Abstract：
:N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this phenomenon remain poorly understood. Recruitment of the TREX mRNA export complex to mRNA is driven by transcription, 5' capping and pre-mRNA splicing. Here we identify a fourth mechanism in human cells driving the association of TREX with mRNA involving the m6A methylase complex. We show that the m6A complex recruits TREX to m6A modified mRNAs and this process is essential for their efficient export. TREX also stimulates recruitment of the m6A reader protein YTHDC1 to the mRNA and the m6A complex influences the interaction of TREX with YTHDC1. Together our studies reveal a key role for TREX in the export of m6A modified mRNAs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lesbirel S,Viphakone N,Parker M,Parker J,Heath C,Sudbery I,Wilson SAdoi
10.1038/s41598-018-32310-8subject
Has Abstractpub_date
2018-09-14 00:00:00pages
13827issue
1issn
2045-2322pii
10.1038/s41598-018-32310-8journal_volume
8pub_type
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