Abstract:
:Transcriptome diversity in adult neurons is partly mediated by RNA binding proteins (RBPs), including the RBFOX factors. RBFOX3/NeuN, a neuronal maturity marker, is strangely depleted in suprachiasmatic nucleus (SCN) neurons, and may be compensated by a change in Rbfox2 expression. In this study, we found no superficial changes in Rbfox2 expression in the SCN, but mRNA population analysis revealed a distinct SCN transcript profile that includes multiple novel Rbfox2 isoforms. Of eleven isoforms in SCN and cerebral cortex that exhibit exon variation across two protein domains, we found a 3-fold higher abundance of a novel ('-12-40') C-terminal domain (CTD)-variant in the SCN. This isoform embraces an alternative reading frame that imparts a 50% change in CTD protein sequence, and functional impairment of exon 7 exclusion activity in a RBFOX2-target, the L-type calcium channel gene, Cacna1c. We have also demonstrated functional correlates in SCN gene transcripts; inclusion of Cacna1c exon 7, and also exclusion of both NMDA receptor gene Grin1 exon 4, and Enah exon 12, all consistent with a change in SCN RBFOX activity. The demonstrated regional diversity of Rbfox2 in adult brain highlights the functional adaptability of this RBP, enabling neuronal specialization, and potentially responding to disease-related neuronal dysfunction.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Partridge LMM,Carter DAdoi
10.1038/s41598-017-10535-3subject
Has Abstractpub_date
2017-08-30 00:00:00pages
9929issue
1issn
2045-2322pii
10.1038/s41598-017-10535-3journal_volume
7pub_type
杂志文章abstract::The receptor guanylate cyclases (rGCs) in animals serve as sensitive chemoreceptors to detect both chemical and environmental cues. In reproduction, rGCs were shown to be expressed on sperm and serve as receptors for egg-derived sperm-activating and sperm-attracting factors in some echinoderms and mammals. However, sp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51224-7
更新日期:2019-10-10 00:00:00
abstract::The development is reported of an ultra-rapid, point-of-care diagnostic device which harnesses surface acoustic wave (SAW) biochips, to detect HIV in a finger prick of blood within 10 seconds (sample-in-result-out). The disposable quartz biochip, based on microelectronic components found in every consumer smartphone, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11887-6
更新日期:2017-09-20 00:00:00
abstract::Symbiodinium is a dinoflagellate that plays an important role in the physiology of the symbiotic relationships of Cnidarians such as corals and sea anemones. However, it is very difficult to cultivate free-living dinoflagellates after being isolated from the host, as they are very sensitive to environmental changes. H...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15353
更新日期:2015-10-20 00:00:00
abstract::Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening acute inflammatory vesiculobullous reactions of the skin and mucous membranes. These severe cutaneous drug reactions are known to be caused by inciting drugs and infectious agents. Previously, we have reported the association of H...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52619-2
更新日期:2019-11-07 00:00:00
abstract::In optics, when polychromatic light is filtered by an optical filter, the monochromaticity of the light can be improved. In this work, we reported that Ag dopant atoms could be used as an optical filter for nanosized Mn:ZnSe quantum dots (QDs). If no Ag doping, aqueous Mn:ZnSe QDs have low monochromaticity due to coex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14817
更新日期:2015-10-08 00:00:00
abstract::The mechanism by which the HIV-1 MPER epitope is recognized by the potent neutralizing antibody 10E8 at membrane interfaces remains poorly understood. To solve this problem, we have optimized a 10E8 peptide epitope and analyzed the structure and binding activities of the antibody in membrane and membrane-like environm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38177
更新日期:2016-12-01 00:00:00
abstract::The simplest and most commonly used acoustic levitator is comprised of a transmitter and an opposing reflecting surface. This type of device, however, is only able to levitate objects along one direction, at distances multiple of half of a wavelength. In this work, we show how a customised reflective acoustic metamate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60978-4
更新日期:2020-03-06 00:00:00
abstract::A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling the biochemical environment immediately surrounding single molecules. Despite substantial progres...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53151-z
更新日期:2019-11-14 00:00:00
abstract::Technological advances have made it possible to examine dental resin composites using 3D nanometer resolution. This investigation aims to characterize existing dental nano-hybrid and micro-hybrid resin composites through comparing and contrasting nano-computed tomography (nano-CT) with micro-CT and high-resolution SEM...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72599-y
更新日期:2020-09-23 00:00:00
abstract::Tissue fibrosis underlies the majority of human mortality to date with close to half of all reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and reputed irreversible once established. Although some preventive options are being reported, therapeutic options are still scarce and in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67514-4
更新日期:2020-06-30 00:00:00
abstract::X-linked severe combined immunodeficiency (SCID-X1) caused by mutations in interleukin 2 receptor gamma (IL2RG) gene threatens the survival of affected boys during the first year of life unless hematopoietic stem cell transplantation is provided. Although viral vector-mediated gene therapy has been successfully perfor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05043
更新日期:2014-05-23 00:00:00
abstract::The potential angiogenic effect of roxarsone, a feed additive widely used to promote animal growth worldwide, was demonstrated recently. We explored the mechanism of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in roxarsone promotion of rat vascular endothelial cells (ECs) and B16F10 mouse xenogr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53870-3
更新日期:2019-11-22 00:00:00
abstract::To develop an effective, safe, and convenient vaccine for the prevention of highly pathogenic avian influenza (HPAI) H5N1, we have constructed a recombinant Bacillus subtilis strain (B.S.-HA) expressing the hemagglutinin (HA) protein. Then we evaluated the immune function in chicken bone marrow derived dendritic cells...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38403
更新日期:2016-12-16 00:00:00
abstract::Agriculture provides livelihood for 65% of Nepal's population contributing for 27% of its GDP. Smallholder farms constitute 60% of farming segment. Distress farming, with inadequate minimum support price, subsidies and inadequate revenue generation force 29% of the general population to be malnourished. Farming system...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67657-4
更新日期:2020-06-29 00:00:00
abstract::Polycrystalline CeGe is investigated by means of DC and AC susceptibility, non-linear DC susceptibility, electrical transport and heat capacity measurements in the low temperature regime. This compound shows two peaks at low magnetic field around TI ~ 10.7 and TII ~ 7.3 K due to antiferromagnetic ordering and subseque...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41565-8
更新日期:2019-03-26 00:00:00
abstract::The bilateral controlled NOT (CNOT) operation plays a key role in standard entanglement purification process, but the CNOT operation may not be the optimal joint operation in the sense that the output entanglement is maximized. In this paper, the CNOT operations in both the Schmidt-projection based entanglement concen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25958
更新日期:2016-05-18 00:00:00
abstract::The prognostic relevance of strokes in different locations is debated. For example, insular strokes have been associated with increased mortality, but this association could reflect their greater severity. In two independent cohorts of patients with supratentorial ischemic stroke (n = 90 and 105), we studied the progn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27883-3
更新日期:2018-06-22 00:00:00
abstract::Crop wild relatives are valuable resources for future genetic improvement. Here, we report the de novo genome assembly of Musa itinerans, a disease-resistant wild banana relative in subtropical China. The assembled genome size was 462.1 Mb, covering 75.2% of the genome (615.2Mb) and containing 32, 456 predicted protei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31586
更新日期:2016-08-17 00:00:00
abstract::Crypt neurons are a third type of olfactory receptor neurons with a highly unusual "one cell type--one receptor" mode of expression, the same receptor being expressed by the entire population of crypt neurons. Attempts to identify the target region(s) of crypt neurons have been inconclusive so far. We report that TrkA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02063
更新日期:2013-01-01 00:00:00
abstract::Automated image analysis of cells and tissues has been an active research field in medical informatics for decades but has recently attracted increased attention due to developments in computer and microscopy hardware and the awareness that scientific and diagnostic pathology require novel approaches to perform object...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00503
更新日期:2012-01-01 00:00:00
abstract::Previous research has shown that neighborhood-level variables such as social deprivation, social fragmentation or rurality are related to suicide risk, but most of these studies have been conducted in the U.S. or northern European countries. The aim of this study was to analyze the spatio-temporal distribution of suic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25268-0
更新日期:2018-04-30 00:00:00
abstract::Current reports on the changes in peripheral blood regulatory T cell (Tregs) to CD4+ T cell ratio in systemic sclerosis (SSc) patients are varied in their conclusions. We therefore performed a meta-analysis to identify the actual change in the proportion of peripheral Tregs in SSc. Three databases, namely EMBASE, ISI ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep43532
更新日期:2017-03-02 00:00:00
abstract::Lightweight metastructures are designed consisting of prismatic tensegrity building blocks which have excellent strength-to-weight ratio and also enable unique compression-torsion coupling. A theoretical model with a coupled axial-torsional stiffness is first developed to study the band structures of the proposed ligh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29816-6
更新日期:2018-07-31 00:00:00
abstract::Targeting micrometer sized metal droplets with near-infrared sub-picosecond laser pulses generates intense stress-confined acoustic waves within the droplet. Spherical focusing amplifies their pressures. The rarefaction wave nucleates cavitation at the center of the droplet, which explosively expands with a repeatable...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-19140-w
更新日期:2018-01-12 00:00:00
abstract::For a high-performance cocatalyst-modified photocatalyst, an effective interfacial separation of photogenerated electron from its corresponding holes and its following reduction reaction at the active sites are highly required. However, it is difficult for a single-component cocatalyst to simultaneously realize the cr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13083
更新日期:2015-08-14 00:00:00
abstract::Many plant essential oils and their terpenoid constituents possess bioactivities including insecticidal activity, and they sometimes act synergistically when mixed. Although several hypotheses for this have been proposed, the underlying mechanism has not been fully elucidated thus far. In the present study, we report ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42432
更新日期:2017-02-09 00:00:00
abstract::A metal-free three component cyclization reaction with amidation is devised for direct synthesis of DFT-designed amido-phenazine derivative bearing noncovalent gluing interactions to fabricate organic nanomaterials. Composition-dependent organic nanoelectronics for nonvolatile memory devices are discovered using mixed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13754-w
更新日期:2017-10-17 00:00:00
abstract::Spin switching of organometallic complexes by ferromagnetic surfaces is an important topic in the area of molecular nanospintronics. Moreover, graphene has been shown as a 2D surface for physisorption of molecular magnets and strain engineering on graphene can tune the spin state of an iron porphyrin (FeP) molecule fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03405
更新日期:2013-12-03 00:00:00
abstract::We have investigated the emission from InGaN/GaN quantum disks grown on the tip of GaN nanorods. The emission at 3.21 eV from the InGaN quantum disk doesn't show a Stark shift, and it is linearly polarized when excited perpendicular to the growth direction. The degree of linear polarization is about 39.3% due to the a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26642-8
更新日期:2018-05-25 00:00:00
abstract::Marek's disease virus (MDV) is a preferred vector in the construction of recombinant vaccines. However, bivalent vaccine based on MDV that confers full protection against both very virulent Marek's and infectious bursal disease virus (IBDV) infections in chickens has not been produced. Here we developed a system utili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39263
更新日期:2016-12-16 00:00:00