Abstract：
:Egg oil from Portunus trituberculatus (Pt-egg oil) can overcome insulin resistance resulting from abundant bioactive lipids. However, its effects on obesity and gut microbiota were unclear. Here, we evaluated whether Pt-egg oil could improve obesity and gut microbiota or not in high-fat diet feeding mice. Results exhibited that Pt-egg oil markedly reduced body weight and adipose weight gain, improved lipid accumulation and circulatory cytokines, inhibited epididymal adipose cell size. Moreover, Pt-egg oil modified gut microbiota, involving decreases in the ratio of Firmicutes to Bacteroidetes, Proteobacteria, Actinobacteria, and increase in Verrucomicrobia phylum. Pt-egg oil reduced serum and fecal lipopolysaccharide (LPS) levels and down-regulated Toll-like receptor 4 pathway in both epididymal adipose and liver tissues. Meanwhile, Pt-egg oil increased short chain fatty acids and up-regulated of G-protein-coupled receptors in both epididymal adipose and liver tissues. These suggest that Pt-egg oil could be alternative food supplement for the prophylactic effects on anti-obesity and improvement in human gut health.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hu S,Yang H,Gao X,Li S,Jiang W,Liu Ydoi
10.1038/s41598-020-65199-3subject
Has Abstractpub_date
2020-05-21 00:00:00pages
8454issue
1issn
2045-2322pii
10.1038/s41598-020-65199-3journal_volume
10pub_type
杂志文章abstract：:The differential conductance of graphene is shown to exhibit a zero-bias anomaly at low temperatures, arising from a suppression of the quantum corrections due to weak localization and electron interactions. A simple rescaling of these data, free of any adjustable parameters, shows that this anomaly exhibits a univers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62313-3
更新日期：2020-03-27 00:00:00
abstract：:This study aims to identify patterns of surface heat fluxes, and corresponding surface ocean responses, associated with synoptic-scale atmospheric events and their modulation on seasonal time scales. In particular, northerly and southerly wind events associated with atmospheric disturbances were analyzed using high-te...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80665-8
更新日期：2021-01-11 00:00:00
abstract：:The present study investigated the effect of aldehyde dehydrogenase2 (ALDH2) rs671 polymorphism and alcohol consumption on the severity of primary open-angle glaucoma (POAG). The questionnaire for alcohol consumption pattern and targeted genotyping for ALDH2 rs671 polymorphism was performed from 445 Korean POAG patien...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74470-6
更新日期：2020-10-15 00:00:00
abstract：:This study investigates the efficacy of systemic growth hormone (GH) therapy in ameliorating the deleterious effects of chronic denervation (CD) injury on nerve regeneration and resulting motor function. Using a forelimb CD model, 4 groups of Lewis rats were examined (n = 8 per group): Group-1 (negative control) 8 wee...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39738-6
更新日期：2019-02-28 00:00:00
abstract：:Coordination polymerization leads to various metal-organic frameworks (MOFs) with unique physical properties and chemical functionalities. One of the challenges towards their applications as porous materials is to make MOFs optimally conductive to be used as electronic components. Here, it is demonstrated that Co-MOF-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02618-y
更新日期：2017-05-26 00:00:00
abstract：:Ovarian cancer (OC) is the most lethal gynecological carcinoma due to the lack of diagnostic markers and effective drug targets. Discovery of new therapeutic targets in OC to improve the treatment outcome is urgently needed. We performed proteomic analysis of OC specimens and the paired normal tissues and revealed tha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48992-7
更新日期：2019-09-02 00:00:00
abstract：:The second-in-class proteasome inhibitor (PI) carfilzomib (Kyprolis, Cfz) has contributed to a substantial advancement in multiple myeloma treatment by improving patient survival and quality of life. A considerable portion of patients however display intrinsic resistance to Cfz. Our mechanistic understanding of intrin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40635-1
更新日期：2019-03-11 00:00:00
abstract：:Angiogenesis is one of the hallmarks of cancer and, as such, one of the alternative general targets for anticancer therapy. Since angiogenesis is a complex process involving a high number of interconnected components, a network approach would be a convenient systemic way to analyse responses to directed drug attacks. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00061
更新日期：2011-01-01 00:00:00
abstract：:Sesquiterpene lactones (STL) are a subclass of isoprenoids with many known bioactivities frequently found in the Asteraceae family. In recent years, remarkable progress has been made regarding the biochemistry of STL, and today the biosynthetic pathway of the core backbones of many STLs has been elucidated. Consequent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50520-6
更新日期：2019-10-04 00:00:00
abstract：:Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels in the prefrontal cortex (PFC) of LPS-treated mice. PTN is an inhibitor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76415-5
更新日期：2020-11-20 00:00:00
abstract：:Inhibitors of cyclin-dependent kinases (ICKs) are key regulators of cyclin-dependent kinase activities and cell division. Herein, we identified eight ICKs in maize, which we named Zeama;ICKs (ZmICKs). Primary sequencing and phylogenetic analyses were used to divide the ZmICK family into two classes: group B and group ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43818
更新日期：2017-03-06 00:00:00
abstract：:Rotaviruses (RVs) are the most common cause of severe diarrheal disease. To date two rotavirus oral vaccines are licensed: Rotarix and Rotateq. Our aim was to contribute to the post-marketing evaluation of these vaccines safety profile. We collected all RV vaccines-related reports of Adverse Events Following Immunizat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70653-3
更新日期：2020-08-12 00:00:00
abstract：:Persistent shortage and heterogeneous quality of liver grafts encourages the optimization of donor-recipient matching in liver transplantation (LT). We explored whether or not there was a survival benefit (SB) of LT according to the quality of grafts assessed by the Donor Quality Index (DQI) and recipients' disease se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60973-9
更新日期：2020-03-05 00:00:00
abstract：:The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we explored the effects of the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13054-3
更新日期：2017-10-06 00:00:00
abstract：:The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and fro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21317-w
更新日期：2018-02-12 00:00:00
abstract：:Predicting regions at risk from introductions of non-native species and the subsequent invasions is a fundamental aspect of horizon scanning activities that enable the development of more effective preventative actions and planning of management measures. The Asian cyprinid fish topmouth gudgeon Pseudorasbora parva ha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26316
更新日期：2016-05-20 00:00:00
abstract：:The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis results in sustained elevated levels of glucocorticoids which impair neu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39867-y
更新日期：2019-03-01 00:00:00
abstract：:The human ether-à-go-go related gene (hERG) channel is crucial for the cardiac action potential by contributing to the fast delayed-rectifier potassium current. Mutations in the hERG channel result in type 2 long QT syndrome (LQT2). The hERG channel contains a cyclic nucleotide-binding homology domain (CNBHD) and this...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23712
更新日期：2016-03-30 00:00:00
abstract：:The monitoring and early detection of abnormalities or variations in the cardiac cycle functionality are very critical practices and have significant impact on the prevention of heart diseases and their associated complications. Currently, in the field of biomedical engineering, there is a growing need for devices cap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37093
更新日期：2016-11-17 00:00:00
abstract：:Recently, detecting biological particles by analyzing their mechanical properties has attracted increasing attention. To detect and identify different bioparticles and estimate their dimensions, a mechanical nanosensor is introduced in this paper. To attract particles, numerous parts of the substrate are coated with d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60296-9
更新日期：2020-02-25 00:00:00
abstract：:Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42518
更新日期：2017-02-13 00:00:00
abstract：:Microbial life below the seafloor has changed over geological time, but these changes are often not obvious, as they are not recorded in the sediment. Sulphur (S) isotope values in pyrite extracted from a Plio- to Holocene sequence of the Peru Margin (Ocean Drilling Program, ODP, Site 1229) show a down-core pattern th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36943-7
更新日期：2019-01-24 00:00:00
abstract：:Phytoplankton play key roles in the oceans by regulating global biogeochemical cycles and production in marine food webs. Global warming is thought to affect phytoplankton production both directly, by impacting their photosynthetic metabolism, and indirectly by modifying the physical environment in which they grow. In...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59989-y
更新日期：2020-02-25 00:00:00
abstract：:Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41131
更新日期：2017-01-25 00:00:00
abstract：:Natural variability in pH in the diffusive boundary layer (DBL), the discrete layer of seawater between bulk seawater and the outer surface of organisms, could be an important factor determining the response of corals and coralline algae to ocean acidification (OA). Here, two corals with different morphologies and one...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49044-w
更新日期：2019-09-06 00:00:00
abstract：:The study reported here focuses on inertial internal wave currents on the west Florida midshelf in 50 m depth. In situ observations showed that the seasonal shifts in stratification change both the frequency range of inertial internal waves and their modulation time scales. According to the analysis, the subinertial f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34346-2
更新日期：2018-10-29 00:00:00
abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68106-y
更新日期：2020-07-14 00:00:00
abstract：:The magnetization process is a very important probe to study magnetic materials, particularly in search of spin-liquid states in quantum spin systems. Regrettably, however, progress of the theoretical analysis has been unsatisfactory, mostly because it is hard to obtain sufficient numerical data to support the theory....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70389-0
更新日期：2020-08-26 00:00:00
abstract：:In the last decade, extracellular vesicles (EVs) have become a hot topic. The findings on EVs content and effects have made them a major field of interest in cancer research. EVs, are able to be internalized through integrins expressed in parental cells, in a tissue specific manner, as a key step of cancer progression...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62920-0
更新日期：2020-04-16 00:00:00
abstract：:Magnetotactic bacteria biomineralize ordered chains of uniform, membrane-bound magnetite or greigite nanocrystals that exhibit nearly perfect crystal structures and species-specific morphologies. Transmission electron microscopy (TEM) is a critical technique for providing information regarding the organization of cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06854
更新日期：2014-10-31 00:00:00
