Abstract：
:The spread of multidrug resistance via mobile genetic elements is a major clinical and veterinary concern. Pathogenic Escherichia coli harbour antibiotic resistance and virulence genes mainly on plasmids, but also bacteriophages and hybrid phage-like plasmids. In this study, the genomes of three E. coli phage-like plasmids, pJIE250-3 from a human E. coli clinical isolate, pSvP1 from a porcine ETEC O157 isolate, and pTZ20_1P from a porcine commensal E. coli, were sequenced (PacBio RSII), annotated and compared. All three elements are coliphage P1 variants, each with unique adaptations. pJIE250-3 is a P1-derivative that has lost lytic functions and contains no accessory genes. In pTZ20_1P and pSvP1, a core P1-like genome is associated with insertion sequence-mediated acquisition of plasmid modules encoding multidrug resistance and virulence, respectively. The transfer ability of pTZ20_1P, carrying antibiotic resistance markers, was also tested and, although this element was not able to transfer by conjugation, it was able to lysogenize a commensal E. coli strain with consequent transfer of resistance. The incidence of P1-like plasmids (~7%) in our E. coli collections correlated well with that in public databases. This study highlights the need to investigate the contribution of phage-like plasmids to the successful spread of antibiotic resistant pathotypes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Venturini C,Zingali T,Wyrsch ER,Bowring B,Iredell J,Partridge SR,Djordjevic SPdoi
10.1038/s41598-019-54895-4subject
Has Abstractpub_date
2019-12-11 00:00:00pages
18861issue
1issn
2045-2322pii
10.1038/s41598-019-54895-4journal_volume
9pub_type
杂志文章abstract：:Development of highly efficient and potential material for toxic p-nitrophenol is an important design for sensitive detection of hazardous species from ecology and environment. Here it is developed, an efficient as well as selective of p-nitrophenol using binary material by electrochemical performances, including good...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55891-4
更新日期：2019-12-17 00:00:00
abstract：:Inspired by the well-documented tumor protecting ability of paullones, recently, we synthesized novel paullone-like scaffolds, indole-fused benzo-oxazepines (IFBOs), and screened them against hepatocellular carcinoma (HCC) specific Hep-G2 cells. Three of the synthesized compounds significantly attenuated the progressi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24288-0
更新日期：2018-04-12 00:00:00
abstract：:Extremely low frequency magnetic fields (ELF-MF) could be an alternative neuroprotective approach for ischemic stroke because preclinical studies have demonstrated their effects on the mechanisms underlying ischemic damage. The purpose of this open-label, one arm, dose-escalation, exploratory study is to evaluate the ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-12371-x
更新日期：2017-09-22 00:00:00
abstract：:Identifying similarities and differences in choice behavior across species is informative about how basic mechanisms give rise to more complex processes. In the present study, we compared pre- and post-choice latencies between rats and humans under two paradigms. In Experiment 1, we used a cued choice paradigm where s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20583
更新日期：2016-02-10 00:00:00
abstract：:Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cysts in males and postmenopau...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-04036-6
更新日期：2017-06-19 00:00:00
abstract：:Gaze-following behaviour is considered crucial for social interactions which are influenced by social similarity. We investigated whether the degree of similarity, as indicated by the perceived age of another person, can modulate gaze following. Participants of three different age-groups (18-25; 35-45; over 65) perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04746
更新日期：2014-04-22 00:00:00
abstract：:A detailed characterisation of the molecular determinants of membrane binding by α-synuclein (αS), a 140-residue protein whose aggregation is associated with Parkinson's disease, is of fundamental significance to clarify the manner in which the balance between functional and dysfunctional processes are regulated for t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27125
更新日期：2016-06-08 00:00:00
abstract：:While H2N2 viruses have been sporadically isolated from wild and domestic birds, H2N2 viruses have not been detected among human populations since 1968. Should H2N2 viruses adapt to domestic poultry they may pose a risk of infection to people, as most anyone born after 1968 would likely be susceptible to their infecti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07588
更新日期：2014-12-23 00:00:00
abstract：:This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population. A total of 556 GDM patients and 500 Non-GDM were included. Eighteen single nucleotide polymorphisms (SNPs) were evalu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30686
更新日期：2016-07-28 00:00:00
abstract：:This paper has been retracted. ...
journal_title：Scientific reports
pub_type： 已发布勘误,撤回出版物
doi：10.1038/s41598-019-44557-w
更新日期：2019-06-11 00:00:00
abstract：:Stochastic surface patterns form an important requirement to facilitate digital image correlation and to subsequently quantify material properties of various tissues when loaded and deformed without artefacts arising from material slippage. Depending on the samples' natural colour, a surface pattern is created by spec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77299-1
更新日期：2020-11-27 00:00:00
abstract：:Although rare in the U.S., outbreaks due to Neisseria meningitidis do occur. Rapid, early outbreak detection is important for timely public health response. In this study, we characterized U.S. meningococcal isolates (N = 201) from 15 epidemiologically defined outbreaks (2009-2015) along with temporally and geographic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33622-5
更新日期：2018-10-25 00:00:00
abstract：:Ferroelectric tunneling junctions (FTJs) with tunable tunneling electroresistance (TER) are promising for many emerging applications, including non-volatile memories and neurosynaptic computing. One of the key challenges in FTJs is the balance between the polarization value and the tunneling current. In order to achie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56816-x
更新日期：2019-12-31 00:00:00
abstract：:BPA is an oestrogenic endocrine disrupting chemical compound. Exposure to BPA in as early as pregnancy leads to lifelong effects. Since endocrine and immune systems interact in a bidirectional manner, endocrine disruption may cause permanent alterations of the immune system, affecting a future anti-tumoral response. N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10135-1
更新日期：2017-09-05 00:00:00
abstract：:Two novel species of the fungal genus Ochroconis, O. lascauxensis and O. anomala have been isolated from the walls of the Lascaux Cave, France. The interest in these fungi and their melanins lies in the formation of black stains on the walls and rock art which threatens the integrity of the paintings. Here we report s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13862-7
更新日期：2017-10-18 00:00:00
abstract：:Human behaviors exhibit ubiquitous correlations in many aspects, such as individual and collective levels, temporal and spatial dimensions, content, social and geographical layers. With rich Internet data of online behaviors becoming available, it attracts academic interests to explore human mobility similarity from t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12274-x
更新日期：2017-09-20 00:00:00
abstract：:A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in isc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38161
更新日期：2016-12-02 00:00:00
abstract：:Emerging evidence suggests that the mammalian target of rapamcyin (mTOR) pathway is associated with radio-resistance in cancer treatment. We hypothesised that phosphorylated ribosomal S6 kinase 1 (p-S6K1), a major downstream regulator of the mTOR pathway, may play a role in predicting radio-resistance. Therefore, we e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57496-8
更新日期：2020-01-20 00:00:00
abstract：:Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of these lines with their other properties. The analysis revealed a r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41241
更新日期：2017-01-25 00:00:00
abstract：:Chromobox 6 (CBX6) is a subunit of Polycomb Repressive Complex 1 (PRC1) that mediates epigenetic gene repression and acts as an oncogene or tumor suppressor in a cancer type-dependent manner. The specific function of CBX6 in breast cancer is currently undefined. In this study, a comprehensive analysis of The Cancer Ge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36560-4
更新日期：2019-01-17 00:00:00
abstract：:Excessive retention of neutral lipids in cardiac lipid droplets (LDs) is a common observation in cardiomyopathy. Thus, the systematic investigation of the cardiac LD proteome will help to dissect the underlying mechanisms linking cardiac steatosis and myocardial dysfunction. Here, after isolation of LDs from normal an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19782
更新日期：2016-01-22 00:00:00
abstract：:Cells regulate their intracellular mRNA levels by using specific ribonucleases. Oligoribonuclease (ORN) is a 3'-5' exoribonuclease for small RNA molecules, important in RNA degradation and re-utilisation. However, there is no structural information on the ligand-binding form of ORNs. In this study, the crystal structu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39641-0
更新日期：2019-02-25 00:00:00
abstract：:Irisin is conventionally regarded as a myokine involved in the browning of white adipose tissue, energy expenditure and glucose tolerance. Its potential link to fat accumulation and metabolic dysfunction is debated. We sought to explore the relationship between circulating irisin and components of body composition in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57855-5
更新日期：2020-01-23 00:00:00
abstract：:Immunoproteasomes are known for their involvement in antigen presentation. However, their broad tissue presence and other evidence are indicative of nonimmune functions. We examined a role for immunoproteasomes in cellular responses to the endogenous and environmental carcinogen formaldehyde (FA) that binds to cytosol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00757-w
更新日期：2017-04-05 00:00:00
abstract：:This study presents a modular-based implementation of augmented reality to provide an immersive experience in learning or teaching the planning phase, control system, and machining parameters of a fully automated work cell. The architecture of the system consists of three code modules that can operate independently or...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27380
更新日期：2016-06-07 00:00:00
abstract：:Neurologic complications associated with viral encephalitis, including seizures and cognitive impairment, are a global health issue, especially in children. We previously showed that hippocampal injury during acute picornavirus infection in mice is associated with calpain activation and is the result of neuronal death...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28699
更新日期：2016-06-27 00:00:00
abstract：ABSRACT:Vegetation cover is crucial to controlling aeolian erosion but highly efficient vegetation is critical. How this efficiency is influenced by vegetation response to airflow is not clear. Here we evaluate the responses of Cosmos bipinnatus and Ligustrum lucidum Ait to a range of wind speeds in a wind tunnel. For ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13084-x
更新日期：2017-10-09 00:00:00
abstract：:We introduce a low-melting-point (MP) Sn-P-F-O glass ceramic material into the phosphor-in-glass (PIG) material to realize an 'on-chip' chip-on-board (COB) type of phosphor-converted (pc) white light-emitting diode (WLED) with green (BaSr)2SiO4:Eu2+ and red (SrCa)AlSiN3:Eu2+ (SCASN) phosphors. The optimum Sn-P-F-O-bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25680-6
更新日期：2018-05-09 00:00:00
abstract：:Hallmarks of Retinitis Pigmentosa (RP), a family of genetic diseases, are a typical rod-cone-degeneration with initial night blindness and loss of peripheral vision, followed by decreased daylight sight and progressive visual acuity loss up to legal blindness. Great heterogeneity in nature and function of mutated gene...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06045-x
更新日期：2017-07-18 00:00:00
abstract：:A novel characterization technique using both in situ reflection high-energy electron diffraction (RHEED) transmission mode and transmission electron microscopy (TEM) has been developed to investigate the growth behaviour of semiconductor nanostructures. RHEED employed in transmission mode enables the acquisition of s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19857-2
更新日期：2018-01-26 00:00:00
