Abstract:
:Non-arteritic anterior ischemic optic neuropathy (NAION) causes a sudden loss of vision and lacks effective treatment. Granulocyte colony-stimulating factor (G-CSF) provides neuroprotection against the experimental optic nerve injuries but also induce leukocytosis upon typical administration. We found synergetic neuroprotective effects of meloxicam and low dose G-CSF without leukocytosis in a rat model of anterior ischemic optic neuropathy (rAION). The WBC counts in the low-dose G-CSF-plus meloxicam-treated group were similar to the sham-operated group. Combination treatment of low-dose G-CSF plus meloxicam preserved RGCs survival and visual function, reduced RGC apoptosis and the macrophages infiltration, and promote more M2 phenotype of macrophage/microglial transition than the low-dose GCSF treatment or the meloxicam treatment. Moreover, the combination treatment induced higher serine/threonine kinase 1 (Akt1) expression. The combination treatment of low-dose G-CSF plus meloxicam lessened the leukocytotic side effect and provided neuroprotective effects via Akt1 activation in the rAION model. This approach provides crucial preclinical information for the development of alternative therapy in AION.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu PK,Wen YT,Lin W,Kapupara K,Tai M,Tsai RKdoi
10.1038/s41598-020-66977-9subject
Has Abstractpub_date
2020-06-25 00:00:00pages
10351issue
1issn
2045-2322pii
10.1038/s41598-020-66977-9journal_volume
10pub_type
杂志文章abstract::The prevalence of type 2 diabetes (T2D) has increased dramatically in Middle Eastern populations that represent the largest non-European immigrant group in Sweden today. As proneurotensin predicts T2D, the aim of this study was to investigate differences in proneurotensin levels across populations of Middle Eastern an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50040-3
更新日期:2019-09-20 00:00:00
abstract::Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pKa) abolished pain by selectively ac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27313-4
更新日期:2018-06-12 00:00:00
abstract::The detection and assessment of intravascular filling defects is important, because they may represent a process central to cerebral malaria pathogenesis: neurovascular sequestration. We have developed and validated a framework that can automatically detect intravascular filling defects in fluorescein angiogram images...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11154
更新日期:2015-06-08 00:00:00
abstract::Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09937
更新日期:2015-04-24 00:00:00
abstract::The exact extent, by which the hydrologic cycle in the Neotropics was affected by external forcing during the last deglaciation, remains poorly understood. Here we present a new paleo-rainfall reconstruction based on high-resolution speleothem δ18O records from the core region of the South American Monsoon System (SAM...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44267
更新日期:2017-03-10 00:00:00
abstract::There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77753-0
更新日期:2020-11-26 00:00:00
abstract::Biofilm is recognized as a contributing factor to the capacity of Acinetobacter baumannii to persist and prosper in medical settings, but it is still unknown whether biofilms contribute to the spread of A. baumannii. In this study, the biofilm formation of 114 clinical A. baumannii isolates and 32 non-baumannii Acinet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32066
更新日期:2016-08-25 00:00:00
abstract::Light-sheet fluorescence microscopy has emerged as a powerful platform for 3-D volumetric imaging in the life sciences. Here, we introduce an important step towards its use deep inside biological tissue. Our new technique, based on digital holography, enables delivery of the light-sheet through a multimode optical fib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18050
更新日期:2015-12-14 00:00:00
abstract::Survivin is an independent prognostic factor for joint destruction in rheumatoid arthritis (RA). However, the expression and function of survivin in RA synoviocytes remain unclear. We certified the expression of survivin in RA synovial tissues and performed the experiment using RA fibroblast-like synoviocytes (RA-FLS)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09795
更新日期:2015-05-22 00:00:00
abstract::Solid state memory and switching devices aimed at replacing the flash memory technology operate by switching from the high to low resistance when conductive filaments are created in response to the electric pulse. The filaments are identified with either structurally different protrusions or purely electronic conducti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30700-6
更新日期:2018-08-15 00:00:00
abstract::The inner ear, or cochlea, is a fluid-filled organ housing the mechanosensitive hair cells. Sound stimulation is relayed to the hair cells through waves that propagate on the elastic basilar membrane. Sensorineural hearing loss occurs from damage to the hair cells and cannot currently be cured. Although drugs have bee...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79946-z
更新日期:2021-01-08 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD), the most predominant liver disease worldwide, is a progressive condition that encompasses a spectrum of disorders ranging from steatosis to steatohepatitis, and, ultimately, cirrhosis and hepatocellular carcinoma. Although the underlying mechanism is complex and multifactoria...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44563-y
更新日期:2019-05-30 00:00:00
abstract::For people with synaesthesia ordinary stimuli such as digits or letters induce concurrent experiences such as colours. Synaesthesia is associated with a memory advantage and the aim of this study was to investigate whether this advantage persists across time. We tested recognition memory of four different types of syn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60388-6
更新日期:2020-02-26 00:00:00
abstract::We successfully realised plasmon-driven selective reduction reactions of 2-amino-5-nitrobenzenethiol (2A-5-NBT) to 3,3'-dimercapto-4,4'-diaminoazobenzene , an azobenzene derivative, using surface-enhanced Raman scattering (SERS) spectroscopy, and supported by the theoretical calculations. The SERS spectra demonstrated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10269
更新日期:2015-06-01 00:00:00
abstract::In this paper, a multi-band metal-insulator-metal (MIM) perfect absorber with refractive index sensing capability has been investigated in near-infrared region. The proposed structure has been studied for biomedical applications such as detection of solution of glucose in water, diagnosis of different stages of malari...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63459-w
更新日期:2020-04-14 00:00:00
abstract::The goal of this study was to evaluate if isolated sarcomeres and half-sarcomeres produce a long-lasting increase in force after a stretch is imposed during activation. Single and half-sarcomeres were isolated from myofibrils using micro-needles, which were also used for force measurements. After full force developmen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02320
更新日期:2013-01-01 00:00:00
abstract::We developed hybrid slot antenna structures for microbial sensing in the THz frequency range, where silver nanowires (AgNWs) were employed to increase the sensitivity. In order to fabricate the hybrid devices, we partially etched the AgNW in the slot antenna region, where we can expect the field enhancement effect at ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33617-2
更新日期:2018-10-19 00:00:00
abstract::In recent and future synchrotron radiation facilities, relativistic electron bunches with increasingly high charge density are needed for producing brilliant light at various wavelengths, from X-rays to terahertz. In such conditions, interaction of electron bunches with their own emitted electromagnetic fields leads t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45024-2
更新日期:2019-07-17 00:00:00
abstract::Predictive coding theories propose that the brain creates internal models of the environment to predict upcoming sensory input. Hierarchical predictive coding models of vision postulate that higher visual areas generate predictions of sensory inputs and feed them back to early visual cortex. In V1, sensory inputs that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16093-y
更新日期:2017-11-28 00:00:00
abstract::The increase in volume and variety of pharmaceuticals found in natural water bodies has become an increasingly serious environmental problem. The implementation of cold plasma technology, specifically gas-phase pulsed corona discharge (PCD), for sulfamethizole abatement was studied in the present work. It was observed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27061-5
更新日期:2018-06-07 00:00:00
abstract::Coronary computed tomography angiography is an established technique in clinical practice and a valuable tool in the diagnosis of coronary artery disease in humans. Imaging of coronaries in preclinical research, i.e. in small animals, is very difficult due to the high demands on spatial and temporal resolution. Mice e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73735-4
更新日期:2020-10-08 00:00:00
abstract::We demonstrate application of the method of higher-order operators to nonlinear standard optomechanics. It is shown that a symmetry breaking in frequency shifts exists, corresponding to inequivalency of red and blue side-bands. This arises from nonlinear higher-order processes leading to inequal detunings. Similarly, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30068-7
更新日期:2018-08-01 00:00:00
abstract::The high manufacturing cost for metallic glasses hampers actual commercial applications of this class of fascinating materials. In this letter, the effect of oxygen impurity on the glass forming ability and tensile properties of Zr-BMG composites were studied. Our results have demonstrated that oxygen was absorbed and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02097
更新日期:2013-01-01 00:00:00
abstract::Peatlands perform important ecosystem functions, such as carbon storage and nutrient retention, which are affected, among other factors, by vegetation and peat decomposition. The availability of silicon (Si) in peatlands differs strongly, ranging from <1 to >25 mg L-1. Since decomposition of organic material was recen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09130-3
更新日期:2017-08-18 00:00:00
abstract::In the last decades, AC powered atmospheric dielectric barrier discharges (DBDs) in air with a liquid electrode have been proposed as a promising plasma technology with versatile applicability in medicine, agriculture and water treatment. The fundamental features of the micro-discharge filaments that make up this type...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29189-w
更新日期:2018-07-19 00:00:00
abstract::Malaria in India, while decreasing, remains a serious public health problem, and the contribution of submicroscopic and asymptomatic infections to its persistence is poorly understood. We conducted community surveys and clinic studies at three sites in India differing in their eco-epidemiologies: Chennai (Tamil Nadu),...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53386-w
更新日期:2019-11-19 00:00:00
abstract::We study the coherent and semi-coherent Al/α-Al2O3 interfaces using molecular dynamics simulations with a mixed, metallic-ionic atomistic model. For the coherent interfaces, both Al-terminated and O-terminated nonstoichiometric interfaces have been studied and their relative stability has been established. To understa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04485
更新日期:2014-03-27 00:00:00
abstract::Shortest paths are not always simple. In planar networks, they can be very different from those with the smallest number of turns--the simplest paths. The statistical comparison of the lengths of the shortest and simplest paths provides a non trivial and non local information about the spatial organization of these gr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03495
更新日期:2013-12-13 00:00:00
abstract::To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18519-z
更新日期:2018-01-09 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-74208-4
更新日期:2020-10-06 00:00:00