Functional Roles of Metabolic Intermediates in Regulating the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme.

abstract：:Metal pollution in drinking water source has been under scrutiny as it seriously affects human health. This work examined 12 dissolved metals in the surface and overlying water of the Xiangjiang River, an important drinking water source in southern China, and characterized their distribution, identified their possible...

journal_title：Scientific reports

authors： Huang Z,Zheng S,Liu Y,Zhao X,Qiao X,Liu C,Zheng B,Yin D

更新日期：2021-01-08 00:00:00

abstract：:CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) plays an important role in tumor progression and a number of studies have suggested that it is an indicator of tumor prognosis. This current meta-analysis systematically reevaluated the predictive potential of CD147/EMMPRIN in various cancers. We searched ...

journal_title：Scientific reports

authors： Xin X,Zeng X,Gu H,Li M,Tan H,Jin Z,Hua T,Shi R,Wang H

更新日期：2016-09-09 00:00:00

abstract：:Superior cervical ganglion neurons (SCGN) are often used to investigate neurotransmitter release mechanisms. In this study, we optimized the dissociation and culture conditions of rat SCGN cultures for dual patch clamp recordings. Two weeks in vitro are sufficient to achieve a significant CNTF-induced cholinergic swit...

journal_title：Scientific reports

authors： Amendola J,Boumedine N,Sangiardi M,El Far O

更新日期：2015-09-24 00:00:00

abstract：:Detection of subclinical mastitis (SCM) in its initial stage can save great economic losses, improve milk quality and animal welfare. We have developed a semiquantitative lateral flow assay for the detection of SCM in dairy cows targeting myeloperoxidase (MPO) enzyme of milk neutrophils. A competitive immunoassay form...

journal_title：Scientific reports

authors： Alhussien MN,Dang AK

更新日期：2020-07-07 00:00:00

abstract：:Oceanic archipelagos are the ideal setting for investigating processes that shape species assemblages. Focusing on keyhole limpets, genera Fissurella and Diodora from Cape Verde Islands, we used an integrative approach combining molecular phylogenetics with ocean transport simulations to infer species distribution pat...

journal_title：Scientific reports

authors： Cunha RL,Assis JM,Madeira C,Seabra R,Lima FP,Lopes EP,Williams ST,Castilho R

更新日期：2017-02-02 00:00:00

abstract：:We investigated gender differences in the optic nerve head (ONH) microcirculation status in association with obstructive sleep apnea (OSA) by using laser speckle flowgraphy (LSFG). We evaluated 150 men (60.5 ± 11.0 yrs) and 45 women (63.0 ± 10.6 yrs) who underwent overnight polysomnography. The mean blur rate (MBR), m...

journal_title：Scientific reports

authors： Shiba T,Takahashi M,Matsumoto T,Hori Y

更新日期：2019-12-11 00:00:00

abstract：:Despite the increasing number of studies conducted recently to evaluate the association between HPV infections and the risk of prostate cancer, the results remain inconclusive. Furthermore, the prevalence and distribution of overall and individual HPV types worldwide in prostate cancer has not been reported until now....

journal_title：Scientific reports

authors： Yang L,Xie S,Feng X,Chen Y,Zheng T,Dai M,Zhou CK,Hu Z,Li N,Hang D

更新日期：2015-10-06 00:00:00

abstract：:Despite aggressive antimicrobial therapy, many respiratory pathogens persist in the lung, underpinning the chronic inflammation and eventual lung decline that are characteristic of respiratory disease. Recently, bile acid aspiration has emerged as a major comorbidity associated with a range of lung diseases, shaping t...

journal_title：Scientific reports

authors： Reen FJ,Flynn S,Woods DF,Dunphy N,Chróinín MN,Mullane D,Stick S,Adams C,O'Gara F

更新日期：2016-07-19 00:00:00

abstract：:Large bowel preparation may cause a substantial change in the gut microbiota and metabolites. Here, we included a bowel prep group and a no-procedure control group and evaluated the effects of bowel prep on the stability of the gut microbiome and metabolome as well as on recovery. Gut microbiota and metabolome composi...

journal_title：Scientific reports

authors： Nagata N,Tohya M,Fukuda S,Suda W,Nishijima S,Takeuchi F,Ohsugi M,Tsujimoto T,Nakamura T,Shimomura A,Yanagisawa N,Hisada Y,Watanabe K,Imbe K,Akiyama J,Mizokami M,Miyoshi-Akiyama T,Uemura N,Hattori M

更新日期：2019-03-11 00:00:00

abstract：:We have recently reported that Kupffer cells consist of two subsets, radio-resistant resident CD68+ Kupffer cells and radio-sensitive recruited CD11b+ Kupffer cells/macrophages (Mφs). Non-alcoholic steatohepatitis (NASH) is characterized not only by hepatic steatosis but also chronic inflammation and fibrosis. In the ...

journal_title：Scientific reports

authors： Nakashima H,Nakashima M,Kinoshita M,Ikarashi M,Miyazaki H,Hanaka H,Imaki J,Seki S

更新日期：2016-10-06 00:00:00

abstract：:Sensitivity of the anatase and rutile phases of titanium dioxide to Swift Heavy Ion (SHI) irradiation was experimentally probed and compared with the predictions of the Coulomb explosion, analytical and inelastic thermal spike models of ion-matter interaction. Conforming to the predictions of all these models, our stu...

journal_title：Scientific reports

authors： Rath H,Dash BN,Benyagoub A,Mishra NC

更新日期：2018-08-06 00:00:00

abstract：:Rapid vertebrate diversity evaluation is invaluable for monitoring changing ecosystems worldwide. Wild blow flies naturally recover DNA and chemical signatures from animal carcasses and feces. We demonstrate the power of blow flies as biodiversity monitors through sampling of flies in three environments with varying h...

journal_title：Scientific reports

authors： Owings CG,Banerjee A,Asher TMD,Gilhooly WP 3rd,Tuceryan A,Huffine M,Skaggs CL,Adebowale IM,Manicke NE,Picard CJ

更新日期：2019-07-22 00:00:00

abstract：:Insertion sequences (ISs) are ubiquitous and abundant mobile genetic elements in prokaryotic genomes. ISs often encode only one protein, the transposase, which catalyzes their transposition. Recent studies have shown that transposases of many different IS families interact with the β sliding clamp, a DNA replication f...

journal_title：Scientific reports

authors： Díaz-Maldonado H,Gómez MJ,Moreno-Paz M,San Martín-Úriz P,Amils R,Parro V,López de Saro FJ

更新日期：2015-08-26 00:00:00

abstract：:We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...

journal_title：Scientific reports

authors： Katagiri S,Nishina S,Yokoi T,Mikami M,Nakayama Y,Tanaka M,Azuma N

更新日期：2017-02-16 00:00:00

abstract：:Species abundance distributions (SAD) are central to the description of diversity and have played a major role in the development of theories of biodiversity and biogeography. However, most work on species abundance distributions has focused on one single spatial scale. Here we used data on arthropods to test predicti...

journal_title：Scientific reports

authors： Borda-de-Água L,Whittaker RJ,Cardoso P,Rigal F,Santos AMC,Amorim IR,Parmakelis A,Triantis KA,Pereira HM,Borges PAV

更新日期：2017-06-20 00:00:00

abstract：:The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We foun...

journal_title：Scientific reports

authors： Liang Y,Zhu F,Zhang H,Chen D,Zhang X,Gao Q,Li Y

更新日期：2016-07-05 00:00:00

abstract：:The ZIC proteins are a family of transcription regulators with a well-defined zinc finger DNA-binding domain and there is evidence that they elicit functional DNA binding at a ZIC DNA binding site. Little is known, however, regarding domains within ZIC proteins that confer trans-activation or -repression. To address t...

journal_title：Scientific reports

authors： Ahmed JN,Diamand KEM,Bellchambers HM,Arkell RM

更新日期：2020-08-04 00:00:00

abstract：:We analysed the ligand-based activation mechanism of the prostate-specific G-protein coupled receptor (PSGR), which is an olfactory receptor that mediates cellular growth in prostate cancer cells. Furthermore, it is an olfactory receptor with a known chemically near identic antagonist/agonist pair, α- and β-ionone. Us...

journal_title：Scientific reports

authors： Wolf S,Jovancevic N,Gelis L,Pietsch S,Hatt H,Gerwert K

更新日期：2017-11-22 00:00:00

abstract：:We study the global spatio-temporal patterns of influenza dynamics. This is achieved by analysing and modelling weekly laboratory confirmed cases of influenza A and B from 138 countries between January 2006 and January 2015. The data were obtained from FluNet, the surveillance network compiled by the the World Health ...

journal_title：Scientific reports

authors： He D,Lui R,Wang L,Tse CK,Yang L,Stone L

更新日期：2015-06-05 00:00:00

abstract：:Zooplankton provide the key link between primary production and higher levels of the marine food web and they play an important role in mediating carbon sequestration in the ocean. All commercially harvested fish species depend on zooplankton populations. However, spatio-temporal distributions of zooplankton are notor...

journal_title：Scientific reports

authors： Basedow SL,McKee D,Lefering I,Gislason A,Daase M,Trudnowska E,Egeland ES,Choquet M,Falk-Petersen S

更新日期：2019-01-24 00:00:00

abstract：:Recently proposed tumor fitness measures, based on profiling neoepitopes for reactive viral epitope similarity, have been proposed to predict response to immune checkpoint inhibitors in melanoma and small-cell lung cancer. Here we applied these checkpoint based fitness measures to the matched checkpoint treatment naiv...

journal_title：Scientific reports

authors： Bubie A,Gonzalez-Kozlova E,Akers N,Villanueva A,Losic B

更新日期：2020-03-19 00:00:00

abstract：:The objective of this study was to investigate the effects of slightly elevated atmospheric temperature in the spring on photosynthetic products in wheat seedlings and on organic compounds and biological activity in rhizosphere soil under cadmium (Cd) stress. Elevated temperature was associated with increased soluble ...

journal_title：Scientific reports

authors： Jia X,Zhao Y,Wang W,He Y

更新日期：2015-09-23 00:00:00

abstract：:Millions of people are blind worldwide. Sensory substitution (SS) devices (e.g., vOICe) can assist the blind by encoding a video stream into a sound pattern, recruiting visual brain areas for auditory analysis via crossmodal interactions and plasticity. SS devices often require extensive training to attain limited fun...

journal_title：Scientific reports

authors： Stiles NR,Shimojo S

更新日期：2015-10-22 00:00:00

abstract：:Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...

journal_title：Scientific reports

authors： Lu J,Shao Y,Qin X,Liu D,Chen A,Li D,Liu M,Wang X

更新日期：2017-02-20 00:00:00

abstract：:Stroke is a leading cause of death and the leading cause of long-term disability, but its electrophysiological basis is poorly understood. Characterizing acute ischemic neuronal activity dynamics is important for understanding the temporal and spatial development of ischemic pathophysiology and determining neuronal ac...

journal_title：Scientific reports

authors： Wann EG,Wodeyar A,Srinivasan R,Frostig RD

更新日期：2020-12-08 00:00:00

abstract：:Xenotransplantation of human cancers into immunodeficient mice is a very useful approach for studying human tumor biology. However, the occasional occurrence of lymphomagenesis in some mice can spoil the model and must be investigated in detail. We found that a high percentage (32.5%, 26/80) of cancer patient-derived ...

journal_title：Scientific reports

authors： Zhang L,Liu Y,Wang X,Tang Z,Li S,Hu Y,Zong X,Wu X,Bu Z,Wu A,Li Z,Li Z,Huang X,Jia L,Kang Q,Liu Y,Sutton D,Wang L,Luo L,Ji J

更新日期：2015-03-30 00:00:00

abstract：:microRNAs (miRNAs) are small double stranded RNA molecules consisting of two complementary strands called the 5p and 3p arms. Following imprecise processing and/or addition of nucleotides at the ends, miRNA biogenesis can give rise to variants called isomiRs. Exosomes are small vesicles released by cells. They have at...

journal_title：Scientific reports

authors： Karlsen TA,Aae TF,Brinchmann JE

更新日期：2019-12-27 00:00:00

abstract：:Antimicrobial peptides (AMPs) are peptide antibiotics with a broad spectrum of antimicrobial activities. Activity prediction of AMPs from their amino acid sequences is of great therapeutic importance but imposes challenges on prediction methods due to label interactions. In this paper we propose a novel multi-label le...

journal_title：Scientific reports

authors： Wang P,Ge R,Liu L,Xiao X,Li Y,Cai Y

更新日期：2017-05-19 00:00:00

abstract：:Breast cancer brain metastasis (BCBM) remains a major clinical problem. Approximately 10-16% of patients with breast cancer develop brain metastases (BCBM). However, no systemic therapy has gained regulatory approval for the specific treatment of BCBM and this remains an area of persistent, unmet medical need. Rapid, ...

journal_title：Scientific reports

authors： Liu Z,Wang Y,Kabraji S,Xie S,Pan P,Liu Z,Ni J,Zhao JJ

更新日期：2019-01-24 00:00:00

abstract：:Dehydration (water loss >2.0% of body weight) has significant negative effects on physical and mental performance. In two studies the effects of minor hypo-hydration (water loss <1.0% of body weight) on CNS function, mood and cardiovascular functioning were measured. Study 1: On two mornings twelve male participants w...

journal_title：Scientific reports

authors： Young HA,Cousins A,Johnston S,Fletcher JM,Benton D

更新日期：2019-11-11 00:00:00