LC-MS based case-by-case analysis of the impact of acidic and basic charge variants of bevacizumab on stability and biological activity.

abstract：:Interleukin-6 (IL-6) overproduction has been involved in the pathogenesis of several chronic inflammatory diseases and the administration of an anti-IL-6 receptor monoclonal antibody has been proven clinically efficient to treat them. However, the drawbacks of monoclonal antibodies have led our group to develop an inn...

journal_title：Scientific reports

authors： Desallais L,Bouchez C,Mouhsine H,Moreau G,Ratsimandresy R,Montes M,Do H,Quintin-Colonna F,Zagury JF

更新日期：2016-01-19 00:00:00

abstract：:The present work aimed to find out the effect of different levels of hydrolysable tannin (HT) on serum hormonal profile, biochemical indices, lipid profile, apparent digestibility of nutrients and body weight gain in healthy female rats. Forty five adult healthy female rats of 8 weeks old were randomly divided into fi...

journal_title：Scientific reports

authors： Manzoor F,Nisa MU,Hussain HA,Ahmad N,Umbreen H

更新日期：2020-11-26 00:00:00

abstract：:Adipose tissue dysfunction is considered an important contributor to systemic insulin resistance and Type 2 diabetes (T2D). Recently, a novel family of endogenous lipids, palmitic acid hydroxy stearic acids (PAHSAs), was discovered. These have anti-diabetic and anti-inflammatory effects in mice and are reduced in seru...

journal_title：Scientific reports

authors： Hammarstedt A,Syed I,Vijayakumar A,Eliasson B,Gogg S,Kahn BB,Smith U

更新日期：2018-10-25 00:00:00

abstract：:Lipomas are benign fatty tumors with a high prevalence rate, mostly found in adults but have a good prognosis. Until now, reason for lipoma occurrence not been identified. We performed whole exome sequencing to define the mutational spectrum in ten lipoma patients along with their matching control samples. We presente...

journal_title：Scientific reports

authors： Kanojia D,Dakle P,Mayakonda A,Parameswaran R,Puhaindran ME,Min VLK,Madan V,Koeffler P

更新日期：2019-10-07 00:00:00

abstract：:Habitat fragmentation can reduce population viability, especially for area-sensitive species. The Minimum Area Requirements (MAR) of a population is the area required for the population's long-term persistence. In this study, the response of occupancy probability of giant pandas against habitat patch size was studied ...

journal_title：Scientific reports

authors： Qing J,Yang Z,He K,Zhang Z,Gu X,Yang X,Zhang W,Yang B,Qi D,Dai Q

更新日期：2016-12-08 00:00:00

abstract：:In this study, an interval optimization model is developed to maximize the benefits of a water rights transfer system that comprises industry and agriculture sectors in the Ningxia Hui Autonomous Region in China. The model is subjected to a number of constraints including water saving potential from agriculture and ec...

journal_title：Scientific reports

authors： Sun L,Li C,Cai Y,Wang X

更新日期：2017-06-14 00:00:00

abstract：:We present a new class of TiBw/Ti6Al4V composites with a network reinforcement architecture that exhibits a significant creep resistance compared to monolithic Ti6Al4V alloys. Creep tests performed at temperatures between 773 K and 923 K and stress range of 100 MPa-300 MPa indicate both a significant improvement of th...

journal_title：Scientific reports

authors： Wang S,Huang LJ,Geng L,Scarpa F,Jiao Y,Peng HX

更新日期：2017-01-17 00:00:00

abstract：:The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(D,L-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(ε-caprolactone) (PCL) lay...

journal_title：Scientific reports

authors： Milosevic M,Stojanovic DB,Simic V,Grkovic M,Bjelovic M,Uskokovic PS,Kojic M

更新日期：2020-07-07 00:00:00

abstract：:We present a new transcriptome assembly of the Pacific whiteleg shrimp (Litopenaeus vannamei), the species most farmed for human consumption. Its functional annotation, a substantial improvement over previous ones, is provided freely. RNA-Seq with Illumina HiSeq technology was used to analyze samples extracted from sh...

journal_title：Scientific reports

authors： Ghaffari N,Sanchez-Flores A,Doan R,Garcia-Orozco KD,Chen PL,Ochoa-Leyva A,Lopez-Zavala AA,Carrasco JS,Hong C,Brieba LG,Rudiño-Piñera E,Blood PD,Sawyer JE,Johnson CD,Dindot SV,Sotelo-Mundo RR,Criscitiello MF

更新日期：2014-11-25 00:00:00

abstract：:Electron-hole exchange interaction in semiconductor quantum dots (QDs) splits the band-edge exciton manifold into optically active ("bright") and passive ("dark") states, leading to a complicated exciton fine structure. In the present work, we resolve by atomistic million-atom many-body pseudopotential calculations th...

journal_title：Scientific reports

authors： Baskoutas S,Zeng Z,Garoufalis CS,Bester G

更新日期：2017-08-24 00:00:00

abstract：:Hyperentangled Bell-state analysis (HBSA) is an essential method in high-capacity quantum communication and quantum information processing. Here by replacing the two-qubit controlled-phase gate with the two-qubit SWAP gate, we propose a scheme to distinguish the 16 hyperentangled Bell states completely in both the pol...

journal_title：Scientific reports

authors： Wang TJ,Wang C

更新日期：2016-01-19 00:00:00

abstract：:Biological armors such as mollusk shells have long been recognized and studied for their values in inspiring novel designs of engineering materials with higher toughness and strength. However, no material is invincible and biological armors also have their rivals. In this paper, our attention is focused on the teeth o...

journal_title：Scientific reports

authors： Fu J,He C,Xia B,Li Y,Feng Q,Yin Q,Shi X,Feng X,Wang H,Yao H

更新日期：2016-03-22 00:00:00

abstract：:The complex phase transitions of vanadium dioxide (VO2) have drawn continual attention for more than five decades. Dynamically, ultrafast electron diffraction (UED) with atomic-scale spatiotemporal resolution has been employed to study the reaction pathway in the photoinduced transition of VO2, using bulk and strain-f...

journal_title：Scientific reports

authors： He X,Punpongjareorn N,Liang W,Lin Y,Chen C,Jacobson AJ,Yang DS

更新日期：2017-08-30 00:00:00

abstract：:Conformational behavior of intrinsically disordered proteins, such as Phe-Gly repeat domains, alters drastically when they are confined in, and tethered to, nan channels. This has challenged our understanding of how they serve to selectively facilitate translocation of nuclear transport receptor (NTR)-bearing macromol...

journal_title：Scientific reports

authors： Moussavi-Baygi R,Mofrad MR

更新日期：2016-07-29 00:00:00

abstract：:There are many types of autoregressive patterns in financial time series, and they form a transmission process. Here, we define autoregressive patterns quantitatively through an econometrical regression model. We present a computational algorithm that sets the autoregressive patterns as nodes and transmissions between...

journal_title：Scientific reports

authors： Gao X,An H,Fang W,Huang X,Li H,Zhong W

更新日期：2014-09-05 00:00:00

abstract：:Developing an effective universal influenza vaccine against influenza virus with highly conserved antigenic epitopes could induce a broad-spectrum immune response to prevent infection. The soluble protein M1 that can induce the M1 specific immune response was first confirmed in our previous study. In this study, we ch...

journal_title：Scientific reports

authors： Liu F,Wang X,Zheng M,Xiong F,Liu X,Zhou L,Tan W,Chen Z

更新日期：2020-03-05 00:00:00

abstract：:The presence of genetically modified organisms (GMO) is commonly assessed using real-time PCR methods targeting the most common transgenic elements found in GMOs. Once the presence of GM material has been established using these screening methods, GMOs are further identified using a battery of real-time PCR methods, e...

journal_title：Scientific reports

authors： Boutigny AL,Fioriti F,Rolland M

更新日期：2020-09-15 00:00:00

abstract：:Diagnostic testing often assesses the cardiovascular or respiratory systems in isolation, ignoring the major pathophysiologic interactions between the systems in many diseases. When both systems are assessed currently, multiple modalities are utilized in costly fashion with burdensome logistics and decreased accessibi...

journal_title：Scientific reports

authors： Cheng JY,Zhang T,Alley MT,Uecker M,Lustig M,Pauly JM,Vasanawala SS

更新日期：2017-07-13 00:00:00

abstract：:Spinal cord injury (SCI) leads to wide-spread neurodegeneration across the neuroaxis. We explored trajectories of surface morphology, demyelination and iron concentration within the basal ganglia-thalamic circuit over 2 years post-SCI. This allowed us to explore the predictive value of neuroimaging biomarkers and dete...

journal_title：Scientific reports

authors： Huber E,Patel R,Hupp M,Weiskopf N,Chakravarty MM,Freund P

更新日期：2020-08-24 00:00:00

abstract：:In this paper, a novel explanation on high directive emission of Fabry-Perot resonator antenna with subwavelength metasurface is proposed. Based on image theory and effective constitutive parameter retrieval, the whole Fabry-Perot resonant cavity structure composed of a single-layer metasurface with square ring elemen...

journal_title：Scientific reports

authors： Liu ZG,Lu WB,Yang W

更新日期：2017-09-13 00:00:00

abstract：:Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (BVN) and PCV subtypes throug...

journal_title：Scientific reports

authors： Yeung L,Lai CC,Chen SN,Cheng CK,Yang CM,Hsieh YT,Tsai A,Yang CH

更新日期：2021-01-11 00:00:00

abstract：:The cooling performance of an optomechanical system comprising both dispersive and dissipative coupling is studied. Here, we present a scheme to cool a mechanical resonator to its ground state in finite time using a chirped pulse. We show that there is distinct advantage in using the chirp-pulse scheme to cool a reson...

journal_title：Scientific reports

authors： Chen T,Wang XB

更新日期：2015-01-13 00:00:00

abstract：:Methods for estimating the spatial distribution of PM2.5 concentrations have been developed but have not yet been able to effectively include spatial correlation. We report on the development of a spatial back-propagation neural network (S-BPNN) model designed specifically to make such correlations implicit by incorpo...

journal_title：Scientific reports

authors： Wang W,Zhao S,Jiao L,Taylor M,Zhang B,Xu G,Hou H

更新日期：2019-09-24 00:00:00

abstract：:Fear of predation can induce profound changes in the behaviour and physiology of prey species even if predator encounters are infrequent. For echolocating toothed whales, the use of sound to forage exposes them to detection by eavesdropping predators, but while some species exploit social defences or produce cryptic a...

journal_title：Scientific reports

authors： Aguilar de Soto N,Visser F,Tyack PL,Alcazar J,Ruxton G,Arranz P,Madsen PT,Johnson M

更新日期：2020-02-06 00:00:00

abstract：:After injury to the mature central nervous system (CNS), myelin-derived inhibitory ligands bind to the Nogo-66 tripartite receptor complex expressed on axonal growth cones, comprised of LINGO-1 and p75NTR/TROY and induce growth cone collapse through the RhoA pathway. We have also shown that amphoterin-induced gene and...

journal_title：Scientific reports

authors： Almutiri S,Berry M,Logan A,Ahmed Z

更新日期：2018-07-16 00:00:00

abstract：:Macrophages and resident microglia play an import role in the secondary neuroinflammation response following spinal cord injury. Reprogramming of macrophage/microglia polarization is an import strategy for spinal cord injury restoration. Low-level laser therapy (LLLT) is a noninvasive treatment that has been widely us...

journal_title：Scientific reports

authors： Song JW,Li K,Liang ZW,Dai C,Shen XF,Gong YZ,Wang S,Hu XY,Wang Z

更新日期：2017-04-04 00:00:00

abstract：:A complete understanding of signaling processes at the plasma membrane depends on a quantitative characterization of the interactions of the involved proteins. Fluorescence recovery after photobleaching (FRAP) is a widely used and convenient technique to obtain kinetic parameters on protein interactions in living cell...

journal_title：Scientific reports

authors： Motsch V,Brameshuber M,Baumgart F,Schütz GJ,Sevcsik E

更新日期：2019-03-01 00:00:00

abstract：:A new approach for achieving two - dimensional (2D) atom localization microscopy based on the projection of three - dimensional (3D) localization in the plane of the detector is described in the present work. Spatial variation of the position-dependent 2D-localization pattern in the xy-plane is obtained with the shift...

journal_title：Scientific reports

authors： Dutta BK,Panchadhyayee P,Bayal I,Das N,Mahapatra PK

更新日期：2020-01-17 00:00:00

abstract：:New computer vision solutions combined with artificial intelligence algorithms can help recognize patterns in biological images, reducing subjectivity and optimizing the analysis process. The aim of this study was to propose an approach based on interactive and traditional machine learning methods to classify soybean ...

journal_title：Scientific reports

authors： de Medeiros AD,Capobiango NP,da Silva JM,da Silva LJ,da Silva CB,Dos Santos Dias DCF

更新日期：2020-07-09 00:00:00

abstract：:Influenza A and B viruses cause seasonal flu epidemics. The M2 protein of influenza B (BM2) is a membrane-embedded tetrameric proton channel that is essential for the viral lifecycle. BM2 is a functional analog of AM2 but shares only 24% sequence identity for the transmembrane (TM) domain. The structure and function o...

journal_title：Scientific reports

authors： Mandala VS,Liao SY,Gelenter MD,Hong M

更新日期：2019-03-06 00:00:00