Abstract：
:Protein phosphorylation is an important type of post-translational modification that is involved in a variety of biological activities. Most phosphorylation events occur on serine, threonine and tyrosine residues in eukaryotes. In recent years, many phosphorylation sites have been identified as a result of advances in mass-spectrometric techniques. However, a large percentage of phosphorylation sites may be non-functional. Systematically prioritizing functional sites from a large number of phosphorylation sites will be increasingly important for the study of their biological roles. This study focused on exploring the intrinsic features of functional phosphorylation sites to predict whether a phosphosite is likely to be functional. We found significant differences in the distribution of evolutionary conservation, kinase association, disorder score, and secondary structure between known functional and background phosphorylation datasets. We built four different types of classifiers based on the most representative features and found that their performances were similar. We also prioritized 213,837 human phosphorylation sites from a variety of phosphorylation databases, which will be helpful for subsequent functional studies. All predicted results are available for query and download on our website (Predict Functional Phosphosites, PFP, http://pfp.biosino.org/).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xiao Q,Miao B,Bi J,Wang Z,Li Ydoi
10.1038/srep24735subject
Has Abstractpub_date
2016-04-19 00:00:00pages
24735issn
2045-2322pii
srep24735journal_volume
6pub_type
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journal_title：Scientific reports
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更新日期：2017-04-05 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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更新日期：2019-02-28 00:00:00
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pub_type： 杂志文章
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更新日期：2019-09-10 00:00:00
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pub_type： 杂志文章
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更新日期：2016-01-27 00:00:00
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pub_type： 杂志文章
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更新日期：2017-04-03 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2017-03-20 00:00:00
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pub_type： 杂志文章,meta分析,评审
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journal_title：Scientific reports
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