Abstract:
:Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian oocyte vitrification. In this study we evaluated the efficiency and safety of the new cryoprotectant in oocyte vitrification. The results indicated that L-proline improves the survival rate of vitrified oocytes, protects mitochondrial functions and could be applied as a new cryoprotectant in mouse oocyte vitrification.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang L,Xue X,Yan J,Yan LY,Jin XH,Zhu XH,He ZZ,Liu J,Li R,Qiao Jdoi
10.1038/srep26326subject
Has Abstractpub_date
2016-07-14 00:00:00pages
26326issn
2045-2322pii
srep26326journal_volume
6pub_type
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