Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model.

abstract：:A central challenge in designing and administering effective anticoagulants is achieving the proper therapeutic window and dosage for each patient. The Hill coefficient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of this therapeutic window. We sought to measure the Hill coe...

journal_title：Scientific reports

authors： Chang JB,Quinnies KM,Realubit R,Karan C,Rand JH,Tatonetti NP

更新日期：2016-07-21 00:00:00

abstract：:Bacterial cell wall is targeted by many antibiotics. Among them are lantibiotics, which realize their function via interaction with plasma membrane lipid-II molecule - a chemically conserved part of the cell wall synthesis pathway. To investigate structural and dynamic properties of this molecule, we have performed a ...

journal_title：Scientific reports

authors： Chugunov A,Pyrkova D,Nolde D,Polyansky A,Pentkovsky V,Efremov R

更新日期：2013-01-01 00:00:00

abstract：:The microRNA (miR)-183/96/182 cluster plays important roles in the development and functions of sensory organs, including the inner ear. Point-mutations in the seed sequence of miR-96 result in non-syndromic hearing loss in both mice and humans. However, the lack of a functionally null mutant has hampered the evaluati...

journal_title：Scientific reports

authors： Geng R,Furness DN,Muraleedharan CK,Zhang J,Dabdoub A,Lin V,Xu S

更新日期：2018-12-21 00:00:00

abstract：:Cellular membrane distortion invokes variations in cellular physiology. However, lack of an appropriate system to control the stress and facilitate molecular analyses has hampered progress of relevant studies. In this study, a microfluidic system that finely manipulates membrane distortion of Chlamydomonas reinhardtii...

journal_title：Scientific reports

authors： Min SK,Yoon GH,Joo JH,Sim SJ,Shin HS

更新日期：2014-04-14 00:00:00

abstract：:We present here a broadband, wide-angle, and polarization-independent nearly perfect absorber consisting of mirror-backed nanoporous alumina. By electrochemically anodizing the disordered multicomponent aluminum and properly tailoring the thickness and air-filling fraction of nanoporous alumina, according to the Maxwe...

journal_title：Scientific reports

authors： Farhat M,Cheng TC,Le KQ,Cheng MM,Bağcı H,Chen PY

更新日期：2016-01-28 00:00:00

abstract：:The evaporation of seawater in arid climates is currently the main accepted driving mechanism for the formation of ancient and recent salt deposits in shallow basins. However, the deposition of huge amounts of marine salts, including the formation of tens of metres of highly soluble types (tachyhydrite and bischofite)...

journal_title：Scientific reports

authors： Debure M,Lassin A,Marty NC,Claret F,Virgone A,Calassou S,Gaucher EC

更新日期：2019-08-12 00:00:00

abstract：:Synchrotron radiation core-level photoemission spectroscopy, scanning tunneling microscopy (STM), and first-principles calculations have been utilized to explore the growth processes and the atomic structure of the resulting films during the two-step molecular beam epitaxy (MBE) of In and Bi on the Si(111) surface. De...

journal_title：Scientific reports

authors： Lin CY,Hsu CH,Huang YZ,Hsieh SC,Chen HD,Huang L,Huang ZQ,Chuang FC,Lin DS

更新日期：2019-01-24 00:00:00

abstract：:The sulfur-selenium doped carbon quantum dots (S,Se-CQDs) were synthesized by one-step through hydrothermal method in this study, which have high fluorescence quantum yield (43%) and advanced ability to scavenge reactive oxygen species (ROS). They were characterized by transmission electron microscope (TEM), nuclear m...

journal_title：Scientific reports

authors： Huang G,Lin Y,Zhang L,Yan Z,Wang Y,Liu Y

更新日期：2019-12-23 00:00:00

abstract：:The exposure of humans to erionite fibres of appropriate morphology and dimension has been unambiguously linked to the occurrence of Malignant Mesothelioma. For this reason, a detailed morpho-structural investigation through Electron Microscopy techniques has been performed on erionite samples collected at two differe...

journal_title：Scientific reports

authors： Matassa R,Familiari G,Relucenti M,Battaglione E,Downing C,Pacella A,Cametti G,Ballirano P

更新日期：2015-11-16 00:00:00

abstract：:Photoluminescence (PL) was used to estimate the concentration of carbon in GaN grown by hydride vapor phase epitaxy (HVPE). The PL data were compared with profiles of the impurities obtained from secondary ion mass spectrometry (SIMS) measurements. Comparison of PL and SIMS data has revealed that apparently high conce...

journal_title：Scientific reports

authors： Reshchikov MA,Vorobiov M,Andrieiev O,Ding K,Izyumskaya N,Avrutin V,Usikov A,Helava H,Makarov Y

更新日期：2020-02-10 00:00:00

abstract：:This study aimed to investigate whether single nucleotide polymorphisms (SNPs) of five NLR family genes (NOD1, NOD2, NLRP1, NLRP3 and CIITA) are associated with Behcet's disease (BD) in a Chinese Han population. The study was carried out in 950 BD patients and 1440 controls for 19 SNPs in the selected NLR genes. In th...

journal_title：Scientific reports

authors： Li L,Yu H,Jiang Y,Deng B,Bai L,Kijlstra A,Yang P

更新日期：2016-02-01 00:00:00

abstract：:Alcohol dependence (AD) and aggression-impulsivity are both associated with increased suicide risk. There is a need to evaluate clinical tools in order to improve suicide risk assessment of AD patients. The present study consisted of 95 individuals with a diagnosis of AD, consecutively admitted for addiction treatment...

journal_title：Scientific reports

authors： Khemiri L,Jokinen J,Runeson B,Jayaram-Lindström N

更新日期：2016-01-19 00:00:00

abstract：:Increased risk of comorbidities has been reported in Rheumatic and Musculoskeletal Diseases (RMD). We aimed to evaluate the prevalence and pattern of comorbidities in RMD patients nationwide, to identify multimorbidity clusters and to evaluate the gap between recommendations and real screening. Cross-sectional, multic...

journal_title：Scientific reports

authors： Ziade N,El Khoury B,Zoghbi M,Merheb G,Abi Karam G,Mroue' K,Messaykeh J

更新日期：2020-05-06 00:00:00

abstract：:Identification of hot spots, a small portion of protein-protein interface residues that contribute the majority of the binding free energy, can provide crucial information for understanding the function of proteins and studying their interactions. Based on our previous method (PredHS), we propose a new computational a...

journal_title：Scientific reports

authors： Wang H,Liu C,Deng L

更新日期：2018-09-24 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK) is a member of the family of mitogen-activated protein kinases (MAPKs) and coordinately regulates a multitude of cellular processes. In response to a variety of extracellular stimuli, phosphorylation of both threonine and tyrosine residues activates ERK. Recent evidence indi...

journal_title：Scientific reports

authors： Kurioka T,Matsunobu T,Satoh Y,Niwa K,Endo S,Fujioka M,Shiotani A

更新日期：2015-11-18 00:00:00

abstract：:We identify a new instability in electrostatic actuators dubbed quasi-static pull-in. We report experimental evidence of the instability and study its characteristics in two types of micro actuators operating in ambient air. We found that the underlying mechanism is a fast-slow dynamic interaction between slowly-varyi...

journal_title：Scientific reports

authors： Al-Ghamdi MS,Khater ME,Abdel-Rahman EM,Nepomuceno EG

更新日期：2020-03-19 00:00:00

abstract：:Soybean is an important source of protein, oil and carbohydrates, as well as other beneficial nutrients. A major function of proteins in nutrition is to supply adequate amounts of amino acids. Although they are essential for human nutrition, the sulfur-containing amino acids cysteine (Cys) and methionine (Met) are oft...

journal_title：Scientific reports

authors： Malle S,Eskandari M,Morrison M,Belzile F

更新日期：2020-12-11 00:00:00

abstract：:Genetic circuit-based biosensors have emerged as an effective analytical tool in synthetic biology; these biosensors can be applied to high-throughput screening of new biocatalysts and metabolic pathways. Sigma 54 (σ54)-dependent transcription factor (TF) can be a valuable component of these biosensors owing to its in...

journal_title：Scientific reports

authors： Kwon KK,Yeom SJ,Choi SL,Rha E,Lee H,Kim H,Lee DH,Lee SG

更新日期：2020-04-08 00:00:00

abstract：:Ferti-fortification of wheat with zinc, an essential micronutrient is one of the strategies for combating 'hidden hunger' in a large proportion of people all over the world. During fertilization, application of large quantities of micronutrients often results in nutrient wastage and subsequent environmental pollution....

journal_title：Scientific reports

authors： Dapkekar A,Deshpande P,Oak MD,Paknikar KM,Rajwade JM

更新日期：2018-05-01 00:00:00

abstract：:Chloroplast genomes have been widely considered an informative and valuable resource for molecular marker development and phylogenetic reconstruction in plant species. This study evaluated the complete chloroplast genomes of the traditional Chinese medicine Gleditsia sinensis and G. japonica, an adulterant of the form...

journal_title：Scientific reports

authors： Tan W,Gao H,Jiang W,Zhang H,Yu X,Liu E,Tian X

更新日期：2020-10-01 00:00:00

abstract：:The vertical migration of zooplankton and micronekton (hereafter 'zooplankton') has ramifications throughout the food web. Here, we present the first evidence that climate fluctuations affect the vertical migration of zooplankton in the Southern Ocean, based on multi-year acoustic backscatter data from one of the deep...

journal_title：Scientific reports

authors： La HS,Park K,Wåhlin A,Arrigo KR,Kim DS,Yang EJ,Atkinson A,Fielding S,Im J,Kim TW,Shin HC,Lee S,Ha HK

更新日期：2019-07-12 00:00:00

abstract：:When and where animals breed can shape the genetic structure and diversity of animal populations. The importance of drivers of genetic diversity is amplified in island populations that tend to have more delineated gene pools compared to continental populations. Studies of relatedness as a function of the spatial distr...

journal_title：Scientific reports

authors： Garrett LJH,Myatt JP,Sadler JP,Dawson DA,Hipperson H,Colbourne JK,Dickey RC,Weber SB,Reynolds SJ

更新日期：2020-11-26 00:00:00

abstract：:Climate change profoundly influences the geospatial distribution of secondary metabolites and causes the geographical migration of plants. We planted seedlings of the same species in eighteen ecological regions along a latitudinal gradient in eastern and western China, in order to explore the regulation of multi-clima...

journal_title：Scientific reports

authors： Zhang C,Yang D,Liang Z,Liu J,Yan K,Zhu Y,Yang S

更新日期：2019-01-29 00:00:00

abstract：:Silver nanobelts (AgNBs) have attracted a great interest due to their excellent electrical conductivity and mechanical strength, leading a facile synthesis of these AgNBs in great demand. In here, we are reporting a simple, aqueous phase, size tunable synthesis of smooth surfaced 1D-silver nanobelts using a Polyanilin...

journal_title：Scientific reports

authors： Padmanaban S,Kim M,Yoon S

更新日期：2017-03-20 00:00:00

abstract：:ideR, an essential gene of Mycobacterium tuberculosis, is an attractive drug target as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To the best of our knowledge, no inhibitors of IdeR are identified. We carried out virtual screening of NCI database against the IdeR DNA binding d...

journal_title：Scientific reports

authors： Rohilla A,Khare G,Tyagi AK

更新日期：2017-07-05 00:00:00

abstract：:Biomaterial development for tissue engineering applications is rapidly increasing but necessitates efficacy and safety testing prior to clinical application. Current in vitro and in vivo models hold a number of limitations, including expense, lack of correlation between animal models and human outcomes and the need to...

journal_title：Scientific reports

authors： Moreno-Jiménez I,Hulsart-Billstrom G,Lanham SA,Janeczek AA,Kontouli N,Kanczler JM,Evans ND,Oreffo RO

更新日期：2016-08-31 00:00:00

abstract：:Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks....

journal_title：Scientific reports

authors： Nikolopoulos GK,Pavlitina E,Muth SQ,Schneider J,Psichogiou M,Williams LD,Paraskevis D,Sypsa V,Magiorkinis G,Smyrnov P,Korobchuk A,Vasylyeva TI,Skaathun B,Malliori M,Kafetzopoulos E,Hatzakis A,Friedman SR

更新日期：2016-12-05 00:00:00

abstract：:A negative correlation between body size and the latitudinal temperature gradient is well established for extant terrestrial endotherms but less so in the fossil record. Here we analyze the middle Eocene site of Geiseltal (Germany), whose record is considered to span ca. 5 Myrs of gradual global cooling, and generate ...

journal_title：Scientific reports

authors： Ring SJ,Bocherens H,Wings O,Rabi M

更新日期：2020-03-04 00:00:00

abstract：:Cardiopulmonary resuscitation (CPR) training and its quality are critical in improving the survival rate of cardiac arrest. This randomized controlled study investigated the efficacy of a newly developed CPR training program for the public in a Taiwanese setting. A total of 832 adults were randomized to either a tradi...

journal_title：Scientific reports

authors： Chien CY,Fang SY,Tsai LH,Tsai SL,Chen CB,Seak CJ,Weng YM,Lin CC,Chien WC,Huang CH,Lin CY,Chaou CH,Liu PH,Tseng HJ,Chen JC,Peng SY,Cheng TH,Hsu KH,Ng CJ

更新日期：2020-06-22 00:00:00

abstract：:Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and functional consequences of such changes remain unclear. Here, we used Royal College of Surgeon (RCS) rats as a mod...

journal_title：Scientific reports

authors： Fu Y,Hou B,Weng C,Liu W,Dai J,Zhao C,Yin ZQ

更新日期：2017-04-21 00:00:00