Abstract：
:Early detection and treatment of coronary artery disease (CAD) can reduce incidences of acute myocardial infarction. In this study, we determined the proper use of contributing risk factors and coronary artery calcium score (CACS) when screening asymptomatic patients with coronary arterial stenoses using coronary computed tomography angiography (CCTA). We reviewed 934 consecutive patients who received CACS and CCTA between December 2013 and November 2016. At least one cardiovascular disease risk factor was present in each of the 509 asymptomatic participants. Patients were grouped based on CACS into "zero," "minimal" (0 < CACS ≤ 10), "mild" (10 < CACS ≤ 100), "moderate" (100 < CACS ≤ 400), and "excessive" (CACS > 400). Males over 45 years old with diabetes mellitus and hypertension had a higher risk of significant coronary stenosis. In multivariate analysis, age, sex, hypertension, and diabetes mellitus remained significant predictors of stenosis. A CACS of zero occurred in 227 patients (44.6%). There were no significant differences between the "zero" and "minimal" groups (p = 0.421), but the "mild," "moderate," and "excessive" groups showed correlations with significant coronary stenosis. Age, sex, diabetes mellitus, and hypertension were associated with higher risk of significant coronary stenosis. Asymptomatic patients with CACSs of zero do not require CCTA, and thereby avoid unnecessary radiation exposure.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tay SY,Chang PY,Lao WT,Lin YC,Chung YH,Chan WPdoi
10.1038/s41598-017-17655-wsubject
Has Abstractpub_date
2017-12-15 00:00:00pages
17653issue
1issn
2045-2322pii
10.1038/s41598-017-17655-wjournal_volume
7pub_type
杂志文章abstract：:Neonatal mice exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). Cardiac biomechanics intricately affect long-term heart function, but whether regenerated cardiac muscle is biomechanically similar to native myocardium remains u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63324-w
更新日期：2020-04-30 00:00:00
abstract：:Biofilm is recognized as a contributing factor to the capacity of Acinetobacter baumannii to persist and prosper in medical settings, but it is still unknown whether biofilms contribute to the spread of A. baumannii. In this study, the biofilm formation of 114 clinical A. baumannii isolates and 32 non-baumannii Acinet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32066
更新日期：2016-08-25 00:00:00
abstract：:Enhanced and immediate expression of cyclooxygenase-2 (COX-2) mRNA is observed in IL-1β-stimulated OA chondrocytes but the synthesis of protein found significantly delayed. Here we investigated the role of stress granules (SGs), ribonucleoprotein complexes that regulate mRNA translation, in the delayed translation of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27611
更新日期：2016-06-08 00:00:00
abstract：:Hepatic steatosis (HS) can exacerbate acute pancreatitis (AP). This study aimed to investigate the relation between α1-antitrypsin (AAT) and acute pancreatitis when patients have HS. Using proteomic profiling, we identified 18 differently expressed proteins pots in the serum of rats with or without HS after surgical e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17833
更新日期：2015-12-04 00:00:00
abstract：:Warburg effect or aerobic glycolysis provides selective growth advantage to aggressive cancers. However, targeting oncogenic regulators of Warburg effect has always been challenging owing to the wide spectrum of roles of these molecules in multitude of cells. In this study, we present ADP-dependent glucokinase (ADPGK)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70014-0
更新日期：2020-08-12 00:00:00
abstract：:Reducing macrophage recruitment by silencing chemokine (C-C motif) receptor 2 (CCR2) expression is a promising therapeutic approach against atherosclerosis. However the transfection of macrophages with siRNA is often technically challenging. EGFP-EGF1-conjugated poly (lactic-co-glycolic acid) (PLGA) nanoparticles (ENP...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76416-4
更新日期：2020-11-12 00:00:00
abstract：:The corrosion of steel in concrete is mainly due to the chemical reaction between the chloride ions and iron ions. Indeed, this is a serious threaten for reinforced concrete structure, especially for the reinforced concrete structure in the sea. So it is urgent and important to protect concrete against chloride ions c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03359
更新日期：2013-11-28 00:00:00
abstract：:The fundamental plasticity mechanisms in thin freestanding Zr65Ni35 metallic glass films are investigated in order to unravel the origin of an outstanding strength/ductility balance. The deformation process is homogenous until fracture with no evidence of catastrophic shear banding. The creep/relaxation behaviour of t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49910-7
更新日期：2019-09-17 00:00:00
abstract：:Transgenic rice producing insecticidal proteins from Bacillus thuringiensis (Bt) could help protect the plants from damage by lepidopteran pests. However, one concern is the potential of Bt rice to harm non-target natural enemies, which play a vital role in pest control. In the present study, the potential effects of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08173-w
更新日期：2017-08-10 00:00:00
abstract：:The influenza A virus RNA polymerase cleaves the 5' end of host pre-mRNAs and uses the capped RNA fragments as primers for viral mRNA synthesis. We performed deep sequencing of the 5' ends of viral mRNAs from all genome segments transcribed in both human (A549) and mouse (M-1) cells infected with the influenza A/HongK...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06181
更新日期：2014-08-26 00:00:00
abstract：:Glaulactams A-C (1-3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33748-6
更新日期：2018-10-18 00:00:00
abstract：:Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encoura...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14990-w
更新日期：2017-11-02 00:00:00
abstract：:Current medications inadequately treat the symptoms of chronic pain experienced by over 50 million people in the United States, and may come with substantial adverse effects signifying the need to find novel treatments. One novel therapeutic target is the Transient Receptor Potential A1 channel (TRPA1), an ion channel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38852-9
更新日期：2019-02-20 00:00:00
abstract：:A number of studies have suggested that the irradiation behavior and damage processes occurring during sequential and simultaneous particle irradiations can significantly differ. Currently, there is no definite answer as to why and when such differences are seen. Additionally, the conventional multi-particle irradiati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30191
更新日期：2016-07-28 00:00:00
abstract：:Increasing attention is given to personalized tumour therapy, where α-emitters can potentially play an important role. Alpha particles are ideal for localized cell killing because of their high linear energy transfer and short ranges. However, upon the emission of an α particle the daughter nuclide experiences a recoi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48298-8
更新日期：2019-08-12 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-44437-3
更新日期：2019-06-05 00:00:00
abstract：:Color vision requires the activity of cone photoreceptors to be compared in post-receptoral circuitry. Decades of psychophysical measurements have quantified the nature of these comparative interactions on a coarse scale. How such findings generalize to a cellular scale remains unclear. To answer that question, we qua...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26754-1
更新日期：2018-06-04 00:00:00
abstract：:Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). Ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09795-w
更新日期：2017-08-24 00:00:00
abstract：:Most organisms are able to maintain systemic water homeostasis over a wide range of external or dietary osmolarities. The excretory system, composed of the kidneys in mammals and the Malpighian tubules and hindgut in insects, can increase water conservation and absorption to maintain systemic water homeostasis, which ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07993
更新日期：2015-01-23 00:00:00
abstract：:This paper has been retracted at the request of the authors. ...
journal_title：Scientific reports
pub_type： 撤回出版物
doi：10.1038/s41598-018-31224-9
更新日期：2018-09-04 00:00:00
abstract：:X-ray diffraction, Amorphous silicon, Multi-objective optimization, Monte Carlo methods. This paper addresses a difficult inverse problem that involves the reconstruction of a three-dimensional model of tetrahedral amorphous semiconductors via inversion of diffraction data. By posing the material-structure determinati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64327-3
更新日期：2020-05-08 00:00:00
abstract：:We study the interaction between localized vibrational modes and propagating phonons in graphene nanoribbons with different types of localized internal and edge defects. We analyze discrete eigenmodes of the nanoribbons with defects and also employ direct numerical simulations of the ballistic phonon and heat transpor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04987-w
更新日期：2017-07-05 00:00:00
abstract：:Genetic characterization of local breeds is essential to preserve their genomic variability, to advance conservation policies and to contribute to their promotion and sustainability. Genomic diversity of twenty European local pig breeds and a small sample of Spanish wild pigs was assessed using high density SNP chips....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49830-6
更新日期：2019-09-19 00:00:00
abstract：:The phosphatases of regenerating liver (PRLs) are involved in tumorigenesis and metastatic cancer yet their cellular function remains unclear. Recent reports have shown PRL phosphatases bind tightly to the CNNM family of membrane proteins to regulate magnesium efflux. Here, we characterize the interactions between the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00147-2
更新日期：2017-03-03 00:00:00
abstract：:Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines with different responses to NDV, Fayoumi and Leghorn, were challenged with LaSota N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19754-8
更新日期：2018-01-19 00:00:00
abstract：:Vitamin D deficiency, a major public-health worldwide, is associated with hyperuricemia but casual association is questioned. The study was conducted to determine potential causal associations between 25-hydroxy vitamin D (25(OH)D) and uric acid (UA). A cross-sectional study of the Electricity Generating Authority of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14528
更新日期：2015-09-29 00:00:00
abstract：:Recent research tried to analyze the conjugation of some chemotherapeutic drugs to the biologically produced gold nanoparticles (GNPs) in one step, without the use of any additional linkers. GNPs was produced using Fusarium oxysporum and their presence was confirmed using spectrophotometer, transmission electron micro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46602-0
更新日期：2019-07-15 00:00:00
abstract：:The interaction of (quasi)particles with a periodic potential arises in various domains of science and engineering, such as solid-state physics, chemical physics, and communication theory. An attractive test ground to investigate this interaction is represented by superconductors with artificial pinning sites, where m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14232-z
更新日期：2017-10-23 00:00:00
abstract：:N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this phenomenon remain poorly understood. Recruitment of the TREX mRNA export complex to mRNA is driven by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32310-8
更新日期：2018-09-14 00:00:00
abstract：:Alternatives to antibiotics for improving productivity and maintaining the health of livestock health are urgently needed. The scope of this research was conducted to investigate the effects of two alternatives (Bacillus licheniformis and Saccharomyces cerevisiae) to monensin on growth performance, antioxidant capacit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35081-4
更新日期：2018-11-12 00:00:00
