Abstract:
:Several studies have reported that weight control is of paramount importance in reducing the risk of metabolic syndrome. Nevertheless, this well-known association does not provide any practical information on how much weight loss in a given period would reduce the risk of metabolic syndrome in individuals in a personalized setting. This study aimed to develop and validate a risk prediction model for metabolic syndrome in 2 years, based on an individual's baseline health status and body weight after 2 years. We recruited 3,447 and 3,874 participants from the Ansan and Anseong cohorts of the Korean Genome and Epidemiology Study, respectively. Among the former, 8636 longitudinal observations of 2,412 participants (70%) and 3,570 of 1,034 (30%) were used for training and internal validation, respectively. Among the latter, all 15,739 observations of 3,874 participants were used for external validation. Compared to logistic regression, Gaussian Naïve Bayes, random forest, and deep neural network, XGBoost showed the highest performance (area under curve of 0.879) and a significantly enhanced calibration of the predictive score with the prevalence rate. The model was ported onto an application to provide the 2-year probability of developing metabolic syndrome by simulating selected target body weights, based on an individual's baseline health profiles. Further prospective studies are required to determine whether weight-control programs could lead to favorable health outcomes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee S,Lee H,Choi JR,Koh SBdoi
10.1038/s41598-020-67238-5subject
Has Abstractpub_date
2020-06-19 00:00:00pages
10006issue
1issn
2045-2322pii
10.1038/s41598-020-67238-5journal_volume
10pub_type
杂志文章abstract::The effect of rotational disorder on the microwave transmission through thin metallic checkerboard arrays has been experimentally studied. Broad resonant features below the onset of diffraction, attributed to electromagnetic radiation coupling through the structure via the evanescent fields of bound surface waves, are...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16608
更新日期:2015-11-16 00:00:00
abstract::Degradation of the biologically potent octapeptide angiotensin Ang II-(1-8) is mediated by the activities of several peptidases. The conversion of Ang II to the septapeptide Ang-(1-7) is of particular interest as the latter also confers organ protection. The conversion is catalyzed by angiotensin-converting enzyme 2 a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45473
更新日期:2017-04-05 00:00:00
abstract::Aminopeptidases have emerged as new promising drug targets for the development of novel anti-parasitic drugs. An aspartyl aminopeptidase-like gene has been identified in the Toxoplasma gondii genome (TgAAP), although its function remains unknown. In this study, we characterized TgAAP and performed functional analysis ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34448
更新日期:2016-09-28 00:00:00
abstract::The spirochete Leptospira spp. can move in liquid and on a solid surface using two periplasmic flagella (PFs), and its motility is an essential virulence factor for the pathogenic species. Mammals are infected with the spirochete through the wounded dermis, which implies the importance of behaviors on the boundary wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70897-z
更新日期:2020-08-18 00:00:00
abstract::Here we present a set of measurements using Differential Scanning Fluorimetry (DSF) as an inexpensive, high throughput screening method to investigate the folding of silk protein molecules as they abandon their first native melt conformation, dehydrate and denature into their final solid filament conformation. Our fir...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05625
更新日期:2014-07-09 00:00:00
abstract::Bronchospasm compresses the bronchial epithelium, and this compressive stress has been implicated in asthma pathogenesis. However, the molecular mechanisms by which this compressive stress alters pathways relevant to disease are not well understood. Using air-liquid interface cultures of primary human bronchial epithe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57755-8
更新日期:2020-01-22 00:00:00
abstract::Herbal medicines usually contain a large group of chemical components, which may be transformed into more complex metabolites in vivo. In this study, we proposed a knowledge-transmitting strategy for metabolites identification of compound formulas. Gegen-Qinlian Decoction (GQD) is a classical formula in traditional Ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39534
更新日期:2016-12-20 00:00:00
abstract::Extracellular vesicles (EVs) have important roles in physiology, pathology, and more recently have been identified as efficient carriers of therapeutic cargoes. For efficient study of EVs, a single-step, rapid and scalable isolation strategy is necessary. Chromatography techniques are widely used for isolation of biol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24163-y
更新日期:2018-04-10 00:00:00
abstract::Silver nanobelts (AgNBs) have attracted a great interest due to their excellent electrical conductivity and mechanical strength, leading a facile synthesis of these AgNBs in great demand. In here, we are reporting a simple, aqueous phase, size tunable synthesis of smooth surfaced 1D-silver nanobelts using a Polyanilin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44796
更新日期:2017-03-20 00:00:00
abstract::Hologram memory is expected to be the next-generation of optical data storage technology. Bismuth-substituted yttrium iron garnet is typically used for rewritable magnetic hologram media. The diffraction efficiency of magnetic holography depends on the Faraday rotation angle, but the experimental diffraction efficienc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12442-z
更新日期:2017-10-09 00:00:00
abstract::Lipid droplet (LD)-associated hydrolase (LDAH) is a newly identified LD protein abundantly expressed in tissues that predominantly store triacylglycerol (TAG). However, how LDAH regulates TAG metabolism remains unknown. We found that upon oleic acid loading LDAH translocalizes from the ER to newly formed LDs, and indu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02963-y
更新日期:2017-06-02 00:00:00
abstract::The regular rise and fall of the sun resulted in the development of 24-h rhythms in virtually all organisms. In an evolutionary heartbeat, humans have taken control of their light environment with electric light. Humans are highly sensitive to light, yet most people now use light until bedtime. We evaluated the impact...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75622-4
更新日期:2020-11-05 00:00:00
abstract::As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to form biofilms on medical devices resulting in high mortality. Biofilms formed by C. albicans are a c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31124
更新日期:2016-08-08 00:00:00
abstract::Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12511
更新日期:2015-07-27 00:00:00
abstract::Different subtypes of bone marrow-derived stem cells are characterized by varying functionality and activity after transplantation into the infarcted heart. Improvement of stem cell therapeutics requires deep knowledge about the mechanisms that mediate the benefits of stem cell treatment. Here, we demonstrated that co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10122-6
更新日期:2017-08-29 00:00:00
abstract::Current research on the influence of environmental and physicochemical factors in shaping the soil bacterial structure has seldom been approached from a pedological perspective. We studied the bacterial communities of eight soils selected along a pedogenic gradient at the local scale in a Mediterranean calcareous moun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15133-x
更新日期:2017-11-06 00:00:00
abstract::Hybridization between heterospecific individuals has been documented as playing a direct role in promoting paternal leakage and mitochondrial heteroplasmy in both natural populations and laboratory conditions, by relaxing the egg-sperm recognition mechanisms. Here, we tested the hypothesis that hybridization can lead ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55764-w
更新日期:2019-12-16 00:00:00
abstract::Vascular leakage is a life-threatening complication of dengue virus (DENV) infection. Previously, association between "paracellular" endothelial hyperpermeability and plasma leakage had been extensively investigated. However, whether "transcellular" endothelial leakage is involved in dengue hemorrhagic fever (DHF) and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31855
更新日期:2016-08-22 00:00:00
abstract::Flavonoids are potential antibacterial agents. However, key substituents and mechanism for their antibacterial activity have not been fully investigated. The quantitative structure-activity relationship (QSAR) and molecular docking of flavonoids relating to potent anti-Escherichia coli agents were investigated. Compar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23634
更新日期:2016-04-06 00:00:00
abstract::SARS-CoV-2 can transmit efficiently in humans, but it is less clear which other mammals are at risk of being infected. SARS-CoV-2 encodes a Spike (S) protein that binds to human ACE2 receptor to mediate cell entry. A species with a human-like ACE2 receptor could therefore be at risk of being infected by SARS-CoV-2. We...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80573-x
更新日期:2021-01-18 00:00:00
abstract::The immune responses of males and females to bacterial infections display differences. The mechanisms that underlie this sexual dimorphism are multifactorial. Lipopolysaccharide (LPS) contributes to the pathogenesis of endotoxaemia. We have previously demonstrated that the plasma protein beta-2 glycoprotein-1 (β2GPI) ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07945-8
更新日期:2017-08-15 00:00:00
abstract::We have demonstrated a 45 μm core diameter Neodymium-doped all-solid silicate glass photonic crystal fiber laser with a single mode laser output. The structure parameters and modes information of the fiber are both demonstrated by theoretical calculations using Finite Difference Time Domain (FDTD) method and experimen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12547
更新日期:2015-07-24 00:00:00
abstract::We aim to evaluate the association of systolic and diastolic blood pressure (SBP and DBP) with estimated urinary sodium (Na) and potassium(K) excretions, and their gram-to-gram Na/K ratio across various salt-diet regions during 2005-2009 in China. A prospective cohort study was conducted to recruit 46,285 participants...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25097-1
更新日期:2018-04-30 00:00:00
abstract::Salt crystallization is a major cause of weathering of rocks, artworks and monuments. Damage can only occur if crystals continue to grow in confinement, i.e. within the pore space of these materials, thus generating mechanical stress. We report the direct measurement, at the microscale, of the force exerted by growing...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30856
更新日期:2016-08-05 00:00:00
abstract::Deriving cell populations from human embryonic stem cells (hESCs) for cell-based therapy is considered a promising strategy to achieve functional cells, yet its translation to clinical practice depends on achieving fully defined differentiated cells. In this work, we generated a miRNA-responsive lethal mRNA construct ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50899-2
更新日期:2019-10-10 00:00:00
abstract::The low-fear model of primary psychopathy has been supported by empirical findings such as attenuated physiological arousal in anticipation of threatening stimuli. The somatic marker hypothesis proposes that salient changes in the bodily state are processed as signals of whether a situation is good or bad and guide an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54676-z
更新日期:2019-12-02 00:00:00
abstract::Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally correct cartilage tissue when cultured. Thus, culture conditions, which enhance the maintenance of chondrocyte phenotype would be very useful for cartilage research...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03958-5
更新日期:2017-06-16 00:00:00
abstract::Obesity involves alterations in transcriptional programs that can change in response to genetic and environmental signals through chromatin modifications. Since chromatin modifications involve different biochemical, neurological and molecular signaling pathways related to energy homeostasis, we hypothesize that geneti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22231-x
更新日期:2018-03-02 00:00:00
abstract::Rice bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most destructive rice diseases worldwide. Therefore, in addition to breeding disease-resistant rice cultivars, it is desirable to develop effective biocontrol agents against Xoo. Here, we report that a soil bacterium Pseudomonas taiwanen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32950
更新日期:2016-09-08 00:00:00
abstract::Spatiotemporal tracking of tracer particles or objects of interest can reveal localized behaviors in biological and physical systems. However, existing tracking algorithms are most effective for relatively low numbers of particles that undergo displacements smaller than their typical interparticle separation distance....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23488-y
更新日期:2018-04-03 00:00:00