Abstract:
:We aimed to investigate the potential of preoperative mammographic breast density (MBD) as a prognostic factor in breast cancer. Data of 969 patients with primary breast cancer were analyzed. We defined low MBD as fatty or fibroglandular breast, and high MBD as heterogeneously dense or extremely dense breast, respectively. The high MBD group demonstrated a superior overall survival rate compared to the low MBD group (p < 0.001). Favorable prognostic effects of high MBD were observed in subgroups aged >50 years (p < 0.001) and with positive hormone receptor (HRc) and negative human epidermal growth factor receptor 2 (HER2) (p < 0.001). The high MBD group had a higher proportion of patients aged ≤50 years (p < 0.001) and patients with body mass index (BMI) ≤25 kg/m2 (p < 0.001), and a higher proportion of patients who received chemotherapy (p < 0.001). MBD was a significant independent prognostic factor by multivariable analysis (hazard ratio, 0.382; 95% confidence interval, 0.206-0.708). The high MBD group was associated with superior overall survival rates. Preoperative MBD was a strong independent prognostic factor in operable primary invasive female breast cancer, especially in patients with age >50 years and the HRc(+)/HER2(-) subtype. Favorable clinicopathologic features, active treatments, and other factors could contribute to this causality.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hwang KT,Chu AJ,Kim J,Lee JY,Chang JH,Oh S,Kim YA,Jung J,Oh Bdoi
10.1038/s41598-018-34297-8subject
Has Abstractpub_date
2018-10-30 00:00:00pages
16075issue
1issn
2045-2322pii
10.1038/s41598-018-34297-8journal_volume
8pub_type
杂志文章abstract::Males of hymenopteran insects, which include ants, bees and wasps, develop as haploids from unfertilized eggs. In order to accommodate their lack of homologous chromosome pairs, some hymenopterans such as the honeybee have been shown to produce haploid sperm through an abortive meiosis. We employed microscopic approac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48332-9
更新日期:2019-08-21 00:00:00
abstract::While a large body of research has focused on the study of functional brain "connectivity", few investigators have focused on directionality of brain-brain interactions which, in spite of the mostly bidirectional anatomical substrates, cannot be assumed to be symmetrical. We employ a multivariate Granger Causality-bas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23996-x
更新日期:2018-04-03 00:00:00
abstract::A pancreatic β-cell line MIN6 was previously established in our lab from an insulinoma developed in an IT6 transgenic mouse expressing the SV40 T antigen in β-cells. This cell line has been widely used for in vitro analysis of β-cell function, but tends to lose the mature β-cell features, including glucose-stimulated ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79992-7
更新日期:2021-01-12 00:00:00
abstract::With the objective to conceive a plasmonic solar cell with enhanced photocurrent, we investigate the role of plasmonic nanoshells, embedded within a ultrathin microcrystalline silicon solar cell, in enhancing broadband light trapping capability of the cell and, at the same time, to reduce the parasitic loss. The thick...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24539
更新日期:2016-04-15 00:00:00
abstract::Chronic venous disease (CVD) is a multifactorial condition representing one of the most common disorders among populations of Western countries. The heritability of about 17% suggests genetic risk factors in CVD etiology. However, so far the genetic causes are unknown. We undertook the hitherto first genome-wide assoc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45652
更新日期:2017-04-04 00:00:00
abstract::Growing evidence suggests persistent mitochondrial permeability transition pore (mPTP) opening is a key pathophysiological event in cell death underlying a variety of diseases. While it has long been clear the mPTP is a druggable target, current agents are limited by off-target effects and low therapeutic efficacy. Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37798
更新日期:2016-11-25 00:00:00
abstract::We report localised-surface-plasmon (LSP) enhanced deep-ultraviolet light-emitting diodes (deep-UV LEDs) using Al nanoparticles for LSP coupling. Polygonal Al nanoparticles were fabricated on the top surfaces of the deep-UV LEDs using the oblique-angle deposition method. Both the top- and bottom-emission electrolumine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04380
更新日期:2014-03-14 00:00:00
abstract::This study aimed to examine hemodynamic responses and the necessity of breaks under long working hours. Thirty-eight healthy males conducted PC-based work from 9:10 to 22:00. Nine 10-minute short breaks and two long breaks (a 1-hour break and a 50-minute break) were provided, and hemodynamic responses were measured re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32908-y
更新日期:2018-09-28 00:00:00
abstract::We previously identified Drosophila REPTOR and REPTOR-BP as transcription factors downstream of mTORC1 that play an important role in regulating organismal metabolism. We study here the mammalian ortholog of REPTOR-BP, Crebl2. We find that Crebl2 mediates part of the transcriptional induction caused by mTORC1 inhibiti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56407-w
更新日期:2019-12-27 00:00:00
abstract::During infection with non-enveloped viruses, antibodies stimulate immunity from inside cells by activating the cytosolic Fc receptor TRIM21. This intracellular humoral response relies on opsonized viral particles reaching the cytosol intact but the antigenic and kinetic constraints involved are unknown. We have solved...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37457
更新日期:2016-11-24 00:00:00
abstract::Energy plants are the main source of bioenergy which will play an increasingly important role in future energy supplies. With limited cultivated land resources in China, the development of energy plants may primarily rely on the marginal land. In this study, based on the land use data from 1990 to 2010(every 5 years i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05816
更新日期:2014-07-24 00:00:00
abstract::Climate can modulate human health at large spatial scales, but the influence of global, regional, and local environments remains poorly understood, especially for neglected diseases, such as mycoses. In this work, we present the correlation between climatic variables and hospitalizations for mycoses in Brazilian state...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43353-w
更新日期:2019-05-06 00:00:00
abstract::Spiders can cause trophic cascades affecting litter decomposition rates. However, it remains unclear how spiders with different foraging strategies influence faunal communities, or present cascading effects on decomposition. Furthermore, increased dry periods predicted in future climates will likely have important con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12396
更新日期:2015-07-23 00:00:00
abstract::Myositis is characterised by muscle inflammation and weakness. Although generally thought to be driven by a systemic autoimmune response, increasing evidence suggests that intrinsic changes in the muscle might also contribute to the pathogenesis. Long non-coding RNAs (lncRNAs) are a family of novel genes that regulate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08603-9
更新日期:2017-08-14 00:00:00
abstract::Bacteria belonging to the genus Acinetobacter have become of clinical importance over the last decade due to the development of a multi-resistant phenotype and their ability to survive under multiple environmental conditions. The development of these traits among Acinetobacter strains occurs frequently as a result of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26180-3
更新日期:2018-05-17 00:00:00
abstract::Invasion of ocean surface waters by anthropogenic CO2 emitted to the atmosphere is expected to reduce surface seawater pH to 7.8 by the end of this century compromising marine calcifiers. A broad range of biological and mineralogical mechanisms allow marine calcifiers to cope with ocean acidification, however these me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19374
更新日期:2016-01-18 00:00:00
abstract::To date, analyses of individual targets have provided evidence of a miRNA targetome that extends beyond the boundaries of messenger RNAs (mRNAs) and can involve non-Watson-Crick base pairing in the miRNA seed region. Here we report our findings from analyzing 34 Argonaute HITS-CLIP datasets from several human and mous...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05947
更新日期:2014-08-08 00:00:00
abstract::Nanostructure based color filtering has been considered an attractive replacement for current colorant pigmentation in the display technologies, in view of its increased efficiencies, ease of fabrication and eco-friendliness. For such structural filtering, iridescence relevant to its angular dependency, which poses a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04921
更新日期:2014-05-12 00:00:00
abstract::Systemic lupus erythematosus (SLE) features a decreased pool of CD4+CD25+Foxp3+ T regulatory (Treg) cells. We had previously observed NKG2D+CD4+ T cell expansion in contrast to a decreased pool of Treg cells in SLE patients, but whether NKG2D+CD4+ T cells contribute to the decreased Treg cells remains unclear. In the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01379-y
更新日期:2017-04-28 00:00:00
abstract::Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer's disease (AD). Therefore, we have formulated the first western-style diet that mimics the fat, carbohydrate, protein, vitamin and mineral levels of wester...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21568
更新日期:2016-02-18 00:00:00
abstract::The current standard treatment for ovarian cancer is aggressive surgery followed by platinum-based combination chemotherapy. Recurrence and chemotherapeutic drug resistance are the two main factors that account for the high mortality of most ovarian cancers. Liposomal doxorubicin is primarily used for the treatment of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36873
更新日期:2016-11-11 00:00:00
abstract::Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit anti-HBV CTL activity in patients with chronic HBV infection (CHB). However, the ongoing anti-HBV CD8(+) T cell...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12159
更新日期:2015-07-22 00:00:00
abstract::Storage of solar radiation is currently accomplished by coupling two separate devices, one that captures and converts the energy into an electrical impulse (a photovoltaic cell) and another that stores this electrical output (a battery or a supercapacitor electrochemical cell). This configuration however has several c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30728-8
更新日期:2018-08-24 00:00:00
abstract::Liver cirrhosis is a severe disease with major impact on the overall health of the patient including poor oral health. Lately, there has been increasing focus on oral diseases as cirrhosis-related complications due to the potential impact on systemic health and ultimately mortality. Periodontitis is one of the most co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28905-w
更新日期:2018-07-16 00:00:00
abstract::Multipotential stromal cells (MSCs) demonstrate strong immunomodulation capabilities following culture expansion. We have previously demonstrated that human cancellous bone fragments (CBFs) clinically used as viable allografts for spinal fusion have resident MSCs that exhibit T cell immunomodulation after monolayer ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31979-1
更新日期:2018-09-10 00:00:00
abstract::Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known to distinguish bor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11200
更新日期:2015-06-10 00:00:00
abstract::Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22322
更新日期:2016-02-29 00:00:00
abstract::Polystyrene sulfonate (PSS), a strong polyelectrolyte, was used to prepare red photoluminescent PSS-penicillamine (PA) copper (Cu) nanoclusters (NC) aggregates, which displayed high selectivity and sensitivity to the detection of hydrogen sulfide (H2S). The size of the PSS-PA-Cu NC aggregates could be readily controll...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24882
更新日期:2016-04-26 00:00:00
abstract::Topological phase transition is accompanied with a change of topological numbers. According to the bulk-edge correspondence, the gap closing and the breakdown of the adiabaticity are necessary at the phase transition point to make the topological number ill-defined. However, the gap closing is not always needed. In th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02790
更新日期:2013-09-27 00:00:00
abstract::Black phosphorus (BP) materials have attracted considerable attention owing to their ultra-sensitive humidity sensing characteristics because of the natural absorption of water (H2O) molecules on the BP surface caused by the specific 2D layer-crystalline structure. On the other hand, the BP-based humidity sensor is le...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10848-3
更新日期:2017-09-05 00:00:00