Abstract：
:Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-22, IFN-γ, and TNF-α) and Tregs from 142 HCC patients. Patients with CTP class A had a significantly lower proportion of detectable IL-4 or IL-6, but a higher proportion of detectable IL-22 than patients with CTP class B/C. IL-6 level was well correlated with tumor stage and undetectable IL-17A was associated with extrahepatic metastasis. The overall survival rate was significantly higher in patients who had undetectable IL-6 or detectable IL-22 than patients who did not. IL-6 among cytokines remained independently predictive factor for survival. Increased IFN-γ/IL-10 ratio and no increase in IL-6 level following TACE were associated with prolonged survival, and baseline Tregs could affect Th1/Th2 balance. T cell cytokines are associated with a variety of clinical aspects of HCC, and IL-6 is the most significant predictor of survival. A shift toward increased Th1 response and no increase in IL-6 level exert favorable immunologic effects on HCC prognosis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee HL,Jang JW,Lee SW,Yoo SH,Kwon JH,Nam SW,Bae SH,Choi JY,Han NI,Yoon SKdoi
10.1038/s41598-019-40078-8subject
Has Abstractpub_date
2019-03-01 00:00:00pages
3260issue
1issn
2045-2322pii
10.1038/s41598-019-40078-8journal_volume
9pub_type
杂志文章abstract：:Indoor simulation experiment was carried out to evaluate the formation and consumption rates of methane (CH4) in Xiangxi Bay of the Three Gorges Reservoir (TGR), China. The results show that both the CH4 formation and consumption rates were significantly positively correlated with temperature. CH4 efflux decreased wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04449
更新日期：2014-03-24 00:00:00
abstract：:Lack of effective anti-metastatic drugs creates a major hurdle for metastatic lung cancer therapy. For successful lung cancer treatment, there is a strong need of newer therapeutics with metastasis-inhibitory potential. In the present study, we determined the anti-metastatic and anti-angiogenic potential of a natural ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21860
更新日期：2016-02-24 00:00:00
abstract：:Graphene and its analogs in combination with metal nanopowders are among the most promising catalysts for various industry valuable processes. The newly obtained solution combustion synthesized graphene-Cu and graphene-CuNi nanocomposites were examined in heterogeneous catalysis of thermal activated CO oxidation and p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72872-0
更新日期：2020-09-30 00:00:00
abstract：:Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49923-2
更新日期：2019-09-19 00:00:00
abstract：:Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79540-3
更新日期：2021-01-11 00:00:00
abstract：:Caterpillars have long been used as models for studying animal defence. Their impressive armour, including flamboyant warning colours, poisonous spines, irritating sprays, and mimicry of plant parts, snakes and bird droppings, has been extensively documented. But research has mainly focused on visual and chemical disp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31469
更新日期：2016-08-11 00:00:00
abstract：:Glutamate dehydrogenase (GDH) is a key enzyme interlinking carbon and nitrogen metabolism. Recent discoveries of the GDH specific role in breast cancer, hyperinsulinism/hyperammonemia (HI/HA) syndrome, and neurodegenerative diseases have reinvigorated interest on GDH regulation, which remains poorly understood despite...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73743-4
更新日期：2020-10-05 00:00:00
abstract：:The origin of (ferro)magnetic ordering in transition metal doped ZnO is a still open question. For applications it is fundamental to establish if it arises from magnetically ordered impurity clusters embedded into the semiconducting matrix or if it originates from ordering of magnetic ions dilute into the host lattice...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36336-w
更新日期：2019-01-16 00:00:00
abstract：:Endothelial and mesenchymal stromal cells (ECs/MSCs) are crucial components of hematopoietic bone marrow stem cell niches. Both cell types appear to be required to support the maintenance and expansion of multipotent hematopoietic cells, i.e. hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs). With the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49221-x
更新日期：2019-09-09 00:00:00
abstract：:Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) has a dimer of dimers quaternary structure with two independent allosteric sites in each monomer. Here, we reveal the different effects of nucleotide ligands on the quaternary structure regulation and functional role of the human m-NAD(P)-ME exosite. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45282-0
更新日期：2019-06-24 00:00:00
abstract：:The production of tuberous roots is usually reduced by vigorous vegetative growth because of the competition for resource between the vegetative parts and reproductive organs. In this study, we conducted root pruning to examine the vigorous vegetative growth by regulating root growth, subsequently limiting vegetative ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22586-1
更新日期：2018-03-13 00:00:00
abstract：:Persistent shortage and heterogeneous quality of liver grafts encourages the optimization of donor-recipient matching in liver transplantation (LT). We explored whether or not there was a survival benefit (SB) of LT according to the quality of grafts assessed by the Donor Quality Index (DQI) and recipients' disease se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60973-9
更新日期：2020-03-05 00:00:00
abstract：:The triple negative basal-like (TNBL) breast carcinoma is an aggressive and unfavorable prognosis disease. Inhibitors of poly(ADP-ribose) polymerase such as Olaparib could represent a promising targeted therapy but their sensitivity against Multidrug Resistance proteins (MDR), which causes resistance, is not well defi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12670
更新日期：2015-08-03 00:00:00
abstract：:Tolerance to Dutch elm disease (DED) has been linked to the rapid and/or high induction of disease-responsive genes after infection with the fungus Ophiostoma novo-ulmi. Although the fungal infection by O. novo-ulmi primarily takes places in xylem vessels, it is still unclear how xylem contributes to the defense again...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07779-4
更新日期：2017-08-02 00:00:00
abstract：:Conserving crop wild relatives (CWR) is critical for maintaining food security. However, CWR-focused conservation plans are lacking, and are often based on the entire genus, even though only a few taxa are useful for crop improvement. We used taxonomic and geographic prioritisation to identify the best locations for i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05247
更新日期：2014-06-17 00:00:00
abstract：:For the application of formic acid as a liquid organic hydrogen carrier, development of efficient catalysts for dehydrogenation of formic acid is a challenging topic, and most studies have so far focused on the composition of metals and supports, the size effect of metal nanoparticles, and surface chemistry of support...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33502
更新日期：2016-09-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42749-y
更新日期：2019-04-19 00:00:00
abstract：:Inbreeding can depress individuals' fitness traits and reduce population viability. However, studies that directly translate inbreeding depression on fitness traits into consequences for population viability, and further, into consequences for management choices, are lacking. Here, we estimated impacts of inbreeding d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79979-4
更新日期：2021-01-12 00:00:00
abstract：:Site-specific genome modification (SSM) is an important tool for mosquito functional genomics and comparative gene expression studies, which contribute to a better understanding of mosquito biology and are thus a key to finding new strategies to eliminate vector-borne diseases. Moreover, it allows for the creation of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43883
更新日期：2017-03-07 00:00:00
abstract：:Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential as...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep15300
更新日期：2015-10-16 00:00:00
abstract：:This study aims to identify promising biomarkers for the early detection of lung cancer and evaluate the prognosis of lung cancer patients. Genome-wide mRNA expression data obtained from the Gene Expression Omnibus (GSE19188, GSE18842 and GSE40791), including 231 primary tumor samples and 210 normal samples, were used...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08615-5
更新日期：2017-08-14 00:00:00
abstract：:The intermediate filament protein nestin is expressed during embryonic development, but considered largely restricted to areas of regeneration in the adult. Here, we perform a body-wide transcriptome and protein-profiling analysis to reveal that nestin is constitutively, and highly-selectively, expressed in adult huma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32859-4
更新日期：2018-10-02 00:00:00
abstract：:Carbon uptake by terrestrial ecosystems is increasing along with the rising of atmospheric CO2 concentration. Embedded in this trend, recent studies suggested that the interannual variability (IAV) of global carbon fluxes may be dominated by semi-arid ecosystems, but the underlying mechanisms of this high variability ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39748
更新日期：2016-12-23 00:00:00
abstract：:Light-sheet fluorescence microscopy has emerged as a powerful platform for 3-D volumetric imaging in the life sciences. Here, we introduce an important step towards its use deep inside biological tissue. Our new technique, based on digital holography, enables delivery of the light-sheet through a multimode optical fib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18050
更新日期：2015-12-14 00:00:00
abstract：:Fiber shaped supercapacitors are promising candidates for wearable electronics because they are flexible and light-weight. However, a critical challenge of the widespread application of these energy storage devices is their low cell voltages and low energy densities, resulting in limited run-time of the electronics. H...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26890
更新日期：2016-06-01 00:00:00
abstract：:Third permanent molars (M3s) are the last tooth to form but have not been used to estimate age at dental maturation in early fossil hominins because direct histological evidence for the timing of their growth has been lacking. We investigated an isolated maxillary M3 (SK 835) from the 1.5 to 1.8-million-year-old (Mya)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76032-2
更新日期：2020-11-04 00:00:00
abstract：:Tumor growth and metastasis are responsible for most cancer patients' deaths. Here, we report that eupolyphaga sinensis walker has an essential role in resisting hepatocellular carcinoma growth and metastasis. Compared with proliferation, colony formation, transwell assay and transplantable tumor in nude mouse in vitr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05518
更新日期：2014-07-01 00:00:00
abstract：:The Arabidopsis Tóxicos en Levadura (ATL) protein family is a class of E3 ubiquitin ligases with a characteristic RING-H2 Zn-finger structure that mediates diverse physiological processes and stress responses in plants. We carried out a genome-wide survey of grapevine (Vitis vinifera L.) ATL genes and retrieved 96 seq...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38260
更新日期：2016-12-02 00:00:00
abstract：:The use of engineered viral strains such as gene therapy vectors and oncolytic viruses (OV) to selectively destroy cancer cells is poised to make a major impact in the clinic and revolutionize cancer therapy. In particular, several studies have shown that OV therapy is safe and well tolerated in humans and can infect ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26786
更新日期：2016-05-26 00:00:00
abstract：:V2O5 based materials are attractive cathode alternatives due to the many oxidation state switches of vanadium bringing about a high theoretical specific capacity. However, significant capacity losses are eminent for crystalline V2O5 phases related to the irreversible phase transformations and/or vanadium dissolution s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07113
更新日期：2014-11-19 00:00:00
