Abstract：
:We investigated the metabolic outcome of different coping strategies in 129S6/SvEvTac (129Sv) and C57BL/6Ntac (Bl6) strains. Two different batches of male 129Sv and Bl6 mice were used. One batch was not subjected to any behavioral manipulations (home cage control; HCC), whereas the other batch was treated with saline for 11 days and exposed after every treatment to the motor activity measurement (repeated motility tested; RMT). Bl6 RMT mice displayed a robust increase in number of rearings during repeated testing. 129Sv RMT mice experienced significant loss of body weight, but showed enhanced weight gain in HCC batch compared to Bl6. Serum metabolites (acylcarnitines, amino acids, biogenic amines, hexoses, glycerophospholipids and sphingolipids) were determined with AbsoluteIDQ p180 kit. Results of the metabolomic study revealed prominent peculiarities between strains in two different conditions. Comparison of both batches of mice demonstrated that in Bl6 biogenic amines (acetyl-ornithine, alpha-amionadipic acid, carnosine) and lysophosphatidylcholine PC(16:1/0:0) dominated. However in 129Sv acylcarnitine C5 clearly dominated, indicating shift towards short-chain acylcarnitines. Stable strain-specific ratios also emerged for both lines, ratio of glycine/PC ae C38:2 for Bl6 and ratios of C5/C0 as well as PC(16:0/0:0)/PC(16:1/0:0) for 129Sv. The described metabolic changes probably reflect different behavioral coping strategies of 129Sv and Bl6 mice.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Narvik J,Vanaveski T,Innos J,Philips MA,Ottas A,Haring L,Zilmer M,Vasar Edoi
10.1038/s41598-018-21752-9subject
Has Abstractpub_date
2018-02-21 00:00:00pages
3405issue
1issn
2045-2322pii
10.1038/s41598-018-21752-9journal_volume
8pub_type
杂志文章abstract：:Calotropis gigantea (C. gigantea) extract with an ecofriendly nanotechnology approach could provide promising antimicrobial activity against skin pathogens. This study investigates the antimicrobial capability of green synthesized binary ZnO-CuO nanocomposites from C. gigantea against non-MDR (Staphylococcus aureus an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79547-w
更新日期：2021-01-08 00:00:00
abstract：:Haemonchus contortus is arguably the most injurious helminth parasite for small ruminants. We characterized the impact of H. contortus infection on the caprine abomasal microbiome. Fourteen parasite naive goats were inoculated with 5,000 H. contortus infective larvae and followed for 50 days. Six age-matched naïve goa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20606
更新日期：2016-02-08 00:00:00
abstract：:Superconductivity in noncentrosymmetric compounds has attracted sustained interest in the last decades. Here we present a detailed study on the transport, thermodynamic properties and the band structure of the noncentrosymmetric superconductor La 7 Ir 3 (T c ~ 2.3 K) that was recently proposed to break the time-rever...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19042-x
更新日期：2018-01-12 00:00:00
abstract：:α-MnO2 nanotubes were fabricated using a hydrothermal technique. Li, Na and K ions were introduced into MnO2 nanotubes to tailor their magnetic properties. It was found that with a doping concentration lower than 12 at%, the nanotubes showed ferromagnetic-like ordering at low temperature (<50 K), while antiferromagnet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09094
更新日期：2015-03-13 00:00:00
abstract：:We propose a new express method of the correlation characterization of the particles suspended in the volume of optically transparent medium. It utilizes inline digital holography technique for obtaining two images of the adjacent layers from the investigated volume with subsequent matching of the cross-correlation fu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43840
更新日期：2017-03-02 00:00:00
abstract：:Coccolithophores are single-celled photosynthesizing marine algae, responsible for half of the calcification in the surface ocean, and exert a strong influence on the distribution of carbon among global reservoirs, and thus Earth's climate. Calcification in the surface ocean decreases the buffering capacity of seawate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34263
更新日期：2016-09-28 00:00:00
abstract：:Identifying early life-stage transitions limiting seagrass recruitment could improve our ability to target demographic processes most responsive to management. Here we determine the magnitude of life-stage transitions along gradients in physical disturbance limiting seedling establishment for the marine angiosperm, Po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13833-y
更新日期：2017-11-01 00:00:00
abstract：:Mammalian parental genomes contribute differently to early embryonic development. Before activation of the zygotic genome, the maternal genome provides all transcripts and proteins required for the transition from a highly specialized oocyte to a pluripotent embryo. Depletion of these maternally-encoded transcripts fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44667
更新日期：2017-03-20 00:00:00
abstract：:Bears are iconic mammals with a complex evolutionary history. Natural bear hybrids and studies of few nuclear genes indicate that gene flow among bears may be more common than expected and not limited to polar and brown bears. Here we present a genome analysis of the bear family with representatives of all living spec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46487
更新日期：2017-04-19 00:00:00
abstract：:Knowledge of the direct role humans have had in changing the landscape requires the perspective of historical and archaeological sources, as well as climatic and ecologic processes, when interpreting paleoecological records. People directly impact land at the local scale and land use decisions are strongly influenced ...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-018-20286-4
更新日期：2018-02-01 00:00:00
abstract：:Basic leucine zippers (bZIPs) form a large plant transcription factor family. C and S1 bZIP groups can heterodimerize, fulfilling crucial roles in seed development and stress response. S1 sequences also harbor a unique regulatory mechanism, termed Sucrose-Induced Repression of Translation (SIRT). The conservation of b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30444
更新日期：2016-07-26 00:00:00
abstract：:Hesperiidae is one of the largest families of butterflies. Our knowledge of the higher systematics on hesperiids from China is still very limited. We infer the phylogenetic relationships of the subfamilies of Chinese skippers based on three mitochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11140
更新日期：2015-06-10 00:00:00
abstract：:In this study the damselfly Ischnura senegalensis (Rambur, 1842) was first found to produce strong photoluminescence (PL) emissions from various colored-body portions, such as the eighth abdominal segment of the tail. The colors of the colored-body portions can be enhanced or modified by the PL emissions for assistanc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38051
更新日期：2016-12-14 00:00:00
abstract：:The elastic modulus of ZnO nanowires was measured using a resonance method based on laser Doppler effect and their fracture strains were determined via two-point bending with the aid of optical nanomanipulation. The elastic moduli of ZnO nanowires with diameters of 78 to 310 nm vary from 123 to 154 GPa, which are clos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09843-5
更新日期：2017-08-25 00:00:00
abstract：:Rapid integration of high-quality functional devices in microchannels is in highly demand for miniature lab-on-a-chip applications. This paper demonstrates the embellishment of existing microfluidic devices with integrated micropatterns via femtosecond laser MRAF-based holographic patterning (MHP) microfabrication, wh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33281
更新日期：2016-09-13 00:00:00
abstract：:Inappropriate sleep duration and poor sleep quality are associated with risk of stroke, but their interactive effect on stroke is unknown. We explored the interactive effect of sleep quality and duration on stroke risk. A prospective cohort study was conducted with 41,786 adults. Sleep quality was assessed using the P...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65611-y
更新日期：2020-05-26 00:00:00
abstract：:Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD have been carried out by now. In this study, we conducted a two-stage bivariate genome-wide association study (BGWAS) of the KBD...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31792
更新日期：2016-08-22 00:00:00
abstract：:The advent of Fluorescence Microscopy over the last few years have dramatically improved the problem of visualization and tracking of specific cellular objects for biological inference. But like any other imaging system, fluorescence microscopy has its own limitations. The resultant images suffer from the effect of no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43973-2
更新日期：2019-05-22 00:00:00
abstract：:Motivational, cognitive and action goals are processed by distinct, topographically organized, corticostriatal circuits. We aimed to test whether processing in the striatum is under causal control by cortical regions in the human brain by investigating the effects of offline transcranial magnetic stimulation (TMS) ove...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21346-5
更新日期：2018-02-19 00:00:00
abstract：:The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown. However, the recent discovery of the thick filament activation, a second pathway beside the well-known calcium mediated thin filament activation, is promising for eluc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36706-4
更新日期：2019-02-04 00:00:00
abstract：:Delivery of proteins has been regarded as the safest and most useful application in therapeutic application of stem cells, because proteins can regulate gene expression transiently without any genomic alteration. However, it is difficult to accurately measure efficiency or quantity of intracellular protein uptake. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04378
更新日期：2014-03-14 00:00:00
abstract：:To investigate wavefront aberrations in the entire eye and in the internal optics (lens) and retinal image qualities according to different lenticular opacity types and densities. Forty-one eyes with nuclear cataract, 33 eyes with cortical cataract, and 29 eyes with posterior subcapsular cataract were examined. In eac...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-15245-4
更新日期：2017-11-10 00:00:00
abstract：:In the last decades, AC powered atmospheric dielectric barrier discharges (DBDs) in air with a liquid electrode have been proposed as a promising plasma technology with versatile applicability in medicine, agriculture and water treatment. The fundamental features of the micro-discharge filaments that make up this type...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29189-w
更新日期：2018-07-19 00:00:00
abstract：:The development and maturation of cortical circuits relies on the coordinated actions of long and short range axonal guidance cues. In this regard, the class 3 semaphorins and their receptors have been seen to be involved in the development and maturation of the hippocampal connections. However, although the role of m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19794-0
更新日期：2018-01-22 00:00:00
abstract：:During rescue operations related to the elimination of the effects of industrial accidents or natural disasters, extinguishing agents are used that affect the migration and transformation of contamination in the environment. Firefighting foam sprayed onto an oil spill slowly drains to an aqueous solution and penetrate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65660-3
更新日期：2020-06-01 00:00:00
abstract：:Seeds of tomato were magnetoprimed at 100 mT for 30 min followed by imbibition for 12 and 24 h, respectively, at 20 °C, to examine the biochemical and molecular changes involved in homeostasis of hydrogen peroxide (H2O2) and its signaling associated with hormone interactions for promoting vigor. The relative transcrip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45102-5
更新日期：2019-06-19 00:00:00
abstract：:The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42383-8
更新日期：2019-04-10 00:00:00
abstract：:Environmental DNA (eDNA) metabarcoding has been used increasingly to assess biodiversity of aquatic vertebrates. However, there still remains to be developed a sampling design of eDNA metabarcoding that can ensure high detection rates of species with minimum total survey effort, especially for large-scale surveys of a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14978-6
更新日期：2017-11-01 00:00:00
abstract：:Fire blight, caused by the enterobacterium Erwinia amylovora, is a destructive disease, which can affect most members of the Rosaceae family. Since no significant genomic differences have been found by others to explain differences in virulence, we used here a gel-based proteomic approach to elucidate mechanisms and k...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30064-x
更新日期：2018-08-03 00:00:00
abstract：:Osteochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, which remains a significant challenge in orthopedic surgery. Layered structure of bone, cartilage and the bone-cartilage interface must be taken into account in the case of biofabrication of the osteochondral (OC) i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69960-6
更新日期：2020-08-04 00:00:00
