Neuroprotection mediated by inhibition of calpain during acute viral encephalitis.

abstract：:Recent studies have demonstrated functions of miR-145 in vascular smooth muscle cells (VSMCs) phenotypes and vascular diseases. In this study, we aim to determine whether CD40 is involved in miR-145 mediated switch of VSMC phenotypes. In cultured VSMCs, the effects of miR-145 and CD40 on TNF-α, TGF-β, and Homocysteine...

journal_title：Scientific reports

authors： Guo X,Li D,Chen M,Chen L,Zhang B,Wu T,Guo R

更新日期：2016-10-12 00:00:00

abstract：:The widespread use of electric light and electronic devices has resulted in an excessive exposure to light during the late-evening and at night. This late light exposure acutely suppresses melatonin and sleepiness and delays the circadian clock. Here we investigate whether the acute effects of late-evening light expos...

journal_title：Scientific reports

authors： Te Kulve M,Schlangen LJM,van Marken Lichtenbelt WD

更新日期：2019-11-05 00:00:00

abstract：:The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be u...

journal_title：Scientific reports

authors： Akita M,Tak YS,Shimura T,Matsumoto S,Okuda-Shimizu Y,Shimizu Y,Nishi R,Saitoh H,Iwai S,Mori T,Ikura T,Sakai W,Hanaoka F,Sugasawa K

更新日期：2015-06-04 00:00:00

abstract：:The bronchoscopy, though usually safe, is occasionally associated with complications, such as pneumonia. However, the use of prophylactic antibiotics is not recommended by the guidelines of the British Thoracic Society. Thus far there are few reports of the risk factors for post-bronchoscopy pneumonia; the purpose of ...

journal_title：Scientific reports

authors： Sato Y,Murata K,Yamamoto M,Ishiwata T,Kitazono-Saitoh M,Wada A,Takamori M

更新日期：2020-11-17 00:00:00

abstract：:The same prebiotics have produced inconsistent effects on microbiota when evaluated in different batch fermentation studies. To understand the reasons behind these discrepancies, we compared impact of one prebiotic formula on the same inoculated fecal microbiota in two frequently used batch systems: phosphate-buffered...

journal_title：Scientific reports

authors： Long W,Xue Z,Zhang Q,Feng Z,Bridgewater L,Wang L,Zhao L,Pang X

更新日期：2015-08-25 00:00:00

abstract：:In most organisms, ribosomal RNA (rRNA) contributes to >85% of total RNA. Thus, to obtain useful information from RNA-sequencing (RNA-seq) analyses at reasonable sequencing depth, typically, mature polyadenylated transcripts are enriched or rRNA molecules are depleted. Targeted depletion of rRNA is particularly useful...

journal_title：Scientific reports

authors： Kraus AJ,Brink BG,Siegel TN

更新日期：2019-08-22 00:00:00

abstract：:The high metabolic activity associated with endurance flights and intense fuelling of migrant birds may produce large quantities of reactive oxygen species, which cause oxidative damage. Yet it remains unknown how long-lived birds prepare for oxidative challenges prior to extreme flights. We combined blood measurement...

journal_title：Scientific reports

authors： Gutiérrez JS,Sabat P,Castañeda LE,Contreras C,Navarrete L,Peña-Villalobos I,Navedo JG

更新日期：2019-11-26 00:00:00

abstract：:In this report, we propose and demonstrate an air-mode photonic crystal ring resonator (PhCRR) on silicon-on-insulator platform. Air mode is utilized to confine the optical field into photonic crystal (PhC) air holes, which is confirmed by the three-dimensional finite-difference time-domain simulation. PhCRR structure...

journal_title：Scientific reports

authors： Gao G,Zhang Y,Zhang H,Wang Y,Huang Q,Xia J

更新日期：2016-01-28 00:00:00

abstract：:Ontogenetic information is crucial to understand life histories and represents a true challenge in dinosaurs due to the scarcity of growth series available. Mussaurus patagonicus was a sauropodomorph dinosaur close to the origin of Sauropoda known from hatchling, juvenile and mature specimens, providing a sufficiently...

journal_title：Scientific reports

authors： Otero A,Cuff AR,Allen V,Sumner-Rooney L,Pol D,Hutchinson JR

更新日期：2019-05-20 00:00:00

abstract：:In this paper, the periodic double-layer graphene ribbon arrays placed near a metallic ground plate coated by a dielectric layer are proposed and analyzed by the coupled-mode theory (CMT) to predict the perfect absorption response in the mid-infrared region. Numerical simulations of the finite-difference time-domain (...

journal_title：Scientific reports

authors： Li H,Wang L,Zhai X

更新日期：2016-11-15 00:00:00

abstract：:Heterodonty is one of the hallmarks of mammals. It has been suggested that, homeobox genes, differentially expressed in the ectomesenchyme of the jaw primordium along the distal-proximal axis, would determine the tooth classes (homeobox code model) based on mouse studies. Because mouse has highly specialized tooth pat...

journal_title：Scientific reports

authors： Wakamatsu Y,Egawa S,Terashita Y,Kawasaki H,Tamura K,Suzuki K

更新日期：2019-09-06 00:00:00

abstract：:Remote photoplethysmography (PPG) is an optical measurement technique with established applications in vital signs monitoring. Recently, the consensual understanding of blood volume variations (BVVs) as the origin of PPG signals was challenged, raising validity concerns about the remote SpO2 methodology. Recognizing t...

journal_title：Scientific reports

authors： Moço AV,Stuijk S,de Haan G

更新日期：2018-05-31 00:00:00

abstract：:That stalks reorient after flowering to face upwards is a common phenomenon in many flowering plants, indicating the potential importance of fruit orientation on seed dispersal. But this idea has not been subject to an empirical test. We examined this hypothesis by analysing the evolutionary correlation between fruit ...

journal_title：Scientific reports

authors： Niu Y,Zhou Z,Sha W,Sun H

更新日期：2016-02-02 00:00:00

abstract：:The genome of influenza A virus (IAV) comprises eight RNA segments (vRNA) which are transcribed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp). RdRp consists of three subunits (PA, PB1 and PB2) and binds both the highly conserved 3'- and 5'-ends of the vRNA segment. The IAV RdRp is an imp...

journal_title：Scientific reports

authors： Swale C,Monod A,Tengo L,Labaronne A,Garzoni F,Bourhis JM,Cusack S,Schoehn G,Berger I,Ruigrok RW,Crépin T

更新日期：2016-04-20 00:00:00

abstract：:Mesothelin is an emerging cell surface target in mesothelioma and other solid tumors. Most antibody drug candidates recognize highly immunogenic Region I (296-390) on mesothelin. Here, we report a group of high-affinity non-Region I rabbit monoclonal antibodies. These antibodies do not compete for mesothelin binding w...

journal_title：Scientific reports

authors： Zhang YF,Phung Y,Gao W,Kawa S,Hassan R,Pastan I,Ho M

更新日期：2015-05-21 00:00:00

abstract：:The positioning of electrodes in electrical impedance myography (EIM) is critical for accurately assessing disease progression and effectiveness of treatment. In human and animal trials for neuromuscular disorders, inconsistent electrode positioning adds errors to the muscle impedance. Despite its importance, how the ...

journal_title：Scientific reports

authors： Sanchez B,Pacheck A,Rutkove SB

更新日期：2016-09-02 00:00:00

abstract：:Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cystic Fibrosis (CF) that develop CF related diabetes (CFRD). CF is caused by a mutat...

journal_title：Scientific reports

authors： Edlund A,Pedersen MG,Lindqvist A,Wierup N,Flodström-Tullberg M,Eliasson L

更新日期：2017-03-07 00:00:00

abstract：:We report on a novel electrically tunable hybrid graphene-gold Fano resonator. The proposed metamaterial consists of a square graphene patch and a square gold frame. The destructive interference between the narrow- and broadband dipolar surface plasmons, which are induced respectively on the surfaces of the graphene p...

journal_title：Scientific reports

authors： Amin M,Farhat M,Baǧcı H

更新日期：2013-01-01 00:00:00

abstract：:Insects are extremely successful animals whose odor perception is very prominent due to their sophisticated olfactory system. The main chemosensory organ, antennae play a critical role in detecting odor in ambient environment before initiating appropriate behavioral responses. The antennal chemosensory receptor genes ...

journal_title：Scientific reports

authors： Ahmed T,Zhang T,Wang Z,He K,Bai S

更新日期：2016-04-19 00:00:00

abstract：:There is increasing demand for safe and effective sanitizers for irrigation water disinfection to prevent transmission of foodborne pathogens to fresh produce. Here we compared the efficacy of pH-neutral electrolyzed oxidizing water (EOW), sodium hypochlorite (NaClO) and chlorine dioxide (ClO2) against single and mixe...

journal_title：Scientific reports

authors： Ogunniyi AD,Dandie CE,Ferro S,Hall B,Drigo B,Brunetti G,Venter H,Myers B,Deo P,Donner E,Lombi E

更新日期：2019-12-27 00:00:00

abstract：:Electrostatic gates are of paramount importance for the physics of devices based on high-mobility two-dimensional electron gas (2DEG) since they allow depletion of electrons in selected areas. This field-effect gating enables the fabrication of a wide range of devices such as, for example, quantum point contacts (QPC)...

journal_title：Scientific reports

authors： Bennaceur K,Schmidt BA,Gaucher S,Laroche D,Lilly MP,Reno JL,West KW,Pfeiffer LN,Gervais G

更新日期：2015-09-22 00:00:00

abstract：:Diverse communities can adjust their trait composition to altered environmental conditions, which may strongly influence their dynamics. Previous studies of trait-based models mainly considered only one or two trophic levels, whereas most natural system are at least tritrophic. Therefore, we investigated how the addit...

journal_title：Scientific reports

authors： Ceulemans R,Gaedke U,Klauschies T,Guill C

更新日期：2019-05-17 00:00:00

abstract：:Varroa destructor mites express strong avoidance of the Apis cerana worker brood in the field. The molecular mechanism for this phenomenon remains unknown. We identified a Varroa toxic protein (VTP), which exhibited toxic activity toward A. cerana worker larvae, in the saliva of these mites, and expressed VTP in an Es...

journal_title：Scientific reports

authors： Zhang Y,Han R

更新日期：2018-02-21 00:00:00

abstract：:In many cancers, the establishment of a patient's future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the 'pathological response' to a given therapy. However, histopathological assessment of pathological response remains subjective. Here we...

journal_title：Scientific reports

authors： Patterson NH,Alabdulkarim B,Lazaris A,Thomas A,Marcinkiewicz MM,Gao ZH,Vermeulen PB,Chaurand P,Metrakos P

更新日期：2016-11-14 00:00:00

abstract：:Type 1 diabetes can be overcome by regulatory T cells (Treg) in NOD mice yet an efficient method to generate and maintain antigen-specific Treg is difficult to come by. Here, we devised a combination therapy of peptide/MHC tetramers and IL-2/anti-IL-2 monoclonal antibody complexes to generate antigen-specific Treg and...

journal_title：Scientific reports

authors： Izquierdo C,Ortiz AZ,Presa M,Malo S,Montoya A,Garabatos N,Mora C,Verdaguer J,Stratmann T

更新日期：2018-05-25 00:00:00

abstract：:The use of biopurification systems (BPS) constitutes an efficient strategy to eliminate pesticides from polluted wastewaters from farm activities. BPS environments contain a high microbial density and diversity facilitating the exchange of information among bacteria, mediated by mobile genetic elements (MGEs), which p...

journal_title：Scientific reports

authors： Martini MC,Wibberg D,Lozano M,Torres Tejerizo G,Albicoro FJ,Jaenicke S,van Elsas JD,Petroni A,Garcillán-Barcia MP,de la Cruz F,Schlüter A,Pühler A,Pistorio M,Lagares A,Del Papa MF

更新日期：2016-06-20 00:00:00

abstract：:A patient's pain during mandibular third molar extraction often creates problems for a dental surgeon and can also cause immense patient discomfort, such as decreased quality of life, serious complications, or even danger to the patients' lives. Effective pain management is therefore of great importance. Conventional ...

journal_title：Scientific reports

authors： Yu F,Xiao Y,Liu H,Wu F,Lou F,Chen D,Bai M,Huang D,Wang C,Ye L

更新日期：2017-01-20 00:00:00

abstract：:Open algal cultivation platforms often suffer crop losses to herbivorous grazers that have potential to devastate biomass production within a few days. While a number of studies suggest synthetic chemicals as control agents for voracious algal grazers, environmental and safety concerns associated with the use of these...

journal_title：Scientific reports

authors： Yun JH,Cho DH,Lee B,Kim HS,Chang YK

更新日期：2018-03-29 00:00:00

abstract：:The transport properties of films assembled from metal nanoclusters can be significantly different from the metals in their bulk or thin film forms due to quantum confinement effects and several competing energy and length scales. For a film composed of metal nanoclusters as its building blocks, the cluster size and t...

journal_title：Scientific reports

authors： Bansal C,Praveen SG,Kumaran JT,Chatterjee A

更新日期：2015-01-08 00:00:00

abstract：:In ART programs in sub-Saharan Africa, a growing proportion of HIV-infected persons initiating first-line antiretroviral therapy (ART) have a history of prior antiretroviral drug use (PAU). We assessed the effect of PAU on the risk of pre-treatment drug resistance (PDR) and virological failure (VF) in a multicountry c...

journal_title：Scientific reports

authors： Inzaule SC,Kityo CM,Siwale M,Akanmu AS,Wellington M,de Jager M,Ive P,Mandaliya K,Stevens W,Boender TS,Ondoa P,Sigaloff KCE,Naniche D,Rinke de Wit TF,Hamers RL

更新日期：2018-10-25 00:00:00