Temporal dynamics of choice behavior in rats and humans: an examination of pre- and post-choice latencies.

abstract：:Spinal muscular atrophy (SMA) is caused by homozygous mutation of the survival motor neuron 1 (SMN1) gene. Disease severity inversely correlates to the amount of SMN protein produced from the homologous SMN2 gene. We show that SMN protein is naturally released in exosomes from all cell types examined. Fibroblasts from...

journal_title：Scientific reports

authors： Nash LA,McFall ER,Perozzo AM,Turner M,Poulin KL,De Repentigny Y,Burns JK,McMillan HJ,Warman Chardon J,Burger D,Kothary R,Parks RJ

更新日期：2017-10-24 00:00:00

abstract：:Long-term daylight deprivation such as during the Antarctic winter has been shown to lead to delayed sleep timing and sleep fragmentation. We aimed at testing whether retinal sensitivity, sleep and circadian rest-activity will change during long-term daylight deprivation on two Antarctic bases (Concordia and Halley VI...

journal_title：Scientific reports

authors： Kawasaki A,Wisniewski S,Healey B,Pattyn N,Kunz D,Basner M,Münch M

更新日期：2018-11-01 00:00:00

abstract：:Natural arches, pillars and other exotic sandstone formations have always been attracting attention for their unusual shapes and amazing mechanical balance that leave a strong impression of intelligent design rather than the result of a stochastic process. It has been recently demonstrated that these shapes could have...

journal_title：Scientific reports

authors： Ostanin I,Safonov A,Oseledets I

更新日期：2017-12-11 00:00:00

abstract：:Application of PCR to multiplexing assays is not trivial; it requires multiple fluorescent labels for amplicon detection and sophisticated software for data interpretation. Alternative PCR-free methods exploiting new concepts in nanotechnology exhibit high sensitivities but require multiple labeling and/or amplificati...

journal_title：Scientific reports

authors： Papadakis G,Tsortos A,Kordas A,Tiniakou I,Morou E,Vontas J,Kardassis D,Gizeli E

更新日期：2013-01-01 00:00:00

abstract：:Adding fluoride into bioactive glasses leads to fluorapatite formation and a decrease in glass transition temperature. Recently, chloride has been introduced into glasses as an alternative to fluoride. The presence of the large chloride ion lowers glass crystallisation tendency and increases glass molar volume, which ...

journal_title：Scientific reports

authors： Chen X,Chen X,Pedone A,Apperley D,Hill RG,Karpukhina N

更新日期：2018-01-22 00:00:00

abstract：:Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphro...

journal_title：Scientific reports

authors： Offenburger SL,Bensaddek D,Murillo AB,Lamond AI,Gartner A

更新日期：2017-06-28 00:00:00

abstract：:Voice disorder such as vocal fatigue is a common and complex multifaceted clinical problem that presents a significant impact on quality of life. In this study, the functional near-infrared diffuse optical technique (fNIRS-DOT) was proposed as a novel approach for human vocal cords oxidative metabolism detection and a...

journal_title：Scientific reports

authors： Lin TC,Chen JC,Liu CH,Lee CY,Tsou YA,Chuang CC

更新日期：2017-12-05 00:00:00

abstract：:Stable electroluminescence from micro-pixelated light-emitting diode (μLED) occurs when electrons and holes are continuously injected from external electrodes. Different from the general recognition, in this work, μLED works in an operation mode, namely, non-electrical contact and non-carrier injection mode, and can b...

journal_title：Scientific reports

authors： Wang K,Liu Y,Wu C,Li D,Lv S,Zhang Y,Zhou X,Guo T

更新日期：2020-05-15 00:00:00

abstract：:Members of the diffusible signal factor (DSF) family are a novel class of quorum sensing (QS) signals in diverse Gram-negative bacteria. Although previous studies have identified RpfF as a key enzyme for the biosynthesis of DSF family signals, many questions in their biosynthesis remain to be addressed. In this study ...

journal_title：Scientific reports

authors： Zhou L,Yu Y,Chen X,Diab AA,Ruan L,He J,Wang H,He YW

更新日期：2015-08-20 00:00:00

abstract：:A considerable body of evidence links together mitochondrial dysfunctions, toxic action of metalloid oxyanions, and system and neurodegenerative disorders. In this study we have used the model yeast Saccharomyces cerevisiae to investigate the genetic determinants associated with tellurite resistance/sensitivity. Nitro...

journal_title：Scientific reports

authors： Pontieri P,Hartings H,Di Salvo M,Massardo DR,De Stefano M,Pizzolante G,Romano R,Troisi J,Del Giudice A,Alifano P,Del Giudice L

更新日期：2018-08-13 00:00:00

abstract：:The triple negative basal-like (TNBL) breast carcinoma is an aggressive and unfavorable prognosis disease. Inhibitors of poly(ADP-ribose) polymerase such as Olaparib could represent a promising targeted therapy but their sensitivity against Multidrug Resistance proteins (MDR), which causes resistance, is not well defi...

journal_title：Scientific reports

authors： Dufour R,Daumar P,Mounetou E,Aubel C,Kwiatkowski F,Abrial C,Vatoux C,Penault-Llorca F,Bamdad M

更新日期：2015-08-03 00:00:00

abstract：:We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 ...

journal_title：Scientific reports

authors： Jia Z,Huang X,Wu H,Zhang T,Li N,Ding P,Sun Y,Liu Z,Wei F,Zhang H,Jiao Y,Ji Y,Zhang Y,Guo C,Li W,Mou D,Xia W,Li Z,Chen D,Yan H,Chen X,Zhao J,Meyers K,Cohen T,Mayer K,Salomon JA,Lu Z,Dye C

更新日期：2015-07-02 00:00:00

abstract：:The changes of balance control mechanism caused by lumbar disc herniation (LDH) has not been well understood. This study aimed to investigate the effects of LDH on the balance control during standing on sloped surfaces. Ten patients with LDH and 10 gender- and age-matched healthy subjects were instructed to stand quie...

journal_title：Scientific reports

authors： Li J,Zhang Y,Song S,Hou Y,Hong Y,Yue S,Li K

更新日期：2020-02-03 00:00:00

abstract：:Affinity maturation is one of the cardinal strategies for improving antibody function using in vitro evolutionary methods; one such well-established method is phage display. To minimise gene deletion, we previously developed an open sandwich (OS) method wherein selection was performed using only phage-displaying VH fr...

journal_title：Scientific reports

authors： Sanada H,Kobayashi K,Oyama K,Maru T,Nakanishi T,Umetsu M,Asano R,Kumagai I

更新日期：2018-04-03 00:00:00

abstract：:Oysters are unusual among bivalves in that they possess chambers, often filled with soft, chalky calcite, that are irregularly scattered throughout the shell. Because the function of these so-called chalky deposits is still unclear, evaluating the growth and distribution of chalk is important for elucidating the ecolo...

journal_title：Scientific reports

authors： Banker RMW,Sumner DY

更新日期：2020-07-21 00:00:00

abstract：:Why lightning sometimes has multiple discharges to ground is an unanswered question. Recently, the observation of small plasma structures on positive leaders re-ignited the search. These small plasma structures were observed as pulsing radio sources along the positive leader length and were named "needles". Needles ma...

journal_title：Scientific reports

authors： Saba MMF,de Paiva AR,Concollato LC,Warner TA,Schumann C

更新日期：2020-10-15 00:00:00

abstract：:Group-IVa elements silicon and germanium are known for their semiconducting properties at room temperature, which are technologically critical. Metallicity and superconductivity are found at higher pressures only, Ge β-tin (tI4) being the first high-pressure metallic phase in the phase diagram. However, recent experim...

journal_title：Scientific reports

authors： Selli D,Baburin IA,Martoňák R,Leoni S

更新日期：2013-01-01 00:00:00

abstract：:Dysregulation in cytokine production has been linked to the pathogenesis of various immune-mediated traits, in which genetic variability contributes to the etiopathogenesis. GWA studies have identified many genetic variants in or near cytokine genes, nonetheless, the translation of these findings into knowledge of fun...

journal_title：Scientific reports

authors： Salnikova LE,Khadzhieva MB,Kolobkov DS,Gracheva AS,Kuzovlev AN,Abilev SK

更新日期：2020-09-07 00:00:00

abstract：:Organisms possess multiple DNA polymerases (Pols) and use each for a different purpose. One of the five Pols in Escherichia coli, DNA polymerase IV (Pol IV), encoded by the dinB gene, is known to participate in lesion bypass at certain DNA adducts. To understand how cells choose Pols when the replication fork encounte...

journal_title：Scientific reports

authors： Le TT,Furukohri A,Tatsumi-Akiyama M,Maki H

更新日期：2017-10-16 00:00:00

abstract：:Epidemiologic studies have identified a positive association between obesity and colorectal neoplasia. Adiposity induces systemic low-grade inflammation, which is commonly assessed with a sensitive biomarker, C-reactive protein (CRP). To understand the molecular mechanisms of obesity in the etiology of colorectal neop...

journal_title：Scientific reports

authors： Kigawa N,Budhathoki S,Yamaji T,Iwasaki M,Inoue M,Tsugane S

更新日期：2017-06-30 00:00:00

abstract：:Inner Mongolia cashmere goats, as an important part of animal husbandry production, play an important role in animal fiber industry. In recent years, scientific research has made a lot of explorations on the molecular regulation mechanism of hair follicle cycle growth, but few studies have been reported on the develop...

journal_title：Scientific reports

authors： Han W,Yang F,Wu Z,Guo F,Zhang J,Hai E,Shang F,Su R,Wang R,Wang Z,Liu Z,Zhao Y,Wang Z,Zhang Y,Li J

更新日期：2020-03-11 00:00:00

abstract：:Higher and lower levels of alertness typically lead to a leftward and rightward bias in attention, respectively. This relationship between alertness and spatial attention potentially has major implications for health and safety. The current study examined alertness and spatial attention under simulated shiftworking co...

journal_title：Scientific reports

authors： Chandrakumar D,Dorrian J,Banks S,Keage HAD,Coussens S,Gupta C,Centofanti SA,Stepien JM,Loetscher T

更新日期：2020-09-11 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) are expected to be both a revolutionary cell source for regenerative medicine and a powerful tool to investigate the molecular mechanisms underlying human cell development in vitro. In the present study, we tried to elucidate the steroidogenic differentiation processes usi...

journal_title：Scientific reports

authors： Matsuo K,Sone M,Honda-Kohmo K,Toyohara T,Sonoyama T,Taura D,Kojima K,Fukuda Y,Ohno Y,Inoue M,Ohta A,Osafune K,Nakao K,Inagaki N

更新日期：2017-11-09 00:00:00

abstract：:In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden, and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite, and single nucleotide polymorphism (SNP) loci, forming 25 MLST sub...

journal_title：Scientific reports

authors： Wang R,Zhang L,Axén C,Bjorkman C,Jian F,Amer S,Liu A,Feng Y,Li G,Lv C,Zhao Z,Qi M,Dong H,Wang H,Sun Y,Ning C,Xiao L

更新日期：2014-02-27 00:00:00

abstract：:The prevalence of patients on automated peritoneal dialysis (APD) is increasing worldwide and may be guided by clinical characteristics, financial issues and patient option. Whether socioeconomic factors at the patient level may influence the decision for the initial peritoneal dialysis (PD) modality is unknown. This ...

journal_title：Scientific reports

authors： Pecoits-Filho R,Ribeiro SC,Kirk A,da Silva HS,Pille A,Falavinha RS Jr,Filho SS,Figueiredo AE,Barretti P,de Moraes TP

更新日期：2017-07-12 00:00:00

abstract：:Chemotherapy (CTx)-induced premature ovarian failure (POF) in woman remains clinically irreversible. Amniotic fluid stem cells (AFSCs) have shown the potential to treat CTx-induced POF; however, the underlying mechanism is unclear. Here we demonstrate that AFSC-derived exosomes recapitulate the anti-apoptotic effect o...

journal_title：Scientific reports

authors： Xiao GY,Cheng CC,Chiang YS,Cheng WT,Liu IH,Wu SC

更新日期：2016-03-16 00:00:00

abstract：:Gut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and richness indices in fecal mi...

journal_title：Scientific reports

authors： Vesterbacka J,Rivera J,Noyan K,Parera M,Neogi U,Calle M,Paredes R,Sönnerborg A,Noguera-Julian M,Nowak P

更新日期：2017-07-24 00:00:00

abstract：:Novel tools in humane animal research should benefit the animal as well as the experimentally obtained data. Imaging technologies have proven to be versatile and also in accordance with the demands of the 3 R principle. However, most imaging technologies are either limited by the target organs, number of repetitive im...

journal_title：Scientific reports

authors： Bahlmann J,Madrahimov N,Daniel F,Theidel D,DeTemple DE,Buettner M,Bleich A,Haverich A,Heisterkamp A,Kalies S

更新日期：2020-06-08 00:00:00

abstract：:Agrostemma githago L. (corn cockle) is an herbaceous plant mainly growing in Europe. The seeds of the corn cockle are toxic and poisonings were widespread in the past by consuming contaminated flour. The toxic principle of Agrostemma seeds was attributed to triterpenoid secondary metabolites. Indeed, this is in part t...

journal_title：Scientific reports

authors： Weise C,Schrot A,Wuerger LTD,Adolf J,Gilabert-Oriol R,Sama S,Melzig MF,Weng A

更新日期：2020-09-21 00:00:00

abstract：:Besides clinical characteristics, easy-accessible laboratory markers could be of value to refine risk stratification in peripheral artery disease. In the current study, we investigated whether α-hydroxybutyrate dehydrogenase (HBDH) is associated with atherothrombotic events in 83 stable patients undergoing infrainguin...

journal_title：Scientific reports

authors： Lee S,Koppensteiner R,Kopp CW,Gremmel T

更新日期：2019-12-03 00:00:00