS allow us to separate carbohydrate isomers with subtle conformational differences, but the relationship between CCS and atomic structur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20012-0
更新日期:2018-01-26 00:00:00
abstract::Given the complex nature of the interaction between gas and solid atoms, the development of nanoscale science and technology has engendered a need for further understanding of gas transport behavior through nanopores and more tractable models for large-scale simulations. In the present paper, we utilize molecular dyna...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23629
更新日期:2016-03-29 00:00:00
abstract::The negatively-charged nitrogen vacancy (NV(-)) center in diamond is of great interest for quantum information processing and quantum key distribution applications due to its highly desirable long coherence times at room temperature. One of the challenges for their use in these applications involves the requirement to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11179
更新日期:2015-06-25 00:00:00
abstract::Fourier ptychographic microscopy (FPM) is a novel computational coherent imaging technique for high space-bandwidth product imaging. Mathematically, Fourier ptychographic (FP) reconstruction can be implemented as a phase retrieval optimization process, in which we only obtain low resolution intensity images correspond...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27384
更新日期:2016-06-10 00:00:00
abstract::Little is known on the causes and pathogenesis of the adipose tissue disorder (familial) Multiple Symmetric Lipomatosis (MSL). In a four-generation MSL-family, we performed whole exome sequencing (WES) in 3 affected individuals and 1 obligate carrier and identified Calcyphosine-like (CAPSL) as the most promising candi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44382-1
更新日期:2019-06-11 00:00:00
abstract::Oil palm (Elaeis guinensis Jacquin) is the most important source of vegetable oil and fat. Several linkage maps had been constructed using dominant and co-dominant markers to facilitate mapping of QTL. However, dominant markers are not easily transferable among different laboratories. We constructed a consensus linkag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08232
更新日期:2015-02-04 00:00:00
abstract::In contrast to mammals, adult fish display a remarkable ability to fully regenerate central nervous system (CNS) axons, enabling functional recovery from CNS injury. Both fish and mammals normally undergo a developmental downregulation of axon growth activity as neurons mature. Fish are able to undergo damage-induced ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50485-6
更新日期:2019-10-02 00:00:00
abstract::Light pollution and its consequences on ecosystems are increasing worldwide. Knowledge on the threshold levels of light pollution at which significant ecological impacts emerge and the size of dark refuges to maintain natural nocturnal processes is crucial to mitigate its negative consequences. Seabird fledglings are ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10670
更新日期:2015-06-02 00:00:00
abstract::We investigate collective modes in three dimensional (3D) gapless multi-Weyl semimetals with anisotropic energy band dispersions (i.e., with a positive integer J). For comparison, we also consider the gapless semimetals with the isotropic band dispersions (i.e. E ~ kJ). We calculate analytically long-wavelength plasma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34023
更新日期:2016-09-30 00:00:00
abstract::Although differentiated thyroid carcinoma (DTC) has a good prognosis and survival rate, long-term medication and recurrence monitoring might be needed. The factors that affect postoperative health-related quality of life (HRQoL) in patients with DTC in different regions remain unclear or conflicting. The purpose of th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62731-3
更新日期:2020-04-01 00:00:00
abstract::Orofacial pain impairs a patient's speech, swallowing, eating and interpersonal relations. Thirty-seven patients with a premalignant oral lesion, 124 patients with oral squamous cell carcinoma (OSSC), and 21 patients with a recurrence of OSSC were evaluated for their orofacial pain. The University of California San Fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00370-x
更新日期:2017-03-16 00:00:00
abstract::Helicobacter pylori (H. pylori ) infection is a major cause of chronic gastritis and is highly related to duodenal ulcer (DU) and gastric cancer (GC). To identify H. pylori-related GC biomarkers with high seropositivity in GC patients, differences in levels of protein expression between H. pylori from GC and DU patien...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36442
更新日期:2016-11-07 00:00:00
abstract::Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinations against methicillin-resi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25714-z
更新日期:2018-05-08 00:00:00