Abstract：
:BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to understand the prevalence of BKV infection and identified of BKV various strains in the urine of liver transplant recipients. There was not significant difference of renal outcome between high BKV viruria and low BKV viruria in the liver transplant recipients. The WW-non-coding control region (NCCR) BKV detected in urine was associated with higher urinary BKV load, whereas the Dunlop-NCCR BKV was detected in the urine of low urinary BKV load. An in vitro cultivation system demonstrated that WW-BKV strain exhibiting the higher viral DNA replication efficiency and higher BKV load. Altogether, this is the first study to demonstrate the impact of BKV strains on the occurrence of BK viruria in the liver transplant recipients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang RY,Li YJ,Lee WC,Wu HH,Lin CY,Lee CC,Chen YC,Hung CC,Yang CW,Tian YCdoi
10.1038/srep28491subject
Has Abstractpub_date
2016-06-24 00:00:00pages
28491issn
2045-2322pii
srep28491journal_volume
6pub_type
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