Abstract：
:In neuroblastoma (NB), one of the most common paediatric solid tumours, activation of anaplastic lymphoma kinase (ALK) is often associated with poor outcomes. Although genetic studies have identified copy number alteration and nonsynonymous mutations of ALK, the regulatory mechanism of ALK signalling at protein levels is largely elusive. Neuronal leucine-rich repeat 1 (NLRR1) is a type 1 transmembrane protein that is highly expressed in unfavourable NB and potentially influences receptor tyrosine kinase signalling. Here, we showed that NLRR1 and ALK exhibited a mutually exclusive expression pattern in primary NB tissues by immunohistochemistry. Moreover, dorsal root ganglia of Nlrr1+/+ and Nlrr1-/- mice displayed the opposite expression patterns of Nlrr1 and Alk. Of interest, NLRR1 physically interacted with ALK in vitro through its extracellular region. Notably, the NLRR1 ectodomain impaired ALK phosphorylation and proliferation of ALK-mutated NB cells. A newly identified cleavage of the NLRR1 ectodomain also supported NLRR1-mediated ALK signal regulation in trans. Thus, we conclude that NLRR1 appears to be an extracellular negative regulator of ALK signalling in NB and neuronal development. Our findings may be beneficial to comprehend NB heterogeneity and to develop a novel therapy against unfavourable NB.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Satoh S,Takatori A,Ogura A,Kohashi K,Souzaki R,Kinoshita Y,Taguchi T,Hossain MS,Ohira M,Nakamura Y,Nakagawara Adoi
10.1038/srep32682subject
Has Abstractpub_date
2016-09-08 00:00:00pages
32682issn
2045-2322pii
srep32682journal_volume
6pub_type
杂志文章abstract：:Abnormalities in actin cytoskeleton have been linked to Friedreich's ataxia (FRDA), an inherited peripheral neuropathy characterised by an early loss of neurons in dorsal root ganglia (DRG) among other clinical symptoms. Despite all efforts to date, we still do not fully understand the molecular events that contribute...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62050-7
更新日期：2020-03-23 00:00:00
abstract：:The present study aimed to evaluate the accuracy and repeatability of morphological contour interpolation (MCI)-based semiautomatic segmentation method for volumetric measurements of bone grafts around dental implants. Three in vitro (one with a cylinder and two with a geometrically complex form) and four ex vivo mode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71651-1
更新日期：2020-09-10 00:00:00
abstract：:Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53199-x
更新日期：2019-11-28 00:00:00
abstract：:In dentistry, the wet-bonding approach relies on water to maintain demineralized collagen expanded for proper resin infiltration; nevertheless, hydrolytic instability of the resin-dentin interface is inevitable with current bonding techniques. Considering dimethyl sulfoxide's (DMSO) ability to "biomodify" collagen and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34726-8
更新日期：2018-11-15 00:00:00
abstract：:Tumor growth and metastasis are responsible for most cancer patients' deaths. Here, we report that eupolyphaga sinensis walker has an essential role in resisting hepatocellular carcinoma growth and metastasis. Compared with proliferation, colony formation, transwell assay and transplantable tumor in nude mouse in vitr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05518
更新日期：2014-07-01 00:00:00
abstract：:Upregulated Wnt/β-catenin signaling is associated with increased cancer cell resistance and cancer cell-elicited immunosuppression. In non-neoplastic immune cells, upregulated Wnt/β-catenin is, however, associated with either immunosuppression or immunostimulation. Therefore, it is difficult to predict the therapeutic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41182-5
更新日期：2019-03-18 00:00:00
abstract：:In everyday life, people must often determine how much time and effort to allocate to cooperative activities. In the current study, we tested the hypothesis that the perception of others' effort investment in a cooperative activity may elicit a sense of commitment, leading people to allocate more time and effort to th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34096-1
更新日期：2018-10-24 00:00:00
abstract：:Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide database of forest-inv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50323-9
更新日期：2019-09-25 00:00:00
abstract：:Polymer derived ceramic (PDC) composite coatings were deposited on AISI 304 substrates using siloxane based preceramic polymer polymethlysilsquioxane (PMS) and ZrSi2 as active filler or Ag as passive filler. The tribological performance of the composite coatings was evaluated at room temperature and moderately high te...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33441-8
更新日期：2018-10-10 00:00:00
abstract：:An in vitro-transcribed RNA aptamer (trans-RA16) that targets non-small cell lung cancer (NSCLC) was previously identified through in vivo SELEX. Trans-RA16 can specifically target and inhibit human NCI-H460 cells in vitro and xenograft tumors in vivo. Here, in a follow-up study, we obtained a chemically-synthesized v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55280-x
更新日期：2019-12-11 00:00:00
abstract：:Cardiac magnetic resonance (CMR) is becoming the imaging modality of choice in multicenter studies where highly reproducible measurements are necessary. The purpose of this study was to assess the effect of comprehensive initial training on reproducibility of quantitative left ventricular (LV) parameters estimated usi...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-48685-1
更新日期：2019-08-21 00:00:00
abstract：:The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem cells (mEpiSCs), but its function in these cells is unknown. To understand the function of Cdh2 in mEpiSCs, we compared the expression of plurip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14722
更新日期：2015-09-30 00:00:00
abstract：:Conditional genome engineering in the human malaria pathogen Plasmodium falciparum remains highly challenging. Here we describe a strategy for facile and rapid functional analysis of genes using an approach based on the Cre/lox system and tailored for organisms with short and few introns. Our method allows the conditi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21800
更新日期：2016-02-19 00:00:00
abstract：:Practical applications of bacteriophages in medicine and biotechnology induce a great need for technologies of phage purification. None of the popular methods offer solutions for separation of a phage from another similar phage. We used affinity chromatography combined with competitive phage display (i) to purify T4 b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03220
更新日期：2013-11-14 00:00:00
abstract：:When and where animals breed can shape the genetic structure and diversity of animal populations. The importance of drivers of genetic diversity is amplified in island populations that tend to have more delineated gene pools compared to continental populations. Studies of relatedness as a function of the spatial distr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77517-w
更新日期：2020-11-26 00:00:00
abstract：:Modern Computed Tomography (CT) scanners are capable of acquiring contrast dynamics of the whole brain, adding functional to anatomical information. Soft tissue segmentation is important for subsequent applications such as tissue dependent perfusion analysis and automated detection and quantification of cerebral patho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00239-z
更新日期：2017-03-09 00:00:00
abstract：:Sealed-bid auction is an important tool in modern economic especially concerned with networks. However, the bidders still lack the privacy protection in previously proposed sealed-bid auction schemes. In this paper, we focus on how to further protect the privacy of the bidders, especially the non-winning bidders. We f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44030-8
更新日期：2019-05-20 00:00:00
abstract：:Switching magnetizations with femtosecond circularly polarized lasers may have revolutionary impacts on magnetic data storage and relevant applications. Achievements in ferrimagnetic and ferromagnetic materials of various structures strongly imply a general phenomenon of fundamental atom-laser interaction. Rotating an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41294
更新日期：2017-01-24 00:00:00
abstract：:Unprecedented coastal upwelling off the southern coast of the Korean Peninsula was reported during the summer of 2013. The upwelling continued for more than a month after a plunge in upwelling-favourable winds and had serious impacts on fisheries. This is a rare phenomenon, as most coastal upwelling events relax a few...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67785-x
更新日期：2020-07-20 00:00:00
abstract：:There has been a rapid increase in Danish pig herds testing positive for livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA) since the first screening in 2008. Despite a national action plan to control LA-MRSA in the Danish pig population, 88% of pig herds tested positive in a 2016 cross-section...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37075-8
更新日期：2019-01-24 00:00:00
abstract：:Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol to 25-hydroxycholesterol (25-HC). 25-HC has been demonstrated to be involved in the pathogenesis of inflammatory bowel disease. However, the role of CH25H in experimental colitis remains unknown. Dextran sulfate sodium (DSS)-induced coliti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71198-1
更新日期：2020-08-28 00:00:00
abstract：:Saccharomyces cerevisiae is used as a host strain in bioproduction, because of its rapid growth, ease of genetic manipulation, and high reducing capacity. However, the heat produced during the fermentation processes inhibits the biological activities and growth of the yeast cells. We performed whole-genome sequencing ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23157
更新日期：2016-03-17 00:00:00
abstract：:Network analysis is an important tool to analyze the structure of complex systems such as tropical forests. Here, we infer spatial proximity networks in tropical forests by using network science. First, we focus on tree neighborhoods to derive spatial tree networks from forest inventory data. In a second step, we cons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70052-8
更新日期：2020-08-06 00:00:00
abstract：:Kinetic restriction of a thermodynamically favourable equilibrium is a common theme in materials processing. The interfacial instability in systems where rate of material exchange is far greater than the mass transfer through respective bulk phases is of specific interest when tracking the transient interfacial area, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14638-9
更新日期：2017-10-30 00:00:00
abstract：:Annually averaged solar radiation in the McMurdo Dry Valleys, Antarctica has varied by over 20 W m-2 during the past three decades; however, the drivers of this variability are unknown. Because small differences in radiation are important to water availability and ecosystem functioning in polar deserts, determining th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23390-7
更新日期：2018-03-22 00:00:00
abstract：:Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45703-0
更新日期：2019-06-24 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-44364-3
更新日期：2019-06-06 00:00:00
abstract：:Bacterial lipopolysaccharides (LPS) activate the TRPA1 cation channels in sensory neurons, leading to acute pain and inflammation in mice and to aversive behaviors in fruit flies. However, the precise mechanisms underlying this effect remain elusive. Here we assessed the hypothesis that TRPA1 is activated by mechanica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30534-2
更新日期：2018-08-13 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58622-2
更新日期：2020-01-28 00:00:00
abstract：:Methadone maintenance treatment (MMT) can induce impairments in brain function and structure, despite its clinical effectiveness. However, the effect of chronic MMT on brain white matter (WM) is not fully known. Thirty-three MMT patients underwent diffusion tensor imaging (DTI) twice - at the start of the study (Scan1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19662
更新日期：2016-01-22 00:00:00
