Abstract：
:The present study investigated the effect of aldehyde dehydrogenase2 (ALDH2) rs671 polymorphism and alcohol consumption on the severity of primary open-angle glaucoma (POAG). The questionnaire for alcohol consumption pattern and targeted genotyping for ALDH2 rs671 polymorphism was performed from 445 Korean POAG patients. Retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured and compared according to alcohol consumption and ALDH2 rs671 genotype. Heavy drinking group eyes had thinner RNFL thickness than did abstinence group eyes (65.0 ± 10.9 vs. 70.9 ± 11.5 µm, P = 0.023). Both mild (65.8 ± 9.6 µm) and heavy (63.8 ± 8.4 µm) drinking group eyes had significantly thinner macular GCIPL thickness than did abstinence group eyes (68.1 ± 8.2 µm, P = 0.003). However, ALDH2 rs671 polymorphism did not show any significant association with RNFL or GCIPL thickness. Alcohol consumption was significantly associated with GCIPL thinning (β = -0.446, P = 0.035) after adjustment for multiple confounding factors. As excessive alcohol consumption was significantly associated with thinner GCIPL thickness while ALDH2 polymorphism had no significant effect on RNFL or GCIPL thickness, glaucoma patients should avoid excessive alcohol consumption regardless of ALDH2 polymorphism.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Han YS,Kim YW,Kim YJ,Park KH,Jeoung JWdoi
10.1038/s41598-020-74470-6subject
Has Abstractpub_date
2020-10-15 00:00:00pages
17422issue
1issn
2045-2322pii
10.1038/s41598-020-74470-6journal_volume
10pub_type
杂志文章abstract：:Visualization of the surgically operated tissues is vital to improve surgical model animals including mouse. Urological surgeries for urethra include series of fine manipulations to treat the increasing number of birth defects such as hypospadias. Hence visualization of the urethral status is vital. Inappropriate uret...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75184-5
更新日期：2020-10-26 00:00:00
abstract：:Graphene thin films have great potential to function as transparent electrodes in organic electronic devices, due to their excellent conductivity and high transparency. Recently, organic light-emitting diodes (OLEDs)have been successfully demonstrated to possess high luminous efficiencies with p-doped graphene anodes....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09693
更新日期：2015-04-20 00:00:00
abstract：:Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) has a dimer of dimers quaternary structure with two independent allosteric sites in each monomer. Here, we reveal the different effects of nucleotide ligands on the quaternary structure regulation and functional role of the human m-NAD(P)-ME exosite. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45282-0
更新日期：2019-06-24 00:00:00
abstract：:The Antarctic silverfish (Pleuragramma antarctica) is a critically important forage species with a circumpolar distribution and is unique among other notothenioid species for its wholly pelagic life cycle. Previous studies have provided mixed evidence of population structure over regional and circumpolar scales. The a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36030-x
更新日期：2018-12-14 00:00:00
abstract：:Case-control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free model to simultaneously chara...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01791-4
更新日期：2017-05-16 00:00:00
abstract：:Anomalous transport in porous media is commonly believed to be induced by the highly complex pore space geometry. However, this phenomenon is also observed in porous media with rather simple pore structure. In order to answer how ubiquitous can anomalous transport be in porous media, we in this work systematically inv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39363-3
更新日期：2019-03-14 00:00:00
abstract：:We investigated the incidence, perioperative risk factors, and outcomes of postoperative acute kidney injury (AKI) in neurosurgical critically ill patients. A prospective multicenter cohort study was conducted, enrolling adult patients who underwent neurosurgical procedure and admitted to the neurosurgical intensive c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04627-3
更新日期：2017-06-26 00:00:00
abstract：:The tricarboxylic acid cycle produces NADH for oxidative phosphorylation and fumarase [EC 4.2.1.2] is a critical enzyme in this cycle, catalysing the reversible conversion of fumarate and L-malate. Fumarase is applied to industrial L-malate production as a biocatalyst. L-malate is used in a wide range of industries su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47025-7
更新日期：2019-07-23 00:00:00
abstract：:Flotation of small solid objects and liquid droplets on water is critical to natural and industrial activities. This paper reports the floating mechanism of liquid marbles, or liquid droplets coated with hydrophobic microparticles. We used X-ray computed tomography (XCT) to acquire cross-sectional images of the floati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21777
更新日期：2016-02-23 00:00:00
abstract：:The aim of the present study was to evaluate the healthy lifestyle behaviors in hypertensive patients (aware, n = 1364 and not aware, n = 1213) based on 2011 national survey of risk factors of non-communicable disease (SuRFNCD) of Iran. Lifestyle score was calculated based on lifestyle behaviors, including smoking sta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26823-5
更新日期：2018-05-31 00:00:00
abstract：:Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22322
更新日期：2016-02-29 00:00:00
abstract：:Quantum information technologies harness the intrinsic nature of quantum theory to beat the limitations of the classical methods for information processing and communication. Recently, the application of quantum features to metrology has attracted much attention. Quantum optical coherence tomography (QOCT), which util...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18042
更新日期：2015-12-14 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is conventionally confirmed with oral glucose tolerance test (OGTT) in 24 to 28 weeks of gestation, but it is still uncertain whether it can be predicted with secondary use of electronic health records (EHRs) in early pregnancy. To this purpose, the cost-sensitive hybrid model (CSHM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16665-y
更新日期：2017-11-27 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-67129-9
更新日期：2020-06-17 00:00:00
abstract：:Adding fluoride into bioactive glasses leads to fluorapatite formation and a decrease in glass transition temperature. Recently, chloride has been introduced into glasses as an alternative to fluoride. The presence of the large chloride ion lowers glass crystallisation tendency and increases glass molar volume, which ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19544-2
更新日期：2018-01-22 00:00:00
abstract：:Fat character is an important index in duck culture that linked to local flavor, feed cost and fat intake for costumers. Since the regulation networks in duck lipid metabolism had not been reported very clearly, we aimed to explore the potential miRNA-mRNA pairs and their regulatory roles in duck lipid metabolism. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27418
更新日期：2016-06-08 00:00:00
abstract：:Bacterial microcompartments (BMCs) are promising natural protein structures for applications that require the segregation of certain metabolic functions or molecular species in a defined microenvironment. To understand how endogenous cargos are packaged inside the protein shell is key for using BMCs as nano-scale reac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33074-x
更新日期：2018-10-10 00:00:00
abstract：:Spermatogenesis in the mouse has been extensively studied for decades. Previous methods, such as histological staining or bulk transcriptome analysis, either lacked resolution at the single-cell level or were focused on a very narrowly defined set of factors. Here, we present the first comprehensive, unbiased single-c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24725-0
更新日期：2018-04-25 00:00:00
abstract：:The ability to arrange cells and/or microparticles into the desired pattern is critical in biological, chemical, and metamaterial studies and other applications. Researchers have developed a variety of patterning techniques, which either have a limited capacity to simultaneously trap massive particles or lack the spat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14802-1
更新日期：2017-10-30 00:00:00
abstract：:A three-year-long field experiment was conducted in a continuous grazing system with a variable stocking rate to evaluate effects of increasing nitrogen levels in Marandu grass (Brachiaria brizantha Hochst ex A. Rich Stapf "marandu") on herbage mass, forage accumulation rate (FAR), forage quality, stocking rate (SR), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44138-x
更新日期：2019-05-20 00:00:00
abstract：:The North Sea is one of the most extensively studied marine regions of the world. Hence, large amounts of molecular data for species identification are available in public repositories, and expectations to find numerous new species in this well-known region are rather low. However, molecular reference data for harpact...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45718-7
更新日期：2019-06-24 00:00:00
abstract：:We report two brothers from a non-consanguineous Irish family presenting with a novel syndrome characterised by intellectual disability, facial dysmorphism, scoliosis and long QT. Their mother has a milder phenotype including long QT. X-linked inheritance was suspected. Whole exome sequencing identified a novel missen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16022
更新日期：2015-11-02 00:00:00
abstract：:Subsea hypersaline anoxic brine pools are among the most extreme habitable environments on Earth that offer clues to life on other planets. Brine is toxic to macrofauna as remotely operated vehicles commonly observe dead and preserved remains in brine pools. While brine pools are often assumed to be stable stratified ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36781-7
更新日期：2019-01-15 00:00:00
abstract：:The beetle Homalinotus depressus (Coleoptera: Curculionidae) is a major pest of coconuts in the Northern region of Brazil, for which environmentally friendly methods of control are desired. Behavioral responses of H. depressus to airborne volatile extracts from conspecifics suggested the presence of a male-produced ag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37156-8
更新日期：2019-01-28 00:00:00
abstract：:In this paper, phosphorene nanoribbons (PNRs) are theoretically studied using a multiscale simulation flow from the ab initio level to the tight binding (TB) level. The scaling effects of both armchair PNRs (aPNRs) and zigzag PNRs (zPNRs) from material properties to device properties are explored. The much larger effe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38009
更新日期：2016-11-29 00:00:00
abstract：:The interplay between structure and function is critical in the understanding of complex systems, their dynamics and their behavior. We investigated the interplay between structural and functional networks by means of the differential identifiability framework, which here quantifies the ability of identifying a partic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71373-4
更新日期：2020-09-04 00:00:00
abstract：:Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related behaviors by using mice lackin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63427-4
更新日期：2020-04-10 00:00:00
abstract：:Organic light-emitting devices and solar cells are devices that create, manipulate, and convert excited states in organic semiconductors. It is crucial to characterize these excited states, or excitons, to optimize device performance in applications like displays and solar energy harvesting. This is complicated if the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03797
更新日期：2014-01-21 00:00:00
abstract：:The synthesis of artificial cell is a route for searching the origin of protocell. Here, we create a novel cell model of graphene capsules with selective ion channels, indicating that graphene might be an embryo of protocell membrane. Firstly, we found that the highly oxidized graphene and phospholipid-graphene oxide ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10258
更新日期：2015-05-19 00:00:00
abstract：:In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been associated with mutatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34163
更新日期：2016-09-26 00:00:00
