Abstract：
:During bacterial infections, damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) activate immune cells. Here, we investigated whether plasma and sputum levels of High Mobility Group Box 1 (HMGB1), a prototypic DAMP, are associated with disease severity and aetiology in community-acquired pneumonia (CAP). In addition, in patients with pneumococcal CAP, the impact of the level of sputum lytA DNA load, a PAMP, was investigated. We studied patients hospitalised for bacterial CAP (n = 111), and samples were collected at admission. HMGB1 was determined by enzyme-linked immunosorbent assays, and pneumococcal lytA DNA load was determined by quantitative polymerase chain reaction. Plasma and sputum HMGB1 levels did not correlate to disease severity (pneumonia severity index or presence of sepsis), but high sputum HMGB1 level was correlated to pneumococcal aetiology (p = 0.002). In pneumococcal pneumonia, high sputum lytA DNA load was associated with respiratory failure (low PaO2/FiO2 ratio; p = 0.019), and high sputum HMGB1 level was associated with bacteraemia (p = 0.006). To conclude, high sputum HMGB1 was not associated with severe disease, but with pneumococcal bacteraemia, indicating a potential role for HMGB1 in bacterial dissemination. High sputum lytA was associated with severe disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Alpkvist H,Athlin S,Mölling P,Norrby-Teglund A,Strålin Kdoi
10.1038/s41598-018-31504-4subject
Has Abstractpub_date
2018-09-07 00:00:00pages
13428issue
1issn
2045-2322pii
10.1038/s41598-018-31504-4journal_volume
8pub_type
临床试验,杂志文章abstract：:Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative phenotypic states. Integrins are a class of transmembrane proteins that have been implicated as novel therapeutic targets for asthma treatment. We previously showed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46260-2
更新日期：2019-07-09 00:00:00
abstract：:This study demonstrated the usefulness of radiomic features based on the Hessian index of differential topology for the prediction of prognosis prior to treatment in head-and-neck (HN) cancer patients. The Hessian index, which can indicate tumor heterogeneity with convex, concave, and other points (saddle points), was...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78338-7
更新日期：2020-12-04 00:00:00
abstract：:In this paper, we present the design, fabrication and optical characterization of computer-generated holograms (CGH) encoding information for light beams carrying orbital angular momentum (OAM). Through the use of a numerical code, based on an iterative Fourier transform algorithm, a phase-only diffractive optical ele...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18147-7
更新日期：2017-12-21 00:00:00
abstract：:The most consistent sex differences in cognition are found for spatial ability, in which males, on average, outperform females. Utilizing a twin design, two studies have shown that females with male co-twins perform better than females with female co-twins on a mental rotation task. According to the Twin Testosterone ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31704-y
更新日期：2018-09-12 00:00:00
abstract：:Silver nanoparticles (AgNPs) have been extensively used and are considered as an emerging contaminant in the ocean. The environmental contamination of AgNPs is expected to increase greatly over time, and cetaceans, as the top ocean predators, will suffer the negative impacts of AgNPs. In the present study, we investig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23737-0
更新日期：2018-04-04 00:00:00
abstract：:Addiction to cocaine and other psychostimulants represents a major public health crisis. The development and persistence of addictive behaviors comes from a complex interaction of genes and environment - the precise mechanisms of which remain elusive. In recent years a surge of evidence has suggested that the gut micr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35455
更新日期：2016-10-18 00:00:00
abstract：:Deconvolution is widely used to improve the contrast and clarity of a 3D focal stack collected using a fluorescence microscope. But despite being extensively studied, deconvolution algorithms can introduce reconstruction artifacts when their underlying noise models or priors are violated, such as when imaging biologic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29768-x
更新日期：2018-07-31 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23597-8
更新日期：2018-04-11 00:00:00
abstract：:The identification of clinically-relevant early diagnostic and prognostic protein biomarkers is essential to maximize therapeutic efficacy and prevent cancer progression. The aim of the current study is to determine whether aberrant plasma protein profile can be applied as a surrogate tool for early diagnosis of bladd...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67929-z
更新日期：2020-07-03 00:00:00
abstract：:Non-fibrillar protein aggregates that appear in the earlier stages of amyloid fibril formation are sometimes considered to play a key role in amyloid nucleation; however, the structural features of these aggregates currently remain unclear. We herein identified a characteristic pathway of fibril formation by human ins...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18390-y
更新日期：2018-01-08 00:00:00
abstract：:The possibility of cluster radioactivity (CR) of the neutron-deficient nuclei in the trans-tin region is explored by using the effective liquid drop model (ELDM), generalized liquid drop model (GLDM), and several sets of analytic formulas. It is found that the minimal half-lives are at Nd = 50 (Nd is the neutron numbe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65585-x
更新日期：2020-06-04 00:00:00
abstract：:Denitrification in coastal sediments can provide resilience to eutrophication in estuarine ecosystems, but this key ecosystem function is impacted directly and indirectly by increasing stressors. The erosion and loading of fine sediments from land, resulting in sedimentation and elevated sediment muddiness, presents a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54192-0
更新日期：2019-11-26 00:00:00
abstract：:The domestic dog (Canis familiaris) is a promising animal model. Yet, the canine neuroscience literature is predominantly comprised of studies wherein (semi-)invasive methods and intensive training are used to study awake dog behavior. Given prior findings with humans and/or dogs, our goal was to assess, in 16 family ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25546-x
更新日期：2018-05-08 00:00:00
abstract：:Among the biologically active triterpenes, friedelin has the most-rearranged structure produced by the oxidosqualene cyclases and is the only one containing a cetonic group. In this study, we cloned and functionally characterized friedelin synthase and one cycloartenol synthase from Maytenus ilicifolia (Celastraceae)....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36858
更新日期：2016-11-22 00:00:00
abstract：:All grain boundaries are not equal in their predisposition for fracture due to the complex coupling between lattice geometry, interfacial structure, and mechanical properties. The ability to understand these relationships is crucial to engineer materials resilient to grain boundary fracture. Here, a methodology is pre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08637-z
更新日期：2017-08-21 00:00:00
abstract：:Searching, defined for the purpose of the present study as the displacement of an individual to locate resources, is a fundamental behavior of all mobile organisms. In humans this behavior underlies many aspects of everyday life, involving cognitive processes such as sustained attention, memory and inhibition. We expl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19664
更新日期：2016-01-25 00:00:00
abstract：:Nanofluids using nanoencapsulated Phase Change Materials (nePCM) allow increments in both the thermal conductivity and heat capacity of the base fluid. Incremented heat capacity is produced by the melting enthalpy of the nanoparticles core. In this work two important advances in this nanofluid type are proposed and ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17841-w
更新日期：2017-12-14 00:00:00
abstract：:Individuals who are well integrated into society have greater access to resources and tend to live longer. Why some individuals are socially isolated and others are not is therefore puzzling from an evolutionary perspective. Answering this question requires establishing the mix of intrinsic and contextual factors that...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18104-4
更新日期：2017-12-19 00:00:00
abstract：:The genetic data of 17 Y chromosome short tandem repeats in 146 unrelated donor residents in the provinces of Granada, Málaga, and Almería (GMA) were analyzed to determine the genetic legacy of the male inhabitants of the former Kingdom of Granada. A total of 139 unique haplotypes were identified. Observed allele freq...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41580-9
更新日期：2019-03-26 00:00:00
abstract：:Current chemical markers based quality assessment methods largely fail to reflect intrinsic chemical complexity and multiple mechanisms of action of botanical drugs (BD). The development of novel quality markers is greatly needed. Here we propose bioactive chemical markers (BCM), defined as a group of chemo-markers th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02305-y
更新日期：2017-05-25 00:00:00
abstract：:The aim of this study was to develop a novel method to detect circulating histones H3 and H2B in plasma based on multiple reaction monitoring targeted mass spectrometry and a multiple reaction monitoring approach (MRM-MS) for its clinical application in critical bacteriaemic septic shock patients. Plasma samples from ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10830-z
更新日期：2017-09-06 00:00:00
abstract：:We have designed a new type of composite materials which not only has a Young's modulus much larger than the Voigt limit, but also is always nearly isotropic. Moreover, its Poisson's ratio can be designed at a desired value, e.g. positive, or negative, or zero. We have also demonstrated that structural hierarchy can h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14103
更新日期：2015-09-11 00:00:00
abstract：:Behavioural ecology research increasingly focuses on why genetic behavioural variation can persist despite selection. Evolutionary theory predicts that directional selection leads to evolutionary change while depleting standing genetic variation. Nevertheless, evolutionary stasis may occur for traits involved in socia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08258-6
更新日期：2017-08-31 00:00:00
abstract：:In sugarcane (Saccharum spp. hybrid) breeding, introgression of useful genes via intergeneric hybridization is a powerful strategy for improving the crop productivity. Erianthus arundinaceus shows great potential in terms of useful traits; however, little is known about the cytogenetic and agronomic characteristics of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38316-6
更新日期：2019-02-11 00:00:00
abstract：:Understanding the behaviour of humpback whale mother-calf pairs and the acoustic environment on their breeding grounds is fundamental to assessing the biological and ecological requirements needed to ensure a successful migration and survival of calves. Therefore, on a breeding/resting ground, Exmouth Gulf, Western Au...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36870-7
更新日期：2019-01-25 00:00:00
abstract：:Microbial secondary metabolites are valuable resources for novel drug discovery. In particular, actinomycetes expressed a range of antibiotics against a spectrum of bacteria. In genus level, strain Allosalinactinospora lopnorensis CA15-2(T) is the first new actinomycete isolated from the Lop Nor region, China. Antimic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20667
更新日期：2016-02-11 00:00:00
abstract：:We investigate temperature smearing effects on the electron-boson spectral density function (I(2)χ(ω)) obtained from optical data using a maximum entropy inversion method. We start with two simple model input I(2)χ(ω), calculate the optical scattering rates at selected temperatures using the model input spectral densi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23647
更新日期：2016-03-31 00:00:00
abstract：:Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome of the host as an important factor determining susceptibility to respiratory disease caused by RSV. We sequenced the complete exomes of 54 patients i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15752-4
更新日期：2017-11-21 00:00:00
abstract：:To date there are thirteen species validly assigned to the genus Anaerococcus. Most of the species in this genus are anaerobic and of human origin. Anaerococcus urinimassiliensis sp. nov., strain Marseille-P2143T is member of family Peptoniphilaceae, which was isolated from the urine of a 17-year-old boy affected by a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82420-z
更新日期：2021-01-29 00:00:00
abstract：:Induction of autophagy can have beneficial effects in several human diseases, e.g. cancer and neurodegenerative diseases (ND). Here, we therefore evaluated the potential of two novel autophagy-inducing compounds, i.e. STF-62247 and pimozide, to stimulate autophagy as well as autophagic cell death (ACD) using mouse emb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56990-y
更新日期：2020-01-20 00:00:00
