A network intervention that locates and intervenes with recently HIV-infected persons: The Transmission Reduction Intervention Project (TRIP).

Abstract:

:Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks. Based on HIV status, testing history, and the results of an assay to detect recent infections, TRIP classified drug injector "Seeds" into groups: Recent Seeds (RS), and Control Seeds with Long-term HIV infection (LCS). The network members of RS and LCS were traced for two steps. The analysis included 23 RS, 171 network members of the RS, 19 LCS, and 65 network members of the LCS. The per-seed number of recents detected in the network of RS was 5 times the number in the network of LCS (Ratio RS vs. LCS: 5.23; 95% Confidence Interval (CI): 1.54-27.61). The proportion of recents among HIV positives in the network of RS (27%) was approximately 3 times (Ratio RS vs. LCS: 3.30; 95% CI: 1.04-10.43) that in the network of LCS (8%). Strategic network tracing that starts with recently infected persons could support public health efforts to find and treat people early in their HIV infection.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Nikolopoulos GK,Pavlitina E,Muth SQ,Schneider J,Psichogiou M,Williams LD,Paraskevis D,Sypsa V,Magiorkinis G,Smyrnov P,Korobchuk A,Vasylyeva TI,Skaathun B,Malliori M,Kafetzopoulos E,Hatzakis A,Friedman SR

doi

10.1038/srep38100

subject

Has Abstract

pub_date

2016-12-05 00:00:00

pages

38100

issn

2045-2322

pii

srep38100

journal_volume

6

pub_type

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