Abstract:
:This prospective, single-blind, randomized study was designed to evaluate the effect of genotype-based warfarin dosing compared with standard warfarin dosing in Korean patients with mechanical cardiac valves. Patients were assigned to either the genotype-based dosing group or the standard dosing group using stratified block randomization. The genotype-based dosing equation was adopted from a previous study which included VKORC1 rs9934438, CYP2C9 rs1057910, CYP4F2 rs2108622, and age. Primary outcomes included the percentage of time in the therapeutic range (pTTR): (i) during the first week following initiation of warfarin therapy, (ii) during hospitalization and (iii) until the first outpatient visit. A total of 91 patients were included in the analysis, 42 treated with genotype-based warfarin dosing and 49 treated with standard warfarin dosing. The genotype frequency differences of the three SNPs included in this study (ie, VKORC1, CYP2C9, CYP4F2), between the genotype-based dosing and standard dosing groups were not different. The genotype-based dosing group trended toward higher pTTR when compared with the standard dosing group, although this difference was not statistically significant. In patients with aortic valve replacement, TTRTraditional and TTRRosendaal were significantly higher in the genotype-based dosing group when compared with the standard dosing group during the first week following treatment initiation [ie, 58.5% vs. 38.1% (p = 0.009) and 64.0% vs. 44.6% (p = 0.012), respectively]. Based on the results, the genotype-guided dosing did not offer a significant clinical advantage, but a possible benefit in patients with aortic valve replacement has been suggested.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee KE,Yee J,Lee GY,Chung JE,Seong JM,Chang BC,Gwak HSdoi
10.1038/s41598-020-63985-7subject
Has Abstractpub_date
2020-04-24 00:00:00pages
6988issue
1issn
2045-2322pii
10.1038/s41598-020-63985-7journal_volume
10pub_type
杂志文章,随机对照试验abstract::Crypt neurons are a third type of olfactory receptor neurons with a highly unusual "one cell type--one receptor" mode of expression, the same receptor being expressed by the entire population of crypt neurons. Attempts to identify the target region(s) of crypt neurons have been inconclusive so far. We report that TrkA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02063
更新日期:2013-01-01 00:00:00
abstract::Living organisms dynamically and flexibly operate a great number of components. As one of such redundant control mechanisms, low-dimensional coordinative structures among multiple components have been investigated. However, structures extracted from the conventional statistical dimensionality reduction methods do not ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53187-1
更新日期:2019-11-14 00:00:00
abstract::Antibody phage display has been pivotal in the quest to generate human monoclonal antibodies for biomedical and research applications. Target antigen preparation is a main bottleneck associated with the panning process. This includes production complexity, downstream purification, quality and yield. In many instances,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42628-6
更新日期:2019-04-15 00:00:00
abstract::The lack of bone morphological markers associated with the human control of wild animals has prevented the documentation of incipient animal domestication in archaeology. Here, we assess whether direct environmental changes (i.e. mobility reduction) could immediately affect ontogenetic changes in long bone structure, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75496-6
更新日期:2020-11-04 00:00:00
abstract::When coming to identify new 2D materials, our intuition would suggest us to look from layered instead of 3D materials. However, since graphite can be hypothetically derived from diamond by stretching it along its [111] axis, many 3D materials can also potentially be explored as new candidates for 2D materials. Using a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24660
更新日期:2016-04-19 00:00:00
abstract::Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79393-w
更新日期:2021-01-13 00:00:00
abstract::Sensory development of the human brain begins prenatally, allowing cortical auditory responses to be recorded at an early age in preterm infants. Despite several studies focusing on the temporal characteristics of preterm infants' cortical responses, few have been conducted on frequency analysis of these responses. In...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47064-0
更新日期:2019-07-23 00:00:00
abstract::Only a few previous studies have investigated paraspinal musculature (i.e., multifidus (MF), psoas major (PSM), erector spinae (ES)) in longitudinal, population-based settings. This study aimed to evaluate changes in the cross-sectional area (CSA) of the paraspinal muscles between the ages of 20 and 30 years. The stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56186-4
更新日期:2019-12-20 00:00:00
abstract::Nano-scale investigations of bainitic structures formed at temperatures below 350 °C have shown that the bainitic ferrite lattice is super-saturated in carbon. A high density of intrinsic defects would be playing a part in the carbon-supersaturation levels detected. In this work, the role of C-vacancy complexes on car...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57469-x
更新日期:2020-01-16 00:00:00
abstract::Sufficient tissue oxygenation is required for regular brain function; thus oxygen supply must be tightly regulated to avoid hypoxia and irreversible cell damage. If hypoxia occurs the transcription factor complex hypoxia-inducible factor (HIF) will accumulate and coordinate adaptation of cells to hypoxia. However, eve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75838-4
更新日期:2020-11-05 00:00:00
abstract::This study was initiated to improve E. coli succinate production by engineering the E. coli global transcription factor, Cra (catabolite repressor/activator). Random mutagenesis libraries were generated through error-prone PCR of cra. After re-screening and mutation site integration, the best mutant strain was Tang154...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36526
更新日期:2016-11-04 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-59761-2
更新日期:2020-02-11 00:00:00
abstract::SIRT1 is one of seven mammalian homologs of Sir2 that catalyzes NAD(+)-dependent protein deacetylation. The aim of the present study is to explore the effect of SIRT1 small molecule activator on the anticancer activity and the underlying mechanism. We examined the anticancer activity of a novel oral agent, curcumin, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13429
更新日期:2015-08-24 00:00:00
abstract::Urban coach cabin is an important indoor environment for long journey, formaldehyde (HCHO) is a carcinogenic gas and damages indoor air quality of cabins. In order to control the HCHO pollution, the air samples inside cabins were analysed with a thermally desorbed gas chromatograph, and the HCHO diffusion was simulate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57263-4
更新日期:2020-01-15 00:00:00
abstract::In the phytopathogenic basidiomycete Ustilago maydis, the Num1 protein has a pivotal function in hyphal morphogenesis. Num1 functions as a core component of the spliceosome-associated Prp19/CDC5 complex (NTC). The interaction of Num1 with the kinesin motor Kin1 suggests a connection between a component of the splicing...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21628-y
更新日期:2018-02-26 00:00:00
abstract::Apolipoprotein E4 (E4) and type 2 diabetes are major risk factors for cognitive decline and late onset Alzheimer's disease (AD). E4-associated phenotypes and insulin resistance (IR) share several features and appear to interact in driving cognitive dysfunction. However, shared mechanisms that could explain their overl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43701
更新日期:2017-03-08 00:00:00
abstract::Sacroiliac (SI) screw loosening may indicate persistent instability, non-union and contribute to pain. Yet, there is no reliable objective measurement technique to detect and monitor SI screw loosening. In 9 cadaveric pelvises one of two SI screw was turned back approximately 20 mm and subsequently assessed by optical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40052-4
更新日期:2019-02-28 00:00:00
abstract::How the human auditory system learns to map complex pinna-induced spectral-shape cues onto veridical estimates of sound-source elevation in the median plane is still unclear. Earlier studies demonstrated considerable sound-localisation plasticity after applying pinna moulds, and to altered vision. Several factors may ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36422-z
更新日期:2018-12-18 00:00:00
abstract::The endo-levanase BT1760 of a human gut commensal Bacteroides thetaiotaomicron randomly cuts a β-2,6-linked fructan, levan, into fructo-oligosaccharides providing a prebiotic substrate for gut microbiota. Here we introduce the crystal structure of BT1760 at resolution of 1.65 Å. The fold of the enzyme is typical for G...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44785-0
更新日期:2019-06-11 00:00:00
abstract::The Mont-Blanc massif, being iconic with its large glaciers and peaks of over 4,000 m, will experience a sharp increase in summer temperatures during the twenty-first century. By 2100, the impact of climate change on the cryosphere and hydrosphere in the Alps is expected to lead to a decrease in annual river discharge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67379-7
更新日期:2020-06-26 00:00:00
abstract::The present study investigated the treatment and survival outcomes of patients with synchronous primary esophageal squamous cell carcinoma and gastric adenocarcinoma. The medical records of 10,783 patients with primary esophageal squamous cancer treated at our institution between 1995 and 2012 were retrospectively rev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13335
更新日期:2015-08-20 00:00:00
abstract::Hologram memory is expected to be the next-generation of optical data storage technology. Bismuth-substituted yttrium iron garnet is typically used for rewritable magnetic hologram media. The diffraction efficiency of magnetic holography depends on the Faraday rotation angle, but the experimental diffraction efficienc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12442-z
更新日期:2017-10-09 00:00:00
abstract::We examined how plant-pollinator interactions were affected by time since habitat restoration and landscape connectivity by comparing plant-pollinator networks in restored, abandoned and continuously grazed semi-natural pastures in south-central Sweden. We measured richness of flowering plants and pollinators, and loc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51912-4
更新日期:2019-10-29 00:00:00
abstract::Natural sensory signals have nonlinear structures dynamically composed of the carrier frequencies and the variation of the amplitude (i.e., envelope). How the human brain processes the envelope information is still poorly understood, largely due to the conventional analysis failing to quantify it directly. Here, we us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53286-z
更新日期:2019-11-15 00:00:00
abstract::Liver disease is a leading cause of morbidity and mortality worldwide. Recently, the liver non-parenchymal cells have gained increasing attention for their potential role in the development of liver disease. Liver sinusoidal endothelial cells (LSECs), a specialized type of endothelial cells that have unique morphology...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32103-z
更新日期:2018-10-02 00:00:00
abstract::Because of the unique selection rule, hyper-Raman scattering (HRS) can provide spectral information that linear Raman and infrared spectroscopy cannot obtain. However, the weak signal is the key bottleneck that restricts the application of HRS technique in study of the molecular structure, surface or interface behavio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30331-x
更新日期:2018-08-08 00:00:00
abstract::We measured the magnitude of submarine fresh groundwater discharge (SFGD) and associated nutrient inputs to Jocheon harbor, on Jeju Island, Korea, during four sampling periods, in order to determine the link between SFGD and Ulva sp. green tide development. Good correlations among salinity, 222Rn, and dissolved inorga...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06711-0
更新日期:2017-07-24 00:00:00
abstract::p53 and aldehyde dehydrogenase (ALDH) have been implicated in key tumorigenesis processes including cancer initiating cell (CIC) maintenance; however, the relationship between these two mediators remains poorly defined. In this study, ALDH isoform expression diversity was revealed in CICs with disparate p53 functional...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57758-5
更新日期:2020-01-23 00:00:00
abstract::The renin-angiotensin system is known to regulate blood pressure as well as water- and electrolyte balance. An activated RAS is involved in the development of hypertension and hypertension-related organ damage. Thus, inhibitors of the RAS are protective and markedly increasing the life span of patients. In contrast, r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76712-z
更新日期:2020-11-12 00:00:00
abstract::This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the li...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71089-5
更新日期:2020-08-26 00:00:00