Abstract:
:Postmortem diagnosis of cantharidin-induced myocardial injury and postmortem interval estimation (PMI) are the challenges in forensic science. Cardiac biomarkers play an important role in the prediction and diagnosis of myocardial injury and can be used to determine the PMI. Based on the evidence, we aimed to explore the biomarkers which may be used for the postmortem diagnosis of cantharidin-induced myocardial injury and PMI estimation using the study of the proteins expression of TN-T, VEGF and HIF-1α by ELISA. Results of this study suggested that postmortem pathological changes were difficult to identify due to the autolysis of myocardium 72 h after death in cantharidin poisoning group. The plasma levels of TN-T and HIF-1α/TN-T are cardiac biomarkers with higher diagnostic accuracy for postmortem diagnosis of cantharidin-induced myocardial injury, VEGF/HIF-1α promises to be a biomarker for PMI estimation. Further studies are needed to verify these biomarkers, based on population, for being a useful tool in postmortem diagnosis of cantharidin-induced myocardial injury and PMI estimation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang Y,Yu Y,Zhang J,Guan C,Liu L,Ren Ldoi
10.1038/s41598-020-69118-4subject
Has Abstractpub_date
2020-07-21 00:00:00pages
12069issue
1issn
2045-2322pii
10.1038/s41598-020-69118-4journal_volume
10pub_type
杂志文章abstract::The yield of pepper plants (Capsicum spp.) is their most important trait and is affected by the flower number and flowering time. Capsicum annuum produces a single flower per node and has an early flowering habit. By contrast, Capsicum chinense yields multiple flowers per node and has a late flowering character. Howev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38370-0
更新日期:2019-01-31 00:00:00
abstract::Three kinds of Al-TiO2 samples and pure TiO2 samples were synthesized via a modified polyacrylamide gel route using different aluminum salts, including Al2(SO4)3∙18H2O, AlCl3, and Al(NO3)3∙9H2O under identical conditions. The influence of different aluminum salts on the phase purity, morphologies, thermal stability of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08216-2
更新日期:2017-08-14 00:00:00
abstract::Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanoma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04611
更新日期:2014-04-09 00:00:00
abstract::Chromosome segment substitution lines (CSSLs) are useful tools for precise mapping of quantitative trait loci (QTLs) and the evaluation of gene action and interaction in inter-specific crosses. In this study, a set of 90 back cross lines at BC2F8 generation derived from Swarna x Oryza nivara IRGC81832 was evaluated fo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64300-0
更新日期:2020-05-08 00:00:00
abstract::Kabuki Syndrome (KS) is a rare disorder characterized by distinctive facial features, short stature, skeletal abnormalities, and neurodevelopmental deficits. Previously, we showed that loss of function of RAP1A, a RAF1 regulator, can activate the RAS/MAPK pathway and cause KS, an observation recapitulated in other gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28709-y
更新日期:2018-07-17 00:00:00
abstract::Cervical oesophageal cancer (CEC) is a relatively uncommon malignancy. The biological behaviour and treatment have not been well studied. This retrospective study reviewed the clinicopathological features of 28 patients with CEC who underwent surgical resection to investigate the biological behaviour, treatment and pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03593-0
更新日期:2017-06-12 00:00:00
abstract::Plasma free amino acid (PFAA) profile is highlighted in its association with visceral obesity and hyperinsulinemia, and future diabetes. Indeed PFAA profiling potentially can evaluate individuals' future risks of developing lifestyle-related diseases, in addition to diabetes. However, few studies have been performed e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11918
更新日期:2015-07-09 00:00:00
abstract::Extracellular vesicles (EVs) are an important class of membrane-bound structures that have been widely investigated for their roles in intercellular communication in the contexts of tumor progression, vascular function, immunity and regenerative medicine. Much of the current knowledge on the functions of EVs pertains ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44021-9
更新日期:2019-05-17 00:00:00
abstract::In humans, stress can be contagiously transmitted via chemosignals on a subconscious level. This study investigates how pregnancy affects neural responses to anxiety chemosignals. Using cotton pads, 28 men donated axillary sweat immediately before an academic examination (anxiety sweat) and during ergometer training (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07985-0
更新日期:2017-08-23 00:00:00
abstract::Fluorescence-activated cell sorting (FACS) applying flow cytometry to separate cells on a molecular basis is a widespread method. We demonstrate that both fluorescent and unlabeled live cells in a Petri dish observed with a microscope can be automatically recognized by computer vision and picked up by a computer-contr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01088
更新日期:2013-01-01 00:00:00
abstract::We report an effective and rare-earth free light conversion material synthesized via a facile fabrication route, in which organic fluorescent dyes, i.e. Rhodamine B (RhB) and fluorescein isothiocyanate (FITC) are embedded into activated boron nitride (αBN) to form a composite phosphor. The composite phosphor shows hig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08492
更新日期:2015-02-16 00:00:00
abstract::Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by findings that perio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44674-6
更新日期:2019-06-10 00:00:00
abstract::Long-term supply of synthetic nitrogen (N) has the potential to affect the soil N processes. This study aimed to (i) establish N response curves to find the best balance between inputs and outputs of N over four ratoons; (ii) use 15N-labeled fertilizer to estimate the N recovery efficiency of fertilizer applied in the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75971-0
更新日期:2020-11-02 00:00:00
abstract::Use of human induced pluripotent stem cells (h-iPSCs) for bone tissue engineering is most appealing, because h-iPSCs are an inexhaustible source of osteocompetent cells. The present study investigated the contribution of undifferentiated h-iPSCs and elucidated aspects of the underlying mechanism(s) of the involvement ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35546-6
更新日期:2018-11-20 00:00:00
abstract::Laparoscopic experience and relevant reports about PD catheter emplacement in Chinese patients are seldom. In this study, we described our experience with advanced laparoscopy for PD catheter implantation in Chinese patients. There were one hundred and thirty Chinese patients accepted advanced laparoscopic approach fo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09596-1
更新日期:2017-08-22 00:00:00
abstract::The new-type electrolysis-integrated ecological floating beds (EEFBs) were set up to study their water removal ability due to the excellent water treatment capacity of electrolysis, this enhanced EEFBs were made of polyethylene filled with biochar substrate and in middle of the substrate placed the Mg-Al alloy served ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64499-y
更新日期:2020-05-06 00:00:00
abstract::Many efforts have been made in the last 30 years to develop more relevant in vitro models to study genotoxic responses of drugs and environmental contaminants. While 2D HepaRG cells are one of the most promising models for liver toxicology, a switch to 3D cultures that integrate both in vivo architecture and cell-cell...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47114-7
更新日期:2019-07-22 00:00:00
abstract::Near infrared (NIR) fluorophores like Pt-porphyrin along with analyte specific enzymes require co-encapsulation in biocompatible and biodegradable carriers in order to be transformed into implantable biosensors for efficient and continuous monitoring of analytes in patients. The main objective of this research is to d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41326-7
更新日期:2019-03-22 00:00:00
abstract::Freshwater reservoirs, in particular tropical ones, are an important source of methane (CH4) to the atmosphere, but current estimates are uncertain. The CH4 emitted from reservoirs is microbially produced in their sediments, but at present, the rate of CH4 formation in reservoir sediments cannot be predicted from sedi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47346-7
更新日期:2019-07-29 00:00:00
abstract::In this study, dye-sensitized solar cells (DSSCs) has been assembled with poly(1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VAc)) gel polymer electrolytes (GPEs) which have been incorporated with binary salt and an ionic liquid. The potential of this combination was studied and reported. The binary salt system GPEs w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27630
更新日期:2016-06-08 00:00:00
abstract::This paper proposes new ways to assess handwriting, a critical skill in any child's school journey. Traditionally, a pen and paper test called the BHK test (Concise Evaluation Scale for Children's Handwriting) is used to assess children's handwriting in French-speaking countries. Any child with a BHK score above a cer...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60011-8
更新日期:2020-02-21 00:00:00
abstract::Networks in nature are often formed within a spatial domain in a dynamical manner, gaining links and nodes as they develop over time. Motivated by the growth and development of neuronal networks, we propose a class of spatially-based growing network models and investigate the resulting statistical network properties a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07047
更新日期:2014-11-14 00:00:00
abstract::We have purified the mammalian synaptophysin/synaptobrevin (SYP/VAMP2) complex to homogeneity in the presence of cholesterol and determined the 3D EM structure by single particle reconstruction. The structure reveals that SYP and VAMP2 assemble into a hexameric ring wherein 6 SYP molecules bind 6 VAMP2 dimers. Using t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13659
更新日期:2015-09-03 00:00:00
abstract::SNPs may restrict cell detoxification activity and be a potential risk factor for cancer chemosensitivity. We evaluated the predictive value of these polymorphisms on the sensitivity of bladder cancer patients to epirubicin and mitomycin chemotherapy instillation as well as their toxicities. SNPs were analyzed by TaqM...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14000
更新日期:2015-09-10 00:00:00
abstract::The Gulf of California, Mexico is home to many cetacean species, including a presumed resident population of fin whales, Balaenoptera physalus. Past studies reported very low levels of genetic diversity among Gulf of California fin whales and a significant level of genetic differentiation from con-specifics in the eas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48700-5
更新日期:2019-08-27 00:00:00
abstract::Flotation of small solid objects and liquid droplets on water is critical to natural and industrial activities. This paper reports the floating mechanism of liquid marbles, or liquid droplets coated with hydrophobic microparticles. We used X-ray computed tomography (XCT) to acquire cross-sectional images of the floati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21777
更新日期:2016-02-23 00:00:00
abstract::Heat shock protein 90 (HSP90) inhibition is an attractive strategy for cancer treatment. Several HSP90 inhibitors have shown promising effects in clinical oncology trials. However, little is known about HSP90 inhibition-mediated bladder cancer therapy. Here, we report a quantitative proteomic study that evaluates alte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00143-6
更新日期:2017-03-15 00:00:00
abstract::Symbiodinium is a dinoflagellate that plays an important role in the physiology of the symbiotic relationships of Cnidarians such as corals and sea anemones. However, it is very difficult to cultivate free-living dinoflagellates after being isolated from the host, as they are very sensitive to environmental changes. H...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15353
更新日期:2015-10-20 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60918-2
更新日期:2020-02-27 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-31948-8
更新日期:2018-09-12 00:00:00