Ezh2 is involved in radial neuronal migration through regulating Reelin expression in cerebral cortex.

Abstract:

:Radial migration of pyramidal neurons is an important event during the development of cerebral cortex. Neurons experience series of morphological and directional transitions to get to their final laminar positions. Here we report that the histone methyltransferase enhancer of zest homolog 2 (Ezh2) is involved in the regulation of cortical radial migration. We show that Ezh2 knockdown leads to disturbed neuronal orientation, which results in the impairment of radial migration. Further results reveal that this migration deficiency may be due to the derepression of Reelin transcription in the migrating neurons. Our study provides evidence that epigenetic regulation of Reelin by Ezh2 maintains appropriate Reelin expression pattern to fulfill proper orientation of migrating neurons.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhao L,Li J,Ma Y,Wang J,Pan W,Gao K,Zhang Z,Lu T,Ruan Y,Yue W,Zhao S,Wang L,Zhang D

doi

10.1038/srep15484

subject

Has Abstract

pub_date

2015-10-26 00:00:00

pages

15484

issn

2045-2322

pii

srep15484

journal_volume

5

pub_type

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