Abstract：
:New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gonzalez R,Garitaonandia I,Abramihina T,Wambua GK,Ostrowska A,Brock M,Noskov A,Boscolo FS,Craw JS,Laurent LC,Snyder EY,Semechkin RAdoi
10.1038/srep01463subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1463issn
2045-2322pii
srep01463journal_volume
3pub_type
杂志文章abstract：:The primary objective of this study was to evaluate how schizophrenia (SCH) spectrum disorders and applied antipsychotic (AP) treatment affect serum level of amino acids (AAs) and biogenic amines (BAs) in the early course of the disorder. We measured 21 different AAs and 10 BAs in a sample of antipsychotic (AP)-naïve ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71014-w
更新日期：2020-08-19 00:00:00
abstract：:A novel bicomponent alkyd system was designed to decrease the usage of Cobalt-based drier due to its latent carcinogensis. The system was polymerized using a Cobalt-salt complex as an air-sensitive drier and an isopropylthioxanthone photoinitiator as a light-sensitive accelerator, as well as using irradiation in the f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38473
更新日期：2016-12-13 00:00:00
abstract：:Delivery of proteins has been regarded as the safest and most useful application in therapeutic application of stem cells, because proteins can regulate gene expression transiently without any genomic alteration. However, it is difficult to accurately measure efficiency or quantity of intracellular protein uptake. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04378
更新日期：2014-03-14 00:00:00
abstract：:We show that H-bonded host-guest systems associate in ionic liquids (ILs), pure salts with melting point below room temperature, in which dipole-dipole electrostatic interactions should be negligible in comparison with dipole-charge interactions. Binding constants (Ka) obtained from titrations of four H-bonded host-gu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71803-3
更新日期：2020-09-22 00:00:00
abstract：:Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22322
更新日期：2016-02-29 00:00:00
abstract：:Genome-scale metabolic network models can be used for various analyses including the prediction of metabolic responses to changes in the environment. Legumes are well known for their rhizobial symbiosis that introduces nitrogen into the global nutrient cycle. Here, we describe a fully compartmentalised, mass and charg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30884-x
更新日期：2018-08-21 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-61219-4
更新日期：2020-03-03 00:00:00
abstract：:To explore the predictive performance of machine learning on the recurrence of patients with gastric cancer after the operation. The available data is divided into two parts. In particular, the first part is used as a training set (such as 80% of the original data), and the second part is used as a test set (the remai...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81188-6
更新日期：2021-01-15 00:00:00
abstract：:Modern flow cytometry instruments have become vital tools for high-throughput analysis of single cells. However, as issues with the cellular labeling techniques often used in flow cytometry have become more of a concern, the development of label-free modalities for cellular analysis is increasingly desired. Non-linear...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10751
更新日期：2015-05-29 00:00:00
abstract：:In this study we characterise three tandem promoters (PR1-1, PR1-2 and PR1-3) within the PR1 regulatory region of the Escherichia coli kps capsule gene cluster. Transcription from promoter PR1-2 was dependent on the activity of the upstream promoter PR1-1, which activated PR1-2 via transcription coupled DNA supercoili...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17891-0
更新日期：2017-12-20 00:00:00
abstract：:Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25706-z
更新日期：2018-05-08 00:00:00
abstract：:The 30-day readmission rate after hospitalization for a sickle cell crisis (SCC) is extremely high. Accurate information on readmission diagnoses, total readmission costs and factors associated with readmission is required to effectively plan resource allocation and to plan interventions to reduce readmission rates. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58934-3
更新日期：2020-02-07 00:00:00
abstract：:We investigated the effect of a new Rho kinase inhibitor, SB772077B (SB77) on aqueous outflow facility (OF) in human eyes using human organ-cultured anterior segment (HOCAS). IOP was monitored for 24 h post-treatment with either SB77 (0.1/10/50 µM) or vehicle after a stable baseline pressure. The hydrodynamic pattern ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33932-8
更新日期：2018-10-19 00:00:00
abstract：:The immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alternate adenovirus s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22464
更新日期：2016-03-03 00:00:00
abstract：:Kluyveromyces marxianus, a non-conventional thermotolerant yeast, is potentially useful for production of ethanol and other products. This species has a strong tendency to randomly integrate transforming DNA fragments, making necessary the development of more precise methods for gene targeting. In this study, we first...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08356-5
更新日期：2017-08-21 00:00:00
abstract：:Salmonids show a high degree of phenotypic plasticity that can differ among genotypes, and this variation is one of the major factors contributing to uncertainty in extrapolating laboratory-based risk assessment data to nature. Many studies have examined the relative growth and survival of transgenic and non-transgeni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35826-1
更新日期：2019-01-23 00:00:00
abstract：:This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population. A total of 556 GDM patients and 500 Non-GDM were included. Eighteen single nucleotide polymorphisms (SNPs) were evalu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30686
更新日期：2016-07-28 00:00:00
abstract：:The network structure of biological systems provides information on the underlying processes shaping their organization and dynamics. Here we examined the structure of the network depicting protein interactions within the spliceosome, the macromolecular complex responsible for splicing in eukaryotic cells. We show the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14865
更新日期：2015-10-07 00:00:00
abstract：:Combination targeted therapy is commonly used to treat acute myeloid leukemia (AML) patients, particularly in refractory/relapse (RR) population. However, concerns have been raised regarding the safety and patient tolerance of combination chemotherapy. It is critical to choose the appropriate treatment for precision t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40361
更新日期：2017-01-18 00:00:00
abstract：:Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02843-5
更新日期：2017-06-02 00:00:00
abstract：:The gene separation anxiety (san) encodes Naa50/San, a N-terminal acetyltransferase required for chromosome segregation during mitosis. Although highly conserved among higher eukaryotes, the mitotic function of this enzyme is still poorly understood. Naa50/San was originally proposed to be required for centromeric sis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39118
更新日期：2016-12-20 00:00:00
abstract：:(1) Objective: Greenhouse workers are considered a special occupational group who are exposed to more toxic and harmful substances than ordinary farmers. The health problem of this group is a public health problem that warrants attention. Taking greenhouse workers in Ningxia, China, as the research sample, this study ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65662-1
更新日期：2020-05-26 00:00:00
abstract：:Cancer cells and non-cancer cells differ in their metabolism and they emit distinct volatile compound profiles, allowing to recognise cancer cells by their scent. Insect odorant receptors are excellent chemosensors with high sensitivity and a broad receptive range unmatched by current gas sensors. We thus investigated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03576
更新日期：2014-01-06 00:00:00
abstract：:We have investigated the valley Chern number and gapless edge states in wide-gap semiconductor SiC and BN monolayers by using the density functional theory calculations. We found that while SiC monolayer has a non-quantized valley Chern number due to a partial mixing of the Berry curvature peaks pertaining to the oppo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61906-2
更新日期：2020-03-19 00:00:00
abstract：:Vascular leakage is a life-threatening complication of dengue virus (DENV) infection. Previously, association between "paracellular" endothelial hyperpermeability and plasma leakage had been extensively investigated. However, whether "transcellular" endothelial leakage is involved in dengue hemorrhagic fever (DHF) and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31855
更新日期：2016-08-22 00:00:00
abstract：:Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedures affect the variability of IC50 values characterizing drug block pot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62344-w
更新日期：2020-03-27 00:00:00
abstract：:Among the biologically active triterpenes, friedelin has the most-rearranged structure produced by the oxidosqualene cyclases and is the only one containing a cetonic group. In this study, we cloned and functionally characterized friedelin synthase and one cycloartenol synthase from Maytenus ilicifolia (Celastraceae)....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36858
更新日期：2016-11-22 00:00:00
abstract：:In this paper, the composition, structure, morphology and kinetics of evolution during isothermal oxidation of Fe48Cr15Mo14Y2C15B6 metallic glass powder in the supercooled region are investigated by an integrated ex-situ and in-situ characterization and modelling approach. Raman and X-ray diffraction spectra establish...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43317-0
更新日期：2019-05-02 00:00:00
abstract：:We investigated the metabolic outcome of different coping strategies in 129S6/SvEvTac (129Sv) and C57BL/6Ntac (Bl6) strains. Two different batches of male 129Sv and Bl6 mice were used. One batch was not subjected to any behavioral manipulations (home cage control; HCC), whereas the other batch was treated with saline ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21752-9
更新日期：2018-02-21 00:00:00
abstract：:Nutrient resorption processes in the plants infected by pathogen remain poorly understood. Huanglongbing (HLB) is a destructive disease of citrus. HLB-pathogen 'Candidatus Liberibacter asiaticus' grows specifically in the phloem of hosts and may cause problems in the plant vascular system after infection. Therefore, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14675
更新日期：2015-09-30 00:00:00
