Compound to Extract to Formulation: a knowledge-transmitting approach for metabolites identification of Gegen-Qinlian Decoction, a traditional Chinese medicine formula.

abstract：:Enzymatic conversion of chitin, a β-1,4 linked polymer of N-acetylglucosamine, is of major interest in areas varying from the biorefining of chitin-rich waste streams to understanding how medically relevant fungi remodel their chitin-containing cell walls. Although numerous chitinolytic enzymes have been studied in de...

journal_title：Scientific reports

authors： Liu Z,Gay LM,Tuveng TR,Agger JW,Westereng B,Mathiesen G,Horn SJ,Vaaje-Kolstad G,van Aalten DMF,Eijsink VGH

更新日期：2017-05-11 00:00:00

abstract：:Stevia is a natural source of commercially important steviol glycosides (SGs), which share biosynthesis route with gibberellic acids (GAs) through plastidal MEP and cytosolic MVA pathways. Ontogeny-dependent deviation in SGs biosynthesis is one of the key factor for global cultivation of Stevia, has not been studied a...

journal_title：Scientific reports

authors： Singh G,Singh G,Singh P,Parmar R,Paul N,Vashist R,Swarnkar MK,Kumar A,Singh S,Singh AK,Kumar S,Sharma RK

更新日期：2017-09-19 00:00:00

abstract：:The relationship between the grain size of as-cast and cold rolled 16%Cr ferritic stainless steel and the surface roughness defect, called ridging during forming was investigated. The ridging height corresponded to the grain size of the as-cast sample. The nitrogen content of 140 ppm yielded the minimum grain size and...

journal_title：Scientific reports

authors： Lee MH,Kim R,Park JH

更新日期：2019-04-24 00:00:00

abstract：:Amazonian wildfires in 2019 have raised awareness about rainforest burning due to increased emissions of particulate matter and carbon. In the context of these emissions, by-products of lignin thermal degradation (i.e. methoxyphenols) are often neglected. Methoxyphenols entering the atmosphere may form intermediates w...

journal_title：Scientific reports

authors： Babić S,Čižmek L,Maršavelski A,Malev O,Pflieger M,Strunjak-Perović I,Popović NT,Čož-Rakovac R,Trebše P

更新日期：2021-01-28 00:00:00

abstract：:Positron emission tomography (PET) imaging can assist in the early-phase diagnostic and therapeutic evaluation of tumors. Here, we report the radiosynthesis, small animal PET imaging, and biological evaluation of a L-type amino acid transporter 1 (LAT1)-specific PET probe, 18F-FIMP. This probe demonstrates increased t...

journal_title：Scientific reports

authors： Nozaki S,Nakatani Y,Mawatari A,Shibata N,Hume WE,Hayashinaka E,Wada Y,Doi H,Watanabe Y

更新日期：2019-10-31 00:00:00

abstract：:Increasing levels of human activity threaten wildlife populations through direct mortality, habitat degradation, and habitat fragmentation. Area closures can improve habitat quality for wildlife, but may be difficult to achieve where tourism or other economic drivers are a priority. Temporal closures that limit human ...

journal_title：Scientific reports

authors： Whittington J,Low P,Hunt B

更新日期：2019-03-07 00:00:00

abstract：:Modern sugarcane is an unusually complex heteroploid crop, and its genome comprises two or three subgenomes. To reduce the complexity of sugarcane genome research, the ploidy level and number of chromosomes can be reduced using flow chromosome sorting. However, a cell cycle synchronization (CCS) protocol for Saccharum...

journal_title：Scientific reports

authors： Yang S,Zeng K,Luo L,Qian W,Wang Z,Doležel J,Zhang M,Gao X,Deng Z

更新日期：2020-03-19 00:00:00

abstract：:Coleoid cephalopods have an elaborate camera eye whereas nautiloids have primitive pinhole eye without lens and cornea. The Nautilus pinhole eye provides a unique example to explore the module of lens formation and its evolutionary mechanism. Here, we conducted an RNA-seq study of developing eyes of Nautilus and pygmy...

journal_title：Scientific reports

authors： Ogura A,Yoshida MA,Moritaki T,Okuda Y,Sese J,Shimizu KK,Sousounis K,Tsonis PA

更新日期：2013-01-01 00:00:00

abstract：:Cigarette smoking is a risk factor for stroke and is linked to stroke severity. Previous studies have shown that cigarette smoke extract (CSE) triggers endothelial dysfunction in vitro by initiating oxidative stress and/or an inflammatory response. In addition, cerebral endothelial dysfunction (particularly at the lev...

journal_title：Scientific reports

authors： Bernard A,Ku JM,Vlahos R,Miller AA

更新日期：2019-10-30 00:00:00

abstract：:Voltage-gated ether à go-go (EAG) K(+) channels are expressed in various types of cancer cells and also in the central nervous system. Aberrant overactivation of human EAG1 (hEAG1) channels is associated with cancer and neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes. Although hEAG1 channel...

journal_title：Scientific reports

authors： Han B,He K,Cai C,Tang Y,Yang L,Heinemann SH,Hoshi T,Hou S

更新日期：2016-03-23 00:00:00

abstract：:Within the last fifteen years, network theory has been successfully applied both to natural sciences and to socioeconomic disciplines. In particular, bipartite networks have been recognized to provide a particularly insightful representation of many systems, ranging from mutualistic networks in ecology to trade networ...

journal_title：Scientific reports

authors： Saracco F,Di Clemente R,Gabrielli A,Squartini T

更新日期：2015-06-01 00:00:00

abstract：:Fibrous scaffolds are used for bone tissue engineering purposes with great success across a variety of polymers with different physical and chemical properties. It is now evident that the correct degree of curvature promotes increased cytoskeletal tension on osteoprogenitors leading to osteogenic differentiation. Howe...

journal_title：Scientific reports

authors： Ozdemir T,Bowers DT,Zhan X,Ghosh D,Brown JL

更新日期：2019-01-30 00:00:00

abstract：:This work reports the first study of current-driven magnetization noise in a single, nanometerscale, ferromagnetic (Co) particle, attached to normal metal leads by high-resistance tunneling junctions. As the tunnel current increases at low temperature, the magnetic switching field decreases, its probability distributi...

journal_title：Scientific reports

authors： Jiang W,Birk FT,Davidović D

更新日期：2013-01-01 00:00:00

abstract：:A structurally simple dielectric barrier discharge based mercury-free plasma UV-light source has been developed for efficient water disinfection. The source comprises of a dielectric barrier discharge arrangement between two co-axial quartz tubes with an optimized gas gap. The outer electrode is an aluminium baked foi...

journal_title：Scientific reports

authors： Prakash R,Hossain AM,Pal UN,Kumar N,Khairnar K,Mohan MK

更新日期：2017-12-12 00:00:00

abstract：:Increased risk of comorbidities has been reported in Rheumatic and Musculoskeletal Diseases (RMD). We aimed to evaluate the prevalence and pattern of comorbidities in RMD patients nationwide, to identify multimorbidity clusters and to evaluate the gap between recommendations and real screening. Cross-sectional, multic...

journal_title：Scientific reports

authors： Ziade N,El Khoury B,Zoghbi M,Merheb G,Abi Karam G,Mroue' K,Messaykeh J

更新日期：2020-05-06 00:00:00

abstract：:In this work the chalcopyrite CuIn3Se5-xTex (x = 0~0.5) with space group through isoelectronic substitution of Te for Se have been prepared, and the crystal structure dilation has been observed with increasing Te content. This substitution allows the anion position displacement ∆u = 0.25-u to be zero at x ≈ 0.15. Howe...

journal_title：Scientific reports

authors： Lu Y,Chen S,Wu W,Du Z,Chao Y,Cui J

更新日期：2017-01-06 00:00:00

abstract：:The Internet of Things is driving extensive efforts to develop intelligent everyday objects. This requires seamless integration of relatively simple electronics, for example through 'stick-on' electronics labels. We believe the future evolution of this technology will be governed by Wright's Law, which was first propo...

journal_title：Scientific reports

authors： Myny K,Smout S,Rockelé M,Bhoolokam A,Ke TH,Steudel S,Cobb B,Gulati A,Gonzalez Rodriguez F,Obata K,Marinkovic M,Pham DV,Hoppe A,Gelinck GH,Genoe J,Dehaene W,Heremans P

更新日期：2014-12-10 00:00:00

abstract：:Gut microbiota acts as a barrier against intestinal pathogens, but species-specific protection of the host from infection remains relatively unexplored. Although lactobacilli and bifidobacteria produce beneficial lactic and short-chain fatty acids in the mammalian gut, the significance of intestinal Escherichia coli p...

journal_title：Scientific reports

authors： Christofi T,Panayidou S,Dieronitou I,Michael C,Apidianakis Y

更新日期：2019-10-08 00:00:00

abstract：:The barnase-barstar complex is one of the most stable protein-protein complexes and has a very wide range of possible applications. Here we report the use of top-down mass spectrometry for the investigation of the structure of this complex, its ionization via ESI, isolation and fragmentation. It was found that the asy...

journal_title：Scientific reports

authors： Kostyukevich Y,Shulga AA,Kononikhin A,Popov I,Nikolaev E,Deyev S

更新日期：2017-07-21 00:00:00

abstract：:Recent studies reveal that tonal language speakers with autism have enhanced neural sensitivity to pitch changes in nonspeech stimuli but not to lexical tone contrasts in their native language. The present ERP study investigated whether the distinct pitch processing pattern for speech and nonspeech stimuli in autism w...

journal_title：Scientific reports

authors： Wang X,Wang S,Fan Y,Huang D,Zhang Y

更新日期：2017-02-22 00:00:00

abstract：:High-k dielectric oxides are supposedly ideal gate-materials for ultra-high doping in graphene and other 2D-crystals. Here, we report a temperature-dependent electronic transport study on chemical vapor deposited-graphene gated with SrTiO₃ (STO) thin film substrate. At carrier densities away from charge neutrality poi...

journal_title：Scientific reports

authors： Saha S,Kahya O,Jaiswal M,Srivastava A,Annadi A,Balakrishnan J,Pachoud A,Toh CT,Hong BH,Ahn JH,Venkatesan T,Özyilmaz B

更新日期：2014-08-22 00:00:00

abstract：:Histone lysine acetyltransferase (KAT)-catalyzed acetylation of lysine residues in histone tails plays a key role in regulating gene expression in eukaryotes. Here, we examined the role of lysine side chain length in the catalytic activity of human KATs by incorporating shorter and longer lysine analogs into synthetic...

journal_title：Scientific reports

authors： Proietti G,Wang Y,Rainone G,Mecinović J

更新日期：2020-08-03 00:00:00

abstract：:Central to intrinsic apoptosis signaling is the release of cytochrome c from mitochondria, which depends on the pro-apoptotic effector proteins Bax, Bak or Bok. These pore-forming effector proteins share four Bcl-2 homology (BH) domains, a functionally essential and conserved sequence of hydrophobic amino acids in the...

journal_title：Scientific reports

authors： Stehle D,Grimm M,Einsele-Scholz S,Ladwig F,Johänning J,Fischer G,Gillissen B,Schulze-Osthoff K,Essmann F

更新日期：2018-08-20 00:00:00

abstract：:Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it als...

journal_title：Scientific reports

authors： Law BY,Chan WK,Xu SW,Wang JR,Bai LP,Liu L,Wong VK

更新日期：2014-07-01 00:00:00

abstract：:In a quest for direct evidence of oscillation entrainment, we analyzed intracerebral electroencephalographic recordings obtained during intracranial electrical stimulation in a cohort of three medication-resistant epilepsy patients tested pre-surgically. Spectral analyses of non-epileptogenic cerebral sites stimulated...

journal_title：Scientific reports

authors： Amengual JL,Vernet M,Adam C,Valero-Cabré A

更新日期：2017-03-03 00:00:00

abstract：:Screening and in silico modeling are critical activities for the reduction of experimental costs. They also speed up research notably and strengthen the theoretical framework, thus allowing researchers to numerically quantify the importance of a particular subset of information. For example, in fields such as cancer a...

journal_title：Scientific reports

authors： Blanco JL,Porto-Pazos AB,Pazos A,Fernandez-Lozano C

更新日期：2018-10-24 00:00:00

abstract：:To investigate the safety and efficiency of using robotic staplers for intracorporeal gastroduodenostomy in reduced-port robotic gastrectomy for gastric adenocarcinoma. We retrospectively reviewed patients who underwent totally robotic and laparoscopic gastrectomy with intracorporeal gastroduodenostomy. Gastroduodenos...

journal_title：Scientific reports

authors： Kim JS,Batajoo H,Son T,Choi S,Seo WJ,Cho M,Kim YM,Lee JH,Kim HI,Hyung WJ

更新日期：2020-09-07 00:00:00

abstract：:Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was down-regulated in Kmmig1. Consistently, introduction of HIS4 ...

journal_title：Scientific reports

authors： Nurcholis M,Murata M,Limtong S,Kosaka T,Yamada M

更新日期：2019-07-09 00:00:00

abstract：:In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been associated with mutatio...

journal_title：Scientific reports

authors： Ow JR,Palanichamy Kala M,Rao VK,Choi MH,Bharathy N,Taneja R

更新日期：2016-09-26 00:00:00

abstract：:The evolution to bipedalism forced humans to develop suitable strategies for dynamically controlling their balance, ensuring stability, and preventing falling. The natural aging process and traumatic events such as lower-limb loss can alter the human ability to control stability significantly increasing the risk of fa...

journal_title：Scientific reports

authors： Monaco V,Tropea P,Aprigliano F,Martelli D,Parri A,Cortese M,Molino-Lova R,Vitiello N,Micera S

更新日期：2017-05-11 00:00:00