Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization.

abstract：:Thin waveguides such as graded-index lenses and fiber bundles are often used as imaging probes for high-resolution endomicroscopes. However, strong back-reflection from the end surfaces of the probes makes it difficult for them to resolve weak contrast objects, especially in the reflectance-mode imaging. Here we propo...

journal_title：Scientific reports

authors： Yoon C,Kang M,Hong JH,Yang TD,Xing J,Yoo H,Choi Y,Choi W

更新日期：2017-07-26 00:00:00

abstract：:Multifunctional materials with more than two good properties are widely required in modern industries. However, some properties are often trade-off with each other by single microstructural designation. For example, nanostructured materials have high strength, but low ductility and thermal stability. Here by means of ...

journal_title：Scientific reports

authors： Zhang YS,Zhao YH,Zhang W,Lu JW,Hu JJ,Huo WT,Zhang PX

更新日期：2017-01-06 00:00:00

abstract：:Major depression (MDD) has been associated with an altered EEG frontal asymmetry measured in resting state; nevertheless, this association has showed a weak consistency across studies. In the present study, which starts from an evolutionistic view of psychiatric disorders, we investigated frontal asymmetry in MDD, usi...

journal_title：Scientific reports

authors： Spironelli C,Maffei A,Romeo Z,Piazzon G,Padovan G,Magnolfi G,Pasini I,Gomez Homen F,Concari G,Angrilli A

更新日期：2020-05-18 00:00:00

abstract：:The iron binding capacities (IBC) of fulvic acid (FA) and humic acid (HA) were determined in the salinity range from 5 to 40. The results indicated that IBC decreased while salinity increased. In addition, dissolved iron (dFe), FA and HA were also determined along the Yangtze River estuary's increasing salinity gradie...

journal_title：Scientific reports

authors： Yang R,Su H,Qu S,Wang X

更新日期：2017-05-03 00:00:00

abstract：:Thyroid hormone (TH) has long been believed to play a minor role in male reproduction. However, evidences from experimental model of thyrotoxicosis or hypothyroidism suggests its role in spermatogenesis. Cellular action of TH requires membrane transport via specific transporters such as monocarboxylate transporter 8 (...

journal_title：Scientific reports

authors： Bae HS,Jin YK,Ham S,Kim HK,Shin H,Cho GB,Lee KJ,Lee H,Kim KM,Koo OJ,Jang G,Lee JM,Lee JY

更新日期：2020-07-07 00:00:00

abstract：:The pathophysiology of stress cardiomyopathy (SCM), also known as takotsubo syndrome, is poorly understood. SCM usually occurs sporadically, often in association with a stressful event, but clusters of cases are reported after major natural disasters. There is some evidence that this is a familial condition. We have e...

journal_title：Scientific reports

authors： Lacey CJ,Doudney K,Bridgman PG,George PM,Mulder RT,Zarifeh JJ,Kimber B,Cadzow MJ,Black MA,Merriman TR,Lehnert K,Bickley VM,Pearson JF,Cameron VA,Kennedy MA

更新日期：2018-05-15 00:00:00

abstract：:The microwave properties of nano-scale structures are important in a wide variety of applications in quantum technology. Here we describe a low-power cryogenic near-field scanning microwave microscope (NSMM) which maintains nano-scale dielectric contrast down to the single microwave photon regime, up to 109 times lowe...

journal_title：Scientific reports

authors： Geaney S,Cox D,Hönigl-Decrinis T,Shaikhaidarov R,Kubatkin SE,Lindström T,Danilov AV,de Graaf SE

更新日期：2019-08-29 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a common health problem during pregnancy and its prevalence is increasing globally, especially in China. The aim of this study was to investigate socioeconomic, environmental and lifestyle factors associated with GDM in Chinese women. A matched pair case-control study was conduct...

journal_title：Scientific reports

authors： Carroll X,Liang X,Zhang W,Zhang W,Liu G,Turner N,Leeper-Woodford S

更新日期：2018-05-25 00:00:00

abstract：:Owing to the growing infectious diseases caused by eukaryotic and prokaryotic pathogens, it is urgent to develop novel antimicrobial agents against clinical pathogenic infections. Biofilm formation and invasion into the host cells are vital processes during pathogenic colonization and infection. In this study, we test...

journal_title：Scientific reports

authors： Yu Q,Li J,Zhang Y,Wang Y,Liu L,Li M

更新日期：2016-05-25 00:00:00

abstract：:This study aimed to detect the spatial distribution and high-risk clusters of female breast cancer mortality for the years 2011 to 2013 in Shandong Province, China. The urban-rural difference in the spatial distribution and clusters of disease mortality were also examined. Breast cancer mortality data were obtained fr...

journal_title：Scientific reports

authors： Chu J,Zhou C,Guo X,Sun J,Xue F,Zhang J,Lu Z,Fu Z,Xu A

更新日期：2017-03-07 00:00:00

abstract：:Little is known of how fungal distribution ranges vary with elevation. We studied fungal diversity and community composition from 740 to 2940 m above sea level on Mt. Norikura, Japan, sequencing the ITS2 region. There was a clear trend, repeated across each of the fungal phyla (Basidiomycota, Ascomycota, Zygomycota, C...

journal_title：Scientific reports

authors： Ogwu MC,Takahashi K,Dong K,Song HK,Moroenyane I,Waldman B,Adams JM

更新日期：2019-04-25 00:00:00

abstract：:The lipopolysaccharide (LPS)- toll-like receptor-4 (TLR4) pathway plays an important role in liver failure. Recombinant alkaline phosphatase (recAP) deactivates LPS. The aim of this study was to determine whether recAP prevents the progression of acute and acute-on-chronic liver failure (ACLF). Eight groups of rats we...

journal_title：Scientific reports

authors： Engelmann C,Adebayo D,Oria M,De Chiara F,Novelli S,Habtesion A,Davies N,Andreola F,Jalan R

更新日期：2020-01-15 00:00:00

abstract：:Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...

journal_title：Scientific reports

authors： Extramiana F,Milleron O,Elbitar S,Uccellini A,Langeois M,Spentchian M,Delorme G,Arnoult F,Denjoy I,Bouleti C,Fressart V,Iserin F,Maison-Blanche P,Abifadel M,Leenhardt A,Boileau C,Jondeau G

更新日期：2018-08-29 00:00:00

abstract：:Biomarkers reflecting the extent of Mycobacterium tuberculosis-induced pathology and normalization during anti-tuberculosis treatment (ATT) would considerably facilitate trials of new treatment regimens and the identification of patients with treatment failure. Therefore, in a cohort of 99 Indian children with intrath...

journal_title：Scientific reports

authors： Jenum S,Bakken R,Dhanasekaran S,Mukherjee A,Lodha R,Singh S,Singh V,Haks MC,Ottenhoff TH,Kabra SK,Doherty TM,Ritz C,Grewal HM

更新日期：2016-12-12 00:00:00

abstract：:Mesenchymal stromal cells (MSC) are used in cell therapies, however cellular senescence increases heterogeneity of cell populations and leads to uncertainty in therapies' outcomes. The determination of cellular senescence is time consuming and logistically intensive. Here, we propose the use of endogenous autofluoresc...

journal_title：Scientific reports

authors： Bertolo A,Baur M,Guerrero J,Pötzel T,Stoyanov J

更新日期：2019-02-14 00:00:00

abstract：:Recent parallel studies clearly indicated that Merkel cells and the mechanosensitive piezo2 ion channel play critical roles in the light-touch somatosensation. Moreover, piezo2 was suggested to be a light-touch sensing ion channel without a role in pain sensing in mammals. However, biophysical characteristics of piezo...

journal_title：Scientific reports

authors： Shin KC,Park HJ,Kim JG,Lee IH,Cho H,Park C,Sung TS,Koh SD,Park SW,Bae YM

更新日期：2019-04-23 00:00:00

abstract：:In this work, we use exact matrix diagonalization to explore the many-body localization (MBL) transitions in quantum Ising chains with disordered nearest-neighbour couplings, disordered next-nearest-neighbour couplings and disordered external fields. It is demonstrated that the fidelity can be used to characterize the...

journal_title：Scientific reports

authors： Hu T,Xue K,Li X,Zhang Y,Ren H

更新日期：2017-04-03 00:00:00

abstract：:This study aimed to examine the effect of transcutaneous electrical nerve stimulation (TENS) on stair climbing capacity in individuals with pre-radiographic to mild knee osteoarthritis (OA). This is a secondary analysis of data from a single, participant-blinded, randomized controlled trial with a pre-post design. Par...

journal_title：Scientific reports

authors： Iijima H,Eguchi R,Shimoura K,Yamada K,Aoyama T,Takahashi M

更新日期：2020-04-29 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit anti-HBV CTL activity in patients with chronic HBV infection (CHB). However, the ongoing anti-HBV CD8(+) T cell...

journal_title：Scientific reports

authors： Wang Y,Zhang Z,Ji D,Chen GF,Feng X,Gong LL,Guo J,Li ZW,Chen CF,Zhao BB,Li ZG,Li QJ,Yan HP,Sempowski G,Wang FS,He YW

更新日期：2015-07-22 00:00:00

abstract：:The sensory neurons in the olfactory epithelium (OSNs) are equipped with a large repertoire of olfactory receptors and the associated signal transduction machinery. In addition to the canonical OSNs, which express odorant receptors (ORs), the epithelium contains specialized subpopulations of sensory neurons that can d...

journal_title：Scientific reports

authors： Xavier AM,Ludwig RG,Nagai MH,de Almeida TJ,Watanabe HM,Hirata MY,Rosenstock TR,Papes F,Malnic B,Glezer I

更新日期：2016-05-05 00:00:00

abstract：:Electrochemically active bacteria (EAB) are ubiquitous in environment and have important application in the fields of biogeochemistry, environment, microbiology and bioenergy. However, rapid and sensitive methods for EAB identification and evaluation of their extracellular electron transfer ability are still lacking. ...

journal_title：Scientific reports

authors： Yuan SJ,He H,Sheng GP,Chen JJ,Tong ZH,Cheng YY,Li WW,Lin ZQ,Zhang F,Yu HQ

更新日期：2013-01-01 00:00:00

abstract：:Compromised activity of the DNA repair enzymes may raise the risk of a number of cancers. We analyzed polymorphisms in the Xeroderma Pigmentosum, Complementation Group C (XPC) gene for their correlation with urinary bladder cancer. Ala499Val and Lys939Gln polymorphisms were genotyped in 234 urinary bladder cancer case...

journal_title：Scientific reports

authors： Sankhwar M,Sankhwar SN,Bansal SK,Gupta G,Rajender S

更新日期：2016-06-01 00:00:00

abstract：:Mitochondrial genomes exhibit diverse features among eukaryotes in the aspect of gene content, genome structure, and the mobile genetic elements such as introns and plasmids. Although the number of published mitochondrial genomes is increasing at tremendous speed, those of several lineages remain unexplored. Here, we ...

journal_title：Scientific reports

authors： Nishimura Y,Shiratori T,Ishida KI,Hashimoto T,Ohkuma M,Inagaki Y

更新日期：2019-03-19 00:00:00

abstract：:We wanted to determine whether subjective sleep disturbance was associated with serum glycated hemoglobin (HbA1c) in people with type 2 diabetes mellitus. In total, 944 randomly-selected people with diabetes completed the Chinese version of the Pittsburgh Sleep Quality Index (PSQI). Participants' glycaemia was assesse...

journal_title：Scientific reports

authors： Xu C,Zhang P,Xiang Q,Chang G,Zhang M,Zhang L,Li T,Qiao C,Qin Y,Lou P

更新日期：2019-10-03 00:00:00

abstract：:The human transcription elongation factor DSIF is highly conserved throughout all kingdoms of life and plays multiple roles during transcription. DSIF is a heterodimer, consisting of Spt4 and Spt5 that interacts with RNA polymerase II (RNAP II). DSIF binds to the elongation complex and induces promoter-proximal pausin...

journal_title：Scientific reports

authors： Zuber PK,Hahn L,Reinl A,Schweimer K,Knauer SH,Gottesman ME,Rösch P,Wöhrl BM

更新日期：2018-08-03 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Acerbi A,van Leeuwen EJC,Haun DBM,Tennie C

更新日期：2019-04-17 00:00:00

abstract：:Phase estimation represents a crucial challenge in many fields of Physics, ranging from Quantum Metrology to Quantum Information Processing. This task is usually pursued by means of interferometric schemes, in which the choice of the input states and of the detection apparatus is aimed at minimizing the uncertainty in...

journal_title：Scientific reports

authors： Bina M,Allevi A,Bondani M,Olivares S

更新日期：2016-05-18 00:00:00

abstract：:Evaluating and tuning the properties of two-dimensional (2D) materials is a major focus of advancing 2D science and technology. While many claim that the photonic properties of a 2D layer provide evidence that the material is "high quality", this may not be true for electronic performance. In this work, we deconvolute...

journal_title：Scientific reports

authors： Zhang K,Borys NJ,Bersch BM,Bhimanapati GR,Xu K,Wang B,Wang K,Labella M,Williams TA,Haque MA,Barnard ES,Fullerton-Shirey S,Schuck PJ,Robinson JA

更新日期：2017-12-05 00:00:00

abstract：:The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental pathophysiology of diabe...

journal_title：Scientific reports

authors： Lee CS,Kim YG,Cho HJ,Park J,Jeong H,Lee SE,Lee SP,Kang HJ,Kim HS

更新日期：2016-07-06 00:00:00

abstract：:With the development of ultra-intense laser technology, MeV ions can be obtained from laser-foil interactions in the laboratory. These energetic ion beams can be applied in fast ignition for inertial confinement fusion, medical therapy, and proton imaging. However, these ions are mainly accelerated in the laser propag...

journal_title：Scientific reports

authors： Wang W,Shen B,Zhang X,Zhang L,Shi Y,Xu Z

更新日期：2015-02-05 00:00:00