Abstract:
:In resampling methods, such as bootstrapping or cross validation, a very similar computational problem (usually an optimization procedure) is solved over and over again for a set of very similar data sets. If it is computationally burdensome to solve this computational problem once, the whole resampling method can become unfeasible. However, because the computational problems and data sets are so similar, the speed of the resampling method may be increased by taking advantage of these similarities in method and data. As a generic solution, we propose to learn the relation between the resampled data sets and their corresponding optima. Using this learned knowledge, we are then able to predict the optima associated with new resampled data sets. First, these predicted optima are used as starting values for the optimization process. Once the predictions become accurate enough, the optimization process may even be omitted completely, thereby greatly decreasing the computational burden. The suggested method is validated using two simple problems (where the results can be verified analytically) and two real-life problems (i.e., the bootstrap of a mixed model and a generalized extreme value distribution). The proposed method led on average to a tenfold increase in speed of the resampling method.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mestdagh M,Verdonck S,Duisters K,Tuerlinckx Fdoi
10.1038/srep16970subject
Has Abstractpub_date
2015-11-24 00:00:00pages
16970issn
2045-2322pii
srep16970journal_volume
5pub_type
杂志文章abstract::We propose a scheme of designing polygonal rotator with homogenous materials by using linear coordinate transformation. Our strategy is available for both time-harmonic electromagnetic field case and static field case. In particular, we found that only one anisotropic material is needed in static field case, and the d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51637-4
更新日期:2019-10-22 00:00:00
abstract::Thermal management and simulation are becoming increasingly important in many areas of engineering applications. There are three cooling routes for thermal management, namely thermal conduction, thermal convection and thermal radiation, among which the first two approaches have been widely studied and applied, while t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21020-w
更新日期:2018-02-08 00:00:00
abstract::The polychaetous annelid Neanthes acuminata complex has a widespread distribution, with the California population referred to as N. arenaceodentata. The reproductive pattern in this complex is unique, in that the female reproduces once and then dies, whereas the male can reproduce up to nine times. The male incubates ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13561
更新日期:2015-09-04 00:00:00
abstract::Plant height (PH) is a key factor in maize (Zea mays L.) yield, biomass, and plant architecture. We investigated the PH of diverse maize inbred lines (117 temperate lines, 135 tropical lines) at four growth stages using unmanned aerial vehicle high-throughput phenotypic platforms (UAV-HTPPs). We extracted PH data usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39448-z
更新日期:2019-03-05 00:00:00
abstract::Globally, a small percentage of oil is recovered from reservoirs using primary and secondary recovery mechanisms, and thus a major focus of the oil industry is toward developing new technologies to increase recovery. Many new technologies utilize surfactants, macromolecules, and even nanoparticles, which are difficult...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11816-7
更新日期:2017-09-14 00:00:00
abstract::Breast cancer is a heterogeneous disease consisting of several subtypes. Among these subtypes, triple negative breast cancer is particularly difficult to treat. This is due to a lack of understanding of the mechanisms behind the disease, and consequently a lack of druggable targets. PAK4 plays critical roles in cell s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42555
更新日期:2017-02-15 00:00:00
abstract::The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61111-1
更新日期:2020-03-09 00:00:00
abstract::Nucleosome not only directly affects cellular processes, such as DNA replication, recombination, and transcription, but also severs as a fundamentally important target of epigenetic modifications. Our previous study indicated that the bending property of DNA is important in nucleosome formation, particularly in predic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27247-x
更新日期:2018-06-11 00:00:00
abstract::The adipokines chemerin and omentin-1 have been suggested to influence cardiovascular function. The study aimed to investigate the longitudinal association between chemerin, omentin-1 concentrations and risk of incident heart failure (HF), respectively. We conducted a case-cohort study nested within the European Prosp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14518-2
更新日期:2017-10-26 00:00:00
abstract::Magnetotactic bacteria biomineralize ordered chains of uniform, membrane-bound magnetite or greigite nanocrystals that exhibit nearly perfect crystal structures and species-specific morphologies. Transmission electron microscopy (TEM) is a critical technique for providing information regarding the organization of cell...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06854
更新日期:2014-10-31 00:00:00
abstract::Cellular clearance mechanisms including the autophagy-lysosome pathway are impaired in amyotrophic lateral sclerosis (ALS). One of the most important proteins involved in the regulation of autophagy is the lysosomal Ca2+ channel Mucolipin TRP channel 1 (TRPML1). Therefore, we investigated the role of TRPML1 in a neuro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46708-5
更新日期:2019-07-24 00:00:00
abstract::Clostridioides difficile is the leading cause of nosocomial infections and a worldwide urgent public health threat. Without doubt, there is an urgent need for new effective anticlostridial agents due to the increasing incidence and severity of C. difficile infection (CDI). The aim of the present study is to investigat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64882-9
更新日期:2020-05-07 00:00:00
abstract::We have found a stable spin-structure of N [Formula: see text] 3 system in which three spin-3 atoms are trapped and coupled to total spin S [Formula: see text] 3. We have proved that a pair of this structure is nearly an exact solution for N [Formula: see text] 6 systems in a very broad district in the parameter-space...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81133-7
更新日期:2021-01-19 00:00:00
abstract::Visceral adiposity index (VAI) has been associated with various cardio-metabolic diseases; however, there is limited information about its association with cerebrovascular diseases. In this study, we evaluated the relationship between VAI and silent brain infarct (SBI). We evaluated a consecutive series of healthy vol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74454-6
更新日期:2020-10-14 00:00:00
abstract::Comprehensive and accurate characterization of brain metabolome is fundamental to brain science, but has been hindered by technical limitations. We profiled the brain metabolome in male Wistar rats at different ages (day 1 to week 111) using high-sensitivity and high-resolution mass spectrometry. Totally 380 metabolit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24125
更新日期:2016-04-11 00:00:00
abstract::Giardia is a worldwide spread protozoan parasite colonizing in small intestines of vertebrates, causing Giardiasis. The controversy about whether it is an extremely primitive eukaryote or just a highly evolved parasite has become a fetter to its uses as a model for both evolutionary and parasitological studies for yea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10054-1
更新日期:2017-08-25 00:00:00
abstract::We aimed to investigate the association of smoking and physical exercise on ventricular function and structure, determined by cardiac magnetic resonance imaging (CMR), in subjects without known cardiovascular diseases. A total of 381 participants (median age 57 years) of the Cooperative Health Research in the Region o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54956-8
更新日期:2019-12-09 00:00:00
abstract::Several studies have reported that weight control is of paramount importance in reducing the risk of metabolic syndrome. Nevertheless, this well-known association does not provide any practical information on how much weight loss in a given period would reduce the risk of metabolic syndrome in individuals in a persona...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67238-5
更新日期:2020-06-19 00:00:00
abstract::During bacterial infections, damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) activate immune cells. Here, we investigated whether plasma and sputum levels of High Mobility Group Box 1 (HMGB1), a prototypic DAMP, are associated with disease severity and aetiology in commu...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-018-31504-4
更新日期:2018-09-07 00:00:00
abstract::We aimed to investigate the efficacy and safety of primary retropupillary iris claw intraocular lens (R-IOL) implantation in patients with complete intraocular lens (IOL) dislocation. In this single-center retrospective case series, we reviewed the medical records of patients who underwent R-IOL implantation surgery w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80292-3
更新日期:2021-01-12 00:00:00
abstract::The ability to process time on the scale of milliseconds and seconds is essential for behaviour. A growing number of studies have started to focus on brain dynamics as a mechanism for temporal encoding. Although there is growing evidence in favour of this view from computational and in vitro studies, there is still a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46053
更新日期:2017-04-10 00:00:00
abstract::Accumulating evidence implies that both AKT1 and GABAA receptor (GABAAR) subunit genes are involved in schizophrenia pathogenesis. Activated Akt promotes GABAergic neuron differentiation and increases GABAAR expression on the plasma membrane. To elucidate the role of Akt1 in modulating GABAergic functions and schizoph...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33095
更新日期:2016-09-12 00:00:00
abstract::Dental caries is an important public health problem worldwide. This study aims to prove how preventive therapies reduce the onset of caries in adult patients, and to identify patients with high or low risk of caries by using Classification and Regression Trees based survival analysis (survival CART). A clinical data s...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/srep29190
更新日期:2016-07-06 00:00:00
abstract::This study reports atomic-scale characterization of structural defects in Yb2Ti2O7, a pyrochlore oxide whose subtle magnetic interactions is prone to small perturbations. Due to discrepancies in the reported magnetic ground states, it has become a pressing issue to determine the nature of defects in this system. In th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35283-w
更新日期:2018-11-21 00:00:00
abstract::Stem cell therapy has long been considered a promising mode of treatment for many incurable diseases. Human mesenchymal stem cells (hMSCs) have provided the most promising results to date for regenerative medicine. Nevertheless, due to several obstacles such as difficulty in sourcing and characterizing hMSCs, they rem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42669-x
更新日期:2019-04-16 00:00:00
abstract::Plasmonically enhanced metal-insulator-metal (MIM) type structures are popular among perfect absorbers and photodetectors in which the field enhancement (for increased absorption) mechanism is directly coupled with collection (photocurrent) processes. In this work we propose a device structure that decouples absorptio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42349
更新日期:2017-02-09 00:00:00
abstract::Landscape's spatial structure has vast implications for the dynamics and distribution of species populations and ecological communities. However, the characterization of the structure of spatial networks has not received nearly as much attention as networks of species interactions counterparts. Recent experiments show...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65669-8
更新日期:2020-05-26 00:00:00
abstract::Caveolins are essential structural proteins driving the formation of caveolae, specialized invaginations of the plasma membrane. Loss of Caveolin-1 (Cav1) function in mice causes distinct neurological phenotypes leading to impaired motor control, however, the underlying developmental mechanisms are largely unknown. In...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73429-x
更新日期:2020-10-05 00:00:00
abstract::The variation in energy bandgaps of amorphous oxide semiconducting SiZnSnO (a-SZTO) has been investigated by controlling the oxygen partial pressure (Op). The systematic change in Op during deposition has been used to control the electrical characteristics and energy bandgap of a-SZTO. As Op increased, the electrical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55807-2
更新日期:2019-12-17 00:00:00
abstract::Nanocrystals of Ln3+ (Ln = Yb, Tm and Ho) doped β-NaLuF4 with average diameter about 200 nm are dispersed in silica-based microtube (MT) by a simple flame heating method. The fabricated microtube has a diameter range from 2 μm to 30 μm and lengths up to hundreds microns. The fluorescence of upconversion nanocrystals (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35941
更新日期:2016-10-25 00:00:00