L-proline: a highly effective cryoprotectant for mouse oocyte vitrification.

Abstract:

:Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian oocyte vitrification. In this study we evaluated the efficiency and safety of the new cryoprotectant in oocyte vitrification. The results indicated that L-proline improves the survival rate of vitrified oocytes, protects mitochondrial functions and could be applied as a new cryoprotectant in mouse oocyte vitrification.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhang L,Xue X,Yan J,Yan LY,Jin XH,Zhu XH,He ZZ,Liu J,Li R,Qiao J

doi

10.1038/srep26326

subject

Has Abstract

pub_date

2016-07-14 00:00:00

pages

26326

issn

2045-2322

pii

srep26326

journal_volume

6

pub_type

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