The WNT/β-catenin signaling inhibitor XAV939 enhances the elimination of LNCaP and PC-3 prostate cancer cells by prostate cancer patient lymphocytes in vitro.

abstract：:Saccharomyces cerevisiae is a robust host for heterologous protein expression. The efficient expression of cellulases in S. cerevisiae is important for the consolidated bioprocess that directly converts lignocellulose into valuable products. However, heterologous proteins are often N-hyperglycosylated in S. cerevisiae...

journal_title：Scientific reports

authors： Tang H,Wang S,Wang J,Song M,Xu M,Zhang M,Shen Y,Hou J,Bao X

更新日期：2016-05-09 00:00:00

abstract：:The objective of the study was to estimate if altered levels of alpha-synuclein can be detected in tear fluid of patients with Parkinson's disease (PD). Therefore, tear fluid samples of 75 PD patients, 75 control subjects and 31 atypical Parkinsonian patients were collected and analyzed in triplicates using an ultra-s...

journal_title：Scientific reports

authors： Maass F,Rikker S,Dambeck V,Warth C,Tatenhorst L,Csoti I,Schmitz M,Zerr I,Leha A,Bähr M,Lingor P

更新日期：2020-05-22 00:00:00

abstract：:Micron-scale droplets isolated by an immiscible liquid can provide miniaturised reaction vessels which can be manipulated in microfluidic networks, and has seen a rapid growth in development. In many experiments, the precise volume of these microdroplets is a critical parameter which can be influenced by many external...

journal_title：Scientific reports

authors： Crawford DF,Smith CA,Whyte G

更新日期：2017-09-05 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Fujishima K,Wang KM,Palmer JA,Abe N,Nakahigashi K,Endy D,Rothschild LJ

更新日期：2019-04-12 00:00:00

abstract：:Telomerase activation and telomere maintenance are critical for cellular immortalization and transformation. PIN2/TERF1-interacting telomerase inhibitor 1 (PinX1) is a telomerase regulator and the aberrant expression of PinX1 causes telomere shortening. Identifying PinX1-interacting proteins is important for understan...

journal_title：Scientific reports

authors： Cheung DH,Ho ST,Lau KF,Jin R,Wang YN,Kung HF,Huang JJ,Shaw PC

更新日期：2017-03-03 00:00:00

abstract：:The concept of substrate inhibition to prevent its phosphorylation has potential in drug discovery and is envisioned to treat the autoimmune disorder multiple sclerosis (MS). Glia maturation factor-β (GMF-β) Ser83 phosphorylation by protein kinase A (PKA) is pivotal in the activation of GMF-β-p38MAPK-NFκB biochemical ...

journal_title：Scientific reports

authors： Vattathara JJ,Prakash O,Subhramanian S,Satheeshkumar MK,Xavier T,Anil M,Pillai GS,Anandakuttan A,Radhakrishnan S,Sivanarayanan TB,Akk U,Mohan CG,Menon KN

更新日期：2020-03-02 00:00:00

abstract：:Improving the affinity of protein-protein interactions is a challenging problem that is particularly important in the development of antibodies for diagnostic and clinical use. Here, we used structure-based computational methods to optimize the binding affinity of VHNAC1, a single-domain intracellular antibody (intrab...

journal_title：Scientific reports

authors： Mahajan SP,Meksiriporn B,Waraho-Zhmayev D,Weyant KB,Kocer I,Butler DC,Messer A,Escobedo FA,DeLisa MP

更新日期：2018-12-04 00:00:00

abstract：:Neurokinin B (NKB) is a hypothalamic neuropeptide binding preferentially to the neurokinin 3 receptor. Expression of the gene encoding NKB is elevated in postmenopausal women. Furthermore, rodent studies suggest that NKB signalling may mediate menopausal hot flushes. However, the effects of NKB administration on hot f...

journal_title：Scientific reports

authors： Jayasena CN,Comninos AN,Stefanopoulou E,Buckley A,Narayanaswamy S,Izzi-Engbeaya C,Abbara A,Ratnasabapathy R,Mogford J,Ng N,Sarang Z,Ghatei MA,Bloom SR,Hunter MS,Dhillo WS

更新日期：2015-02-16 00:00:00

abstract：:Virtual planning of open cranial vault reconstruction is used to simulate and define an pre-operative plan for craniosynostosis surgery. However, virtual planning techniques are subjective and dependent on the experience and preferences of the surgical team. To develop an objective automated 3D pre-operative planning ...

journal_title：Scientific reports

authors： Tolhuisen ML,de Jong GA,van Damme RJM,van der Heijden F,Delye HHK

更新日期：2018-02-20 00:00:00

abstract：:Recent advances in RNA-seq methodologies from limiting amounts of mRNA have facilitated the characterization of rare cell-types in various biological systems. So far, however, technical variations in these methods have not been adequately characterized, vis-à-vis sensitivity, starting with reduced levels of mRNA. Here...

journal_title：Scientific reports

authors： Bhargava V,Head SR,Ordoukhanian P,Mercola M,Subramaniam S

更新日期：2014-01-14 00:00:00

abstract：:In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria ar...

journal_title：Scientific reports

authors： Rox K,Jansen R,Loof TG,Gillen CM,Bernecker S,Walker MJ,Chhatwal GS,Müller R

更新日期：2017-09-18 00:00:00

abstract：:Trichosporon asahii is a pathogenic fungus that causes deep mycosis in patients with neutropenia. Establishing an experimental animal model for quantitatively evaluating pathogenicity and developing a genetic recombination technology will help to elucidate the infection mechanism of T. asahii and promote the developme...

journal_title：Scientific reports

authors： Matsumoto Y,Yamazaki H,Yamasaki Y,Tateyama Y,Yamada T,Sugita T

更新日期：2020-07-03 00:00:00

abstract：:We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pr...

journal_title：Scientific reports

authors： Basu A,Munir S,Mulaw MA,Singh K,Crisan D,Sindrilaru A,Treiber N,Wlaschek M,Huber-Lang M,Gebhard F,Scharffetter-Kochanek K

更新日期：2018-04-18 00:00:00

abstract：:Lactobacilli are thought to be beneficial for human health, with lactobacilli-associated infections being confined to immune-compromised individuals. However, Lactobacillus fermentum AGR1487 negatively affects barrier integrity in vitro so we hypothesized that it caused a pro-inflammatory response in the host. We comp...

journal_title：Scientific reports

authors： Anderson RC,Ulluwishewa D,Young W,Ryan LJ,Henderson G,Meijerink M,Maier E,Wells JM,Roy NC

更新日期：2016-02-04 00:00:00

abstract：:Qinghai Lake is a major migrating bird breeding site that has experienced several recent highly pathogenic avian influenza virus (HPAIV) epizootics. From 2006 to 2009 we studied Qinghai's wild birds and pikas for evidence of AIV infections. We sampled 941 healthy wild animals and isolated seventeen H7N2 viruses (eight...

journal_title：Scientific reports

authors： Su S,Xing G,Wang J,Li Z,Gu J,Yan L,Lei J,Ji S,Hu B,Gray GC,Yan Y,Zhou J

更新日期：2016-08-24 00:00:00

abstract：:Here, we assessed the sulfated derivative of the microbial polysaccharide gellan gum and derivatives of λ and κ-carrageenans for their ability to inhibit Plasmodium falciparum 3D7 and Dd2 growth and invasion of red blood cells in vitro. Growth inhibition was assessed by means of flow cytometry after a 96-h exposure to...

journal_title：Scientific reports

authors： Recuenco FC,Kobayashi K,Ishiwa A,Enomoto-Rogers Y,Fundador NG,Sugi T,Takemae H,Iwanaga T,Murakoshi F,Gong H,Inomata A,Horimoto T,Iwata T,Kato K

更新日期：2014-04-17 00:00:00

abstract：:Adipose tissue inflammation is a central pathological element that regulates obesity-mediated insulin resistance and type II diabetes. Evidence demonstrates that extracellular signal-regulated kinase (ERK 1/2) activation (i.e. phosphorylation) links tumor necrosis factor α (TNFα) to pro-inflammatory gene expression in...

journal_title：Scientific reports

authors： Habibian JS,Jefic M,Bagchi RA,Lane RH,McKnight RA,McKinsey TA,Morrison RF,Ferguson BS

更新日期：2017-10-10 00:00:00

abstract：:Multiexcitonic transitions and emission of several photons per excitation comprise a very attractive feature of semiconductor quantum dots for optoelectronics applications. However, these higher-order radiative processes are usually quenched in colloidal quantum dots by Auger and other nonradiative decay channels. To ...

journal_title：Scientific reports

authors： Matsuzaki K,Vassant S,Liu HW,Dutschke A,Hoffmann B,Chen X,Christiansen S,Buck MR,Hollingsworth JA,Götzinger S,Sandoghdar V

更新日期：2017-02-14 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic subunit (TERT) and telomerase RNA (TER), contains accessory proteins Est1 and Es...

journal_title：Scientific reports

authors： Shepelev NM,Mariasina SS,Mantsyzov AB,Malyavko AN,Efimov SV,Petrova OA,Rodina EV,Zvereva MI,Dontsova OA,Polshakov VI

更新日期：2020-07-06 00:00:00

abstract：:Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1∆/∆ mice are deaf, Tmc2∆/∆ mice have normal hearing, and double homozygous Tmc1∆/∆; Tmc2∆/∆ mice have deafness and profound vestibular dysfunction. These phenotypes are consistent with their different spatio...

journal_title：Scientific reports

authors： Nakanishi H,Kurima K,Pan B,Wangemann P,Fitzgerald TS,Géléoc GS,Holt JR,Griffith AJ

更新日期：2018-08-14 00:00:00

abstract：:Crops expressing Bacillus thuringiensis (Bt)-derived insecticidal protein genes have been commercially available for over 15 years and are providing significant value to growers. However, there remains the need for alternative insecticidal actives due to emerging insect resistance to certain Bt proteins. A screen of b...

journal_title：Scientific reports

authors： Yalpani N,Altier D,Barry J,Kassa A,Nowatzki TM,Sethi A,Zhao JZ,Diehn S,Crane V,Sandahl G,Guan R,Poland B,Perez Ortega C,Nelson ME,Xie W,Liu L,Wu G

更新日期：2017-06-08 00:00:00

abstract：:We present the design and performance characterization of a Faraday laser directly lasing on the Rb 1529 nm transition (Rb, 5P 3/2 - 4D 5/2) with high stability, narrow spectral linewidth and low cost. This system does not need an additional frequency-stabilized pump laser as a prerequisite to preparing Rb atom from 5...

journal_title：Scientific reports

authors： Chang P,Peng H,Zhang S,Chen Z,Luo B,Chen J,Guo H

更新日期：2017-08-21 00:00:00

abstract：:Social context influences social decisions and outcome processing, partially depending on inter-individual differences. The present study investigated social context-dependent modulation of behavior and feedback processing in the ultimatum game (UG) in relation to inter-individual differences in social anxiety. Thirty...

journal_title：Scientific reports

authors： Peterburs J,Voegler R,Liepelt R,Schulze A,Wilhelm S,Ocklenburg S,Straube T

更新日期：2017-03-09 00:00:00

abstract：:The present work assessed the effects of dietary ratios of essential fatty acids, arachidonic (ARA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), on liver and intestine oxidative status, intestinal histomorphology and gut microbiota of gilthead sea bream. Four isoproteic and isolipidic plant-based diets were...

journal_title：Scientific reports

authors： Magalhães R,Guerreiro I,Santos RA,Coutinho F,Couto A,Serra CR,Olsen RE,Peres H,Oliva-Teles A

更新日期：2020-08-14 00:00:00

abstract：:With the advent of nanotechnology, a variety of nanoarchitectures with varied physicochemical properties have been designed. Owing to the unique characteristics, DNAs have been used as a functional building block for novel nanoarchitecture. In particular, a self-assembly of long DNA molecules via a piece DNA staple ha...

journal_title：Scientific reports

authors： Song IH,Shin SW,Park KS,Lansac Y,Jang YH,Um SH

更新日期：2015-12-04 00:00:00

abstract：:Networks are widely used as a tool for describing diverse real complex systems and have been successfully applied to many fields. The distance between networks is one of the most fundamental concepts for properly classifying real networks, detecting temporal changes in network structures, and effectively predicting th...

journal_title：Scientific reports

authors： Shimada Y,Hirata Y,Ikeguchi T,Aihara K

更新日期：2016-10-11 00:00:00

abstract：:Inhaled corticosteroids (ICSs) are widely prescribed in chronic obstructive pulmonary disease (COPD). However, little is known about predictors of ICSs therapeutic response. To investigate whether the variation in glucocorticoid-induced transcript 1 (GLCCI1) rs37973 is associated with ICS efficacy. A total of 204 clin...

journal_title：Scientific reports

authors： Lei Y,Gao Y,Chen J,Li M,Wu X,Ning Q,Zhao J,Xiong W,Xu Y,Xie J

更新日期：2017-02-10 00:00:00

abstract：:Whether the stress-loading of faults to failure in earthquakes appears to be random or to an extent explainable, given constraints on fault/shear-zone interaction and the build-up and release of stress over many earthquake cycles, is a key question for seismic hazard assessment. Here we investigate earthquake recurren...

journal_title：Scientific reports

authors： Sgambato C,Faure Walker JP,Mildon ZK,Roberts GP

更新日期：2020-07-29 00:00:00

abstract：:Liquid pumping can occur along the outer surface of an electrode under a DC electric field. For biological applications, a better understanding of the ionic solution pumping mechanism is required. Here, we fabricated CNT wire electrodes (CWEs) and tungsten wire electrodes (TWEs) of various diameters to assess an ionic...

journal_title：Scientific reports

authors： Shin JH,Kim GH,Kim I,Jeon H,An T,Lim G

更新日期：2015-07-02 00:00:00

abstract：:Fusarium Head Blight (FHB) caused by Fusarium graminearum pathogens constitutes a major threat to agricultural production because it frequently reduces the yield and quality of the crop. The disease severity is predicted to increase in various regions owing to climate change. Integrated management where biocontrol pla...

journal_title：Scientific reports

authors： Timmusk S,Copolovici D,Copolovici L,Teder T,Nevo E,Behers L

更新日期：2019-01-24 00:00:00