当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > RNAi-based bioinsecticide for Aedes mosquito control.

RNAi-based bioinsecticide for Aedes mosquito control.

Abstract：

:Zika virus infection and dengue and chikungunya fevers are emerging viral diseases that have become public health threats. Their aetiologic agents are transmitted by the bite of genus Aedes mosquitoes. Without effective therapies or vaccines, vector control is the main strategy for preventing the spread of these diseases. Increased insecticide resistance calls for biorational actions focused on control of the target vector population. The chitin required for larval survival structures is a good target for biorational control. Chitin synthases A and B (CHS) are enzymes in the chitin synthesis pathway. Double-stranded RNA (dsRNA)-mediated gene silencing (RNAi) achieves specific knockdown of target proteins. Our goal in this work, a new proposed RNAi-based bioinsecticide, was developed as a potential strategy for mosquito population control. DsRNA molecules that target five different regions in the CHSA and B transcript sequences were produced in vitro and in vivo through expression in E. coli HT115 and tested by direct addition to larval breeding water. Mature and immature larvae treated with dsRNA targeting CHS catalytic sites showed significantly decreased viability associated with a reduction in CHS transcript levels. The few larval and adult survivors displayed an altered morphology and chitin content. In association with diflubenzuron, this bioinsecticide exhibited insecticidal adjuvant properties.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lopez SBG,Guimarães-Ribeiro V,Rodriguez JVG,Dorand FAPS,Salles TS,Sá-Guimarães TE,Alvarenga ESL,Melo ACA,Almeida RV,Moreira MF

doi

10.1038/s41598-019-39666-5

subject

Has Abstract

pub_date

2019-03-11 00:00:00

pages

4038

issue

1

issn

2045-2322

pii

10.1038/s41598-019-39666-5

journal_volume

9

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Mechanized transplanting with side deep fertilization increases yield and nitrogen use efficiency of rice in Eastern China.

    abstract：:The application of nitrogen (N) fertilizer deep in soil at the same time as mechanical transplanting of rice seedlings is an effective alternative to conventional broadcasting of fertilizer, but its effects on yields and profitability have not been analysed in detail. Here, we analysed the effects of a side deep appli...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42039-7

    authors： Zhu C,Xiang J,Zhang Y,Zhang Y,Zhu D,Chen H

    更新日期：2019-04-04 00:00:00

  • Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma.

    abstract：:Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, with peritoneal metastasis being the prevalent form of recurrence and metastasis in advanced disease. Currently, there are limited clinical ap...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13750

    authors： Zhang J,Huang JY,Chen YN,Yuan F,Zhang H,Yan FH,Wang MJ,Wang G,Su M,Lu G,Huang Y,Dai H,Ji J,Zhang J,Zhang JN,Jiang YN,Chen SJ,Zhu ZG,Yu YY

    更新日期：2015-09-02 00:00:00

  • The impact of Fe atom on the spin-filter and spin thermoelectric properties of Au-Fe@C20-Au monomer and dimer systems.

    abstract：:Based on density functional theory and non-equilibrium Green's function formalism, we explore the effect of Fe atom in Au-Fe@C20-Au monomer and dimer systems in comparison with the C20 fullerene molecular junctions. We calculate the spin-dependent transmission coefficient, spin polarization and also their spin thermoe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78111-w

    authors： Khalatbari H,Vishkayi SI,Soleimani HR

    更新日期：2020-12-03 00:00:00

  • Synergistic effect of N-decorated and Mn(2+) doped ZnO nanofibers with enhanced photocatalytic activity.

    abstract：:Here we report a high efficiency photocatalyst, i.e., Mn(2+)-doped and N-decorated ZnO nanofibers (NFs) enriched with vacancy defects, fabricated via electrospinning and a subsequent controlled annealing process. This nanocatalyst exhibits excellent visible-light photocatalytic activity and an apparent quantum efficie...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32711

    authors： Wang Y,Cheng J,Yu S,Alcocer EJ,Shahid M,Wang Z,Pan W

    更新日期：2016-09-07 00:00:00

  • His-tag protein monitoring by a fast mix-and-measure immunoassay.

    abstract：:Here, we present a fast mix-and-measure immunoassay for the specific semiquantitative detection of His-tagged proteins, for example in E. coli cell lysate. The assay is based on Förster resonance energy transfer (FRET) between a lanthanide dye-labeled low-affinity His-peptide and an acceptor-labeled anti-His-tag antib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05613

    authors： Kreisig T,Prasse AA,Zscharnack K,Volke D,Zuchner T

    更新日期：2014-07-08 00:00:00

  • Manipulation of Auxin Response Factor 19 affects seed size in the woody perennial Jatropha curcas.

    abstract：:Seed size is a major determinant of seed yield but few is known about the genetics controlling of seed size in plants. Phytohormones cytokinin and brassinosteroid were known to be involved in the regulation of herbaceous plant seed development. Here we identified a homolog of Auxin Response Factor 19 (JcARF19) from a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40844

    authors： Sun Y,Wang C,Wang N,Jiang X,Mao H,Zhu C,Wen F,Wang X,Lu Z,Yue G,Xu Z,Ye J

    更新日期：2017-01-19 00:00:00

  • Assessment of Heterotrophic Growth Supported by Soluble Microbial Products in Anammox Biofilm using Multidimensional Modeling.

    abstract：:Anaerobic ammonium oxidation (anammox) is known to autotrophically convert ammonium to dinitrogen gas with nitrite as the electron acceptor, but little is known about their released microbial products and how these are relative to heterotrophic growth in anammox system. In this work, we applied a mathematical model to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27576

    authors： Liu Y,Sun J,Peng L,Wang D,Dai X,Ni BJ

    更新日期：2016-06-07 00:00:00

  • Ultrasound modulates ion channel currents.

    abstract：:Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in animals and humans, but the mechanism of this effect is unknown. It has been hypothesized that US, a mechanical stimulus, may mediate cellular discharge by activating mechanosensitive ion channels embedded within cellular membranes. To ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24170

    authors： Kubanek J,Shi J,Marsh J,Chen D,Deng C,Cui J

    更新日期：2016-04-26 00:00:00

  • Dense Quantum Measurement Theory.

    abstract：:Quantum measurement is a fundamental cornerstone of experimental quantum computations. The main issues in current quantum measurement strategies are the high number of measurement rounds to determine a global optimal measurement output and the low success probability of finding a global optimal measurement output. Eac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43250-2

    authors： Gyongyosi L,Imre S

    更新日期：2019-05-01 00:00:00

  • Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage.

    abstract：:In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little is known about the molecular events that initiate mesenchymal stem c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03145-6

    authors： Babb R,Chandrasekaran D,Carvalho Moreno Neves V,Sharpe PT

    更新日期：2017-06-08 00:00:00

  • The swelling transition of lepidocrocite-type protonated layered titanates into anatase under hydrothermal treatment.

    abstract：:The common facets of anatase crystals are the (001) and (101) planes. However, the phase transformation from lepidocrocite-type titanate into anatase by hydrothermal processing yields an anatase microstructure with high concentration of exposed (010) planes. The phase transformation of a lepidocrocite-type protonated ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04584

    authors： Yuan H,Besselink R,Liao Z,Ten Elshof JE

    更新日期：2014-04-03 00:00:00

  • Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition.

    abstract：:Although optimal therapy for myocardial infarction includes reperfusion to restore blood flow to the ischemic region, ischemia/reperfusion (IR) also initiates an inflammatory response likely contributing to adverse left ventricular (LV) extracellular matrix (ECM) remodeling. Galectin-3 (Gal-3), a β-galactoside-binding...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46119-6

    authors： Ibarrola J,Matilla L,Martínez-Martínez E,Gueret A,Fernández-Celis A,Henry JP,Nicol L,Jaisser F,Mulder P,Ouvrard-Pascaud A,López-Andrés N

    更新日期：2019-07-03 00:00:00

  • The association between polyomavirus BK strains and BKV viruria in liver transplant recipients.

    abstract：:BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to und...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28491

    authors： Wang RY,Li YJ,Lee WC,Wu HH,Lin CY,Lee CC,Chen YC,Hung CC,Yang CW,Tian YC

    更新日期：2016-06-24 00:00:00

  • Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization.

    abstract：:No licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including genetically modified live-attenuated parasite vaccines. Studies with live attenuated Leishmania vaccines such as centrin deleted Leishmania donovani parasites (LdCen -...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05088-4

    authors： Gannavaram S,Torcivia J,Gasparyan L,Kaul A,Ismail N,Simonyan V,Nakhasi HL

    更新日期：2017-07-05 00:00:00

  • Deletion of biosynthetic genes, specific SNP patterns and differences in transcript accumulation cause variation in hydroxynitrile glucoside content in barley cultivars.

    abstract：:Barley (Hordeum vulgare L.) produces five leucine-derived hydroxynitrile glucosides, potentially involved in alleviating pathogen and environmental stresses. These compounds include the cyanogenic glucoside epiheterodendrin. The biosynthetic genes are clustered. Total hydroxynitrile glucoside contents were previously ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41884-w

    authors： Ehlert M,Jagd LM,Braumann I,Dockter C,Crocoll C,Motawia MS,Møller BL,Lyngkjær MF

    更新日期：2019-04-05 00:00:00

  • Extractable pool of biochar controls on crop productivity rather than greenhouse gas emission from a rice paddy under rice-wheat rotation.

    abstract：:The role of extractable pool of biochar in crop productivity and soil greenhouse gas (GHGs) emission is not yet clear. In this study, two biochars with and without extraction was added to a paddy before rice transplantation at 20 t·ha-1. Crop yield, plant traits and greenhouse gas emission monitored throughout a rice-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19331-z

    authors： Korai PK,Xia X,Liu X,Bian R,Omondi MO,Nahayo A,Pan G

    更新日期：2018-01-16 00:00:00

  • Mapping motion of antiferromagnetic interfacial uncompensated magnetic moment in exchange-biased bilayers.

    abstract：:In this work, disordered-IrMn3/insulating-Y3Fe5O12 exchange-biased bilayers are studied. The behavior of the net magnetic moment ΔmAFM in the antiferromagnet is directly probed by anomalous and planar Hall effects, and anisotropic magnetoresistance. The ΔmAFM is proved to come from the interfacial uncompensated magnet...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09183

    authors： Zhou X,Ma L,Shi Z,Fan WJ,Evans RF,Zheng JG,Chantrell RW,Mangin S,Zhang HW,Zhou SM

    更新日期：2015-03-17 00:00:00

  • Direct incorporation of mesenchymal stem cells into a Nanofiber scaffold - in vitro and in vivo analysis.

    abstract：:Bony defects are a common problem in musculoskeletal surgery. Replacement with autologous bone grafts is limited by availability of transplant material. Sterilized cancellous bone, while being osteoconductive, has limited osteoinductivity. Nanofiber scaffolds are currently used for several purposes due to their capabi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66281-6

    authors： Schüttler KF,Bauhofer MW,Ketter V,Giese K,Eschbach DA,Yenigün M,Fuchs-Winkelmann S,Paletta JRJ

    更新日期：2020-06-12 00:00:00

  • Consequences of Nosema apis infection for male honey bees and their fertility.

    abstract：:The queens of eusocial bees, ants and wasps mate only during a very short period early in life and males therefore produce ejaculates consisting of large numbers of high quality sperm. Such extreme selection for high fecundity resulted in males investing minimally into their somatic survival, including their immune sy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10565

    authors： Peng Y,Baer-Imhoof B,Millar AH,Baer B

    更新日期：2015-06-30 00:00:00

  • The outcome of skeletofacial reconstruction with mandibular rotation for management of asymmetric skeletal class III deformity: A three-dimensional computer-assisted investigation.

    abstract：:The mandibular proximal ramus segments should be moved and rotated during orthognathic surgery-based skeletofacial reconstruction for the correction of challenging patients with facial asymmetry and malocclusion, but quantitative data regarding this rotation were not sufficient to date. This 3D computer-assisted study...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49946-9

    authors： Wu TY,Denadai R,Lin HH,Ho CT,Lo LJ

    更新日期：2019-09-16 00:00:00

  • Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis.

    abstract：:The PRL phosphatases are oncogenic when overexpressed but their in vivo biological function is less well understood. Previous gene deletion study revealed a role for PRL2 in spermatogenesis. We report here the first knockout mice lacking PRL1, the most related homolog of PRL2. We found that loss of PRL1 does not affec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34211

    authors： Bai Y,Zhou HM,Zhang L,Dong Y,Zeng Q,Shou W,Zhang ZY

    更新日期：2016-09-26 00:00:00

  • Genotype-guided warfarin dosing may benefit patients with mechanical aortic valve replacements: randomized controlled study.

    abstract：:This prospective, single-blind, randomized study was designed to evaluate the effect of genotype-based warfarin dosing compared with standard warfarin dosing in Korean patients with mechanical cardiac valves. Patients were assigned to either the genotype-based dosing group or the standard dosing group using stratified...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-020-63985-7

    authors： Lee KE,Yee J,Lee GY,Chung JE,Seong JM,Chang BC,Gwak HS

    更新日期：2020-04-24 00:00:00

  • Kir3 channel blockade in the cerebellar cortex suppresses performance of classically conditioned Purkinje cell responses.

    abstract：:In the eyeblink conditioning paradigm, cerebellar Purkinje cells learn to respond to the conditional stimulus with an adaptively timed pause in its spontaneous firing. Evidence suggests that the pause is elicited by glutamate released from parallel fibers and acting on metabotropic receptors (mGluR7) which initiates a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72581-8

    authors： Johansson F,Hesslow G

    更新日期：2020-09-24 00:00:00

  • Site-selective local fluorination of graphene induced by focused ion beam irradiation.

    abstract：:The functionalization of graphene remains an important challenge for numerous applications expected by this fascinating material. To keep advantageous properties of graphene after modification or functionalization of its structure, local approaches are a promising road. A novel technique is reported here that allows p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19719

    authors： Li H,Daukiya L,Haldar S,Lindblad A,Sanyal B,Eriksson O,Aubel D,Hajjar-Garreau S,Simon L,Leifer K

    更新日期：2016-01-29 00:00:00

  • Assessing fatty acid oxidation flux in rodent cardiomyocyte models.

    abstract：:The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements are crucial to investigate early metabolic (mal)adaptations. While measurements in intact c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19478-9

    authors： Rech M,Luiken JJFP,Glatz JFC,van Bilsen M,Schroen B,Nabben M

    更新日期：2018-01-24 00:00:00

  • Identification and functional analysis of the ICK gene family in maize.

    abstract：:Inhibitors of cyclin-dependent kinases (ICKs) are key regulators of cyclin-dependent kinase activities and cell division. Herein, we identified eight ICKs in maize, which we named Zeama;ICKs (ZmICKs). Primary sequencing and phylogenetic analyses were used to divide the ZmICK family into two classes: group B and group ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43818

    authors： Xiao Q,Zhang C,Li H,Wei B,Wang Y,Huang H,Li Y,Yu G,Liu H,Zhang J,Liu Y,Hu Y,Huang Y

    更新日期：2017-03-06 00:00:00

  • Effects of MeJA on Arabidopsis metabolome under endogenous JA deficiency.

    abstract：:Jasmonates (JAs) play important roles in plant growth, development and defense. Comprehensive metabolomics profiling of plants under JA treatment provides insights into the interaction and regulation network of plant hormones. Here we applied high resolution mass spectrometry based metabolomics approach on Arabidopsis...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37674

    authors： Cao J,Li M,Chen J,Liu P,Li Z

    更新日期：2016-11-24 00:00:00

  • Mediating role of attenuated physiological arousal on the association between psychopathic traits and fairness norm violation.

    abstract：:The low-fear model of primary psychopathy has been supported by empirical findings such as attenuated physiological arousal in anticipation of threatening stimuli. The somatic marker hypothesis proposes that salient changes in the bodily state are processed as signals of whether a situation is good or bad and guide an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54676-z

    authors： Osumi T

    更新日期：2019-12-02 00:00:00

  • Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish.

    abstract：:An unresolved mystery in the field of spinal muscular atrophy (SMA) is why a reduction of the ubiquitously expressed Smn protein causes defects mostly in motoneurons. We addressed the possibility that this restricted vulnerability stems from elevated Smn expression in motoneurons. To explore this, we established an ex...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27470

    authors： Spiró Z,Koh A,Tay S,See K,Winkler C

    更新日期：2016-06-07 00:00:00

  • Discovery of a receptor guanylate cyclase expressed in the sperm flagella of stony corals.

    abstract：:The receptor guanylate cyclases (rGCs) in animals serve as sensitive chemoreceptors to detect both chemical and environmental cues. In reproduction, rGCs were shown to be expressed on sperm and serve as receptors for egg-derived sperm-activating and sperm-attracting factors in some echinoderms and mammals. However, sp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51224-7

    authors： Zhang Y,Chiu YL,Chen CJ,Ho YY,Shinzato C,Shikina S,Chang CF

    更新日期：2019-10-10 00:00:00