Abstract：
:In the eyeblink conditioning paradigm, cerebellar Purkinje cells learn to respond to the conditional stimulus with an adaptively timed pause in its spontaneous firing. Evidence suggests that the pause is elicited by glutamate released from parallel fibers and acting on metabotropic receptors (mGluR7) which initiates a delayed-onset suppression of firing. We suggested that G protein activation of hyperpolarizing Kir3 channels (or 'GIRK', G protein-coupled inwardly-rectifying K+ channels) could be part of such a mechanism. Application of the Kir3 antagonist Tertiapin-LQ locally in the superficial layers of the cerebellar cortex in decerebrate ferrets suppressed normal performance of Purkinje cell pause responses to the conditional stimulus. Importantly, there was no detectable effect on spontaneous firing. These findings suggest that intact functioning of Kir3 channels in the cerebellar cortex is required for normal conditioned Purkinje cell responses.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Johansson F,Hesslow Gdoi
10.1038/s41598-020-72581-8subject
Has Abstractpub_date
2020-09-24 00:00:00pages
15654issue
1issn
2045-2322pii
10.1038/s41598-020-72581-8journal_volume
10pub_type
杂志文章abstract：:Plants are constantly exposed to pathogens and environmental stresses. To minimize damage caused by these potentially harmful factors, plants respond by massive transcriptional reprogramming of various stress-related genes via major transcription factor families. One of the transcription factor families, WRKY, plays a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07981
更新日期：2015-01-23 00:00:00
abstract：:Hepatitis B Virus (HBV) replication in hepatocytes is restricted by the host innate immune system and related intracellular signaling pathways. Transforming growth factor β-activated kinase 1 (TAK1) is a key mediator of toll-like receptors and pro-inflammatory cytokine signaling pathways. Here, we report that silencin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39901
更新日期：2017-01-03 00:00:00
abstract：:Bone is a dynamic organ continuously undergoing shaping, repairing and remodeling. The homeostasis of bone is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Osteoclasts (OCs) are specialized multinucleated cells derived from hematopoietic stem cells (HSCs) or monocytes/...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21499
更新日期：2016-02-09 00:00:00
abstract：:Macrophages and resident microglia play an import role in the secondary neuroinflammation response following spinal cord injury. Reprogramming of macrophage/microglia polarization is an import strategy for spinal cord injury restoration. Low-level laser therapy (LLLT) is a noninvasive treatment that has been widely us...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00553-6
更新日期：2017-04-04 00:00:00
abstract：:In the presence of a lateral periodic potential modulation, two-dimensional electrons may exhibit interesting phenomena, such as a graphene-like energy-momentum dispersion, Bloch oscillations, or the Hofstadter butterfly band structure. To create a sufficiently strong potential modulation using conventional semiconduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20967
更新日期：2016-02-11 00:00:00
abstract：:After HSP70 binds to the J domain of the substrate and co-chaperone protein, ATP is hydrolyzed to ADP, and the nucleotide exchange factors (NEFs) promote the release of ADP. Under physiological conditions, the nucleotide exchange step is the rate-limiting step, which is accelerated by NEFs. In this study, the promoter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74381-6
更新日期：2020-10-14 00:00:00
abstract：:Increasing levels of human activity threaten wildlife populations through direct mortality, habitat degradation, and habitat fragmentation. Area closures can improve habitat quality for wildlife, but may be difficult to achieve where tourism or other economic drivers are a priority. Temporal closures that limit human ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40581-y
更新日期：2019-03-07 00:00:00
abstract：:Spatially uniform reconstitution of dried reagents is critical to the function of paper microfluidic devices. Advancing fluid fronts in paper microfluidic devices drive (convect) and concentrate rehydrated reagents to the edges, causing steep chemical gradients and imperfect mixing. This largely unsolved problem in pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52202-9
更新日期：2019-10-31 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-66769-1
更新日期：2020-06-16 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-53160-y
更新日期：2019-11-05 00:00:00
abstract：:Chronic airway infections caused by Pseudomonas aeruginosa contribute to the progression of pulmonary disease in individuals with cystic fibrosis (CF). In the setting of CF, within-patient adaptation of a P. aeruginosa strain generates phenotypic diversity that can complicate microbiological analysis of patient sample...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10932
更新日期：2015-06-05 00:00:00
abstract：:Nanostructure arrays such as nanowire, nanopillar, and nanocone arrays have been proposed to be promising antireflection structures for photovoltaic applications due to their great light trapping ability. In this paper, the optical properties of Si nanopillar and nanocone arrays in visible and infrared region were stu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07810
更新日期：2015-01-15 00:00:00
abstract：:The present work conducted laboratory experiments of fracturing in fat coals, anthracites, and mudstones. Three different fluids were selected as the fracturing fluids, including water, liquid CO2 (L-CO2), and supercritical CO2 (Sc-CO2). The resulting fracture morphologies and fracture apertures of the coal specimens ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75787-y
更新日期：2020-10-29 00:00:00
abstract：:The Fusarium solani species complex (FSSC) has been studied intensively but its association with legumes, particularly under European agro-climatic conditions, is still poorly understood. In the present study, we investigated phylogenetic relationships and aggressiveness of 79 isolates of the FSSC collected from pea, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19779-z
更新日期：2018-01-19 00:00:00
abstract：:Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40078-8
更新日期：2019-03-01 00:00:00
abstract：:In solid state science, multifunctional materials and especially multiferroics have attracted a great deal of attention, as they open the possibility for next generation spintronic and data storage devices. Interestingly, while many of them host coexisting 3d and 4f elements, the role of the coupling between these two...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15150-w
更新日期：2017-11-06 00:00:00
abstract：:We present experimental demonstrations of two-photon interference involving temporally separated photons within two types of interferometers: a Mach-Zehnder interferometer and a polarization-based Michelson interferometer. The two-photon states are probabilistically prepared in a symmetrically superposed state within ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34805
更新日期：2016-10-06 00:00:00
abstract：:We aimed to investigate the potential of preoperative mammographic breast density (MBD) as a prognostic factor in breast cancer. Data of 969 patients with primary breast cancer were analyzed. We defined low MBD as fatty or fibroglandular breast, and high MBD as heterogeneously dense or extremely dense breast, respecti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34297-8
更新日期：2018-10-30 00:00:00
abstract：:Although guidelines recommend BRCA testing for all women with non-mucinous epithelial ovarian cancer, there is significant variability in access to testing across the UK. A germline BRCA mutation (BRCAm) in ovarian cancer patients provides prognostic and predictive information and influences clinical management, such ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60149-5
更新日期：2020-02-25 00:00:00
abstract：:Differences in the pathogenesis and clinical characteristics between lamellar macular hole (LMH) with and without LMH-associated epiretinal proliferation (LHEP) can have surgical implications. This study investigated the effects of treating LHEP by foveolar internal limiting membrane (ILM) non-peeling and epiretinal p...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-52447-4
更新日期：2019-11-05 00:00:00
abstract：:Short-range interaction can give rise to particle pairing with a short-range correlation, which may be destroyed in the presence of an external field. We study the transition between correlated and uncorrelated particle states in the framework of one- dimensional Hubbard model driven by a field. We show that the long ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27189
更新日期：2016-06-02 00:00:00
abstract：:The Sansha Yongle Blue Hole (SYBH) is the deepest blue hole found anywhere to date. Study of the SYBH can provide insight into the interactions between hole wall morphology and many geological/hydrological mechanisms. A comprehensive investigation of the SYBH was carried out for the first time in 2017 using a professi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35220-x
更新日期：2018-11-20 00:00:00
abstract：:Age-hardening in Al alloys has been used for over a century to improve its mechanical properties. However, the lack of direct observation limits our understanding of the dynamic nature of the evolution of nanoprecipitates during age-hardening. Using in-situ (scanning) transmission electron microscopy (S/TEM) while hea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02081-9
更新日期：2017-05-19 00:00:00
abstract：:The addition of a small amount of dopant impurities to crystals is a common method to tune the properties of materials. Usually the doping grade is restricted by the low solubility of the dopants; increasing the doping concentration beyond this solubility limit leads to supersaturated solutions in which dopant cluster...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12730-8
更新日期：2017-10-03 00:00:00
abstract：:Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated the effects of liraglutide on HSC phenotype and hepatic microvascular function using diverse pre-clinical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02866-y
更新日期：2017-06-12 00:00:00
abstract：:An inexpensive and compact frequency multi-mode diode laser enables a compact two-photon polarization entanglement source via the continuous wave broadband pumped spontaneous parametric down-conversion (SPDC) process. Entanglement degradation caused by polarization mode dispersion (PMD) is one of the critical issues i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25846
更新日期：2016-05-13 00:00:00
abstract：:Water-saving and drought-resistantce rice (WDR) breeding practices have greatly increased grain yield and drought resistance. To study the genetic basis of adaptation to drought, transcriptome sequences from the WDR maintainer line HuHan2B and the recurrent parent HanFengB were analyzed for alternative splicing (AS) c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12020-3
更新日期：2017-09-15 00:00:00
abstract：:The present study investigates the impact of charge variants on bevacizumab's structure, stability, and biological activity. Five basic and one acidic charge variants were separated using semi-preparative cation exchange chromatography using linear pH gradient elution with purity > 85%. Based on the commercial biosimi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79541-2
更新日期：2021-01-29 00:00:00
abstract：:Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfoli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50065-8
更新日期：2019-09-17 00:00:00
abstract：:DNA-directed RNA polymerase II (pol II) is composed of ten core and two dissociable subunits. The dissociable subcomplex is a heterodimer of Rpb4/Polr2d and Rpb7/Polr2g, which are encoded by RPB4/polr2d and RPB7/polr2g genes, respectively. Functional studies of Rpb4/Polr2d in yeast have revealed that Rpb4 plays a role...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70110-1
更新日期：2020-08-06 00:00:00
