Compositions and antimicrobial properties of binary ZnO-CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens.

Abstract:

:Calotropis gigantea (C. gigantea) extract with an ecofriendly nanotechnology approach could provide promising antimicrobial activity against skin pathogens. This study investigates the antimicrobial capability of green synthesized binary ZnO-CuO nanocomposites from C. gigantea against non-MDR (Staphylococcus aureus and Escherichia coli) and MDR (Klebsiella pneumoniae, Pseudomonas aeruginosa and methicillin-resistant S. aureus) skin pathogens. Scanning electron microscopy and transmission electron microscopy revealed the size and shape of B3Z1C sample. Results of X-ray powder diffraction, energy-dispersive spectroscopy, FTIR and UV-Vis spectroscopy analyses confirmed the presence of mixed nanoparticles (i.e., zinc oxide, copper oxide, carbon and calcium) and the stabilising phytochemical agents of plant (i.e., phenol and carbonyl). Antimicrobial results showed that carbon and calcium decorated binary ZnO-CuO nanocomposites with compositions of 75 wt% of ZnO and 25 wt% CuO (B3Z1C) was a strong bactericidal agent with the MBC/MIC ratio of ≤ 4 and ≤ 2 for non-MDR and MDR pathogens, respectively. A significant non-MDR zone of inhibitions were observed for BZC by Kirby-Bauer disc-diffusion test. Further time-kill observation revealed significant fourfold reduction in non-MDR pathogen viable count after 12 h study period. Further molecular studies are needed to explain the biocidal mechanism underlying B3Z1C potential.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Govindasamy GA,Mydin RBSMN,Sreekantan S,Harun NH

doi

10.1038/s41598-020-79547-w

subject

Has Abstract

pub_date

2021-01-08 00:00:00

pages

99

issue

1

issn

2045-2322

pii

10.1038/s41598-020-79547-w

journal_volume

11

pub_type

杂志文章
  • Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival.

    abstract::The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally me...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47440-w

    authors: Nair NU,Das A,Rogkoti VM,Fokkelman M,Marcotte R,de Jong CG,Koedoot E,Lee JS,Meilijson I,Hannenhalli S,Neel BG,de Water BV,Le Dévédec SE,Ruppin E

    更新日期:2019-07-29 00:00:00

  • Interferon-alpha therapy for refractory kaposiform hemangioendothelioma: a single-center experience.

    abstract::Kaposiform hemangioendothelioma (KHE) is a relatively rare vascular tumor with an aggressive and infiltrating nature. Previous studies have revealed an exclusive relationship between KHE and Kasabach-Merritt Phenomenon (KMP), which is associated with high morbidity and mortality. No universally accepted treatment moda...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/srep36261

    authors: Wu HW,Wang X,Zhang L,Zhao HG,Wang YA,Su LX,Fan XD,Zheng JW

    更新日期:2016-10-31 00:00:00

  • Broad-scale morpho-functional traits of the mandible suggest no hard food adaptation in the hominin lineage.

    abstract::An on-going debate concerning the dietary adaptations of archaic hominins and early Homo has been fuelled by contradictory inferences obtained using different methodologies. This work presents an extensive comparative sample of 30 extant primate species that was assembled to perform a morpho-functional comparison of t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63739-5

    authors: Marcé-Nogué J,Püschel TA,Daasch A,Kaiser TM

    更新日期:2020-04-22 00:00:00

  • Different diversity-dependent declines in speciation rate unbalances species richness in terrestrial slugs.

    abstract::Two genera of terrestrial slugs (Arion and Geomalacus) display a striking disproportion in species richness in the Iberian Peninsula. While there are 17 Iberian endemic species in Arion, morphological criteria only recognize four species within Geomalacus. Sequence data were used to test whether these differences coul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16417-y

    authors: Cunha RL,Patrão C,Castilho R

    更新日期:2017-11-23 00:00:00

  • Tailoring femtosecond 1.5-μm Bessel beams for manufacturing high-aspect-ratio through-silicon vias.

    abstract::Three-dimensional integrated circuits (3D ICs) are an attractive replacement for conventional 2D ICs as high-performance, low-power-consumption, and small-footprint microelectronic devices. However, one of the major remaining challenges is the manufacture of high-aspect-ratio through-silicon vias (TSVs), which is a cr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40785

    authors: He F,Yu J,Tan Y,Chu W,Zhou C,Cheng Y,Sugioka K

    更新日期:2017-01-18 00:00:00

  • Differential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model.

    abstract::Previously, long-term effects on body weight and reproductive performance have been demonstrated in the chicken model of prenatal protein undernutrition by albumen removal. Introduction of such persistent alterations in phenotype suggests stable changes in gene expression. Therefore, a genome-wide screening of the hep...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20837

    authors: Willems E,Guerrero-Bosagna C,Decuypere E,Janssens S,Buyse J,Buys N,Jensen P,Everaert N

    更新日期:2016-02-10 00:00:00

  • Classical ROS-dependent and early/rapid ROS-independent release of Neutrophil Extracellular Traps triggered by Leishmania parasites.

    abstract::Neutrophil extracellular traps (NETs) extruded from neutrophils upon activation are composed of chromatin associated with cytosolic and granular proteins, which ensnare and kill microorganisms. This microbicidal mechanism named classical netosis has been shown to dependent on reactive oxygen species (ROS) generation b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18302

    authors: Rochael NC,Guimarães-Costa AB,Nascimento MT,DeSouza-Vieira TS,Oliveira MP,Garcia e Souza LF,Oliveira MF,Saraiva EM

    更新日期:2015-12-17 00:00:00

  • Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation.

    abstract::We developed a reporter system that can be used in a dual manner in visualizing mature osteoblast formation. The system is based on a helper-dependent adenoviral vector (HDAdV), in which a fluorescent protein, Venus, is expressed under the control of the 19-kb human osteocalcin (OC) genomic locus. By infecting human a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46105-y

    authors: Sone T,Shin M,Ouchi T,Sasanuma H,Miyamoto A,Ohte S,Tsukamoto S,Nakanishi M,Okano H,Katagiri T,Mitani K

    更新日期:2019-07-04 00:00:00

  • Peaches Preceded Humans: Fossil Evidence from SW China.

    abstract::Peach (Prunus persica, Rosaceae) is an extremely popular tree fruit worldwide, with an annual production near 20 million tons. Peach is widely thought to have origins in China, but its evolutionary history is largely unknown. The oldest evidence for the peach has been Chinese archaeological records dating to 8000-7000...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16794

    authors: Su T,Wilf P,Huang Y,Zhang S,Zhou Z

    更新日期:2015-11-26 00:00:00

  • Bioelectronic interfaces by spontaneously organized peptides on 2D atomic single layer materials.

    abstract::Self-assembly of biological molecules on solid materials is central to the "bottom-up" approach to directly integrate biology with electronics. Inspired by biology, exquisite biomolecular nanoarchitectures have been formed on solid surfaces. We demonstrate that a combinatorially-selected dodecapeptide and its variants...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33778

    authors: Hayamizu Y,So CR,Dag S,Page TS,Starkebaum D,Sarikaya M

    更新日期:2016-09-22 00:00:00

  • Integrin α7 expression is increased in asthmatic patients and its inhibition reduces Kras protein abundance in airway smooth muscle cells.

    abstract::Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative phenotypic states. Integrins are a class of transmembrane proteins that have been implicated as novel therapeutic targets for asthma treatment. We previously showed ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46260-2

    authors: Teoh CM,Tan SSL,Langenbach SY,Wong AH,Cheong DHJ,Tam JKC,New CS,Tran T

    更新日期:2019-07-09 00:00:00

  • Effects of maternal obesity on Wharton's Jelly mesenchymal stromal cells.

    abstract::We investigated whether maternal metabolic environment affects mesenchymal stromal/stem cells (MSCs) from umbilical cord's Wharton's Jelly (WJ) on a molecular level, and potentially render them unsuitable for clinical use in multiple recipients. In this pilot study on umbilical cords post partum from healthy non-obese...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18034-1

    authors: Badraiq H,Cvoro A,Galleu A,Simon M,Miere C,Hobbs C,Schulz R,Siow R,Dazzi F,Ilic D

    更新日期:2017-12-14 00:00:00

  • A novel technique to prepare a single cell suspension of isolated quiescent human hepatic stellate cells.

    abstract::To explore a simple and easy-to-learn procedure for the isolation of human quiescent hepatic stellate cells (HSCs) that requires no advanced training. Thus reducing costs and increasing efficiency. This protocol will provide sufficient primary cells with minimal contaminants for future basic research on diseases assoc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49287-7

    authors: Zhai X,Wang W,Dou D,Ma Y,Gang D,Jiang Z,Shi B,Jin B

    更新日期:2019-09-04 00:00:00

  • Impact of controlled-release urea on rice yield, nitrogen use efficiency and soil fertility in a single rice cropping system.

    abstract::Overuse of nitrogen (N) fertilizer has led to low N use efficiency (NUE) and high N loss in single rice cropping systems in southeast China. Application of controlled-release urea (CRU) is considered as an effective N fertilizer practice for improving crop yields and NUE. Here, field experiments were conducted during ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67110-6

    authors: Chen Z,Wang Q,Ma J,Zou P,Jiang L

    更新日期:2020-06-26 00:00:00

  • Transparent Display using a quasi-array of Si-SiO2 Core-Shell Nanoparticles.

    abstract::A novel type of transparent monitor with high-resolution images based on Si-SiO2 core-shell nanoparticles is presented in this contribution. In this monitor, a quasi-array of nanoparticles was used to obtain a very sharp scattering profile. For this purpose, the Si-SiO2 nanoparticles were synthesized and with controll...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-38771-9

    authors: Dolatyari M,Jafari A,Rostami A,Klein A

    更新日期:2019-02-19 00:00:00

  • Suit-type Wearable Robot Powered by Shape-memory-alloy-based Fabric Muscle.

    abstract::A suit-type wearable robot (STWR) is a new type of soft wearable robot (SWR) that can be worn easily anywhere and anytime to assist the muscular strength of wearers because it can be worn like normal clothes and is comfortable to wear even with no power supply. This paper proposes an STWR, in which a shape-memory-allo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45722-x

    authors: Park SJ,Park CH

    更新日期:2019-06-24 00:00:00

  • Instability of 8E5 calibration standard revealed by digital PCR risks inaccurate quantification of HIV DNA in clinical samples by qPCR.

    abstract:ABTRACT:Establishing a cure for HIV is hindered by the persistence of latently infected cells which constitute the viral reservoir. Real-time qPCR, used for quantification of this reservoir by measuring HIV DNA, requires external calibration; a common choice of calibrator is the 8E5 cell line, which is assumed to be st...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01221-5

    authors: Busby E,Whale AS,Ferns RB,Grant PR,Morley G,Campbell J,Foy CA,Nastouli E,Huggett JF,Garson JA

    更新日期:2017-04-26 00:00:00

  • Implementation of iodine biokinetic model for interpreting I-131 contamination in breast milk after the Fukushima nuclear disaster.

    abstract::After the accident at the Fukushima Daiichi Nuclear Power Plant run by Tokyo Electric Power Company in 2011, breast milk samples obtained from volunteers living in Fukushima and neighboring prefectures were examined and small amounts of I-131 (2.2-36.3 Bq/kg) were detected in some samples. In this work, the I-131 conc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12426

    authors: Tani K,Kurihara O,Kim E,Yoshida S,Sakai K,Akashi M

    更新日期:2015-07-22 00:00:00

  • Synthesis of Pt/K2CO3/MgAlOx-reduced graphene oxide hybrids as promising NOx storage-reduction catalysts with superior catalytic performance.

    abstract::Pt/K2CO3/MgAlOx-reduced graphene oxide (Pt/K/MgAlOx-rGO) hybrids were synthesized, characterized and tested as a promising NOx storage and reduction (NSR) catalyst. Mg-Al layered double hydroxides (LDHs) were grown on rGO via in situ hydrothermal crystallization. The structure and morphology of samples were thoroughly...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42862

    authors: Mei X,Yan Q,Lu P,Wang J,Cui Y,Nie Y,Umar A,Wang Q

    更新日期:2017-02-16 00:00:00

  • Hepatic steatosis and liver fat contents in liver transplant recipients are associated with serum adipokines and insulin resistance.

    abstract::Our data about pathogenesis of hepatic steatosis after liver transplantation is scarce. This study aimed to investigate the association between serum adipokines and insulin resistance with hepatic steatosis in liver transplant recipients. We investigated the association between insulin resistance, serum adiponectin, i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69571-1

    authors: Eshraghian A,Nikeghbalian S,Shamsaeefar A,Kazemi K,Fattahi MR,Malek-Hosseini SA

    更新日期:2020-07-29 00:00:00

  • Increased future occurrences of the exceptional 2018-2019 Central European drought under global warming.

    abstract::Since the spring 2018, a large part of Europe has been in the midst of a record-setting drought. Using long-term observations, we demonstrate that the occurrence of the 2018-2019 (consecutive) summer drought is unprecedented in the last 250 years, and its combined impact on the growing season vegetation activities is ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68872-9

    authors: Hari V,Rakovec O,Markonis Y,Hanel M,Kumar R

    更新日期:2020-08-06 00:00:00

  • Responses of solid tumor cells in DMEM to reactive oxygen species generated by non-thermal plasma and chemically induced ROS systems.

    abstract::In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma, we generated superoxide anion (O2(-)), hydroxyl radical (HO·), and hydrogen per...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08587

    authors: Kaushik N,Uddin N,Sim GB,Hong YJ,Baik KY,Kim CH,Lee SJ,Kaushik NK,Choi EH

    更新日期:2015-02-26 00:00:00

  • Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy.

    abstract::Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5'-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-onset severe seizures and subsequent encephalopathy. At present, 27 path...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70598-7

    authors: Barile A,Nogués I,di Salvo ML,Bunik V,Contestabile R,Tramonti A

    更新日期:2020-08-12 00:00:00

  • Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans.

    abstract::Infection with Mycobacterium ulcerans causes Buruli Ulcer, a neglected tropical disease. Mosquito vectors are suspected to participate in the transmission and environmental maintenance of the bacterium. However, mechanisms and consequences of mosquito contamination by M. ulcerans are not well understood. We evaluated ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09242

    authors: Hoxmeier JC,Thompson BD,Broeckling CD,Small P,Foy BD,Prenni J,Dobos KM

    更新日期:2015-03-18 00:00:00

  • Down regulation of ADAM33 as a Predictive Biomarker of Aggressive Breast Cancer.

    abstract::Breast cancer is a heterogeneous disease with differences in its clinical, molecular and biological features. Traditionally, immunohistochemical markers together with clinicopathologic parameters are used to classify breast cancer and to predict disease outcome. Triple-negative breast cancer (TNBC) is a particular typ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44414

    authors: Manica GC,Ribeiro CF,Oliveira MA,Pereira IT,Chequin A,Ramos EA,Klassen LM,Sebastião AP,Alvarenga LM,Zanata SM,Noronha L,Rabinovich I,Costa FF,Souza EM,Klassen G

    更新日期:2017-03-15 00:00:00

  • n and p type character of single molecule diodes.

    abstract::Looking for single molecule electronic devices, we have investigated the charge transport properties of individual tetra-phenylporphyrin molecules on different substrates by ultrahigh-vacuum scanning tunneling microscopy and spectroscopy and by first-principles calculations. The tetra-phenylporphyrins with a Co atom (...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08350

    authors: Zoldan VC,Faccio R,Pasa AA

    更新日期:2015-02-10 00:00:00

  • Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo.

    abstract::Ras mutations (e.g., occur in K-Ras, N-Ras, and H-Ras) are one of the most desirable and promising drug targets in chemotherapy treatments for cancer. However, there are still no approved drugs directly targeting mutated Ras. In 2017, an artificial cyclic peptide, KRpep-2d, was discovered as the first selective inhibi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78712-5

    authors: Sakamoto K,Masutani T,Hirokawa T

    更新日期:2020-12-10 00:00:00

  • Ezh2 is involved in radial neuronal migration through regulating Reelin expression in cerebral cortex.

    abstract::Radial migration of pyramidal neurons is an important event during the development of cerebral cortex. Neurons experience series of morphological and directional transitions to get to their final laminar positions. Here we report that the histone methyltransferase enhancer of zest homolog 2 (Ezh2) is involved in the r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15484

    authors: Zhao L,Li J,Ma Y,Wang J,Pan W,Gao K,Zhang Z,Lu T,Ruan Y,Yue W,Zhao S,Wang L,Zhang D

    更新日期:2015-10-26 00:00:00

  • The role of industrial nitrogen in the global nitrogen biogeochemical cycle.

    abstract::Haber-Bosch nitrogen (N) has been increasingly used in industrial products, e.g., nylon, besides fertilizer. Massive numbers of species of industrial reactive N (Nr) have emerged and produced definite consequences but receive little notice. Based on a comprehensive inventory, we show that (1) the industrial N flux has...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02579

    authors: Gu B,Chang J,Min Y,Ge Y,Zhu Q,Galloway JN,Peng C

    更新日期:2013-01-01 00:00:00

  • Flux balance analysis with or without molecular crowding fails to predict two thirds of experimentally observed epistasis in yeast.

    abstract::Computational predictions of double gene knockout effects by flux balance analysis (FBA) have been used to characterized genome-wide patterns of epistasis in microorganisms. However, it is unclear how in silico predictions are related to in vivo epistasis, as FBA predicted only a minority of experimentally observed ge...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47935-6

    authors: Alzoubi D,Desouki AA,Lercher MJ

    更新日期:2019-08-14 00:00:00