Abstract：
:Comprehensive and accurate characterization of brain metabolome is fundamental to brain science, but has been hindered by technical limitations. We profiled the brain metabolome in male Wistar rats at different ages (day 1 to week 111) using high-sensitivity and high-resolution mass spectrometry. Totally 380 metabolites were identified and 232 of them were quantitated. Compared with anatomical regions, age had a greater effect on variations in the brain metabolome. Lipids, fatty acids and amino acids accounted for the largest proportions of the brain metabolome, and their concentrations varied across the lifespan. The levels of polyunsaturated fatty acids were higher in infancy (week 1 to week 3) compared with later ages, and the ratio of omega-6 to omega-3 fatty acids increased in the aged brain (week 56 to week 111). Importantly, a panel of 20 bile acids were quantitatively measured, most of which have not previously been documented in the brain metabolome. This study extends the breadth of the mammalian brain metabolome as well as our knowledge of functional brain development, both of which are critically important to move the brain science forward.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zheng X,Chen T,Zhao A,Wang X,Xie G,Huang F,Liu J,Zhao Q,Wang S,Wang C,Zhou M,Panee J,He Z,Jia Wdoi
10.1038/srep24125subject
Has Abstractpub_date
2016-04-11 00:00:00pages
24125issn
2045-2322pii
srep24125journal_volume
6pub_type
杂志文章abstract：:Bacterial environmental and surgical site infection (SSI) surveillance was implemented from 2011-2016 in a UK Equine Referral Veterinary Hospital and identified 81 methicillin-resistant Staphylococcus aureus (MRSA) isolates. A cluster of MRSA SSIs occurred in early 2016 with the isolates confirmed as ST398 by multiloc...
journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2017-03-09 00:00:00
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更新日期：2020-01-21 00:00:00
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pub_type： 杂志文章
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更新日期：2016-09-26 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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更新日期：2015-05-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-01-17 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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