Usefulness of Different Pathological Scores to Assess Healing of the Mucosa in Inflammatory Bowel Diseases: A Real Life Study.

abstract：:Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered that crosslinking is...

journal_title：Scientific reports

authors： Wang C,Li X,Yu F,Lu L,Jiang X,Xu X,Wang H,Lai W,Zhang T,Zhang Z,Ye L,Jiang S,Liu K

更新日期：2016-08-26 00:00:00

abstract：:Quantum Key Distribution is carving its place among the tools used to secure communications. While a difficult technology, it enjoys benefits that set it apart from the rest, the most prominent is its provable security based on the laws of physics. QKD requires not only the mastering of signals at the quantum level, b...

journal_title：Scientific reports

authors： Martinez-Mateo J,Elkouss D,Martin V

更新日期：2013-01-01 00:00:00

abstract：:Cell mechanics play a key role in several fundamental biological processes, such as migration, proliferation, differentiation and tissue morphogenesis. In addition, many diseased conditions of the cell are correlated with altered cell mechanics, as in the case of cancer progression. For this there is much interest in ...

journal_title：Scientific reports

authors： Dehoux T,Abi Ghanem M,Zouani OF,Rampnoux JM,Guillet Y,Dilhaire S,Durrieu MC,Audoin B

更新日期：2015-03-03 00:00:00

abstract：:In this study, the effects of different feeding frequencies on the growth and the expression of genes in the GH/IGF axis were assessed in juvenile Chinese sturgeon. The newly hatched Chinese sturgeons were bred for 38 days at three different feeding frequencies groups (feeding frequency of two times a day, TWD; three ...

journal_title：Scientific reports

authors： Hu Y,Xiao K,Yang J,Liu X,Wang B,Zeng Q,Du H

更新日期：2020-10-15 00:00:00

abstract：:Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...

journal_title：Scientific reports

authors： Lu J,Shao Y,Qin X,Liu D,Chen A,Li D,Liu M,Wang X

更新日期：2017-02-20 00:00:00

abstract：:Surface-enhanced Raman spectroscopy (SERS) has attracted a lot of attention in molecular sensing because of the remarkable ability of plasmonic metal nanostructures to enhance the weak Raman scattering process. On the other hand, coherent vibrational spectroscopy triggered by impulsive excitation using ultrafast laser...

journal_title：Scientific reports

authors： Du J,Harra J,Virkki M,Mäkelä JM,Leng Y,Kauranen M,Kobayashi T

更新日期：2016-11-04 00:00:00

abstract：:Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to searc...

journal_title：Scientific reports

authors： Nowak JK,Grzybowska-Chlebowczyk U,Landowski P,Szaflarska-Poplawska A,Klincewicz B,Adamczak D,Banasiewicz T,Plawski A,Walkowiak J

更新日期：2014-04-24 00:00:00

abstract：:Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of AMD to include another extracellular deposit, reticular pseudodruse...

journal_title：Scientific reports

authors： Mishra Z,Ganegoda A,Selicha J,Wang Z,Sadda SR,Hu Z

更新日期：2020-06-12 00:00:00

abstract：:This study shows that DKK-1, a member of the Dickkopf family and a regulator of the Wnt pathways, represents a novel target of statins which, through the inhibition of HMG-CoA reductase and of non-steroidal isoprenoid intermediates, exert extra-beneficial effect in preventing atherosclerosis beyond their effect on the...

journal_title：Scientific reports

authors： Pontremoli M,Brioschi M,Baetta R,Ghilardi S,Banfi C

更新日期：2018-11-12 00:00:00

abstract：:Polarization of macrophages is regulated through complex signaling networks. Correlating miRNA and mRNA expression over time after macrophage polarization has not yet been investigated. We used paired RNA-Seq and miRNA-Seq experiments to measure the mRNA and miRNA expression in bone marrow-derived macrophages over a t...

journal_title：Scientific reports

authors： Lu L,McCurdy S,Huang S,Zhu X,Peplowska K,Tiirikainen M,Boisvert WA,Garmire LX

更新日期：2016-12-16 00:00:00

abstract：:Tick-borne diseases are the most common vector-borne diseases in the United States, with serology being the primary method of diagnosis. We developed the first multiplex, array-based assay for serodiagnosis of tick-borne diseases called the TBD-Serochip. The TBD-Serochip was designed to discriminate antibody responses...

journal_title：Scientific reports

authors： Tokarz R,Mishra N,Tagliafierro T,Sameroff S,Caciula A,Chauhan L,Patel J,Sullivan E,Gucwa A,Fallon B,Golightly M,Molins C,Schriefer M,Marques A,Briese T,Lipkin WI

更新日期：2018-02-16 00:00:00

abstract：:Microtubule-associated protein 1B (MAP1B) is expressed predominantly during the early stages of development of the nervous system, where it regulates processes such as axonal guidance and elongation. Nevertheless, MAP1B expression in the brain persists in adult stages, where it participates in the regulation of the st...

journal_title：Scientific reports

authors： Bodaleo FJ,Montenegro-Venegas C,Henríquez DR,Court FA,Gonzalez-Billault C

更新日期：2016-07-18 00:00:00

abstract：:The exopeptidases of family S46 are exceptional, as the closest homologs of these enzymes are the endopeptidases of clan PA. The three-dimensional structure of S46 enzymes is unknown and only one of the catalytic residues, the serine, has been identified. The catalytic histidine and aspartate residues are not experime...

journal_title：Scientific reports

authors： Suzuki Y,Sakamoto Y,Tanaka N,Okada H,Morikawa Y,Ogasawara W

更新日期：2014-03-06 00:00:00

abstract：:Centrosomal protein 55 (CEP55) is a microtubule-bundling protein that participants in cell mitosis. It is overexpressed in several solid tumours and promotes the growth and invasion of cancer cells. However, the role of CEP55 in pancreatic cancer (PANC) remains unclear. Herein, upregulated expression of CEP55 (associa...

journal_title：Scientific reports

authors： Peng T,Zhou W,Guo F,Wu HS,Wang CY,Wang L,Yang ZY

更新日期：2017-07-19 00:00:00

abstract：:The pace of two-dimensional materials (2DM) research has been greatly accelerated by the ability to identify exfoliated thicknesses down to a monolayer from their optical contrast. Since this process requires time-consuming and error-prone manual assignment to avoid false-positives from image features with similar con...

journal_title：Scientific reports

authors： Jessen BS,Whelan PR,Mackenzie DMA,Luo B,Thomsen JD,Gammelgaard L,Booth TJ,Bøggild P

更新日期：2018-04-23 00:00:00

abstract：:High frequency oscillations (HFOs) are bursts of neural activity in the range of 80 Hz or higher, recorded from intracranial electrodes during epileptiform discharges. HFOs are a proposed biomarker of epileptic brain tissue and may also be useful for seizure forecasting. Despite such clinical utility of HFOs, the spat...

journal_title：Scientific reports

authors： Smith EH,Merricks EM,Liou JY,Casadei C,Melloni L,Thesen T,Friedman DJ,Doyle WK,Emerson RG,Goodman RR,McKhann GM 2nd,Sheth SA,Rolston JD,Schevon CA

更新日期：2020-11-05 00:00:00

abstract：:In summer 2010, a massive bloom appeared in the middle (16-25°N, 160-200°E) of the North Pacific Subtropical Gyre (NPSG) creating a spectacular oasis in the middle of the largest oceanic desert on Earth. Peaked in June 2010 covering over two million km2 in space, this phytoplankton bloom is the largest ever recorded b...

journal_title：Scientific reports

authors： Chow CH,Cheah W,Tai JH,Liu SF

更新日期：2019-10-29 00:00:00

abstract：:The associations of 18F-THK5351 tau positron emission tomography (PET) findings with core domains of progressive supranuclear palsy (PSP) and its diagnostic certainty have yet to be fully elucidated. The 18F-THK5351 PET patterns of 17 patients with PSP (68.9 ± 6.5 years; 8 women) were compared with those observed in 2...

journal_title：Scientific reports

authors： Hsu JL,Chen SH,Hsiao IT,Lu CS,Yen TC,Okamura N,Lin KJ,Weng YH

更新日期：2020-11-10 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is characterized by failure of ovulation and is associated with obesity and chronic inflammation. Recent evidence suggests that anomalous activation of ovarian macrophages and numerical and functional deficits in the Th17 (CD4+IL17A+) and the CD4+CD25+CD127low Tregs plays crucial role ...

journal_title：Scientific reports

authors： Albaghdadi AJH,Feeley CA,Kan FWK

更新日期：2019-04-25 00:00:00

abstract：:In the past few years, the meteoric development of hybrid organic-inorganic perovskite solar cells (PSC) astonished the community. The efficiency has already reached the level needed for commercialization; however, the instability hinders its deployment on the market. Here, we report a mechanism to chemically stabiliz...

journal_title：Scientific reports

authors： El-Mellouhi F,Bentria el T,Rashkeev SN,Kais S,Alharbi FH

更新日期：2016-07-26 00:00:00

abstract：:Transcatheter arterial embolization (TAE), as an alternative to surgery for iatrogenic renal vascular injury (IRVI), may have unsatisfactory outcomes. Nonetheless, there is inadequate information regarding the predictors of TAE outcomes for IRVI in the literature. The aim of this retrospective study was to investigate...

journal_title：Scientific reports

authors： Lee SY,Wang ML,Wong YC,Wu CH,Wang LJ

更新日期：2019-11-19 00:00:00

abstract：:Calcium-activated potassium ion channel-3.1 (KCa3.1) plays a pivotal role in the potassium-calcium exchange involved in atopy. This study aimed to explore the impact of lentiviral-mediated shRNA silencing KCa3.1 on allergic response in a murine allergic rhinitis (AR) model. The BALB/c mice were divided into four group...

journal_title：Scientific reports

authors： Lin H,Zheng C,Li J,Yang C,Hu L

更新日期：2015-08-14 00:00:00

abstract：:Predicting regions at risk from introductions of non-native species and the subsequent invasions is a fundamental aspect of horizon scanning activities that enable the development of more effective preventative actions and planning of management measures. The Asian cyprinid fish topmouth gudgeon Pseudorasbora parva ha...

journal_title：Scientific reports

authors： Fletcher DH,Gillingham PK,Britton JR,Blanchet S,Gozlan RE

更新日期：2016-05-20 00:00:00

abstract：:In this work, we experimentally investigate near-field capacitive coupling between a pair of single-gap split ring resonators (SRRs) in a terahertz metamaterial. The unit cell of our design comprises of two coupled SRRs with the split gaps facing each other. The coupling between two SRRs is examined by changing the ga...

journal_title：Scientific reports

authors： Rao SJM,Srivastava YK,Kumar G,Roy Chowdhury D

更新日期：2018-11-13 00:00:00

abstract：:Few studies have investigated the relationship between chronic rhinosinusitis (CRS) and erectile dysfunction (ED). This case-control study aimed to investigate the association between CRS and the risk of ED in a large national sample. Tapping Taiwan's National Health Insurance Research Database, we identified people 3...

journal_title：Scientific reports

authors： Tai SY,Wang LF,Tai CF,Huang YT,Chien CY

更新日期：2016-08-31 00:00:00

abstract：:An effective metal oxide coating with solution processes by the metal organic decomposition method as deposited at room temperature (RT) poses great challenge. In this study, we report the characterization and evaluation of the semiconductor properties of a zinc hydroxide thin film with RT just as deposition by soluti...

journal_title：Scientific reports

authors： Karakawa M,Sugahara T,Hirose Y,Suganuma K,Aso Y

更新日期：2018-07-20 00:00:00

abstract：:Multi-wavelength lasers have widespread applications (e.g. fiber telecommunications, pump-probe measurements, terahertz generation). Here, we report a nanotube-mode-locked all-fiber ultrafast oscillator emitting three wavelengths at the central wavelengths of about 1540, 1550, and 1560 nm, which are tunable by stretch...

journal_title：Scientific reports

authors： Liu X,Han D,Sun Z,Zeng C,Lu H,Mao D,Cui Y,Wang F

更新日期：2013-01-01 00:00:00

abstract：:Fitness-related costs of evolving insecticide resistance have been reported in a number of insect species, but the interplay between evolutionary adaptation to insecticide pressure and variable environmental conditions has received little attention. We provisioned nymphs from three German cockroach (Blattella germanic...

journal_title：Scientific reports

authors： Jensen K,Ko AE,Schal C,Silverman J

更新日期：2016-06-27 00:00:00

abstract：:Inflammatory reactions activated by pattern recognition receptors (PRRs) on the membrane of innate immune cells play an important role in atherosclerosis. Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be involved in the pathogenesis of atherosclerosis remains largely unknown. Recen...

journal_title：Scientific reports

authors： Thiem K,Hoeke G,van den Berg S,Hijmans A,Jacobs CWM,Zhou E,Mol IM,Mouktaroudi M,Bussink J,Kanneganti TD,Lutgens E,Stienstra R,Tack CJ,Netea MG,Rensen PCN,Berbée JFP,van Diepen JA

更新日期：2019-03-13 00:00:00

abstract：:Since the SOX2 amplification was identified in lung squamous cell carcinoma (lung SCC), SOX2 transcriptional downstream targets have been actively investigated; however, such targets are often cell line specific. Here, in order to identify highly consensus SOX2 downstream genes in lung SCC cells, we used RNA-seq data ...

journal_title：Scientific reports

authors： Fukazawa T,Guo M,Ishida N,Yamatsuji T,Takaoka M,Yokota E,Haisa M,Miyake N,Ikeda T,Okui T,Takigawa N,Maeda Y,Naomoto Y

更新日期：2016-02-05 00:00:00