Structure of melanins from the fungi Ochroconis lascauxensis and Ochroconis anomala contaminating rock art in the Lascaux Cave.

Abstract:

:Two novel species of the fungal genus Ochroconis, O. lascauxensis and O. anomala have been isolated from the walls of the Lascaux Cave, France. The interest in these fungi and their melanins lies in the formation of black stains on the walls and rock art which threatens the integrity of the paintings. Here we report solid-state cross polarization magic-angle spinning 13C and 15N nuclear magnetic resonance (NMR) spectroscopy and surface-enhanced Raman spectroscopy (SERS) of the melanins extracted from the mycelia of O. lascauxensis and O. anomala in order to known their chemical structure. The melanins from these two species were compared with those from other fungi. The melanins from the Ochroconis species have similar SERS and 13C and 15N NMR spectra. Their chemical structures as suggested by the data are not related to 3,4-dihydroxyphenylalanine, 5,6-dihydroxyindole or 1,8-dihydroxynaphthalene precursors and likely the building blocks from the melanins have to be based on other phenols that react with the N-terminal amino acid of proteins. The analytical pyrolysis of the acid hydrolysed melanin from O. lascauxensis supports this assumption.

journal_name

Sci Rep

journal_title

Scientific reports

authors

De la Rosa JM,Martin-Sanchez PM,Sanchez-Cortes S,Hermosin B,Knicker H,Saiz-Jimenez C

doi

10.1038/s41598-017-13862-7

subject

Has Abstract

pub_date

2017-10-18 00:00:00

pages

13441

issue

1

issn

2045-2322

pii

10.1038/s41598-017-13862-7

journal_volume

7

pub_type

杂志文章
  • Author Correction: Correction-free force calibration for magnetic tweezers experiments.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-36219-0

    authors: Ostrofet E,Papini FS,Dulin D

    更新日期:2018-12-10 00:00:00

  • Rituximab-containing therapy for cold agglutinin disease: a retrospective study of 16 patients.

    abstract::Cold agglutinin disease (CAD) is a rare form of autoimmune haemolytic anaemia, and because of its rareness, there is no standard treatment for CAD patients. We retrospectively analysed the response to rituximab-containing therapy in CAD patients at our hospital. All patients received rituximab-containing therapy for a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69465-2

    authors: Jia MN,Qiu Y,Wu YY,Cai H,Zhou DB,Cao XX,Li J

    更新日期:2020-07-29 00:00:00

  • Lithium and GADL1 regulate glycogen synthase kinase-3 activity to modulate KCTD12 expression.

    abstract::Potassium channel tetramerization domain containing 12 (KCTD12), the auxiliary GABAB receptor subunit, is identified as a susceptibility gene for bipolar I (BPI) disorder in the Han Chinese population. Moreover, the single-nucleotide polymorphism (SNP) rs17026688 in glutamate decarboxylase-like protein 1 (GADL1) is sh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46655-1

    authors: Wu TN,Chen CK,Lee CS,Wu BJ,Sun HJ,Chang CH,Chen CY,Wu LS,Cheng AT

    更新日期:2019-07-16 00:00:00

  • Multiaxial Lenticular Stress-Strain Relationship of Native Myocardium is Preserved by Infarct-Induced Natural Heart Regeneration in Neonatal Mice.

    abstract::Neonatal mice exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). Cardiac biomechanics intricately affect long-term heart function, but whether regenerated cardiac muscle is biomechanically similar to native myocardium remains u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63324-w

    authors: Wang H,Bennett-Kennett R,Paulsen MJ,Hironaka CE,Thakore AD,Farry JM,Eskandari A,Lucian HJ,Shin HS,Wu MA,Imbrie-Moore AM,Steele AN,Stapleton LM,Zhu Y,Dauskardt RH,Woo YJ

    更新日期:2020-04-30 00:00:00

  • Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine.

    abstract::Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of DG and venlafaxine (VLX) in a chronic social defeat stress model...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10391-1

    authors: Bai S,Zhang X,Chen Z,Wang W,Hu Q,Liang Z,Shen P,Gui S,Zeng L,Liu Z,Chen J,Xie X,Huang H,Han Y,Wang H,Xie P

    更新日期:2017-08-29 00:00:00

  • Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression.

    abstract::Abnormal expression of microRNAs (miRNAs) contributes to glioma initiation. However, the expression of miRNAs in tumour tissue or blood of spinal cord glioma (SCG) patients, particularly in high-grade spinal gliomas (Grade IV) known as glioblastoma (GBM), remains largely unknown. In this study we aimed to determine di...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42364-x

    authors: An T,Fan T,Zhang XQ,Liu YF,Huang J,Liang C,Lv BH,Wang YQ,Zhao XG,Liu JX,Fu YH,Jiang GJ

    更新日期:2019-06-24 00:00:00

  • Pre-transplant depression decreased overall survival of patients receiving allogeneic hematopoietic stem cell transplantation: a nationwide cohort study.

    abstract::Studies investigating association of depression with overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) yielded conflicting results. A nationwide cohort study, which included all adult patients [n = 7,170; depression group, 13.3% (N = 956); non-depression group, 86.7% (N = 6,214...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71208-2

    authors: Wang SM,Park SS,Park SH,Kim NY,Kang DW,Na HR,Lee JW,Han S,Lim HK

    更新日期:2020-09-17 00:00:00

  • Adipose-derived stromal/stem cells improve epidermal homeostasis.

    abstract::Wound healing is regulated by complex interactions between the keratinocytes and other cell types including fibroblasts. Recently, adipose-derived mesenchymal stromal/stem cells (ASCs) have been reported to influence wound healing positively via paracrine involvement. However, their roles in keratinocytes are still ob...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54797-5

    authors: Moriyama M,Sahara S,Zaiki K,Ueno A,Nakaoji K,Hamada K,Ozawa T,Tsuruta D,Hayakawa T,Moriyama H

    更新日期:2019-12-04 00:00:00

  • Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study.

    abstract::We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (2...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01778-1

    authors: Zhou QF,Zhang MX,Tong SL,Tao RX,Hao JH,Huang K,Tao FB,Zhu P

    更新日期:2017-05-08 00:00:00

  • Th1, Th17, and Treg Responses are Differently Modulated by TNF-α Inhibitors and Methotrexate in Psoriasis Patients.

    abstract::Psoriasis is a chronic, recurrent, immune-mediated, hyperproliferative inflammatory skin disease. The role of the adaptive immune system, particularly of Th1 and Th17 lymphocytes, has been regarded as prominent in the immunopathogenesis of psoriasis, as well as decreased Tregs function. Immunobiological drugs were adm...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43899-9

    authors: Furiati SC,Catarino JS,Silva MV,Silva RF,Estevam RB,Teodoro RB,Pereira SL,Ataide M,Rodrigues V Jr,Rodrigues DBR

    更新日期:2019-05-17 00:00:00

  • Experimental Quantum-enhanced Cryptographic Remote Control.

    abstract::The Internet of Things (IoT), as a cutting-edge integrated cross-technology, promises to informationize people's daily lives, while being threatened by continuous challenges of eavesdropping and tampering. The emerging quantum cryptography, harnessing the random nature of quantum mechanics, may also enable uncondition...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42278-8

    authors: Pang XL,Qiao LF,Sun K,Liu Y,Yang AL,Jin XM

    更新日期:2019-04-09 00:00:00

  • Late-responding normal tissue cells benefit from high-precision radiotherapy with prolonged fraction delivery times via enhanced autophagy.

    abstract::High-precision radiotherapy (HPR) has established its important role in the treatment of tumors due to its precise dose distribution. Given its more complicated delivery process, HPR commonly requires more fraction delivery time (FDT). However, it is unknown whether it has an identical response of prolonged FDT on dif...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09119

    authors: Yao Q,Zheng R,Xie G,Liao G,Du S,Ren C,Li R,Lin X,Hu D,Yuan Y

    更新日期:2015-03-13 00:00:00

  • A plasma membrane localized protein phosphatase in Toxoplasma gondii, PPM5C, regulates attachment to host cells.

    abstract::The propagation of Toxoplasma gondii is accomplished by repeated lytic cycles of parasite attachment to a host cell, invasion, replication within a parasitophorous vacuole, and egress from the cell. This lytic cycle is delicately regulated by calcium-dependent reversible phosphorylation of the molecular machinery that...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42441-1

    authors: Yang C,Broncel M,Dominicus C,Sampson E,Blakely WJ,Treeck M,Arrizabalaga G

    更新日期:2019-04-11 00:00:00

  • Development of miniaturized walking biological machines.

    abstract::The quest to 'forward-engineer' and fabricate biological machines remains a grand challenge. Towards this end, we have fabricated locomotive "bio-bots" from hydrogels and cardiomyocytes using a 3D printer. The multi-material bio-bot consisted of a 'biological bimorph' cantilever structure as the actuator to power the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00857

    authors: Chan V,Park K,Collens MB,Kong H,Saif TA,Bashir R

    更新日期:2012-01-01 00:00:00

  • The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases.

    abstract::Human fetuin-B plays a key physiological role in human fertility through its inhibitory action on ovastacin, a member of the astacin family of metallopeptidases. The inhibitor consists of tandem cystatin-like domains (CY1 and CY2), which are connected by a linker containing a "CPDCP-trunk" and followed by a C-terminal...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51095-y

    authors: Guevara T,Körschgen H,Cuppari A,Schmitz C,Kuske M,Yiallouros I,Floehr J,Jahnen-Dechent W,Stöcker W,Gomis-Rüth FX

    更新日期:2019-10-11 00:00:00

  • Atomic-scale analysis of cation ordering in reduced calcium titanate.

    abstract::The phenomenon of cation ordering is closely related to certain physical properties of complex oxides, which necessitates the search of underlying structure-property relationship at atomic resolution. Here we study the superlattices within reduced calcium titanate single crystal micro-pillars, which are unexpected fro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15120-2

    authors: Li L,Hu X,Jiang F,Jing W,Guo C,Jia S,Gao Y,Wang J

    更新日期:2017-11-03 00:00:00

  • Juvenile hormone biosynthesis in adult Blattella germanica requires nuclear receptors Seven-up and FTZ-F1.

    abstract::In insects, the transition from juvenile development to the adult stage is controlled by juvenile hormone (JH) synthesized from the corpora allata (CA) glands. Whereas a JH-free period during the last juvenile instar triggers metamorphosis and the end of the growth period, the reappearance of this hormone after the im...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40234

    authors: Borras-Castells F,Nieva C,Maestro JL,Maestro O,Belles X,Martín D

    更新日期:2017-01-11 00:00:00

  • A biomolecular anthropological investigation of William Adams, the first SAMURAI from England.

    abstract::William Adams (Miura Anjin) was an English navigator who sailed with a Dutch trading fleet to the far East and landed in Japan in 1600. He became a vassal under the Shogun, Tokugawa Ieyasu, was bestowed with a title, lands and swords, and became the first SAMURAI from England. "Miura" comes from the name of the territ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78723-2

    authors: Mizuno F,Ishiya K,Matsushita M,Matsushita T,Hampson K,Hayashi M,Tokanai F,Kurosaki K,Ueda S

    更新日期:2020-12-10 00:00:00

  • The response of a boreal deep-sea sponge holobiont to acute thermal stress.

    abstract::Effects of elevated seawater temperatures on deep-water benthos has been poorly studied, despite reports of increased seawater temperature (up to 4 °C over 24 hrs) coinciding with mass mortality events of the sponge Geodia barretti at Tisler Reef, Norway. While the mechanisms driving these mortality events are unclear...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01091-x

    authors: Strand R,Whalan S,Webster NS,Kutti T,Fang JKH,Luter HM,Bannister RJ

    更新日期:2017-05-22 00:00:00

  • Author Correction: Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-46785-6

    authors: Rombaut D,Chiu HS,Decaesteker B,Everaert C,Yigit N,Peltier A,Janoueix-Lerosey I,Bartenhagen C,Fischer M,Roberts S,D'Haene N,De Preter K,Speleman F,Denecker G,Sumazin P,Vandesompele J,Lefever S,Mestdagh P

    更新日期:2019-07-17 00:00:00

  • Clinical correlates of nocardiosis.

    abstract::Nocardia is an opportunistic pathogen that most frequently affects the lungs. Evidence is limited regarding the risk factors for nocardiosis. The current study assessed clinical correlates of nocardiosis. A retrospective study was conducted based on medical records of consecutive adult patients (N = 60) with nocardios...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71214-4

    authors: Margalit I,Goldberg E,Ben Ari Y,Ben-Zvi H,Shostak Y,Krause I,Muhsen K

    更新日期:2020-08-31 00:00:00

  • Improving truffle mycelium flavour through strain selection targeting volatiles of the Ehrlich pathway.

    abstract::Truffles (Tuber spp.) are the fruiting bodies of symbiotic fungi, which are prized food delicacies. The marked aroma variability observed among truffles of the same species has been attributed to a series of factors that are still debated. This is because factors (i.e. genetics, maturation, geographical location and t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27620-w

    authors: Vahdatzadeh M,Splivallo R

    更新日期:2018-06-18 00:00:00

  • Attentional deployment impacts neural response to regret.

    abstract::Regret results from comparing non-optimal outcomes containing both gain and loss parts to better alternatives during decision-making. The present fMRI study aimed to explore whether levels of regret could change when gain or loss part of a non-optimal outcome was focused during a sequential risk taking task, i.e. the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41374

    authors: Liu Z,Li L,Zheng L,Xu M,Zhou FA,Guo X

    更新日期:2017-02-01 00:00:00

  • Resonance phenomena controlled by external feedback signals and additive noise in neural systems.

    abstract::Chaotic resonance is a phenomenon that can replace the fluctuation source in stochastic resonance from additive noise to chaos. We previously developed a method to control the chaotic state for suitably generating chaotic resonance by external feedback even when the external adjustment of chaos is difficult, establish...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48950-3

    authors: Nobukawa S,Shibata N,Nishimura H,Doho H,Wagatsuma N,Yamanishi T

    更新日期:2019-09-02 00:00:00

  • Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model.

    abstract::Post-operative pancreatic fistula (POPF) following pancreatic resection is a life-threatening surgical complication. Cell sheets were prepared and harvested using temperature-responsive culture dishes and transplanted as patches to seal POPF. Two different mesenchymal stem cell (MSC) sheets were compared in terms of t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18490-9

    authors: Kim SR,Yi HJ,Lee YN,Park JY,Hoffman RM,Okano T,Shim IK,Kim SC

    更新日期:2018-01-10 00:00:00

  • Characteristics of autologous protein solution and leucocyte-poor platelet-rich plasma for the treatment of osteoarthritis of the knee.

    abstract::Recently, platelet-rich plasma (PRP) has received attention as a treatment for patients with osteoarthritis of the knee (OAK), a chronic degenerative disease, to bridge the gap between conservative and surgical treatments. Here, we investigated the differences in the humoral factors present in two types of PRP purifie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67099-y

    authors: Wasai S,Sato M,Maehara M,Toyoda E,Uchiyama R,Takahashi T,Okada E,Iwasaki Y,Suzuki S,Watanabe M

    更新日期:2020-06-29 00:00:00

  • Key sources and seasonal dynamics of greenhouse gas fluxes from yak grazing systems on the Qinghai-Tibetan Plateau.

    abstract::Greenhouse gas (GHG) emissions from livestock grazing systems are contributing to global warming. To examine the influence of yak grazing systems on GHG fluxes and relationships between GHG fluxes and environmental factors, we measured carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) fluxes over three key s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40857

    authors: Liu Y,Yan C,Matthew C,Wood B,Hou F

    更新日期:2017-01-20 00:00:00

  • Survival Motor Neuron (SMN) protein is required for normal mouse liver development.

    abstract::Spinal Muscular Atrophy (SMA) is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. Decreased levels of, cell-ubiquitous, SMN protein is associated with a range of systemic pathologies reported in severe patients. Despite high levels of SMN protein in normal liver, there is no comprehensive stu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34635

    authors: Szunyogova E,Zhou H,Maxwell GK,Powis RA,Muntoni F,Gillingwater TH,Parson SH

    更新日期:2016-10-04 00:00:00

  • Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator.

    abstract::Deep venous thrombosis (DVT) is a common complication of orthopedic surgery. Genetic risk factors and high heritability carried a substantial risk of DVT. In this study, we aimed to investigate the potential association in the Han Chinese population between the polymorphisms of BDKRB2 and KNG1 and DVT after orthopedic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34868-9

    authors: Wang Q,Cheng G,Wang X,Wang D,Yang Y,Chen K,Ye J,Qing Z

    更新日期:2018-11-26 00:00:00

  • Prevalence of neck/shoulder pain among public hospital workers in China and its associated factors: a cross-sectional study.

    abstract::Studies have reported that neck and/or shoulder pain (NSP) was prevalent and a non-ignorable occupational health problem in healthcare providers. Considering data deficiency on NSP, we aimed to investigate the prevalence and sick leave absence of NSP among public hospital workers in Shandong, China and to explore the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69382-4

    authors: Dong H,Zhang Q,Liu G,Shao T

    更新日期:2020-07-23 00:00:00