Abstract：
:Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated the effects of liraglutide on HSC phenotype and hepatic microvascular function using diverse pre-clinical models of CLD. Human and rat HSC were in vitro treated with liraglutide, or vehicle, and their phenotype, viability and proliferation were evaluated. In addition, liraglutide or vehicle was administered to rats with CLD. Liver microvascular function, fibrosis, HSC phenotype and sinusoidal endothelial phenotype were determined. Additionally, the effects of liraglutide on HSC phenotype were analysed in human precision-cut liver slices. Liraglutide markedly improved HSC phenotype and diminished cell proliferation. Cirrhotic rats receiving liraglutide exhibited significantly improved liver microvascular function, as evidenced by lower portal pressure, improved intrahepatic vascular resistance, and marked ameliorations in fibrosis, HSC phenotype and endothelial function. The anti-fibrotic effects of liraglutide were confirmed in human liver tissue and, although requiring further investigation, its underlying molecular mechanisms suggested a GLP1-R-independent and NF-κB-Sox9-dependent one. This study demonstrates for the first time that liraglutide improves the liver sinusoidal milieu in pre-clinical models of cirrhosis, encouraging its clinical evaluation in the treatment of chronic liver disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
de Mesquita FC,Guixé-Muntet S,Fernández-Iglesias A,Maeso-Díaz R,Vila S,Hide D,Ortega-Ribera M,Rosa JL,García-Pagán JC,Bosch J,de Oliveira JR,Gracia-Sancho Jdoi
10.1038/s41598-017-02866-ysubject
Has Abstractpub_date
2017-06-12 00:00:00pages
3255issue
1issn
2045-2322pii
10.1038/s41598-017-02866-yjournal_volume
7pub_type
杂志文章abstract：:Mammalian innate and acquired immune responses involve a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanism. MicroRNAs have been implicated as a negative regulator for diverse biological events including immune responses. However, the involvement of m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12226
更新日期：2015-07-31 00:00:00
abstract：:Under the usual approximation of treating a biological particle as a spheroidal droplet, we consider the analysis of its size and shape with the high frequency photoacoustics and develop a numerical method which can simulate its characteristic photoacoustic waves. This numerical method is based on the calculation of s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14801
更新日期：2015-10-07 00:00:00
abstract：:Soil water retention curve (SWRC) plays an important role in simulating soil water movement and assessing soil water holding capacity and availability. Comparison of fitness between different models to determine the best SWRC model of specific regions is required. In this study, three popular models, van Genuchten, Br...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54449-8
更新日期：2019-12-05 00:00:00
abstract：:Dietary information is lacking in most of small to mid-sized carnivores due to their elusive predatory behaviour and versatile feeding habits. The leopard cat (LPC; Prionailurus bengalensis) and the Asiatic golden cat (AGC; Catopuma temminckii) are two important yet increasingly endangered carnivore species in the tem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41909
更新日期：2017-02-14 00:00:00
abstract：:Low-noise millimetre-wave signals are valuable for digital sampling systems, arbitrary waveform generation for ultra-wideband communications, and coherent radar systems. However, the phase noise of widely used conventional signal generators (SGs) will increase as the millimetre-wave frequency increases. Our goal has b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24621
更新日期：2016-05-17 00:00:00
abstract：:Understanding the genetic basis of phenotypic diversity is a challenge in contemporary biology. Domestication provides a model for unravelling aspects of the genetic basis of stress sensitivity. The ancestral Red Junglefowl (RJF) exhibits greater fear-related behaviour and a more pronounced HPA-axis reactivity than it...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15345
更新日期：2015-10-16 00:00:00
abstract：:Here we report the discovery and partial characterization of a novel herpesvirus tentatively named Bufonid herpesvirus 1 (BfHV1) from severe dermatitis in free ranging common toads (Bufo bufo) in Switzerland. The disease has been observed in toads every year since 2014, in spring, during the mating season, at differen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32841-0
更新日期：2018-10-03 00:00:00
abstract：:Surfactant solutions typically feature tunable nanoscale, internal structures. Although rarely utilized, they can be a powerful platform for probing thermal transport in nanoscale domains and across interfaces with nanometer-size radius. Here, we examine the structure and thermal transport in solution of AOT (Dioctyl ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16040
更新日期：2015-11-04 00:00:00
abstract：:Hierarchical classification (HC) stratifies and classifies data from broad classes into more specific classes. Unlike commonly used data classification strategies, this enables the probabilistic prediction of unknown classes at different levels, minimizing the burden of incomplete databases. Despite these advantages, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14092-7
更新日期：2017-11-03 00:00:00
abstract：:Sepsis induced cardiac dysfunction (SIC) is a severe complication to sepsis which significantly worsens patient outcomes. It is known that bacteria have the capacity to release outer membrane vesicles (OMVs), which are nano-sized bilayered vesicles composed of lipids and proteins, that can induce a fatal inflammatory ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16363-9
更新日期：2017-12-12 00:00:00
abstract：:Proteins that act as global transcriptional regulators play key roles in bacterial adaptation to new niches. These proteins recognize multiple DNA sites across the bacterial genome by different mechanisms. Enterococcus faecalis is able to survive in various niches of the human host, either as a commensal or as a leadi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42484-4
更新日期：2019-04-16 00:00:00
abstract：:Social projection is the tendency to project one's own characteristics onto others. This phenomenon can potentially explain cooperation in prisoner's dilemma experiments and other social dilemmas. The social projection hypothesis has recently been formalized for symmetric games as co-action equilibrium and for general...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19085-0
更新日期：2018-01-15 00:00:00
abstract：:In this study, the effect of post-deposition tetrafluoromethane (CF4) plasma treatment on the physical and electrical characteristics of an In2TiO5 based electrolyte-insulator-semiconductor (EIS) sensor was investigated. Post-deposition CF4 plasma treatment typically improved the crystalline structure and repaired dan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39012-9
更新日期：2019-02-28 00:00:00
abstract：:The concept of remission for patients with inflammatory bowel diseases has recently evolved, and should also include histological healing of the mucosa, difficult to evaluate since there is no agreement on pathological scores and those available are quite complex to use in the daily routine. We evaluated the possible ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07338-x
更新日期：2017-07-28 00:00:00
abstract：:Experimental evidence has shown that some of the human endogenous hormones significantly affect drug efficacy. Since hormone status varies with individual physiological states, it is essential to understand the interplay of hormones and drugs for precision medicine. Here, we developed an in silico method to predict in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16855-8
更新日期：2017-11-30 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60882-x
更新日期：2020-03-02 00:00:00
abstract：:Fluorescence lifetime imaging microscopy (FLIM) is a key technology that provides direct insight into cell metabolism, cell dynamics and protein activity. However, determining the lifetimes of different fluorescent proteins requires the detection of a relatively large number of photons, hence slowing down total acquis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77737-0
更新日期：2020-12-02 00:00:00
abstract：:Rapid changes observed today in mountain glaciers need to be put into a longer-term context to understand global sea-level contributions, regional climate-glacier systems and local landscape evolution. In this study we determined volume changes for 400 mountain glaciers across the Southern Alps, New Zealand for three ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70276-8
更新日期：2020-08-07 00:00:00
abstract：:Current etching routes to process large graphene sheets into nanoscale graphene so as to open up a bandgap tend to produce structures with rough and disordered edges. This leads to detrimental electron scattering and reduces carrier mobility. In this work, we present a novel yet simple direct-growth strategy to yield ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01238
更新日期：2013-01-01 00:00:00
abstract：:Silica columns from PCR purification and gel extraction kits are widely used in laboratories worldwide to assist in gene cloning. However, the use of these columns can generate plastic waste that has an environmental impact due to their one-off design and massive consumption. Thus, it is important to develop a novel m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30316-w
更新日期：2018-08-27 00:00:00
abstract：:The Gram-negative bacterium B. pertussis is the causative agent of whooping cough. This infection is re-emerging and new features related to Bordetella pathogenesis and microbiology could be relevant to defeat it. Therefore, we focused our attention on BP1253, a predicted exported protein from B. pertussis erroneously...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53171-9
更新日期：2019-11-19 00:00:00
abstract：:Electrosprays operate in several modes depending on the flow rate and electric potential. This allows the deposition of droplets containing nanoparticles into discrete nanodot arrays to fabricate various electronic devices. In this study, seven different suspensions with varying properties were investigated. In the dr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05175-6
更新日期：2017-07-11 00:00:00
abstract：:Laparoscopic experience and relevant reports about PD catheter emplacement in Chinese patients are seldom. In this study, we described our experience with advanced laparoscopy for PD catheter implantation in Chinese patients. There were one hundred and thirty Chinese patients accepted advanced laparoscopic approach fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09596-1
更新日期：2017-08-22 00:00:00
abstract：:Microstructures in nature are ultrafine and ordered in biological roles, which have attracted material scientists. Spirulina forms three-dimensional helical microstructure, one of remarkable features in nature beyond our current processing technology such as lithography in terms of mass-productivity and structural mul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04919
更新日期：2014-05-12 00:00:00
abstract：:Degradation of the biologically potent octapeptide angiotensin Ang II-(1-8) is mediated by the activities of several peptidases. The conversion of Ang II to the septapeptide Ang-(1-7) is of particular interest as the latter also confers organ protection. The conversion is catalyzed by angiotensin-converting enzyme 2 a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45473
更新日期：2017-04-05 00:00:00
abstract：:In this paper, we present the design, fabrication and optical characterization of computer-generated holograms (CGH) encoding information for light beams carrying orbital angular momentum (OAM). Through the use of a numerical code, based on an iterative Fourier transform algorithm, a phase-only diffractive optical ele...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18147-7
更新日期：2017-12-21 00:00:00
abstract：:The regulation of inflammatory responses by innate immune receptors is recognized as a crucial step in the development of atherosclerosis, although the precise molecular mechanisms remain to be elucidated. This study focused on illustrating the roles of dendritic cell-specific intercellular adhesion molecule-3-grabbin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03740-7
更新日期：2017-06-12 00:00:00
abstract：:In this work, we report lateral heterojunction formation in as-exfoliated MoS2 flakes by thickness modulation. Kelvin probe force microscopy is used to map the surface potential at the monolayer-multilayer heterojunction, and consequently the conduction band offset is extracted. Scanning photocurrent microscopy is per...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10990
更新日期：2015-06-30 00:00:00
abstract：:Quantum coherence is one of the old but always important concepts in quantum mechanics, and now it has been regarded as a necessary resource for quantum information processing and quantum metrology. However, the question of how to quantify the quantum coherence has just been paid the attention recently (see, e.g., Bau...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15323-7
更新日期：2017-11-14 00:00:00
abstract：:Glial fibrillary acidic protein expressing (GFAP+) glia modulate nociceptive neuronal activity in both the peripheral nervous system (PNS) and the central nervous system (CNS). Resident GFAP+ glia in dorsal root ganglia (DRG) known as satellite glial cells (SGCs) potentiate neuronal activity by releasing pro-inflammat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71073-z
更新日期：2020-08-25 00:00:00
