Plasma Free Amino Acid Profiles Predict Four-Year Risk of Developing Diabetes, Metabolic Syndrome, Dyslipidemia, and Hypertension in Japanese Population.

abstract：:Surface defect of nanomaterials is an important physical parameter which significantly influences their physical and chemical performances. In this work, high concentration of surface oxygen vancancies (SOVs) are successfully introduced on {001} facets exposed BiOBr nanosheets via a simple surface modification using p...

journal_title：Scientific reports

authors： Wang XJ,Zhao Y,Li FT,Dou LJ,Li YP,Zhao J,Hao YJ

更新日期：2016-04-26 00:00:00

abstract：:The potential energy profile of an ideal binary switch is a symmetric double well. Switching between the wells without energy dissipation requires time-modulating the height of the potential barrier separating the wells and tilting the profile towards the desired well at the precise juncture when the barrier disappear...

journal_title：Scientific reports

authors： Fashami MS,Atulasimha J,Bandyopadhyay S

更新日期：2013-11-13 00:00:00

abstract：:Pyriform sinus fistula (PSF) is a rare congenital entity. We hypothesized that clinical features, diagnosis and treatment may differ between newborns and children. 190 patients diagnosed with PSF were divided into two groups: neonatal (n = 15) and childhood (n = 175). The medical records including demographic and clin...

journal_title：Scientific reports

authors： Sheng Q,Lv Z,Xu W,Liu J

更新日期：2019-12-06 00:00:00

abstract：:Biofuel cells that generate electricity from renewable fuels, such as carbohydrates, must be reusable through repeated refuelling, should these devices be used in consumer electronics. We demonstrate the stable generation of electricity from a glucose-powered mediated biofuel cell through multiple refuelling cycles. T...

journal_title：Scientific reports

authors： Fujita S,Yamanoi S,Murata K,Mita H,Samukawa T,Nakagawa T,Sakai H,Tokita Y

更新日期：2014-05-13 00:00:00

abstract：:Accumulating evidence indicates the absence of paternally derived miRNAs, piwiRNAs, and proteins may be one important factor contributing to developmental failure in somatic cell cloned embryos. In the present study, we found microRNA-449b (miR-449b) was highly expressed in sperm. Target gene predictions and experimen...

journal_title：Scientific reports

authors： Wang M,Gao Y,Qu P,Qing S,Qiao F,Zhang Y,Mager J,Wang Y

更新日期：2017-10-17 00:00:00

abstract：:We set out to determine the usability of serum neurofilament light chain (sNfL), serum glial fibrillary acidic protein (sGFAP), and retinal parameters by using optical coherence tomography (OCT) as reliable biomarkers of the progression of oxaliplatin-induced peripheral neuropathy (OIPN). Forty-three patients schedule...

journal_title：Scientific reports

authors： Kim SH,Choi MK,Park NY,Hyun JW,Lee MY,Kim HJ,Jung SK,Cha Y

更新日期：2020-05-14 00:00:00

abstract：:The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, her...

journal_title：Scientific reports

authors： Tóth G,Neumann T,Berthet A,Masliah E,Spencer B,Tao J,Jobling MF,Gardai SJ,Bertoncini CW,Cremades N,Bova M,Ballaron S,Chen XH,Mao W,Nguyen P,Tabios MC,Tambe MA,Rochet JC,Junker HD,Schwizer D,Sekul R,Ott I,Ander

更新日期：2019-11-18 00:00:00

abstract：:Over the history of carbon, it is generally acknowledged that Bernal AB stacking of the sp2 carbon layers is the unique crystalline form of graphite. The universal graphite structure is synthesized at 2,600~3,000 °C and exhibits a micro-polycrystalline feature. In this paper, we provide evidence for a metastable form ...

journal_title：Scientific reports

authors： Lee JK,Kim JG,Hembram KP,Kim YI,Min BK,Park Y,Lee JK,Moon DJ,Lee W,Lee SG,John P

更新日期：2016-12-21 00:00:00

abstract：:Transcriptome diversity in adult neurons is partly mediated by RNA binding proteins (RBPs), including the RBFOX factors. RBFOX3/NeuN, a neuronal maturity marker, is strangely depleted in suprachiasmatic nucleus (SCN) neurons, and may be compensated by a change in Rbfox2 expression. In this study, we found no superfici...

journal_title：Scientific reports

authors： Partridge LMM,Carter DA

更新日期：2017-08-30 00:00:00

abstract：:Breast cancer is the leading cause of cancer death among women worldwide. Like other cancers, mammary carcinoma progression involves acidification of the tumor microenvironment, which is an important factor for cancer detection and treatment strategies. However, the effects of acidity on mammary carcinoma cell morphol...

journal_title：Scientific reports

authors： Ralph ACL,Valadão IC,Cardoso EC,Martins VR,Oliveira LMS,Bevilacqua EMAF,Geraldo MV,Jaeger RG,Goldberg GS,Freitas VM

更新日期：2020-12-15 00:00:00

abstract：:Mitochondrial disorders are among the most prevalent inborn errors of metabolism but largely lack treatments and have poor outcomes. High-fat, low-carbohydrate ketogenic diets (KDs) have shown beneficial effects in mouse models of mitochondrial myopathies, with induction of mitochondrial biogenesis as the suggested ma...

journal_title：Scientific reports

authors： Purhonen J,Rajendran J,Mörgelin M,Uusi-Rauva K,Katayama S,Krjutskov K,Einarsdottir E,Velagapudi V,Kere J,Jauhiainen M,Fellman V,Kallijärvi J

更新日期：2017-04-19 00:00:00

abstract：:sp-Hybridized carbon atomic wires are appealing systems with large property tunability. In particular, their electronic properties are intimately related to length, structure, and type of functional end-groups as well as to other effects such as the intermolecular charge transfer with metal nanoparticles. Here, by a c...

journal_title：Scientific reports

authors： Milani A,Barbieri V,Facibeni A,Russo V,Li Bassi A,Lucotti A,Tommasini M,Tzirakis MD,Diederich F,Casari CS

更新日期：2019-02-07 00:00:00

abstract：:House dust mites (HDMs) are one of the major causes of allergies in the world. The group 23 allergen, Der p 23, from Dermatophagoides pteronyssinus, is a major allergen amongst HDM-sensitized individuals. This study aims to determine the specific immunoglobulin E (sIgE) binding frequency and IgE-binding residues of re...

journal_title：Scientific reports

authors： Pang SL,Matta SA,Sio YY,Ng YT,Say YH,Ng CL,Chew FT

更新日期：2021-01-13 00:00:00

abstract：:High-throughput screening facilities do not generally support biosafety level 3 organisms such as Mycobacterium tuberculosis. To discover not only antibacterials, but also virulence inhibitors with either bacterial or host cell targets, an assay monitoring lung fibroblast survival upon infection was developed and opti...

journal_title：Scientific reports

authors： Tükenmez H,Edström I,Ummanni R,Fick SB,Sundin C,Elofsson M,Larsson C

更新日期：2019-01-10 00:00:00

abstract：:Vapor condensation is routinely used as an effective means of transferring heat or separating fluids. Dropwise condensation, where discrete droplets form on the condenser surface, offers a potential improvement in heat transfer of up to an order of magnitude compared to filmwise condensation, where a liquid film cover...

journal_title：Scientific reports

authors： Preston DJ,Lu Z,Song Y,Zhao Y,Wilke KL,Antao DS,Louis M,Wang EN

更新日期：2018-01-11 00:00:00

abstract：:In this study, membrane filtration tests showed that the membrane rejection degree of difloxacin hydrochloride (DFHC) increased significantly in the presence of Suwannee River DOM or Aldrich humic acid (2-10 mg-C/L). Titration experiments showed that the excitation and emission of Peak R belonging to DFHC exhibited bl...

journal_title：Scientific reports

authors： Liang S,Lu L,Meng F

更新日期：2017-07-14 00:00:00

abstract：:We have sequenced the genome of the largest freshwater fish species of the world, the arapaima. Analysis of gene family dynamics and signatures of positive selection identified genes involved in the specific adaptations and unique features of this iconic species, in particular it's large size and fast growth. Genome s...

journal_title：Scientific reports

authors： Du K,Wuertz S,Adolfi M,Kneitz S,Stöck M,Oliveira M,Nóbrega R,Ormanns J,Kloas W,Feron R,Klopp C,Parrinello H,Journot L,He S,Postlethwait J,Meyer A,Guiguen Y,Schartl M

更新日期：2019-03-28 00:00:00

abstract：:The maternal environment can influence the intensity of seed dormancy and thus seasonal germination timing and post-germination life history traits. We tested the hypotheses that germination season influences phenotypic expression of post-germination life history traits in the cold desert annual Isatis violascens and ...

journal_title：Scientific reports

authors： Lu JJ,Tan DY,Baskin CC,Baskin JM

更新日期：2016-04-27 00:00:00

abstract：:Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated. Makorin-2 (Mkrn2) is an evolutionarily conserved gene whose biological functions are not fully known. We developed an Mrkn2 knockout mouse model to study t...

journal_title：Scientific reports

authors： Qian X,Wang L,Zheng B,Shi ZM,Ge X,Jiang CF,Qian YC,Li DM,Li W,Liu X,Yin Y,Zheng JT,Shen H,Wang M,Guo XJ,He J,Lin M,Liu LZ,Sha JH,Jiang BH

更新日期：2016-12-23 00:00:00

abstract：:Male Wistar rats were exposed to herbicide, pendimethalin (PND) at varying oral doses of 62.5, 125 and 250 mg/kg b.w. for 14 days. Toxiological effects were assessed in terms of oxidative stress, DNA damage, histopathological alterations and induction of anti-inflammatory and apoptotic responses linked Bax, Bcl-2, IFN...

journal_title：Scientific reports

authors： Ahmad MI,Zafeer MF,Javed M,Ahmad M

更新日期：2018-11-20 00:00:00

abstract：:Gamma radiation is a commonly used adjuvant treatment for abdominally localized cancer. Since its therapeutic potential is limited due to gastrointestinal (GI) syndrome, elucidation of the regenerative response following radiation-induced gut injury is needed to develop a preventive treatment. Previously, we showed th...

journal_title：Scientific reports

authors： Orzechowska EJ,Katano T,Bialkowska AB,Yang VW

更新日期：2020-10-27 00:00:00

abstract：:Dissolved organic carbon (DOC) concentrations and water colour are increasing in many inland waters across northern Europe and northeastern North America. This inland-water "browning" has profound physical, chemical and biological repercussions for aquatic ecosystems affecting water quality, biological community struc...

journal_title：Scientific reports

authors： Meyer-Jacob C,Michelutti N,Paterson AM,Cumming BF,Keller WB,Smol JP

更新日期：2019-11-13 00:00:00

abstract：:Targeting embryonic stem cells (ESCs) is important for ESC labeling, drug delivery and cell fate control. In this study, we identified twenty-two phage clones that bind specifically to the hESC cell line X-01, which was derived from human blastocysts of Chinese origin. One phage (H178), which displays the sequence VGG...

journal_title：Scientific reports

authors： Zhao W,Jin L,Yuan H,Tan Z,Zhou C,Li LS,Ma L

更新日期：2013-11-05 00:00:00

abstract：:In neuroblastoma (NB), one of the most common paediatric solid tumours, activation of anaplastic lymphoma kinase (ALK) is often associated with poor outcomes. Although genetic studies have identified copy number alteration and nonsynonymous mutations of ALK, the regulatory mechanism of ALK signalling at protein levels...

journal_title：Scientific reports

authors： Satoh S,Takatori A,Ogura A,Kohashi K,Souzaki R,Kinoshita Y,Taguchi T,Hossain MS,Ohira M,Nakamura Y,Nakagawara A

更新日期：2016-09-08 00:00:00

abstract：:Electroencephalographic hyperscanning was used to investigate interbrain synchronization patterns in dyads of participants interacting through speech. Results show that brain oscillations are synchronized between listener and speaker during oral narratives. This interpersonal synchronization is mediated in part by a l...

journal_title：Scientific reports

authors： Pérez A,Carreiras M,Duñabeitia JA

更新日期：2017-06-23 00:00:00

abstract：:The Fenton-like activity of nanoceria has attracted intensive attention for wastewater treatment in recent years. During the Fenton-like reaction, the adsorption of organic pollutants on catalyst surface plays a key role in their degradation. In this work, the adsorption-degradation of methylene blue (MB) and Congo re...

journal_title：Scientific reports

authors： Wei X,Wang Y,Feng Y,Xie X,Li X,Yang S

更新日期：2019-03-21 00:00:00

abstract：:While is widely acknowledged that nonmuscle myosin II (NMMII) enables stress fibers (SFs) to generate traction forces against the extracellular matrix, little is known about how specific NMMII isoforms and functional domains contribute to SF mechanics. Here we combine biophotonic and genetic approaches to address thes...

journal_title：Scientific reports

authors： Chang CW,Kumar S

更新日期：2015-09-04 00:00:00

abstract：:Mountain glaciers form landscapes with U-shaped valleys, roche moutonées and overdeepenings through bedrock erosion. However, little evidence for active glacial carving has been provided particularly for areas above the Equilibrium Line Altitude (ELA) where glaciers originate. This is mainly due to our lack of informa...

journal_title：Scientific reports

authors： Nishiyama R,Ariga A,Ariga T,Lechmann A,Mair D,Pistillo C,Scampoli P,Valla PG,Vladymyrov M,Ereditato A,Schlunegger F

更新日期：2019-05-06 00:00:00

abstract：:Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of this genetic variabi...

journal_title：Scientific reports

authors： Sharma A,Osato N,Liu H,Asthana S,Dakal TC,Ambrosini G,Bucher P,Schmitt I,Wüllner U

更新日期：2019-12-05 00:00:00

abstract：:Climate change significantly affects geographic distribution of plants pests and diseases worldwide. Understanding the influence of future climate change on the suitable areas of Diaphorina citri (Kuwayama) in our country and taking timely countermeasures are crucial for improving the effectiveness of control of pest....

journal_title：Scientific reports

authors： Wang R,Yang H,Wang M,Zhang Z,Huang T,Wen G,Li Q

更新日期：2020-06-08 00:00:00