Abstract：
:Breast cancer brain metastasis (BCBM) remains a major clinical problem. Approximately 10-16% of patients with breast cancer develop brain metastases (BCBM). However, no systemic therapy has gained regulatory approval for the specific treatment of BCBM and this remains an area of persistent, unmet medical need. Rapid, predictive and clinically-relevant animal models are critical to study the biology of brain metastases and to identify effective therapeutic approaches for patients with BCBM. Here, we describe a method for efficient establishment of orthotopic mouse models of patient-derived brain metastases via an improved intracarotid injection protocol that permits tumor cell growth in the unique brain microenvironment without compromising the blood-brain barrier (BBB). We demonstrate that our newly improved models of patient-derived brain metastases recapitulate the histologic, molecular, and genetic characteristics of their matched patient tumor specimens and thus represent a potentially powerful tool for pre-clinical and translational research.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu Z,Wang Y,Kabraji S,Xie S,Pan P,Liu Z,Ni J,Zhao JJdoi
10.1038/s41598-018-36874-3subject
Has Abstractpub_date
2019-01-24 00:00:00pages
622issue
1issn
2045-2322pii
10.1038/s41598-018-36874-3journal_volume
9pub_type
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