Abstract:
:Haemonchus contortus is arguably the most injurious helminth parasite for small ruminants. We characterized the impact of H. contortus infection on the caprine abomasal microbiome. Fourteen parasite naive goats were inoculated with 5,000 H. contortus infective larvae and followed for 50 days. Six age-matched naïve goats served as uninfected controls. Reduced bodyweight gain and a significant increase in the abosamal pH was observed in infected goats compared to uninfected controls. Infection also increased the bacterial load while reducing the abundance of the Archaea in the abomasum but did not appear to affect microbial diversity. Nevertheless, the infection altered the abundance of approximately 19% of the 432 species-level operational taxonomic units (OTU) detected per sample. A total of 30 taxa displayed a significantly different abundance between control and infected goats. Furthermore, the infection resulted in a distinct difference in the microbiome structure. As many as 8 KEGG pathways were predicted to be significantly affected by infection. In addition, H. contortus-induced changes in butyrate producing bacteria could regulate mucosal inflammation and tissue repair. Our results provided insight into physiological consequences of helminth infection in small ruminants and could facilitate the development of novel control strategies to improve animal and human health.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li RW,Li W,Sun J,Yu P,Baldwin RL,Urban JFdoi
10.1038/srep20606subject
Has Abstractpub_date
2016-02-08 00:00:00pages
20606issn
2045-2322pii
srep20606journal_volume
6pub_type
杂志文章abstract::The accurate staging of liver fibrosis is of paramount importance to determine the state of disease progression, therapy responses, and to optimize disease treatment strategies. Non-linear optical microscopy techniques such as two-photon excitation fluorescence (TPEF) and second harmonic generation (SHG) can image the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04636
更新日期:2014-04-10 00:00:00
abstract::Virtual planning of open cranial vault reconstruction is used to simulate and define an pre-operative plan for craniosynostosis surgery. However, virtual planning techniques are subjective and dependent on the experience and preferences of the surgical team. To develop an objective automated 3D pre-operative planning ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21662-w
更新日期:2018-02-20 00:00:00
abstract::Respiratory sensations such as breathlessness are prevalent in many diseases and are amplified by increased levels of anxiety. Cortical activation in response to inspiratory occlusions in high- and low-anxious individuals was found different in previous studies using the respiratory-related evoked potential method. Ho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51396-2
更新日期:2019-10-21 00:00:00
abstract::Nanofabrication has seen an increasing demand for applications in many fields of science and technology, but its production still requires relatively difficult, time-consuming, and expensive processes. Here we report a simple but very effective one dimensional (1D) nano-patterning technology that suggests a new nanofa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18892
更新日期:2016-01-04 00:00:00
abstract::Are musicians better able to understand speech in noise than non-musicians? Recent findings have produced contradictory results. Here we addressed this question by asking musicians and non-musicians to understand target sentences masked by other sentences presented from different spatial locations, the classical 'cock...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11628
更新日期:2015-06-26 00:00:00
abstract::Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/s41598-018-31169-z
更新日期:2018-08-27 00:00:00
abstract::Spatially resolved analysis of uranium (U) isotopes in small volumes of actinide-bearing materials is critical for a variety of technical disciplines, including earth and planetary sciences, environmental monitoring, bioremediation, and the nuclear fuel cycle. However, achieving subnanometer-scale spatial resolution f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48479-5
更新日期:2019-08-23 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57833-x
更新日期:2020-01-15 00:00:00
abstract::Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cell-VEGFA with short-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20278-4
更新日期:2018-01-31 00:00:00
abstract::Diabetes is caused by the loss or dysfunction of insulin-secreting β-cells in the pancreas. β-cells reduce their mass and lose insulin-producing ability in vitro, likely due to insufficient cell-cell and cell-extracellular matrix (ECM) interactions as β-cells lose their native microenvironment. Herein, we built an ex-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02863
更新日期:2013-10-04 00:00:00
abstract::Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67951-1
更新日期:2020-07-02 00:00:00
abstract::The human brain has evolved specialised mechanisms to enable the rapid detection of threat cues, including emotional face expressions (e.g., fear and anger). However, contextual cues - such as gaze direction - influence the ability to recognise emotional expressions. For instance, anger paired with direct gaze, and fe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52728-y
更新日期:2019-11-07 00:00:00
abstract::Reporter gene imaging allows for non-invasive monitoring of molecular processes in living cells, providing insights on the mechanisms underlying pathology and therapy. A lysine-rich protein (LRP) chemical exchange saturation transfer (CEST) MRI reporter gene has previously been developed and used to image tumor cells,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77576-z
更新日期:2020-11-26 00:00:00
abstract::Lower corrected calcium (cCa) levels are associated with a better prognosis among incident dialysis patients. However, cCa frequently overestimates ionized calcium (iCa) levels. The prognostic importance of the true calcium status defined by iCa remains to be revealed. We conducted a retrospective cohort study of inci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61459-4
更新日期:2020-03-10 00:00:00
abstract::Because tetragonal structured MnGa alloy has intrinsic (not interface induced) giant perpendicular magnetic anisotropy (PMA), ultra-low damping constant and high spin polarization, it is predicted to be a kind of suitable magnetic electrode candidate in the perpendicular magnetic tunnel junction (p-MTJ) for high densi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43064
更新日期:2017-02-24 00:00:00
abstract::Proton therapy as a promising candidate in cancer treatment has attracted much attentions and many studies have been performed to investigate the new methods to enhance its radiation effectiveness. In this regard, two research groups have suggested that using boron isotopes will lead to a radiation effectiveness enhan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62268-5
更新日期:2020-03-25 00:00:00
abstract::The aim of this study was to develop a novel method to detect circulating histones H3 and H2B in plasma based on multiple reaction monitoring targeted mass spectrometry and a multiple reaction monitoring approach (MRM-MS) for its clinical application in critical bacteriaemic septic shock patients. Plasma samples from ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10830-z
更新日期:2017-09-06 00:00:00
abstract::The intermittent electromagnetic fields with a large [Formula: see text] can enhance the properties of ferromagnetic materials and significantly affect paramagnetic materials. In this study, the effect of a pulsed electromagnetic field on the crystal orientation of the primary phase and microstructure evolution of an ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67352-4
更新日期:2020-06-30 00:00:00
abstract::Little information is available on chemical forms of heavy metals on integrate plant roots. KNO3 (1 M), 0.05M EDTA at pH6 and 0.01 M HCl were used sequentially to extract the exchangeable, complexed and precipitated forms of Cu(II) and Cd(II) from soybean roots and then to investigate chemical form distribution of Cu(...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36373
更新日期:2016-11-02 00:00:00
abstract::The establishment of clinically relevant models for tumor metastasis and drug testing is a major challenge in cancer research. Here we report a physiologically relevant assay enabling quantitative analysis of metastatic capacity of tumor cells following implantation into the chorioallantoic membrane (CAM). Engraftment...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73632-w
更新日期:2020-10-09 00:00:00
abstract::The Hauraki Gulf, a shallow embayment in north-eastern New Zealand, provides an interesting environment for ecological soundscape research. It is situated on a tectonic plate boundary, contains one of the busiest ports in the southern hemisphere and is home to a diverse range of soniferous animals. The underwater soun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06347-0
更新日期:2017-07-18 00:00:00
abstract::Cooperating gene mutations are typically required to transform normal cells enabling growth in soft agar or in immunodeficient mice. For example, mutations in Kras and transformation-related protein 53 (Trp53) are known to transform a variety of mesenchymal and epithelial cells in vitro and in vivo. Identifying other ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53572-w
更新日期:2019-11-20 00:00:00
abstract::Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of inflammation and healing outcome. Immunoregenerative materials leverage the function of endogenous immune cells to orchestrate complex mechanisms of repair; however, a deeper understanding ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00477-1
更新日期:2017-03-27 00:00:00
abstract::An optimization method to reconstruct the object profile is performed by using a flexible laser plane and bi-planar references. The bi-planar references are considered as flexible benchmarks to realize the transforms among two world coordinate systems on the bi-planar references, the camera coordinate system and the i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19928-4
更新日期:2018-01-24 00:00:00
abstract::We aimed to model longitudinal data to create predictive growth charts for weight in preterm infants from birth till discharge, that took into account the differing growth rates post-birth when compared to in-utero growth and therefore was more representative of the data than the UK1990 reference charts. Data from bir...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60895-6
更新日期:2020-03-04 00:00:00
abstract::Breast tissue heterogeneity is related to risk factors that lead to more aggressive tumour growth and worse prognosis, yet such heterogeneity has not been well characterized. The aim of this study is to reveal the heterogeneous signal patterns of the apparent diffusion coefficient (ADC) of a tumour and its surrounding...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03122-z
更新日期:2017-06-06 00:00:00
abstract::Graphene's unique physical and chemical properties make it an attractive platform for use in micro- and nanoelectronic devices. However, electrostatically controlling the flow of electrons in graphene can be challenging as a result of Klein tunneling, where electrons normally incident to a one-dimensional potential ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08435
更新日期:2015-02-13 00:00:00
abstract::The triethylamine promoted three-component reaction of N-(4-nitrobenzyl), N-ethoxycarbonylmethylisoquinolinium bromide, isatins and malononitrile in ethanol afforded spiro[indoline-3,2'-pyrrolo[2,1-a]isoquinolines] in good yields and with high diastereoselectivity. The similar reaction of N-cyanomethylisoquinolinium c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41024
更新日期:2017-01-20 00:00:00
abstract::An in-depth focused study of specific cases of patients with recurrent thrombosis may help to identify novel circumstances, genetic and acquired factors contributing to the development of this disorder. The aim of this study was to carry out a detailed and sequential analysis of samples from a patient suffering from e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44556
更新日期:2017-03-17 00:00:00
abstract::Reconstructed annual streamflows using tree-ring chronologies provide useful information on moisture availability during the pre-historic period, but they have limitations in estimating high flows due to the upper bound on soil water holding capacity and trees' metabolic growth limits. We propose a hybrid approach tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23294-6
更新日期:2018-03-21 00:00:00