Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma.

abstract：:Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. However, whether precise disruption of Mstn in livestock can be achieved and safely used to improve meat productivity has not been proven. We applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and goats and then anal...

journal_title：Scientific reports

authors： Guo R,Wan Y,Xu D,Cui L,Deng M,Zhang G,Jia R,Zhou W,Wang Z,Deng K,Huang M,Wang F,Zhang Y

更新日期：2016-07-15 00:00:00

abstract：:Haemonchus contortus is arguably the most injurious helminth parasite for small ruminants. We characterized the impact of H. contortus infection on the caprine abomasal microbiome. Fourteen parasite naive goats were inoculated with 5,000 H. contortus infective larvae and followed for 50 days. Six age-matched naïve goa...

journal_title：Scientific reports

authors： Li RW,Li W,Sun J,Yu P,Baldwin RL,Urban JF

更新日期：2016-02-08 00:00:00

abstract：:Despite recent advances in cancer management and therapy, resistance to cytotoxic medications remains a major clinical challenge; hence, combination-based anti-cancer treatment regimens are currently gaining momentum. PTC-209 reduced BMI1 protein expression, while palbociclib inhibited CDK4, Rb, and pRbSer795 protein ...

journal_title：Scientific reports

authors： Elango R,Vishnubalaji R,Manikandan M,Binhamdan SI,Siyal AA,Alshawakir YA,Alfayez M,Aldahmash A,Alajez NM

更新日期：2019-09-23 00:00:00

abstract：:Prediction of infection trends, estimating the efficacy of contact tracing, testing or impact of influx of infected are of vital importance for administration during an ongoing epidemic. Most effective methods currently are empirical in nature and their relation to parameters of interest to administrators are not evid...

journal_title：Scientific reports

authors： Raghavan M,Sridharan KS,Mandayam Rangayyan Y

更新日期：2020-10-06 00:00:00

abstract：:Adult stem cells are considered promising candidates for cellular therapies due to their capacity to differentiate and self-renew. Differentiation leads to changes in the metabolism, structure, and gene expression patterns of cells. Hedgehog is one of the pathways that is involved in the enhancement of osteogenesis an...

journal_title：Scientific reports

authors： Shigunov P,Balvedi LT,Santos MDM,Herai RH,de Aguiar AM,Dallagiovanna B

更新日期：2018-05-30 00:00:00

abstract：:Captive breeding programs and aquaculture production have commenced worldwide for the globally distributed yellowtail kingfish (Seriola lalandi), and captive bred fingerlings are being shipped from the Southern Hemisphere to be farmed in the Northern Hemisphere. It was recently proposed that Pacific S. lalandi compris...

journal_title：Scientific reports

authors： Premachandra HKA,la Cruz FL,Takeuchi Y,Miller A,Fielder S,O'Connor W,Frère CH,Nguyen NH,Bar I,Knibb W

更新日期：2017-08-24 00:00:00

abstract：:Long daylength artificial light exposure associates with disorders, and a potential physiological mechanism has been proposed. However, previous studies have examined no more than three artificial light treatments and limited metabolic parameters, which have been insufficient to demonstrate mechanical responses. Here,...

journal_title：Scientific reports

authors： Yang Y,Yu Y,Yang B,Zhou H,Pan J

更新日期：2016-04-21 00:00:00

abstract：:Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and content of a vital ...

journal_title：Scientific reports

authors： Kandimalla R,Das M,Barge SR,Sarma PP,Koiri DJ,Devi A,Karki AK,Kumar A,Devi R,Pal BC,Talukdar NC,Samanta SK

更新日期：2020-11-18 00:00:00

abstract：:This paper investigates the effects of temperature on an InGaP (GaInP) 55Fe X-ray photovoltaic cell prototype for a radioisotope microbattery (also called a nuclear microbattery). An In0.5Ga0.5P p-i-n (5 μm i-layer) mesa photodiode was illuminated by a standard 206 MBq 55Fe radioisotope X-ray source and characterised ...

journal_title：Scientific reports

authors： Butera S,Whitaker MDC,Krysa AB,Barnett AM

更新日期：2017-07-10 00:00:00

abstract：:The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk allele of a variant in LOXL1 has been found to be inverted between Asian and Caucasian populations. Therefore, we newly performed a genome-wid...

journal_title：Scientific reports

authors： Nakano M,Ikeda Y,Tokuda Y,Fuwa M,Ueno M,Imai K,Sato R,Omi N,Adachi H,Kageyama M,Mori K,Kinoshita S,Tashiro K

更新日期：2014-06-18 00:00:00

abstract：:Nanopore-based sensing has emerged as a promising candidate for affordable and powerful DNA sequencing technologies. Herein, we demonstrate that nanopores can be successfully fabricated in Mg alloys via focused electron beam (e-beam) technology. Employing in situ high-resolution transmission electron microscopy techni...

journal_title：Scientific reports

authors： Zheng H,Liu Y,Cao F,Wu S,Jia S,Cao A,Zhao D,Wang J

更新日期：2013-01-01 00:00:00

abstract：:A generation of reactive oxygen species (ROS) from TiO2 under solar light has been long sought since the ROS can disinfect organic pollutants. We found that newly developed crystalline/amorphous reduced TiO2 (rTiO2) that has low energy bandgap can effectively generate ROS under solar light and successfully remove a bl...

journal_title：Scientific reports

authors： Kim Y,Hwang HM,Wang L,Kim I,Yoon Y,Lee H

更新日期：2016-04-28 00:00:00

abstract：:Agamococcidians are enigmatic and poorly studied parasites of marine invertebrates with unexplored diversity and unclear relationships to other sporozoans such as the human pathogens Plasmodium and Toxoplasma. It is believed that agamococcidians are not capable of sexual reproduction, which is essential for life cycle...

journal_title：Scientific reports

authors： Miroliubova TS,Simdyanov TG,Mikhailov KV,Aleoshin VV,Janouškovec J,Belova PA,Paskerova GG

更新日期：2020-09-28 00:00:00

abstract：:Cognitive aging creates major individual and societal burden, motivating search for treatment and preventive care strategies. Behavioural interventions can improve cognitive performance in older age, but effects are small. Basic research has implicated dopaminergic signalling in plasticity. We investigated whether sup...

journal_title：Scientific reports

authors： Lebedev AV,Nilsson J,Lindström J,Fredborg W,Akenine U,Hillilä C,Andersen P,Spulber G,de Lange ECM,van den Berg DJ,Kivipelto M,Lövdén M

更新日期：2020-03-23 00:00:00

abstract：:We study the signatures of the collective modes of a superfluid Fermi gas in its linear response functions for the order-parameter and density fluctuations in the Random Phase Approximation (RPA). We show that a resonance associated to the Popov-Andrianov (or sometimes "Higgs") mode is visible inside the pair-breaking...

journal_title：Scientific reports

authors： Kurkjian H,Tempere J,Klimin SN

更新日期：2020-07-14 00:00:00

abstract：:Pandanus odorifer (Forssk) Kuntze grows naturally along the coastal regions and withstands salt-sprays as well as strong winds. A combination of omics approaches and enzyme activity studies was employed to comprehend the mechanistic basis of high salinity tolerance in P. odorifer. The young seedlings of P. odorifer we...

journal_title：Scientific reports

authors： Rashmi D,Barvkar VT,Nadaf A,Mundhe S,Kadoo NY

更新日期：2019-01-30 00:00:00

abstract：:Analysis of the developing proteome has been complicated by a lack of tools that can be easily employed to label and identify newly synthesized proteins within complex biological mixtures. Here, we demonstrate that the methionine analogs azidohomoalanine and homopropargylglycine can be globally incorporated into the p...

journal_title：Scientific reports

authors： Calve S,Witten AJ,Ocken AR,Kinzer-Ursem TL

更新日期：2016-08-30 00:00:00

abstract：:Two-photon (2P) microscopy is a powerful tool for imaging and exploring label-free biological tissues at high resolution. Although this type of microscopy has been demonstrated in ex vivo ocular tissues of both humans and animal models, imaging the human eye in vivo has always been challenging. This work presents a no...

journal_title：Scientific reports

authors： Ávila FJ,Gambín A,Artal P,Bueno JM

更新日期：2019-07-12 00:00:00

abstract：:Proteins are highly dynamic entities attaining a myriad of different conformations. Protein side chains change their states during dynamics, causing clashes that are propagated at distal sites. A convenient formalism to analyze protein dynamics is based on network theory using Protein Structure Networks (PSNs). Despit...

journal_title：Scientific reports

authors： Salamanca Viloria J,Allega MF,Lambrughi M,Papaleo E

更新日期：2017-06-06 00:00:00

abstract：:Developing an alternative method for fabricating microscale graphene patterns that overcomes the obstacles of organic contamination, linewidth resolution, and substrate damaging is paramount for applications in optoelectronics. Here we propose to pattern chemical vapor deposition grown graphene film through a stencil ...

journal_title：Scientific reports

authors： Wu Y,Tao H,Su S,Yue H,Li H,Zhang Z,Ni Z,Chen X

更新日期：2017-04-19 00:00:00

abstract：:Hypoxia inducible factor-1α (HIF-1α) pathway is associated with many vascular diseases, including atherosclerosis, arterial aneurysms, pulmonary hypertension and chronic venous diseases. Significant HIF-1α expression could be found at the rupture edge at human abdominal aortic aneurysm (AAA) tissues. While our initial...

journal_title：Scientific reports

authors： Tsai SH,Huang PH,Hsu YJ,Peng YJ,Lee CH,Wang JC,Chen JW,Lin SJ

更新日期：2016-07-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) have been extensively used and are considered as an emerging contaminant in the ocean. The environmental contamination of AgNPs is expected to increase greatly over time, and cetaceans, as the top ocean predators, will suffer the negative impacts of AgNPs. In the present study, we investig...

journal_title：Scientific reports

authors： Li WT,Chang HW,Yang WC,Lo C,Wang LY,Pang VF,Chen MH,Jeng CR

更新日期：2018-04-04 00:00:00

abstract：:Bt cotton was genetically modified to produce insecticidal proteins targeting Lepidopteran pests and is therefore only minimally affected by caterpillar damage. This could lead to reduced levels of inherent, systemically inducible defensive compounds in Bt cotton which might benefit other important cotton herbivores s...

journal_title：Scientific reports

authors： Eisenring M,Naranjo SE,Bacher S,Abbott A,Meissle M,Romeis J

更新日期：2019-02-25 00:00:00

abstract：:Pseudooxynicotine amine oxidase (Pnao) is essential to the pyrrolidine pathway of nicotine degradation of Pseudomonas putida strain S16, which is significant for the detoxification of nicotine, through removing the CH3NH2 group. However, little is known about biochemical mechanism of this enzyme. Here, we characterize...

journal_title：Scientific reports

authors： Hu H,Wang W,Tang H,Xu P

更新日期：2015-12-04 00:00:00

abstract：:Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painful syndromes TRPM8 a...

journal_title：Scientific reports

authors： Beccari AR,Gemei M,Lo Monte M,Menegatti N,Fanton M,Pedretti A,Bovolenta S,Nucci C,Molteni A,Rossignoli A,Brandolini L,Taddei A,Za L,Liberati C,Vistoli G

更新日期：2017-09-08 00:00:00

abstract：:Although plants are essentially sessile in nature, these organisms are very much in tune with their environment and are capable of a variety of movements. This may come as a surprise to many non-botanists, but not to Charles Darwin, who reported that plants do produce movements. Following Darwin's specific interest on...

journal_title：Scientific reports

authors： Guerra S,Peressotti A,Peressotti F,Bulgheroni M,Baccinelli W,D'Amico E,Gómez A,Massaccesi S,Ceccarini F,Castiello U

更新日期：2019-11-12 00:00:00

abstract：:From biomarkers to drug carriers, Extracellular Vesicles (EVs) are being used successfully in numerous applications. However, while the subject has been steadily rising in popularity, current methods of isolating EVs are lagging behind, incapable of isolating EVs at a high enough quantity or quality while also requiri...

journal_title：Scientific reports

authors： Kırbaş OK,Bozkurt BT,Asutay AB,Mat B,Ozdemir B,Öztürkoğlu D,Ölmez H,İşlek Z,Şahin F,Taşlı PN

更新日期：2019-12-16 00:00:00

abstract：:This study assessed the efficacy and tolerability of intravenous ibuprofen in the improvement of post-operative pain control and the reduction of opioid usage. Patients were randomly divided into placebo, ibuprofen 400 mg and ibuprofen 800 mg groups. All patients received patient-controlled intravenous morphine analge...

journal_title：Scientific reports

authors： Liu X,Wang X,Zhao W,Wei L,Zhang P,Han F

更新日期：2018-07-05 00:00:00

abstract：:Strain engineering is a widespread strategy used to enhance performance of devices based on semiconductor thin films. In ferroelectrics strain engineering is used to control the domain pattern: When an epitaxial film is biaxially compressed, e.g. due to lattice mismatch with the substrate, the film displays out-of-pla...

journal_title：Scientific reports

authors： Yamada T,Ito D,Sluka T,Sakata O,Tanaka H,Funakubo H,Namazu T,Wakiya N,Yoshino M,Nagasaki T,Setter N

更新日期：2017-07-12 00:00:00

abstract：:Optical thermometry based on the up-conversion intensity ratio of thermally coupled levels of rare earth ions has been widely studied to achieve an inaccessible temperature measurement in submicron scale. In this work, a novel optical temperature sensing strategy based on the energy transfer from charge transfer bands...

journal_title：Scientific reports

authors： Wang J,Bu Y,Wang X,Seo HJ

更新日期：2017-07-20 00:00:00