Humanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma.

abstract：:Proton irradiation is often used as a proxy for neutron irradiation but the irradiated layer is typically <50 μm deep; this presents a problem when trying to obtain mechanical test data as a function of irradiation level. Two novel methodologies have been developed to record stress-strain curves for thin proton-irradi...

journal_title：Scientific reports

authors： Smith AD,Donoghue JM,Garner AJW,Lunt D,Harte A,Wilford K,Withers PJ,Preuss M

更新日期：2020-03-24 00:00:00

abstract：:To investigate the influence of chemical weathering on CO2 consumption, an analysis was performed of water chemistry by applying water chemistry equilibria methods in the Bishuiyan subterranean basin, SW China. The average value of total ion concentrations (TZ+) was 1,854.97 μEq/L, which was significantly higher than ...

journal_title：Scientific reports

authors： Jiang P,Yu G,Zhang Q,Zou Y,Tang Q,Kang Z,Sytharith P,Xiao H

更新日期：2020-07-15 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Wang Y,Lan W,Yan Z,Gao J,Liu X,Wang S,Guo X,Wang C,Zhou H,Ding J,Cao C

更新日期：2020-02-26 00:00:00

abstract：:Isopods of the genus Idotea have an unusual ability to feed on algae containing high amounts of chemical defense molecules, such as species of the genera Fucus and Ulva. In this study, we compared gene expression patterns of Idotea balthica individuals fed with Fucus vesiculosus to individuals fed with Ulva lactuca. W...

journal_title：Scientific reports

authors： De Wit P,Yamada K,Panova M,André C,Johannesson K

更新日期：2018-11-14 00:00:00

abstract：:The phylogenetic characteristics of microbial communities associated with periodontitis have been well studied, however, little is known about the functional endowments of this ecosystem. The present study examined 73 microbial assemblages from 25 individuals with generalized chronic periodontitis and 25 periodontally...

journal_title：Scientific reports

authors： Dabdoub SM,Ganesan SM,Kumar PS

更新日期：2016-12-19 00:00:00

abstract：:Given that drug abuse and dependence are common reasons for hospitalization, we aimed to derive and validate a model allowing early identification of life-threatening hospital admissions for drug dependence or abuse. Using the French National Hospital Discharge Data Base, we extracted 66,101 acute inpatient stays for ...

journal_title：Scientific reports

authors： Nguyen TL,Boudemaghe T,Leguelinel-Blache G,Eiden C,Kinowski JM,Le Manach Y,Peyrière H,Landais P

更新日期：2017-03-14 00:00:00

abstract：:An accurate and efficient solution of the radiative transport equation is proposed for modeling the propagation of photons in the three-dimensional anisotropically scattering half-space medium. The exact refractive index mismatched boundary condition is considered and arbitrary rotationally invariant scattering functi...

journal_title：Scientific reports

authors： Liemert A,Kienle A

更新日期：2013-01-01 00:00:00

abstract：:Transgenic expression of I-E molecules prevents diabetes in NOD mice. So far, the precise role of these non-classical MHC II molecules remains elusive. Here, we showed that transgenic expression of I-E(k) alpha 16 molecule in NOD mice selectively reduced Th17 cells in the thymus and pancreatic draining lymph nodes. Th...

journal_title：Scientific reports

authors： Yang C,Guo N,Liu J,Yang J,Zhu K,Xiao H,Leng Q

更新日期：2015-08-07 00:00:00

abstract：:The aim of this study is to develop an internal-external correlation model for internal motion estimation for lung cancer radiotherapy. Deformation vector fields that characterize the internal-external motion are obtained by respectively registering the internal organ meshes and external surface meshes from the 4DCT i...

journal_title：Scientific reports

authors： Chen H,Zhong Z,Yang Y,Chen J,Zhou L,Zhen X,Gu X

更新日期：2018-02-27 00:00:00

abstract：:The Iberian Mediterranean Basin is home to one of the largest groups of prehistoric rock art sites in Europe. Despite the cultural relevance of prehistoric Spanish Levantine rock art, pigment composition remains partially unknown, and the nature of the binders used for painting has yet to be disclosed. In this work, w...

journal_title：Scientific reports

authors： Roldán C,Murcia-Mascarós S,López-Montalvo E,Vilanova C,Porcar M

更新日期：2018-07-03 00:00:00

abstract：:One of the main azole-resistance mechanisms in Candida pathogens is the upregulation of drug efflux pumps, which compromises the efficacy of azoles and results in treatment failure. The combination of azole-antifungal agents with efflux pump inhibitors represents a promising strategy to combat fungal infection. High-t...

journal_title：Scientific reports

authors： Xie F,Chang W,Zhang M,Li Y,Li W,Shi H,Zheng S,Lou H

更新日期：2016-09-21 00:00:00

abstract：:The sex ratio at birth (SRB) may be patterned by maternal condition and/or environmental stressors. However, despite decades of research, empirical results from across the social and biological sciences are equivocal on this topic. Using longitudinal individual-level data from a US population during the interwar perio...

journal_title：Scientific reports

authors： Schacht R,Tharp D,Smith KR

更新日期：2019-06-21 00:00:00

abstract：:The network structure of biological systems provides information on the underlying processes shaping their organization and dynamics. Here we examined the structure of the network depicting protein interactions within the spliceosome, the macromolecular complex responsible for splicing in eukaryotic cells. We show the...

journal_title：Scientific reports

authors： Pires MM,Cantor M,Guimarães PR,de Aguiar MA,Dos Reis SF,Coltri PP

更新日期：2015-10-07 00:00:00

abstract：:The objective of this study is to investigate the performance of a serpentine channel for acoustically driven selective particle filtering. The channel consists of sharp corners and straight sections, and the acoustic field is affecting the particles throughout the channel. A prototype of the separator channel is manu...

journal_title：Scientific reports

authors： Kandemir MH,Wagterveld RM,Yntema DR,Keesman KJ

更新日期：2019-05-09 00:00:00

abstract：:Drought episodes decrease plant growth and productivity, which in turn cause high economic losses. Plants naturally sense and respond to water stress by activating specific signalling pathways leading to physiological and developmental adaptations. Genetically engineering genes that belong to these pathways might impr...

journal_title：Scientific reports

authors： Roca Paixão JF,Gillet FX,Ribeiro TP,Bournaud C,Lourenço-Tessutti IT,Noriega DD,Melo BP,de Almeida-Engler J,Grossi-de-Sa MF

更新日期：2019-05-30 00:00:00

abstract：:Tolmetin is a non-steroidal anti-inflammatory drug being used to decrease the level of hormones which are the reasons for pain, swelling, tiredness, and stiffness for osteoarthritis and rheumatoid arthritis cases. We evaluated its solubility in supercritical carbon dioxide (SC-CO2) with the aim of drug nanonization, c...

journal_title：Scientific reports

authors： Pishnamazi M,Zabihi S,Sarafzadeh P,Borousan F,Marjani A,Pelalak R,Shirazian S

更新日期：2020-11-11 00:00:00

abstract：:The macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in inhibiting the growth of pathogenic Mycobacterium tuberculosis (M.tb) and regulates immune responses against M.tb pathogen. MIF -173 G > C gene polymorphism may affect immunity in an individual and leads to susceptibility to...

journal_title：Scientific reports

authors： Areeshi MY,Mandal RK,Dar SA,Jawed A,Wahid M,Lohani M,Panda AK,Mishra BN,Akhter N,Haque S

更新日期：2017-12-05 00:00:00

abstract：:Quantitative reverse transcription PCR (RT-qPCR) is one of the most efficient, reliable and widely used techniques to quantify gene expression. In this study, we evaluated the performance of six southern corn rootworm, Diabrotica undecimpunctata howardi (Barber), housekeeping genes (HKG), β-actin (Actin), β-tubulin (T...

journal_title：Scientific reports

authors： Basu S,Pereira AE,Pinheiro DH,Wang H,Valencia-Jiménez A,Siegfried BD,Louis J,Zhou X',Vélez AM

更新日期：2019-07-24 00:00:00

abstract：:Neuroinflammation in utero may result in life-long neurological disabilities. Microglia play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of microglia. We hypothesized that agonism on α7 nicotinic acetylcholine receptor (α7...

journal_title：Scientific reports

authors： Cortes M,Cao M,Liu HL,Moore CS,Durosier LD,Burns P,Fecteau G,Desrochers A,Barreiro LB,Antel JP,Frasch MG

更新日期：2017-09-06 00:00:00

abstract：:CIC-DUX4 sarcoma (CDS) is a group of rare, mesenchymal, small round cell tumours that harbour the unique CIC-DUX4 translocation, which causes aberrant gene expression. CDS exhibits an aggressive course and poor clinical outcome, thus novel therapeutic approaches are needed for CDS treatment. Although patient-derived c...

journal_title：Scientific reports

authors： Oyama R,Takahashi M,Yoshida A,Sakumoto M,Takai Y,Kito F,Shiozawa K,Qiao Z,Arai Y,Shibata T,Araki Y,Endo M,Kawai A,Kondo T

更新日期：2017-07-05 00:00:00

abstract：:Adipose tissue hyperplasia with increased number of adipocytes is implicated in a protective rather than deleterious effect on obesity-associated metabolic disorder. It is poorly understood how the adipose tissue cellularity is regulated. Tc1 is a gene of vertebrates that regulates diverse downstream genes. Young Tc1-...

journal_title：Scientific reports

authors： Jang H,Kim M,Lee S,Kim J,Woo DC,Kim KW,Song K,Lee I

更新日期：2016-10-24 00:00:00

abstract：:Kuding tea is implicated in alleviating metabolic disorders in traditional Chinese medicine. However, the role of Ilex latifolia Thunb (kuding tea), one of the large leaf kuding tea species, in the prevention of the development of obesity remains to be determined. We show here that 7-week-old male mice treated with an...

journal_title：Scientific reports

authors： Wu H,Chen YL,Yu Y,Zang J,Wu Y,He Z

更新日期：2017-11-07 00:00:00

abstract：:Nutritional supplements may be important on cognition but the evidence is heterogeneous. This meta-analysis aimed (1) to determine whether nutritional supplements provided to pregnant women or young children could improve cognitive development of children in developing countries, and (2) to explore how supplementation...

journal_title：Scientific reports

authors： Ip P,Ho FKW,Rao N,Sun J,Young ME,Chow CB,Tso W,Hon KL

更新日期：2017-09-06 00:00:00

abstract：:The chemiresistive thin film gas sensors with fast response, high sensitivity, low power consumption and mass-produced potency, have been expected for practical application. It requires both sensitive materials, especially exquisite nanomaterials, and efficient substrate chip for heating and electrical addressing. How...

journal_title：Scientific reports

authors： Dai Z,Xu L,Duan G,Li T,Zhang H,Li Y,Wang Y,Wang Y,Cai W

更新日期：2013-01-01 00:00:00

abstract：:In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible su...

journal_title：Scientific reports

authors： Boscá A,Pedrós J,Martínez J,Palacios T,Calle F

更新日期：2016-02-10 00:00:00

abstract：:The human cytomegalovirus developed distinct evasion mechanisms from the cellular antiviral response involving vMIA, a virally-encoded protein that is not only able to prevent cellular apoptosis but also to inhibit signalling downstream from mitochondrial MAVS. vMIA has been shown to localize at mitochondria and to tr...

journal_title：Scientific reports

authors： Magalhães AC,Ferreira AR,Gomes S,Vieira M,Gouveia A,Valença I,Islinger M,Nascimento R,Schrader M,Kagan JC,Ribeiro D

更新日期：2016-05-16 00:00:00

abstract：:This study aims to develop a prognostic risk prediction model for the development of silicosis among workers exposed to silica dust in China. The prediction model was performed by using retrospective cohort of 3,492 workers exposed to silica in an iron ore, with 33 years of follow-up. We developed a risk score system ...

journal_title：Scientific reports

authors： Tse LA,Dai J,Chen M,Liu Y,Zhang H,Wong TW,Leung CC,Kromhout H,Meijer E,Liu S,Wang F,Yu IT,Shen H,Chen W

更新日期：2015-06-19 00:00:00

abstract：:Prenatal skeletal muscle development genetically determines postnatal muscle characteristics such as growth and meat quality in pigs. However, the molecular mechanisms underlying prenatal skeletal muscle development remain unclear. Here, we performed the first genome-wide analysis of chimeric RNAs, single nuclear poly...

journal_title：Scientific reports

authors： Yang Y,Tang Z,Fan X,Xu K,Mu Y,Zhou R,Li K

更新日期：2016-06-29 00:00:00

abstract：:This work reports the first study of current-driven magnetization noise in a single, nanometerscale, ferromagnetic (Co) particle, attached to normal metal leads by high-resistance tunneling junctions. As the tunnel current increases at low temperature, the magnetic switching field decreases, its probability distributi...

journal_title：Scientific reports

authors： Jiang W,Birk FT,Davidović D

更新日期：2013-01-01 00:00:00

abstract：:We employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 lung adenocarcinomas and 156 normal lung tissues from 3 separate cohorts. We found that LINC00152 was highly overexpressed in lung tumors as compared to their adjacent normal tissues. Patients with high LINC00152 expression...

journal_title：Scientific reports

authors： Feng S,Zhang J,Su W,Bai S,Xiao L,Chen X,Lin J,Reddy RM,Chang AC,Beer DG,Chen G

更新日期：2017-06-07 00:00:00