Ezh2 is involved in radial neuronal migration through regulating Reelin expression in cerebral cortex.

Abstract:

:Radial migration of pyramidal neurons is an important event during the development of cerebral cortex. Neurons experience series of morphological and directional transitions to get to their final laminar positions. Here we report that the histone methyltransferase enhancer of zest homolog 2 (Ezh2) is involved in the regulation of cortical radial migration. We show that Ezh2 knockdown leads to disturbed neuronal orientation, which results in the impairment of radial migration. Further results reveal that this migration deficiency may be due to the derepression of Reelin transcription in the migrating neurons. Our study provides evidence that epigenetic regulation of Reelin by Ezh2 maintains appropriate Reelin expression pattern to fulfill proper orientation of migrating neurons.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhao L,Li J,Ma Y,Wang J,Pan W,Gao K,Zhang Z,Lu T,Ruan Y,Yue W,Zhao S,Wang L,Zhang D

doi

10.1038/srep15484

subject

Has Abstract

pub_date

2015-10-26 00:00:00

pages

15484

issn

2045-2322

pii

srep15484

journal_volume

5

pub_type

杂志文章
  • Intraventricular Medium B Treatment Benefits an Ischemic Stroke Rodent Model via Enhancement of Neurogenesis and Anti-apoptosis.

    abstract::Enhancement of endogenous neurogenesis after ischemic stroke may improve functional recovery. We previously demonstrated that medium B, which is a combination with epidermal growth factor (EGF) and fibronectin, can promote neural stem/progenitor cell (NSPC) proliferation and migration. Here, we showed that medium B pr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63598-0

    authors: Chen YA,Tsai YC,Chen YD,Liu DZ,Young TH,Tsai LK

    更新日期:2020-04-20 00:00:00

  • Uniaxial compression testing and Cauchy stress modeling to design anatomical silicone replicas.

    abstract::Anatomically realistic organ replicas or phantoms allow for accurate studies and reproducible research. To recreate a human kidney, mimicry of the elastic properties of the human kidney is crucial. However, none of the related work addressed the design and development of a kidney phantom using only silicone as materia...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68886-3

    authors: Hattab G,Ahlfeld T,Klimova A,Koepp A,Schuerer M,Speidel S

    更新日期:2020-07-16 00:00:00

  • TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness.

    abstract::Here we report exquisitely distinct material properties of primary vascular smooth muscle (VSM) cells isolated from the thoracic aorta of adult (8 months) vs. aged (30 months) F344XBN rats. Individual VSM cells derived from the aged animals showed a tense internal network of the actin cytoskeleton (CSK), exhibiting in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20763-w

    authors: Zhu W,Kim BC,Wang M,Huang J,Isak A,Bexiga NM,Monticone R,Ha T,Lakatta EG,An SS

    更新日期:2018-02-08 00:00:00

  • Two-Dimensional Brain Microtubule Structures Behave as Memristive Devices.

    abstract::Microtubules (MTs) are cytoskeletal structures that play a central role in a variety of cell functions including cell division and cargo transfer. MTs are also nonlinear electrical transmission lines that produce and conduct electrical oscillations elicited by changes in either electric field and/or ionic gradients. T...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48677-1

    authors: Cantero MDR,Perez PL,Scarinci N,Cantiello HF

    更新日期:2019-08-27 00:00:00

  • Detection of Cronobacter sakazakii in powdered infant formula using an immunoliposome-based immunomagnetic concentration and separation assay.

    abstract::This study aimed to optimize the applicability of an immunoliposome-based immunomagnetic concentration and separation assay to facilitate rapid detection of Cronobacter sakazakii in powdered infant formula (PIF). To determine the detection limit, specificity, and pre-enrichment incubation time (0, 4, 6, and 8 h), assa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34721

    authors: Shukla S,Lee G,Song X,Park JH,Cho H,Lee EJ,Kim M

    更新日期:2016-10-10 00:00:00

  • Low-temperature remote plasma enhanced atomic layer deposition of ZrO2/zircone nanolaminate film for efficient encapsulation of flexible organic light-emitting diodes.

    abstract::Encapsulation is essential to protect the air-sensitive components of organic light-emitting diodes (OLEDs) such as active layers and cathode electrodes. In this study, hybrid zirconium inorganic/organic nanolaminates were fabricated using remote plasma enhanced atomic layer deposition (PEALD) and molecular layer depo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40061

    authors: Chen Z,Wang H,Wang X,Chen P,Liu Y,Zhao H,Zhao Y,Duan Y

    更新日期:2017-01-06 00:00:00

  • Decreased peripheral arterial volume distensibility in patients with branch retinal vein occlusion in comparison with normal subjects.

    abstract::This study aimed to quantify arterial volume distensibility in patients with branch retinal vein occlusion (BRVO) in comparison with normal subjects and to investigate factors associated with their differences. 40 normal subjects and 30 BRVO patients were studied. Brachial-ankle pulse wave velocity (baPWV) was measure...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06685

    authors: Chen Z,Mao L,Liu C,Blake JR,Zheng D

    更新日期:2014-10-20 00:00:00

  • Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin.

    abstract::Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46060

    authors: Xu Y,Wang S,Chan HF,Lu H,Lin Z,He C,Chen M

    更新日期:2017-04-24 00:00:00

  • Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.

    abstract::Fetal cardiomyocytes actively proliferate to form the primitive heart in utero in mammals, but they stop dividing shortly after birth. The identification of essential molecules maintaining this active cardiomyocyte proliferation is indispensable for potential adult heart regeneration. A recent study has shown that thi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04823-1

    authors: Hashimoto K,Kodama A,Honda T,Hanashima A,Ujihara Y,Murayama T,Nishimatsu SI,Mohri S

    更新日期:2017-06-30 00:00:00

  • Simulating thoughts to measure and study internal attention in mental health.

    abstract::Our mind's eye and the role of internal attention in mental life and suffering has intrigued scholars for centuries. Yet, experimental study of internal attention has been elusive due to our limited capacity to control the timing and content of internal stimuli. We thus developed the Simulated Thoughts Paradigm (STP) ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81756-w

    authors: Amir I,Ruimi L,Bernstein A

    更新日期:2021-01-26 00:00:00

  • M2BP inhibits HIV-1 virion production in a vimentin filaments-dependent manner.

    abstract::M2BP (also called 90K) is an interferon-stimulated gene product that is upregulated in HIV-1 infection. A recent study revealed that M2BP reduces the infectivity of HIV-1 by inhibiting the processing of the viral envelope protein. Here we report that in addition to reducing viral infectivity, M2BP inhibits HIV-1 virio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32736

    authors: Wang Q,Zhang X,Han Y,Wang X,Gao G

    更新日期:2016-09-08 00:00:00

  • Denoising of Aligned Genomic Data.

    abstract::Noise in genomic sequencing data is known to have effects on various stages of genomic data analysis pipelines. Variant identification is an important step of many of these pipelines, and is increasingly being used in clinical settings to aid medical practices. We propose a denoising method, dubbed SAMDUDE, which oper...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51418-z

    authors: Fischer-Hwang I,Ochoa I,Weissman T,Hernaez M

    更新日期:2019-10-21 00:00:00

  • Cadherin 23-C Regulates Microtubule Networks by Modifying CAMSAP3's Function.

    abstract::Cadherin-related 23 (CDH23) is an adhesive protein important for hearing and vision, while CAMSAP3/Marshalin is a microtubule (MT) minus-end binding protein that regulates MT networks. Although both CDH23 and CAMSAP3/Marshalin are expressed in the organ of Corti, and carry several protein-protein interaction domains, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28706

    authors: Takahashi S,Mui VJ,Rosenberg SK,Homma K,Cheatham MA,Zheng J

    更新日期:2016-06-28 00:00:00

  • Electroluminescence from μLED without external charge injection.

    abstract::Stable electroluminescence from micro-pixelated light-emitting diode (μLED) occurs when electrons and holes are continuously injected from external electrodes. Different from the general recognition, in this work, μLED works in an operation mode, namely, non-electrical contact and non-carrier injection mode, and can b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65092-z

    authors: Wang K,Liu Y,Wu C,Li D,Lv S,Zhang Y,Zhou X,Guo T

    更新日期:2020-05-15 00:00:00

  • Allocation of photosynthesized carbon in an intensively farmed winter wheat-soil system as revealed by 14CO2 pulse labelling.

    abstract::Understanding the rhizodeposited carbon (C) dynamics of winter wheat (Triticum aestivum L.), is crucial for soil fertility and C sequestration. Pot-grown winter wheat was pulse labelled with 14CO2 at the key growth stages. 14C in the shoots, roots and soil was measured at 5 or 2 days after 14C-labelling (DAL 5/2) at e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21547-y

    authors: Sun Z,Chen Q,Han X,Bol R,Qu B,Meng F

    更新日期:2018-02-16 00:00:00

  • Synergistic suppression of autoimmune arthritis through concurrent treatment with tolerogenic DC and MSC.

    abstract::Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulato...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43188

    authors: Li R,Zhang Y,Zheng X,Peng S,Yuan K,Zhang X,Min W

    更新日期:2017-02-23 00:00:00

  • Selection and Validation of Reference Genes for Gene Expression Studies in Codonopsis pilosula Based on Transcriptome Sequence Data.

    abstract::Relative gene expression analyses by RT-qPCR (reverse transcription-quantitative PCR) are highly dependent on the reference genes in normalizing the expression data of target genes. Therefore, inappropriate endogenous control genes will lead to inaccurate target gene expression profiles, and the selection and validati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58328-5

    authors: Liang L,He Z,Yu H,Wang E,Zhang X,Zhang B,Zhang C,Liang Z

    更新日期:2020-01-28 00:00:00

  • Author Correction: Common neural value representations of hedonic and utilitarian products in the ventral striatum: An fMRI study.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-58293-z

    authors: Motoki K,Sugiura M,Kawashima R

    更新日期:2020-01-24 00:00:00

  • Endothelial Cell-derived Extracellular Vesicles Size-dependently Exert Procoagulant Activity Detected by Thromboelastometry.

    abstract::Endothelial cells (ECs) are major modulators of hemostasis by expressing and releasing pro- and anticoagulant mediators into the circulation. Previous studies showed that cultured ECs release procoagulant mediators into cell culture supernatants as evidenced by the reduction of viscoelastic clotting time. This effect ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03159-0

    authors: Holnthoner W,Bonstingl C,Hromada C,Muehleder S,Zipperle J,Stojkovic S,Redl H,Wojta J,Schöchl H,Grillari J,Weilner S,Schlimp CJ

    更新日期:2017-06-16 00:00:00

  • A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis.

    abstract::Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. T...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29011-7

    authors: Kou I,Watanabe K,Takahashi Y,Momozawa Y,Khanshour A,Grauers A,Zhou H,Liu G,Fan YH,Takeda K,Ogura Y,Zhou T,Iwasaki Y,Kubo M,Wu Z,Matsumoto M,Japan Scoliosis Clinical Research Group (JSCRG).,Texas Scottish Rite Hospital f

    更新日期:2018-08-01 00:00:00

  • A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain.

    abstract::Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. One of the characteristic features of some tumour types is that their fast growth leads to deficient ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43618-4

    authors: Iglesias P,Penas C,Barral-Cagiao L,Pazos E,Costoya JA

    更新日期:2019-05-08 00:00:00

  • Landau-Zener-Stückelberg Interferometry for Majorana Qubit.

    abstract::Stimulated by a recent experiment observing successfully two superconducting states with even- and odd-number of electrons in a nanowire topological superconductor as expected from the existence of two end Majorana quasiparticles (MQs) [Albrecht et al., Nature 531, 206 (2016)], we propose a way to manipulate Majorana ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26324-5

    authors: Wang Z,Huang WC,Liang QF,Hu X

    更新日期:2018-05-21 00:00:00

  • Toll like receptor7 polymorphisms in relation to disease susceptibility and progression in Chinese patients with chronic HBV infection.

    abstract::Toll-like receptors (TLRs) play a key role in innate and adaptive immunity, protecting the host from viral pathogens. We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults. Blood samples were taken from 612 patients with confirmed...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12698-5

    authors: Zhu J,Zhang T,Cao L,Li A,Zheng K,Zhang N,Su B,Chen Z,Chen N,Wu H,He Q

    更新日期:2017-09-29 00:00:00

  • Magnetic anisotropy, unusual hysteresis and putative "up-up-down" magnetic structure in EuTAl4Si2 (T = Rh and Ir).

    abstract::We present detailed investigations on single crystals of quaternary EuRhAl4Si2 and EuIrAl4Si2. The two compounds order antiferromagnetically at TN1 = 11.7 and 14.7 K, respectively, each undergoing two magnetic transitions. The magnetic properties in the ordered state present a large anisotropy despite Eu(2+)being an S...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12021

    authors: Maurya A,Thamizhavel A,Dhar SK,Bonville P

    更新日期:2015-07-09 00:00:00

  • Publisher Correction: Hyperpolarized [1-13C]-acetate Renal Metabolic Clearance Rate Mapping.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-29057-7

    authors: Mikkelsen EFR,Mariager CØ,Nørlinger T,Qi H,Schulte RF,Jakobsen S,Frøkiær J,Pedersen M,Stødkilde-Jørgensen H,Laustsen C

    更新日期:2018-07-20 00:00:00

  • A jumping shape memory alloy under heat.

    abstract::Shape memory alloys are typical temperature-sensitive metallic functional materials due to superelasticity and shape recovery characteristics. The conventional shape memory effect involves the formation and deformation of thermally induced martensite and its reverse transformation. The shape recovery process usually t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21754

    authors: Yang S,Omori T,Wang C,Liu Y,Nagasako M,Ruan J,Kainuma R,Ishida K,Liu X

    更新日期:2016-02-16 00:00:00

  • Topology of chromosome centromeres in human sperm nuclei with high levels of DNA damage.

    abstract::Several studies have shown that the 'poor' sperm DNA quality appears to be an important factor affecting male reproductive ability. In the case of sperm cells from males with the correct somatic karyotype but with deficient spermatogenesis, resulting in a high degree of sperm DNA fragmentation, we observed changes in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31614

    authors: Wiland E,Fraczek M,Olszewska M,Kurpisz M

    更新日期:2016-08-25 00:00:00

  • Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF.

    abstract::Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair. However, MSCs grafting present disadvantages, such as, a high number of cells required for transplantation and low survival rate when transplanted ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03592-1

    authors: Martins LF,Costa RO,Pedro JR,Aguiar P,Serra SC,Teixeira FG,Sousa N,Salgado AJ,Almeida RD

    更新日期:2017-06-23 00:00:00

  • Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection.

    abstract::The potential for epigenetic changes in host cells following microbial infection has been widely suggested, but few examples have been reported. We assessed genome-wide patterns of DNA methylation in human macrophage-like U937 cells following infection with Burkholderia pseudomallei, an intracellular bacterial pathoge...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30861

    authors: Cizmeci D,Dempster EL,Champion OL,Wagley S,Akman OE,Prior JL,Soyer OS,Mill J,Titball RW

    更新日期:2016-08-03 00:00:00

  • Morphology control of exciton fine structure in polar and nonpolar zinc sulfide nanorods.

    abstract::Electron-hole exchange interaction in semiconductor quantum dots (QDs) splits the band-edge exciton manifold into optically active ("bright") and passive ("dark") states, leading to a complicated exciton fine structure. In the present work, we resolve by atomistic million-atom many-body pseudopotential calculations th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09812-y

    authors: Baskoutas S,Zeng Z,Garoufalis CS,Bester G

    更新日期:2017-08-24 00:00:00